PTCSC1

Summary

PTCSC1 (papillary thyroid carcinoma susceptibility candidate 1, HGNC:37127) is a long non-coding RNA gene on chromosome 8q24.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37127
Approved symbol	PTCSC1
Name	papillary thyroid carcinoma susceptibility candidate 1
Location	8q24
Locus type	RNA, long non-coding
Status	Approved
Aliases	AK023948, NCRNA00197
Ensembl gene	ENSG00000287736
Ensembl biotype	lncRNA
OMIM	617440
Entrez	100302522
RNAcentral	URS00008B234E — lncRNA, 2809 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000664551

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000664551 — 1 exons

Exon	Start	End
ENSE00003870815	133054959	133057767

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 92.61.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1300 / max 68.5524, expressed in 46 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
91128	0.0689	39
91129	0.0557	4
91130	0.0054	1

Top tissues by expression

195 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	92.61	gold quality
bone marrow cell	CL:0002092	83.35	gold quality
buccal mucosa cell	CL:0002336	76.13	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.28	silver quality
sperm	CL:0000019	73.31	gold quality
monocyte	CL:0000576	73.06	gold quality
tibialis anterior	UBERON:0001385	72.30	silver quality
kidney epithelium	UBERON:0004819	72.17	gold quality
leukocyte	CL:0000738	71.81	gold quality
ileal mucosa	UBERON:0000331	71.27	silver quality
right lobe of thyroid gland	UBERON:0001119	69.98	gold quality
colonic epithelium	UBERON:0000397	69.95	gold quality
thyroid gland	UBERON:0002046	69.23	gold quality
left lobe of thyroid gland	UBERON:0001120	68.63	gold quality
epithelial cell of pancreas	CL:0000083	68.57	silver quality
cardiac muscle of right atrium	UBERON:0003379	66.56	gold quality
nasal cavity epithelium	UBERON:0005384	66.47	gold quality
secondary oocyte	CL:0000655	65.91	gold quality
deltoid	UBERON:0001476	65.69	silver quality
blood	UBERON:0000178	65.37	gold quality
myocardium	UBERON:0002349	65.30	gold quality
endothelial cell	CL:0000115	64.96	gold quality
vermiform appendix	UBERON:0001154	64.27	gold quality
left ventricle myocardium	UBERON:0006566	63.54	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	62.45	gold quality
superficial temporal artery	UBERON:0001614	62.00	gold quality
ganglionic eminence	UBERON:0004023	61.96	gold quality
right lung	UBERON:0002167	61.89	gold quality
nipple	UBERON:0002030	61.88	gold quality
bone marrow	UBERON:0002371	61.30	gold quality

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA PTCSC1 drives esophageal squamous cell carcinoma progression through activating Akt signaling. (PMID:32971114)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.