PTENP1-AS
gene geneOn this page
Also known as PTENpg1-asRNA
Summary
PTENP1-AS (PTENP1 antisense RNA, HGNC:48773) is a long non-coding RNA gene on chromosome 9p13.3.
PTENP1-AS encodes an antisense RNA (asRNA) of PTENP1, a PTEN (phosphatase and tensin homolog) pseudogene. PTENP1 regulates PTEN by both sense (GeneID: 11191) and antisense RNAs. This antisense RNA (PTENP1-AS) regulates PTEN transcription and mRNA stability.
Source: NCBI Gene 101243555 — RefSeq curated summary.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:48773 |
| Approved symbol | PTENP1-AS |
| Name | PTENP1 antisense RNA |
| Location | 9p13.3 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Aliases | PTENpg1-asRNA |
| Ensembl gene | ENSG00000281128 |
| Ensembl biotype | lncRNA |
| Entrez | 101243555 |
| RNAcentral | URS00008121D0 — lncRNA, 888 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 3 — 3 lncRNA
ENST00000627688, ENST00000667245, ENST00000667902
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000627688 — 4 exons
| Exon | Start | End |
|---|---|---|
| ENSE00003761915 | 33680894 | 33681073 |
| ENSE00003763713 | 33687759 | 33688011 |
| ENSE00003763809 | 33677268 | 33677509 |
| ENSE00003774251 | 33678090 | 33678287 |
Expression profiles
Bgee: expression breadth ubiquitous, 159 present calls, max score 92.35.
FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1059 / max 10.7769, expressed in 45 samples.
FANTOM5 promoters (2 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 96466 | 0.0604 | 24 |
| 96465 | 0.0455 | 15 |
Top tissues by expression
275 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| buccal mucosa cell | CL:0002336 | 92.35 | silver quality |
| tendon of biceps brachii | UBERON:0008188 | 86.45 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 78.50 | gold quality |
| medial globus pallidus | UBERON:0002477 | 70.68 | gold quality |
| cortical plate | UBERON:0005343 | 70.28 | gold quality |
| ganglionic eminence | UBERON:0004023 | 69.61 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 68.36 | silver quality |
| right hemisphere of cerebellum | UBERON:0014890 | 67.65 | gold quality |
| cerebellar hemisphere | UBERON:0002245 | 67.62 | gold quality |
| cerebellar cortex | UBERON:0002129 | 67.59 | gold quality |
| tendon | UBERON:0000043 | 66.78 | gold quality |
| ventricular zone | UBERON:0003053 | 66.29 | gold quality |
| cerebellum | UBERON:0002037 | 65.42 | gold quality |
| cartilage tissue | UBERON:0002418 | 64.67 | gold quality |
| globus pallidus | UBERON:0001875 | 64.32 | gold quality |
| adenohypophysis | UBERON:0002196 | 62.81 | gold quality |
| pituitary gland | UBERON:0000007 | 61.61 | gold quality |
| embryo | UBERON:0000922 | 61.17 | gold quality |
| C1 segment of cervical spinal cord | UBERON:0006469 | 61.04 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 60.93 | gold quality |
| putamen | UBERON:0001874 | 59.74 | gold quality |
| nucleus accumbens | UBERON:0001882 | 59.44 | gold quality |
| duodenum | UBERON:0002114 | 59.42 | gold quality |
| Brodmann (1909) area 9 | UBERON:0013540 | 59.25 | gold quality |
| spinal cord | UBERON:0002240 | 59.03 | gold quality |
| caudate nucleus | UBERON:0001873 | 58.93 | gold quality |
| blood | UBERON:0000178 | 58.54 | gold quality |
| anterior cingulate cortex | UBERON:0009835 | 58.19 | gold quality |
| cingulate cortex | UBERON:0003027 | 58.15 | gold quality |
| monocyte | CL:0000576 | 58.08 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 0.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | no | 1.93 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 3)
- Long noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21. (PMID:31583718)
- PTENP1-AS contributes to BRAF inhibitor resistance and is associated with adverse clinical outcome in stage III melanoma. (PMID:34040017)
- Long non-coding RNAs PTENP1, GNG12-AS1, MAGI2-AS3 and MEG3 as tumor suppressors in breast cancer and their associations with clinicopathological parameters. (PMID:38277283)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.