PSTPIP2

Summary

PSTPIP2 (proline-serine-threonine phosphatase interacting protein 2, HGNC:9581) is a protein-coding gene on chromosome 18q21.1, encoding Proline-serine-threonine phosphatase-interacting protein 2 (Q9H939). Binds to F-actin.

Predicted to be located in cytoskeleton; cytosol; and membrane. Predicted to be active in cytoplasm.

Source: NCBI Gene 9050 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 48 total
• Druggable target: yes
• MANE Select transcript: NM_024430

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9581
Approved symbol	PSTPIP2
Name	proline-serine-threonine phosphatase interacting protein 2
Location	18q21.1
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000152229
Ensembl biotype	protein_coding
OMIM	616046
Entrez	9050

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 8 protein_coding, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000409746, ENST00000587042, ENST00000588801, ENST00000589328, ENST00000591729, ENST00000593086, ENST00000909790, ENST00000909791, ENST00000909792, ENST00000909793, ENST00000941998, ENST00000941999

RefSeq mRNA: 1 — MANE Select: NM_024430 NM_024430

CCDS: CCDS32820

Canonical transcript exons

ENST00000409746 — 15 exons

Exon	Start	End
ENSE00002835121	46072156	46072260
ENSE00003380285	45993605	45993703
ENSE00003437304	45997749	45997828
ENSE00003468305	46011181	46011287
ENSE00003475928	45991902	45991983
ENSE00003485239	46005469	46005531
ENSE00003486620	45990722	45990756
ENSE00003492888	46015903	46015937
ENSE00003533245	45999436	45999534
ENSE00003544660	45998794	45998839
ENSE00003562734	45988702	45988759
ENSE00003584469	45983536	45985450
ENSE00003616113	46024609	46024686
ENSE00003660837	45992106	45992202
ENSE00003664388	46039947	46040047

Expression profiles

Bgee: expression breadth ubiquitous, 197 present calls, max score 95.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.2782 / max 433.9727, expressed in 1638 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
171789	12.6690	1624
171790	0.2965	120
171791	0.2404	90
171782	0.0634	12
171783	0.0089	3

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	95.57	gold quality
monocyte	CL:0000576	95.54	gold quality
mononuclear cell	CL:0000842	95.12	gold quality
leukocyte	CL:0000738	94.67	gold quality
granulocyte	CL:0000094	90.77	gold quality
bone marrow	UBERON:0002371	90.50	gold quality
blood	UBERON:0000178	90.38	gold quality
hindlimb stylopod muscle	UBERON:0004252	89.61	gold quality
trabecular bone tissue	UBERON:0002483	89.10	gold quality
bone marrow cell	CL:0002092	87.87	gold quality
muscle of leg	UBERON:0001383	86.51	gold quality
gastrocnemius	UBERON:0001388	86.32	gold quality
biceps brachii	UBERON:0001507	86.08	gold quality
mucosa of stomach	UBERON:0001199	85.62	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	85.59	gold quality
muscle organ	UBERON:0001630	84.89	gold quality
right lung	UBERON:0002167	84.01	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	83.49	silver quality
skin of leg	UBERON:0001511	83.03	gold quality
upper lobe of left lung	UBERON:0008952	82.90	gold quality
skin of abdomen	UBERON:0001416	81.97	gold quality
skeletal muscle tissue	UBERON:0001134	81.94	gold quality
upper lobe of lung	UBERON:0008948	81.61	gold quality
right lobe of liver	UBERON:0001114	81.23	gold quality
vastus lateralis	UBERON:0001379	80.48	silver quality
zone of skin	UBERON:0000014	80.36	gold quality
body of stomach	UBERON:0001161	79.40	gold quality
minor salivary gland	UBERON:0001830	78.97	gold quality
gall bladder	UBERON:0002110	78.93	gold quality
muscle tissue	UBERON:0002385	78.85	gold quality

Single-cell (SCXA)

Detected in 8 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	33.97
E-HCAD-6	yes	20.34
E-HCAD-10	yes	16.04
E-MTAB-9067	yes	11.47
E-ANND-3	yes	9.60
E-CURD-6	no	407.73
E-MTAB-8410	no	3.57
E-MTAB-6678	no	3.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

116 targeting PSTPIP2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4713-3P	100.00	65.92	505
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836

