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Atlas / Gene / PTDSS2

PTDSS2

gene
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Also known as PSS2

Summary

PTDSS2 (phosphatidylserine synthase 2, HGNC:15463) is a protein-coding gene on chromosome 11p15.5, encoding Phosphatidylserine synthase 2 (Q9BVG9). Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine.

The protein encoded by this gene catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine, a structural membrane phospholipid that functions in cell signaling, blood coagulation, and apoptosis. The encoded enzyme also has a high affinity for docosahexaenoic acid (DHA) and can use it to make DHA-containing phosphatidylserine.

Source: NCBI Gene 81490 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 65 total
  • Druggable target: yes
  • MANE Select transcript: NM_030783

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:15463
Approved symbolPTDSS2
Namephosphatidylserine synthase 2
Location11p15.5
Locus typegene with protein product
StatusApproved
AliasesPSS2
Ensembl geneENSG00000174915
Ensembl biotypeprotein_coding
OMIM612793
Entrez81490

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 10 protein_coding, 6 retained_intron, 4 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000308020, ENST00000525059, ENST00000525727, ENST00000526558, ENST00000526878, ENST00000527325, ENST00000527479, ENST00000528617, ENST00000530029, ENST00000530087, ENST00000531411, ENST00000531520, ENST00000532614, ENST00000855856, ENST00000855857, ENST00000855858, ENST00000855859, ENST00000926902, ENST00000926903, ENST00000951431, ENST00000951432, ENST00000951433

RefSeq mRNA: 4 — MANE Select: NM_030783 NM_001329544, NM_001329545, NM_001329548, NM_030783

CCDS: CCDS7696

Canonical transcript exons

ENST00000308020 — 12 exons

ExonStartEnd
ENSE00001305299450279450637
ENSE00001318646490420491399
ENSE00003463003479085479152
ENSE00003507236489400489514
ENSE00003520323488529488647
ENSE00003550891489883490068
ENSE00003556424488199488312
ENSE00003582456460187460288
ENSE00003587949486939487073
ENSE00003619411489588489733
ENSE00003658128473895473977
ENSE00003689918487420487470

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 96.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 35.8905 / max 206.2583, expressed in 1814 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
11219922.87561807
1122006.81101637
1122016.20391597

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
left testisUBERON:000453396.50gold quality
right testisUBERON:000453496.40gold quality
right hemisphere of cerebellumUBERON:001489095.90gold quality
testisUBERON:000047395.69gold quality
cerebellar hemisphereUBERON:000224595.34gold quality
cerebellar cortexUBERON:000212995.26gold quality
cerebellumUBERON:000203795.25gold quality
apex of heartUBERON:000209894.41gold quality
right frontal lobeUBERON:000281093.90gold quality
right ovaryUBERON:000211893.24gold quality
left ovaryUBERON:000211993.14gold quality
Brodmann (1909) area 9UBERON:001354092.78gold quality
Ammon’s hornUBERON:000195492.61gold quality
nucleus accumbensUBERON:000188292.55gold quality
C1 segment of cervical spinal cordUBERON:000646992.53gold quality
stromal cell of endometriumCL:000225592.41gold quality
putamenUBERON:000187492.35gold quality
substantia nigraUBERON:000203892.33gold quality
brainUBERON:000095592.29gold quality
ovaryUBERON:000099292.21gold quality
anterior cingulate cortexUBERON:000983592.06gold quality
hypothalamusUBERON:000189892.05gold quality
right atrium auricular regionUBERON:000663192.03gold quality
dorsolateral prefrontal cortexUBERON:000983492.00gold quality
cerebral cortexUBERON:000095691.94gold quality
pituitary glandUBERON:000000791.93gold quality
frontal cortexUBERON:000187091.85gold quality
primary visual cortexUBERON:000243691.79gold quality
caudate nucleusUBERON:000187391.75gold quality
temporal lobeUBERON:000187191.63gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

ExperimentMarker?Max mean expression
E-ANND-3no2.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

  • Purification and characterization of human phosphatidylserine synthases 1 and 2. (PMID:19014349)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_rerioptdss2ENSDARG00000101018
mus_musculusPtdss2ENSMUSG00000025495
rattus_norvegicusPtdss2ENSRNOG00000015912
caenorhabditis_elegansWBGENE00012095
caenorhabditis_elegansWBGENE00013920

Paralogs (1): PTDSS1 (ENSG00000156471)

Protein

Protein identifiers

Phosphatidylserine synthase 2 — Q9BVG9 (reviewed: Q9BVG9)

Alternative names: Serine-exchange enzyme II

All UniProt accessions (3): Q9BVG9, E9PLE4, E9PS47

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine. Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position. Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position.

