PSMB8-AS1

Summary

PSMB8-AS1 (PSMB8 antisense RNA 1, HGNC:39758) is a long non-coding RNA gene on chromosome 6p21.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:39758
Approved symbol	PSMB8-AS1
Name	PSMB8 antisense RNA 1
Location	6p21.32
Locus type	RNA, long non-coding
Status	Approved
Aliases	XXbac-BPG246D15.8, TAP1-AS1
Ensembl gene	ENSG00000204261
Ensembl biotype	lncRNA
Entrez	100507463
RNAcentral	URS000075D022 — lncRNA, 1498 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 lncRNA, 1 retained_intron

ENST00000412095, ENST00000413039, ENST00000415067, ENST00000429600, ENST00000453426, ENST00000458296, ENST00000666376

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412095 — 2 exons

Exon	Start	End
ENSE00001593042	32844134	32844870
ENSE00001620057	32845418	32845695

Expression profiles

Bgee: expression breadth ubiquitous, 132 present calls, max score 97.56.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.0022 / max 206.8757, expressed in 985 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67178	6.3206	869
67177	0.6816	287

Top tissues by expression

132 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	97.56	gold quality
leukocyte	CL:0000738	96.89	gold quality
monocyte	CL:0000576	96.85	gold quality
spleen	UBERON:0002106	96.78	gold quality
lymph node	UBERON:0000029	95.89	gold quality
vermiform appendix	UBERON:0001154	94.75	gold quality
blood	UBERON:0000178	94.44	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.48	gold quality
small intestine	UBERON:0002108	87.54	gold quality
right lung	UBERON:0002167	86.95	gold quality
bone marrow cell	CL:0002092	86.94	gold quality
mucosa of transverse colon	UBERON:0004991	85.88	gold quality
rectum	UBERON:0001052	85.52	gold quality
upper lobe of left lung	UBERON:0008952	85.46	gold quality
gall bladder	UBERON:0002110	85.41	gold quality
bone marrow	UBERON:0002371	85.01	gold quality
duodenum	UBERON:0002114	84.43	gold quality
omental fat pad	UBERON:0010414	84.29	gold quality
lung	UBERON:0002048	84.21	gold quality
adipose tissue	UBERON:0001013	84.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	83.92	gold quality
apex of heart	UBERON:0002098	83.60	gold quality
transverse colon	UBERON:0001157	83.57	gold quality
smooth muscle tissue	UBERON:0001135	83.27	gold quality
intestine	UBERON:0000160	83.09	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.84	gold quality
tonsil	UBERON:0002372	82.08	gold quality
thoracic mammary gland	UBERON:0005200	82.05	gold quality
colon	UBERON:0001155	81.81	gold quality
myometrium	UBERON:0001296	81.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.73

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Our study suggests that lncRNA PSMB8-AS1 could be a new host factor target for developing antiviral therapy against influenza virus infection. (PMID:30669933)
• PSMB8-AS1 activated by ELK1 promotes cell proliferation in glioma via regulating miR-574-5p/RAB10. (PMID:31812014)
• LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p/STAT1/PD-L1 axis. (PMID:32891166)
• Characterization of Long Non-Coding RNAs in Systemic Sclerosis Monocytes: A Potential Role for PSMB8-AS1 in Altered Cytokine Secretion. (PMID:33922041)
• LncRNA PSMB8-AS1 Instigates Vascular Inflammation to Aggravate Atherosclerosis. (PMID:38084631)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.