Literature-anchored findings (GeneRIF, showing 4)

• PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. (PMID:24407241)
• Methylation on PSTPIP2 is associated with the development of anti-tuberculosis drug-induced liver injury. (PMID:31247120)
• PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells. (PMID:33311489)
• PSTPIP2 is associated with disease severity in patients with pressure ulcer sepsis and has anti-inflammatory effects. (PMID:37695226)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	pstpip2	ENSDARG00000089569
mus_musculus	Pstpip2	ENSMUSG00000025429
rattus_norvegicus	Pstpip2	ENSRNOG00000016987
drosophila_melanogaster	CG8176	FBGN0037702
caenorhabditis_elegans		WBGENE00018974

Paralogs (5): GAS7 (ENSG00000007237), SGIP1 (ENSG00000118473), FCHO1 (ENSG00000130475), PSTPIP1 (ENSG00000140368), FCHO2 (ENSG00000157107)

Protein

Protein identifiers

Proline-serine-threonine phosphatase-interacting protein 2 — Q9H939 (reviewed: Q9H939)

All UniProt accessions (4): Q9H939, A0A0S2Z4R2, A0A0S2Z505, A0A0S2Z5F6

UniProt curated annotations — full annotation on UniProt →

Function. Binds to F-actin. May be involved in regulation of the actin cytoskeleton.

Subcellular location. Cytoplasm. Membrane.

Post-translational modifications. Phosphorylated on tyrosine.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H939-1	1	yes
Q9H939-2	2

RefSeq proteins (1): NP_077748* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001060	FCH_dom	Domain
IPR027267	AH/BAR_dom_sf	Homologous_superfamily
IPR031160	F_BAR_dom	Domain
IPR042694	PSTPIP2_F-BAR	Domain

Pfam: PF00611

UniProt features (10 total): modified residue 2, sequence variant 2, chain 1, domain 1, region of interest 1, coiled-coil region 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H939-F1	89.88	0.80

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 323, 329

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 200 (showing top): LEE_NEURAL_CREST_STEM_CELL_DN, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, BOYLAN_MULTIPLE_MYELOMA_D_DN, TANG_SENESCENCE_TP53_TARGETS_UP, BOYLAN_MULTIPLE_MYELOMA_D_CLUSTER_DN, BYSTROEM_CORRELATED_WITH_IL5_DN, BROWN_MYELOID_CELL_DEVELOPMENT_UP, GAVIN_FOXP3_TARGETS_CLUSTER_T7, GAVIN_FOXP3_TARGETS_CLUSTER_P2, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, BEGUM_TARGETS_OF_PAX3_FOXO1_FUSION_AND_PAX3, CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN, SENESE_HDAC1_AND_HDAC2_TARGETS_UP

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (5): cytoplasm (GO:0005737), cytosol (GO:0005829), cytoskeleton (GO:0005856), plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
binding	1
intracellular anatomical structure	1
cytoplasm	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1566 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PSTPIP2	TNFRSF11A	Q9Y6Q6	764
PSTPIP2	LPIN2	Q92539	653
PSTPIP2	IL1RN	P18510	607
PSTPIP2	FBLIM1	Q8WUP2	528
PSTPIP2	TRIP10	Q15642	518
PSTPIP2	ARK2C	Q6ZSG1	505
PSTPIP2	PLA2G4C	Q9UP65	499
PSTPIP2	OSBP	P22059	476
PSTPIP2	FNBP1	Q96RU3	456
PSTPIP2	CSK	P41240	443
PSTPIP2	CIBAR2	Q6ZTR7	424
PSTPIP2	VAPA	Q9P0L0	423
PSTPIP2	PTPN18	Q99952	417
PSTPIP2	FES	P07332	414
PSTPIP2	FCHSD1	Q86WN1	414

IntAct

39 interactions, top by confidence:

A	B	Type	Score
PTPN12	SHC1	psi-mi:“MI:0914”(association)	0.860
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
LPXN	PCNT	psi-mi:“MI:0914”(association)	0.640
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
GRB2	SH3PXD2B	psi-mi:“MI:0914”(association)	0.530
SHC1	BCR/ABL fusion	psi-mi:“MI:0914”(association)	0.460
PSTPIP2	DNAJC5	psi-mi:“MI:0915”(physical association)	0.400
PTPN22	PSTPIP2	psi-mi:“MI:0915”(physical association)	0.400
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.350
PTPN12	AIFM1	psi-mi:“MI:0914”(association)	0.350
ENG	IGKV2-28	psi-mi:“MI:0914”(association)	0.350
PTPN12	PRPSAP2	psi-mi:“MI:0914”(association)	0.350
PTPN12	HSPB1	psi-mi:“MI:0914”(association)	0.350
GRB2	CNOT1	psi-mi:“MI:0914”(association)	0.350
PTPN18	AIP	psi-mi:“MI:0914”(association)	0.350
PTPN18	TIPRL	psi-mi:“MI:0914”(association)	0.350
LPXN	MED14	psi-mi:“MI:0914”(association)	0.350
MFSD1	RP2	psi-mi:“MI:0914”(association)	0.350
SLC22A13	XRCC3	psi-mi:“MI:0914”(association)	0.350
CDC5L		psi-mi:“MI:0914”(association)	0.350
STK38L	SH3PXD2B	psi-mi:“MI:2364”(proximity)	0.270
STK38L	CCDC187	psi-mi:“MI:2364”(proximity)	0.270
PTPN12	ARHGAP10	psi-mi:“MI:2364”(proximity)	0.270
EGFR	FAM171A2	psi-mi:“MI:2364”(proximity)	0.270
ERBB2	NHERF1	psi-mi:“MI:2364”(proximity)	0.270
FGFR1	BLTP3B	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (45): PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Proximity Label-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-RNA), KRT18 (Two-hybrid), PSTPIP2 (Affinity Capture-Luminescence), PSTPIP2 (Affinity Capture-MS), PSTPIP2 (Affinity Capture-MS)

ESM2 similar proteins: A7MBI0, D3ZYR1, O13154, O43586, O55148, O60749, O60861, P09760, P16591, P70451, P97531, P97814, Q0JRZ9, Q15642, Q2HWF0, Q3KR97, Q3UQN2, Q4V920, Q5R411, Q5R807, Q5RCJ1, Q5T0N5, Q5U3Q6, Q60780, Q61644, Q6DCZ7, Q6GNV5, Q6GUF4, Q8CJ53, Q8I190, Q8I1A6, Q8I1C0, Q8I1I3, Q8K012, Q8T390, Q91VH2, Q99JB8, Q99M15, Q99N27, Q9BY11

Diamond homologs: A1C4A5, A1X283, A2AAY5, A5D7F8, A5D8S5, A6NI72, A7E3N2, A8MVU1, A8PWF6, E2RP94, E9Q634, F1LRS8, F1M707, M0R4F8, O01498, O15259, O35413, O42287, O43281, O43586, O70145, O76041, O77506, O77774, O77775, O89032, O94875, P07751, P0CP00, P0CP01, P10569, P13395, P14598, P16086, P16546, P19706, P19878, P20929, P34109, P39743

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 44 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
SHC1 events in ERBB2 signaling	5	82.0×	9e-07
Constitutive Signaling by Aberrant PI3K in Cancer	6	26.2×	6e-06
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	6	20.0×	2e-05
PIP3 activates AKT signaling	6	13.8×	1e-04
RAF/MAP kinase cascade	6	12.6×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2368 predictions. Top by Δscore:

Variant	Effect	Δscore
18:45997734:T:TA	donor_gain	1.0000
18:45997745:GTAC:G	donor_loss	1.0000
18:45997746:TAC:T	donor_loss	1.0000
18:45997748:C:CA	donor_loss	1.0000
18:45997824:TTTGT:T	acceptor_gain	1.0000
18:45997825:TTGT:T	acceptor_gain	1.0000
18:45997826:TGT:T	acceptor_gain	1.0000
18:45997827:GT:G	acceptor_gain	1.0000
18:45997828:TC:T	acceptor_loss	1.0000
18:45997829:C:CA	acceptor_loss	1.0000
18:45997829:C:CC	acceptor_gain	1.0000
18:45997830:T:A	acceptor_loss	1.0000
18:45997833:A:T	acceptor_gain	1.0000
18:45997835:C:CT	acceptor_gain	1.0000
18:45997836:A:T	acceptor_gain	1.0000
18:45998788:CCTCA:C	donor_loss	1.0000
18:45998790:TCACC:T	donor_loss	1.0000
18:45998791:CACCT:C	donor_loss	1.0000
18:45998793:C:CA	donor_loss	1.0000
18:45998849:C:CT	acceptor_gain	1.0000
18:45999534:CCTT:C	acceptor_gain	1.0000
18:45999537:T:TC	acceptor_gain	1.0000
18:45999541:CATTA:C	acceptor_gain	1.0000
18:45999542:A:C	acceptor_gain	1.0000
18:45999542:A:T	acceptor_gain	1.0000
18:45999543:T:C	acceptor_gain	1.0000
18:45999543:T:TC	acceptor_gain	1.0000
18:45999545:A:AC	acceptor_gain	1.0000
18:45999545:A:C	acceptor_gain	1.0000
18:45999550:C:CT	acceptor_gain	1.0000

AlphaMissense

2238 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
18:45993678:C:G	R223P	0.998
18:46024654:A:G	L56P	0.998
18:46024685:C:G	A46P	0.998
18:45993663:C:G	R228P	0.997
18:45997778:A:G	W205R	0.997
18:45997778:A:T	W205R	0.997
18:46024663:C:T	G53D	0.997
18:45999492:C:G	A154P	0.995
18:45992186:C:G	R253P	0.994
18:46024645:A:G	L59P	0.994
18:46039956:A:G	L42P	0.994
18:46011272:G:T	A88E	0.993
18:45992153:T:G	D264A	0.992
18:45992154:C:G	D264H	0.992
18:45997757:C:G	A212P	0.992
18:45997820:A:C	Y191D	0.992
18:46011252:C:G	A95P	0.992
18:46039998:A:G	L28P	0.992
18:46011251:G:T	A95E	0.991
18:46024664:C:G	G53R	0.991
18:46040022:C:T	G20D	0.991
18:45997765:T:G	H209P	0.990
18:46011188:C:G	R116P	0.990
18:46024686:C:A	R45S	0.990
18:46024686:C:G	R45S	0.990
18:45999534:C:G	A140P	0.989
18:46015920:A:G	L77P	0.989
18:45993652:A:G	W232R	0.988
18:45993652:A:T	W232R	0.988
18:45997776:C:A	W205C	0.988

dbSNP variants (sampled 300 via entrez): RS1000103549 (18:46044890 CA>C,CAA), RS1000136214 (18:46045142 A>C,T), RS1000158153 (18:45995235 T>C), RS1000196703 (18:45989485 G>A), RS1000204799 (18:46018546 T>C), RS1000269014 (18:45989106 T>C), RS1000273401 (18:46073921 C>A), RS1000376550 (18:46031927 T>G), RS1000389241 (18:46045552 C>A), RS1000410462 (18:46046068 G>A), RS1000417899 (18:46026039 G>A), RS1000470124 (18:46025848 G>A), RS1000577450 (18:46019135 A>G), RS1000614283 (18:46056918 A>G), RS1000645675 (18:46013062 T>C)

Disease associations

OMIM: gene MIM:616046 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST007741_18	Iris color (b* coordinate)	2.000000e-06
GCST90002400_246	Plateletcrit	3.000000e-09
GCST90002402_428	Platelet count	3.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0009764	eye colour measurement
EFO:0007985	platelet crit
EFO:0004309	platelet count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067297 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.64	Kd	22.88	nM	CHEMBL5653589
7.64	ED50	22.88	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149139: Binding affinity to human PSTPIP2 incubated for 45 mins by Kinobead based pull down assay	kd	0.0229	uM

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects expression, affects methylation, increases expression	5
Valproic Acid	affects cotreatment, increases expression, increases methylation	5
Aflatoxin B1	affects expression, increases expression	4
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
bisphenol A	affects cotreatment, increases methylation, decreases expression	2
(+)-JQ1 compound	decreases expression	2
Acetaminophen	decreases expression, increases expression	2
Estradiol	decreases expression, increases expression, affects cotreatment	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Tobacco Smoke Pollution	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
deoxynivalenol	increases expression	1
trichostatin A	increases expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
benzo(e)pyrene	decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	decreases reaction, increases expression	1
isobutyl alcohol	affects cotreatment, increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants	increases abundance, decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Cytarabine	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652181	Binding	Binding affinity to human PSTPIP2 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.