Subcellular location. Endoplasmic reticulum membrane.

Activity regulation. Requires calcium ions. Inhibited by exogenous phosphatidylserine.

Pathway. Phospholipid metabolism; phosphatidylserine biosynthesis.

Similarity. Belongs to the phosphatidyl serine synthase family.

RefSeq proteins (4): NP_001316473, NP_001316474, NP_001316477, NP_110410* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR004277PSSFamily

Pfam: PF03034

Enzyme classification (BRENDA):

  • EC 2.7.8.29 — L-serine-phosphatidylethanolamine phosphatidyltransferase (BRENDA: 6 organisms, 11 substrates, 7 inhibitors, 1 Km, 0 kcat entries)

Substrate kinetics (BRENDA)

1 substrates with measured Km, best-characterized 1. Km ranges are aggregated across organisms/conditions.

SubstrateKm (mM)Measurements
L-SERINE0.121

Catalyzed reactions (Rhea), 9 shown:

  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:27606)
  • 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:40795)
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:41484)
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine (RHEA:41488)
  • 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoserine + ethanolamine (RHEA:41492)
  • 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:41496)
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + L-serine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoserine + ethanolamine (RHEA:41500)
  • 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:41600)
  • 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + L-serine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + ethanolamine (RHEA:41604)

UniProt features (23 total): topological domain 8, transmembrane region 7, modified residue 3, region of interest 2, chain 1, compositionally biased region 1, glycosylation site 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
9N0XELECTRON MICROSCOPY3.3

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9BVG9-F182.930.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 16, 24, 485

Glycosylation sites (1): 181

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-1483101Synthesis of PS

MSigDB gene sets: 128 (showing top): TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS, GOBP_GLYCEROLIPID_METABOLIC_PROCESS, BLALOCK_ALZHEIMERS_DISEASE_UP, GOBP_GLYCEROLIPID_BIOSYNTHETIC_PROCESS, GOBP_GLYCEROPHOSPHOLIPID_METABOLIC_PROCESS, GOBP_LIPID_METABOLIC_PROCESS, GOBP_LIPID_BIOSYNTHETIC_PROCESS, GOBP_PHOSPHATIDYLSERINE_METABOLIC_PROCESS

GO Biological Process (3): phosphatidylserine biosynthetic process (GO:0006659), lipid metabolic process (GO:0006629), phospholipid biosynthetic process (GO:0008654)

GO Molecular Function (3): CDP-diacylglycerol-serine O-phosphatidyltransferase activity (GO:0003882), transferase activity (GO:0016740), L-serine-phosphatidylethanolamine phosphatidyltransferase activity (GO:0106245)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), membrane (GO:0016020), endoplasmic reticulum (GO:0005783)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Glycerophospholipid biosynthesis1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
phosphatidylserine metabolic process1
modified amino acid biosynthetic process1
glycerophospholipid biosynthetic process1
primary metabolic process1
phospholipid metabolic process1
lipid biosynthetic process1
organophosphate biosynthetic process1
CDP-alcohol phosphatidyltransferase activity1
catalytic activity1
phosphotransferase activity, for other substituted phosphate groups1
organelle membrane1
nuclear outer membrane-endoplasmic reticulum membrane network1
endoplasmic reticulum subcompartment1
cellular anatomical structure1
cytoplasm1
endomembrane system1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

736 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
PTDSS2PISDQ9UG56792
PTDSS2CEPT1Q9Y6K0628
PTDSS2PCYT2Q99447602
PTDSS2PEMTQ9UBM1575
PTDSS2SELENOIQ9C0D9526
PTDSS2CHPT1Q8WUD6505
PTDSS2DBNLP84070484
PTDSS2ETNK2Q9NVF9449
PTDSS2TMEM258P61165444
PTDSS2CHKAP35790438
PTDSS2IPO11Q9UI26428
PTDSS2ETNK1Q9HBU6420
PTDSS2PCYT1AP49585417
PTDSS2PRKCDQ05655414
PTDSS2AGPAT3Q9NRZ7390
PTDSS2HRASP01112390

IntAct

96 interactions, top by confidence:

ABTypeScore
B3GNT3PGRMC1psi-mi:“MI:0914”(association)0.670
PTDSS2F2RL1psi-mi:“MI:0915”(physical association)0.550
CD70METTL15psi-mi:“MI:0914”(association)0.530
APLNRSLC33A1psi-mi:“MI:0914”(association)0.530
TMEM184ASLC33A1psi-mi:“MI:0914”(association)0.530
CCR6PODXLpsi-mi:“MI:0914”(association)0.530
TMEM63AAP3D1psi-mi:“MI:0914”(association)0.530
STOMEI24psi-mi:“MI:0914”(association)0.510
MBOAT1DERL1psi-mi:“MI:0914”(association)0.350
ESYT2psi-mi:“MI:0914”(association)0.350
E5ESYT2psi-mi:“MI:0914”(association)0.350
P2RY12GPR89Apsi-mi:“MI:0914”(association)0.350
repGPR89Apsi-mi:“MI:0914”(association)0.350
CCDC47ESYT2psi-mi:“MI:0914”(association)0.350
PTDSS2URI1psi-mi:“MI:0914”(association)0.350
OPRL1METTL15psi-mi:“MI:0914”(association)0.350
SLC22A4RTL8Cpsi-mi:“MI:0914”(association)0.350
FFAR1SLC12A8psi-mi:“MI:0914”(association)0.350
GPR182SLC12A8psi-mi:“MI:0914”(association)0.350
CLEC2DESYT2psi-mi:“MI:0914”(association)0.350
TSPAN15TMEM223psi-mi:“MI:0914”(association)0.350
KCNK1TMEM223psi-mi:“MI:0914”(association)0.350
ACKR2TMEM223psi-mi:“MI:0914”(association)0.350
ENTPD7TMEM120Bpsi-mi:“MI:0914”(association)0.350
P2RX2TMEM131Lpsi-mi:“MI:0914”(association)0.350
ASIC4TMEM131Lpsi-mi:“MI:0914”(association)0.350
GPR45VWA8psi-mi:“MI:0914”(association)0.350
HS2ST1DENND11psi-mi:“MI:0914”(association)0.350
B3GALT4psi-mi:“MI:0914”(association)0.350
SLC1A1UBXN8psi-mi:“MI:0914”(association)0.350

BioGRID (108): PTDSS2 (Proximity Label-MS), PTDSS2 (Affinity Capture-MS), PTDSS2 (Affinity Capture-MS), PTDSS2 (Affinity Capture-MS), STOM (Affinity Capture-MS), PTDSS2 (Affinity Capture-RNA), PTDSS2 (Affinity Capture-MS), PTDSS2 (Affinity Capture-MS), PTDSS2 (Proximity Label-MS), PTDSS2 (Affinity Capture-MS), PTDSS2 (Proximity Label-MS), PTDSS2 (Proximity Label-MS), PTDSS2 (Proximity Label-MS), PTDSS2 (Two-hybrid), PTDSS2 (Affinity Capture-MS)

ESM2 similar proteins: A2A559, A2V7M9, A6H7B8, A6X919, A7YWP2, A8KBG2, A8WFS8, B2GV22, D4AD75, E1BYA3, F1Q8R9, O08888, O45145, O49639, P25625, P38298, P70245, Q0VFE3, Q15125, Q290J8, Q2ABP2, Q2ABP3, Q3SZ36, Q3TQR0, Q568I2, Q5M9A7, Q60490, Q60WT2, Q68EV0, Q6P0S3, Q753H5, Q7K0P4, Q801D8, Q801G2, Q8C2R7, Q8N4S7, Q8R4X1, Q8T8L8, Q8TDN7, Q91VH1

Diamond homologs: B1H3H9, B2GV22, E1BYA3, E7EY42, F4HXY7, O08888, P48651, Q00576, Q08D11, Q0JR55, Q2KHY9, Q5N8Q3, Q5PQL5, Q5ZM65, Q6I628, Q803C9, Q99LH2, Q9BVG9, Q9VPD3, Q9Z1X2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 137 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Lysosphingolipid and LPA receptors540.9×5e-06
Class A/1 (Rhodopsin-like receptors)1612.8×3e-11
Chemokine receptors bind chemokines612.1×3e-04
GPCR ligand binding149.7×2e-08
G alpha (q) signalling events127.4×5e-06
Peptide ligand-binding receptors97.2×2e-04
G alpha (i) signalling events177.1×2e-08
Signaling by GPCR146.0×5e-06

GO biological processes:

GO termPartnersFoldFDR
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway1324.7×1e-12
positive regulation of cytosolic calcium ion concentration1818.3×2e-15
phospholipase C-activating G protein-coupled receptor signaling pathway1517.2×2e-12
calcium-mediated signaling914.3×2e-06
cell chemotaxis711.3×4e-04
adenylate cyclase-activating G protein-coupled receptor signaling pathway1110.8×1e-06
G protein-coupled receptor signaling pathway319.8×2e-19

Disease & clinical

Clinical variants and AI predictions

ClinVar

65 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance54
Likely benign2
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3374 predictions. Top by Δscore:

