PSORS1C3

Summary

PSORS1C3 (psoriasis susceptibility 1 candidate 3, HGNC:17203) is a long non-coding RNA gene on chromosome 6p21.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17203
Approved symbol	PSORS1C3
Name	psoriasis susceptibility 1 candidate 3
Location	6p21.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00196
Ensembl gene	ENSG00000204528
Ensembl biotype	lncRNA
OMIM	618690
Entrez	100130889
RNAcentral	URS000083C8B0 — lncRNA, 885 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000412143

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412143 — 4 exons

Exon	Start	End
ENSE00001649303	31174238	31174270
ENSE00001673489	31177639	31177899
ENSE00004104686	31173735	31174033
ENSE00004104687	31186026	31186118

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 90.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0344 / max 19.2235, expressed in 14 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
72650	0.0344	14

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.35	gold quality
gall bladder	UBERON:0002110	80.41	gold quality
metanephros cortex	UBERON:0010533	80.22	gold quality
body of pancreas	UBERON:0001150	78.83	gold quality
adult mammalian kidney	UBERON:0000082	78.57	gold quality
cortex of kidney	UBERON:0001225	77.07	gold quality
kidney	UBERON:0002113	76.55	gold quality
endometrium	UBERON:0001295	75.72	gold quality
body of stomach	UBERON:0001161	74.75	gold quality
duodenum	UBERON:0002114	74.64	gold quality
pancreas	UBERON:0001264	74.31	gold quality
urinary bladder	UBERON:0001255	74.13	gold quality
small intestine	UBERON:0002108	73.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	73.75	gold quality
stomach	UBERON:0000945	73.50	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.50	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.00	gold quality
right uterine tube	UBERON:0001302	71.77	gold quality
rectum	UBERON:0001052	71.66	gold quality
fallopian tube	UBERON:0003889	71.18	gold quality
left uterine tube	UBERON:0001303	71.14	gold quality
sural nerve	UBERON:0015488	70.76	gold quality
bone marrow cell	CL:0002092	70.65	silver quality
fundus of stomach	UBERON:0001160	69.36	gold quality
tonsil	UBERON:0002372	68.77	gold quality
transverse colon	UBERON:0001157	68.38	gold quality
right lobe of liver	UBERON:0001114	67.94	gold quality
intestine	UBERON:0000160	67.55	gold quality
liver	UBERON:0002107	66.80	gold quality
prostate gland	UBERON:0002367	66.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Hypomethylation at a differentially methylated region upstream of the PSORS1C3 gene was associated with major depressive disorder suicide cases. (PMID:28045465)
• results show, for the first time, the male-only associations of the PSORS1C3 gene with psoriasis risk and of the PSORS1C1/CDSN gene with severity of disease. However, the age dependent associations need to be validated in larger sample sizes as well as in other populations. (PMID:29589160)
• lncRNA PSORS1C3 is regulated by glucocorticoids and fine-tunes OCT4 expression in non-pluripotent cells. (PMID:31182783)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.