PSMG3-AS1

Summary

PSMG3-AS1 (PSMG3 antisense RNA 1, HGNC:22230) is a long non-coding RNA gene on chromosome 7p22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:22230
Approved symbol	PSMG3-AS1
Name	PSMG3 antisense RNA 1
Location	7p22.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	KIAA1908
Ensembl gene	ENSG00000230487
Ensembl biotype	lncRNA
Entrez	114796
RNAcentral	URS000075E4AC — lncRNA, 3873 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 11 lncRNA

ENST00000437621, ENST00000437964, ENST00000457484, ENST00000524978, ENST00000532358, ENST00000533935, ENST00000612019, ENST00000651857, ENST00000685139, ENST00000842067, ENST00000842068

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437621 — 4 exons

Exon	Start	End
ENSE00001608709	1574715	1574863
ENSE00001648554	1584384	1589626
ENSE00001678633	1575787	1575888
ENSE00001765502	1570073	1570279

Expression profiles

Bgee: expression breadth ubiquitous, 182 present calls, max score 81.74.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3888 / max 56.1225, expressed in 1717 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76936	4.6720	1612
76937	1.7168	960

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.74	gold quality
sural nerve	UBERON:0015488	81.37	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.72	gold quality
right uterine tube	UBERON:0001302	80.03	gold quality
secondary oocyte	CL:0000655	77.51	gold quality
anterior cingulate cortex	UBERON:0009835	77.21	gold quality
right adrenal gland	UBERON:0001233	77.11	gold quality
endothelial cell	CL:0000115	76.84	gold quality
tibial nerve	UBERON:0001323	76.83	gold quality
right adrenal gland cortex	UBERON:0035827	76.67	gold quality
adenohypophysis	UBERON:0002196	76.59	gold quality
right frontal lobe	UBERON:0002810	76.36	gold quality
left adrenal gland cortex	UBERON:0035825	76.23	gold quality
left adrenal gland	UBERON:0001234	76.17	gold quality
amygdala	UBERON:0001876	75.82	gold quality
mucosa of transverse colon	UBERON:0004991	75.75	gold quality
apex of heart	UBERON:0002098	75.62	gold quality
pituitary gland	UBERON:0000007	75.43	gold quality
nucleus accumbens	UBERON:0001882	75.36	gold quality
caudate nucleus	UBERON:0001873	75.24	gold quality
adrenal cortex	UBERON:0001235	75.19	gold quality
putamen	UBERON:0001874	74.93	gold quality
Brodmann (1909) area 9	UBERON:0013540	74.64	gold quality
hypothalamus	UBERON:0001898	74.58	gold quality
islet of Langerhans	UBERON:0000006	74.44	gold quality
adrenal gland	UBERON:0002369	74.41	gold quality
stromal cell of endometrium	CL:0002255	74.37	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.16	gold quality
metanephros cortex	UBERON:0010533	73.89	gold quality
muscle of leg	UBERON:0001383	73.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• Results demonstrated that PSMG3AS1 expression was increased in breast cancer tumor tissues and cell lines. Its knockdown increased the level of miR143 expression, which led to the mitigation of proliferation and migration capacity in breast carcinoma cells. Additionally, its knockdown was demonstrated to reduce the mRNA and protein expression levels of COL1A1. (PMID:31661146)
• MiR-449b-5p targets lncRNA PSMG3-AS1 to suppress cancer cell proliferation in lung adenocarcinoma. (PMID:32471413)
• Overexpression of LncRNA PSMG3-AS1 Distinguishes Glioblastomas from Sarcoidosis. (PMID:32529538)
• LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1. (PMID:33849377)
• LncRNAs PSMG3-AS1 and MEG3 negatively regulate each other to participate in endometrial carcinoma cell proliferation. (PMID:34751795)
• LncRNA PSMG3-AS1 is upregulated in prostate carcinoma and downregulates miR-106b through DNA methylation. (PMID:37023254)
• Investigating the role of LncRNA PSMG3-AS1 in gastric cancer: implications for prognosis and therapeutic intervention. (PMID:37946320)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.