VariantEffectΔscore
11:460177:T:TAacceptor_gain1.0000
11:460178:G:Aacceptor_gain1.0000
11:460181:TTTCA:Tacceptor_loss1.0000
11:460184:CA:Cacceptor_loss1.0000
11:460185:A:AGacceptor_gain1.0000
11:460185:AG:Aacceptor_gain1.0000
11:460185:AGGC:Aacceptor_gain1.0000
11:460186:G:GAacceptor_gain1.0000
11:460186:GG:Gacceptor_gain1.0000
11:460186:GGC:Gacceptor_gain1.0000
11:460186:GGCG:Gacceptor_gain1.0000
11:460186:GGCGA:Gacceptor_gain1.0000
11:460284:AAGAG:Adonor_gain1.0000
11:460285:AGAG:Adonor_gain1.0000
11:460285:AGAGG:Adonor_loss1.0000
11:460286:GAG:Gdonor_gain1.0000
11:460286:GAGG:Gdonor_gain1.0000
11:460287:AG:Adonor_gain1.0000
11:460287:AGG:Adonor_loss1.0000
11:460288:GG:Gdonor_gain1.0000
11:460289:G:GGdonor_gain1.0000
11:460289:GTA:Gdonor_loss1.0000
11:486889:A:Gacceptor_gain1.0000
11:488197:A:AGacceptor_gain1.0000
11:488198:G:GGacceptor_gain1.0000
11:488313:G:GGdonor_gain1.0000
11:488527:A:AGacceptor_gain1.0000
11:488528:G:GGacceptor_gain1.0000
11:488647:AGTA:Adonor_loss1.0000
11:488648:G:GGdonor_gain1.0000

AlphaMissense

3191 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
11:487435:T:CF196L1.000
11:487437:T:AF196L1.000
11:487437:T:GF196L1.000
11:488238:A:CS221R1.000
11:488240:C:AS221R1.000
11:488240:C:GS221R1.000
11:488247:T:CF224L1.000
11:488249:C:AF224L1.000
11:488249:C:GF224L1.000
11:488304:T:AW243R1.000
11:488304:T:CW243R1.000
11:488555:C:AN254K1.000
11:488555:C:GN254K1.000
11:489458:T:AW305R1.000
11:489458:T:CW305R1.000
11:489460:G:CW305C1.000
11:489460:G:TW305C1.000
11:489612:T:CF332L1.000
11:489614:C:AF332L1.000
11:489614:C:GF332L1.000
11:473966:G:CR119T0.999
11:473968:C:TP120S0.999
11:473969:C:AP120H0.999
11:479090:T:AW125R0.999
11:479090:T:CW125R0.999
11:479094:G:TR126M0.999
11:487436:T:GF196C0.999
11:487439:T:AV197D0.999
11:487447:C:GH200D0.999
11:487449:C:AH200Q0.999

dbSNP variants (sampled 300 via entrez): RS1000053565 (11:487390 G>A,T), RS1000080880 (11:467267 G>A), RS1000152383 (11:450307 G>A,C,T), RS1000163191 (11:446579 C>T), RS1000217948 (11:449883 G>C), RS1000268873 (11:450101 C>T), RS1000281784 (11:456885 A>G), RS1000302390 (11:474147 G>A,C), RS1000337443 (11:478978 C>A), RS1000397545 (11:457281 T>A), RS1000421879 (11:474032 C>A,T), RS1000499532 (11:489314 G>A), RS1000504380 (11:459987 T>A), RS1000625007 (11:452559 G>A), RS1000682690 (11:446469 A>G)

Disease associations

OMIM: gene MIM:612793 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST90002385_492High light scatter reticulocyte count7.000000e-11
GCST90002386_413High light scatter reticulocyte percentage of red cells5.000000e-10
GCST90002387_365Immature fraction of reticulocytes5.000000e-14

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0007986reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067347 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

19 total (human), top 19 by PubMed support.

ChemicalActions (top 5)PubMed papers
aristolochic acid Iincreases expression1
FR900359increases phosphorylation1
bisphenol Adecreases methylation1
sodium arsenitedecreases expression1
benzo(e)pyrenedecreases methylation1
aflatoxin B2decreases methylation1
celastrolincreases expression1
di-n-butylphosphoric acidaffects expression1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-olincreases expression1
Benzo(a)pyreneaffects methylation, increases methylation1
Caffeineincreases phosphorylation1
Methapyrilenedecreases methylation1
Pesticidesdecreases methylation1
Smokedecreases expression1
Thiramdecreases expression1
Tobacco Smoke Pollutionincreases expression1
Tretinoindecreases expression1
Aflatoxin B1increases methylation1
Acrylamidedecreases expression1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5652187BindingBinding affinity to human PTDSS2 incubated for 45 mins by Kinobead based pull down assayNVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 78

This page pulls from 78 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_assaychembl_documentchembl_moleculechembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot