PTCSC2

Summary

PTCSC2 (papillary thyroid carcinoma susceptibility candidate 2, HGNC:44086) is a long non-coding RNA gene on chromosome 9q22.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44086
Approved symbol	PTCSC2
Name	papillary thyroid carcinoma susceptibility candidate 2
Location	9q22.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236130
Ensembl biotype	lncRNA
Entrez	101928337
RNAcentral	URS0000BC465E — lncRNA, 1947 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000430058, ENST00000648027, ENST00000648505, ENST00000648625, ENST00000649253, ENST00000649461, ENST00000649526, ENST00000650104, ENST00000824737, ENST00000824738, ENST00000824739, ENST00000824740, ENST00000824741, ENST00000824742, ENST00000824743, ENST00000824744, ENST00000824745, ENST00000824746

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430058 — 3 exons

Exon	Start	End
ENSE00001598600	97809895	97810039
ENSE00001638040	97805840	97806024
ENSE00003833094	97722800	97722934

Expression profiles

Bgee: expression breadth ubiquitous, 120 present calls, max score 94.37.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1201 / max 52.1619, expressed in 29 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
101631	0.0392	4
101632	0.0234	7
101634	0.0233	8
101636	0.0196	4
101633	0.0109	3
101635	0.0038	2

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	94.37	gold quality
right lobe of thyroid gland	UBERON:0001119	93.09	gold quality
left lobe of thyroid gland	UBERON:0001120	92.39	gold quality
thyroid gland	UBERON:0002046	92.19	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.47	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.72	gold quality
sural nerve	UBERON:0015488	72.63	gold quality
tonsil	UBERON:0002372	72.05	gold quality
lower esophagus mucosa	UBERON:0035834	62.10	gold quality
stromal cell of endometrium	CL:0002255	61.38	gold quality
esophagus mucosa	UBERON:0002469	60.95	gold quality
cortical plate	UBERON:0005343	60.20	silver quality
muscle tissue	UBERON:0002385	59.20	gold quality
ganglionic eminence	UBERON:0004023	58.91	gold quality
ventricular zone	UBERON:0003053	58.82	gold quality
bone marrow	UBERON:0002371	58.62	gold quality
skeletal muscle tissue	UBERON:0001134	57.53	gold quality
lymph node	UBERON:0000029	57.30	gold quality
islet of Langerhans	UBERON:0000006	55.74	gold quality
vagina	UBERON:0000996	55.03	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	54.81	gold quality
esophagus	UBERON:0001043	54.04	gold quality
blood	UBERON:0000178	53.54	gold quality
liver	UBERON:0002107	53.47	silver quality
calcaneal tendon	UBERON:0003701	53.42	gold quality
endometrium	UBERON:0001295	52.79	gold quality
monocyte	CL:0000576	51.52	silver quality
pancreas	UBERON:0001264	50.63	gold quality
muscle of leg	UBERON:0001383	50.60	gold quality
gastrocnemius	UBERON:0001388	50.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.43

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Our data suggest a role for PTCSC2, FOXE1, and TSHR in the predisposition to papillary thyroid carcinoma. (PMID:25303483)
• Report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor. (PMID:28049826)
• The Effect of LL37 Antimicrobial Peptide on FOXE1 and lncRNA PTCSC 2 Genes Expression in Colorectal Cancer (CRC) and Normal Cells. (PMID:36308369)
• Suggestive evidence of the genetic association of TMOD1 and PTCSC2 polymorphisms with thyroid carcinoma in the Chinese Han population. (PMID:36316666)
• Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk. (PMID:36737753)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.