PTGES3L

Summary

PTGES3L (prostaglandin E synthase 3 like, HGNC:43943) is a protein-coding gene on chromosome 17q21.31, encoding Putative protein PTGES3L (E9PB15).

Predicted to enable Hsp90 protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus.

Source: NCBI Gene 100885848 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 3 total
• MANE Select transcript: NM_001261430

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43943
Approved symbol	PTGES3L
Name	prostaglandin E synthase 3 like
Location	17q21.31
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000267060
Ensembl biotype	protein_coding
Entrez	100885848

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 13 protein_coding, 2 retained_intron

ENST00000409446, ENST00000424284, ENST00000451885, ENST00000462157, ENST00000464183, ENST00000591916, ENST00000872822, ENST00000872823, ENST00000916932, ENST00000945107, ENST00000945108, ENST00000945109, ENST00000945110, ENST00000945111, ENST00000945112

RefSeq mRNA: 3 — MANE Select: NM_001261430 NM_001142653, NM_001142654, NM_001261430

CCDS: CCDS45692, CCDS45693, CCDS92328

Canonical transcript exons

ENST00000591916 — 7 exons

Exon	Start	End
ENSE00002750923	42980046	42980080
ENSE00002956195	42968103	42969186
ENSE00003511040	42979550	42979663
ENSE00003578157	42970289	42970342
ENSE00003594880	42979170	42979268
ENSE00003639473	42971607	42971696
ENSE00003650476	42979378	42979444

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 94.69.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0622 / max 5.7102, expressed in 31 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166195	0.6914	302
166197	0.0622	31

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	94.69	gold quality
gastrocnemius	UBERON:0001388	94.23	gold quality
muscle of leg	UBERON:0001383	92.69	gold quality
tibialis anterior	UBERON:0001385	90.57	gold quality
right atrium auricular region	UBERON:0006631	89.54	gold quality
heart left ventricle	UBERON:0002084	88.95	gold quality
cardiac ventricle	UBERON:0002082	88.17	gold quality
cardiac atrium	UBERON:0002081	87.58	gold quality
apex of heart	UBERON:0002098	86.86	gold quality
heart	UBERON:0000948	85.13	gold quality
skeletal muscle tissue	UBERON:0001134	84.75	gold quality
quadriceps femoris	UBERON:0001377	83.26	silver quality
deltoid	UBERON:0001476	83.03	silver quality
muscle tissue	UBERON:0002385	82.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.60	gold quality
vastus lateralis	UBERON:0001379	81.68	silver quality
biceps brachii	UBERON:0001507	80.76	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.32	gold quality
muscle layer of sigmoid colon	UBERON:0035805	79.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	79.03	gold quality
lower esophagus	UBERON:0013473	78.99	gold quality
smooth muscle tissue	UBERON:0001135	78.85	gold quality
heart right ventricle	UBERON:0002080	78.53	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	77.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	77.24	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	76.20	gold quality
popliteal artery	UBERON:0002250	74.08	gold quality
tibial artery	UBERON:0007610	74.05	gold quality
mucosa of stomach	UBERON:0001199	73.11	gold quality
left ventricle myocardium	UBERON:0006566	72.52	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-111727	yes	138.72
E-MTAB-5061	no	3.47
E-ANND-3	no	2.71

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

71 targeting PTGES3L, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-30B-3P	99.70	65.76	2325

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ptges3l	ENSDARG00000079462
mus_musculus	Ptges3l	ENSMUSG00000097487
rattus_norvegicus	Ptges3l	ENSRNOG00000050347
drosophila_melanogaster	p23	FBGN0037728
caenorhabditis_elegans		WBGENE00022599

Paralogs (1): PTGES3 (ENSG00000110958)

Protein

Protein identifiers

Putative protein PTGES3L — E9PB15 (reviewed: E9PB15)

Alternative names: Prostaglandin E synthase 3-like

All UniProt accessions (5): A0A7N4I3A5, C9JG77, E9PB15, H7C1Q7, K7N7A2

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the p23/wos2 family.

Isoforms (5)

UniProt ID	Names	Canonical?
E9PB15-1	1	yes
Q9BTE6-2	2
Q9BTE6-3	3
E9PB15-2	4
E9PB15-3	5

RefSeq proteins (3): NP_001136125, NP_001136126, NP_001248359* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007052	CS_dom	Domain
IPR008978	HSP20-like_chaperone	Homologous_superfamily
IPR045250	p23-like	Family

UniProt features (7 total): splice variant 3, chain 1, domain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-E9PB15-F1	74.08	0.29

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 40 (showing top): GOBP_CHAPERONE_MEDIATED_PROTEIN_COMPLEX_ASSEMBLY, GOBP_PROTEIN_MATURATION, GOBP_PROTEIN_FOLDING, GOMF_HEAT_SHOCK_PROTEIN_BINDING, GOMF_HSP90_PROTEIN_BINDING, GOMF_PROTEIN_FOLDING_CHAPERONE_BINDING, FOXN3_TARGET_GENES, NME2_TARGET_GENES, RBM34_TARGET_GENES, ZBTB12_TARGET_GENES, ZNF513_TARGET_GENES, ZNF664_TARGET_GENES, MIR616_5P, MIR371B_5P, MIR373_5P

GO Biological Process (6): protein folding (GO:0006457), chaperone-mediated protein complex assembly (GO:0051131), prostaglandin biosynthetic process (GO:0001516), fatty acid metabolic process (GO:0006631), fatty acid biosynthetic process (GO:0006633), prostaglandin metabolic process (GO:0006693)

GO Molecular Function (3): protein-folding chaperone binding (GO:0051087), Hsp90 protein binding (GO:0051879), isomerase activity (GO:0016853)

GO Cellular Component (3): nucleus (GO:0005634), cytosol (GO:0005829), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cellular process	1
protein maturation	1
protein-containing complex assembly	1
prostaglandin metabolic process	1
prostanoid biosynthetic process	1
lipid metabolic process	1
monocarboxylic acid metabolic process	1
fatty acid metabolic process	1
lipid biosynthetic process	1
monocarboxylic acid biosynthetic process	1
prostanoid metabolic process	1
protein binding	1
heat shock protein binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1
cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

653 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PTGES3L	RUNDC1	Q96C34	442
PTGES3L	SRFBP1	Q8NEF9	399
PTGES3L	RSL24D1	Q9UHA3	395
PTGES3L	SUGT1	Q9Y2Z0	388
PTGES3L	NSA2	O95478	382
PTGES3L	EFCAB11	Q9BUY7	360
PTGES3L	LY6G5C	Q5SRR4	357
PTGES3L	PTGES2	Q9H7Z7	326
PTGES3L	AHSA1	O95433	323
PTGES3L	NOP53	Q9NZM5	318
PTGES3L	PLA2G12B	Q9BX93	311
PTGES3L	CNIH3	Q8TBE1	310
PTGES3L	GMCL1	Q96IK5	309
PTGES3L	OXSR1	O95747	300
PTGES3L	PRXL2B	Q8TBF2	300

IntAct

0 interactions, top by confidence:

BioGRID (2): PTGES3L (Affinity Capture-MS), PTGES3L (Affinity Capture-MS)

ESM2 similar proteins: A2WXR5, A2Y0Q2, A2Y4R8, A9LMC0, B4GDK5, B8ADZ3, B8AMA8, B8B8I3, B8BJV8, E9PB15, F4I2J8, O54917, O60291, O75461, O75896, O81488, P0DOC8, P24051, P58268, P58269, Q08DY6, Q292G3, Q2R837, Q3T0B7, Q40359, Q5XEM9, Q60DW3, Q6IV56, Q6PI47, Q6XL73, Q6Z7F4, Q6ZWY3, Q717R8, Q71UM5, Q75IR6, Q7F2Z1, Q7LKZ5, Q84TV4, Q8H383, Q8LA16

Diamond homologs: E9PB15, G1TGF1, P83868, Q15185, Q3ZBF7, Q5NVM4, Q6PWL5, Q9D9A7, Q9R0Q7, P28707, Q11118, Q23280, Q90955, Q9FR62, Q5ZM57, Q7SY06

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

3 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1139 predictions. Top by Δscore:

Variant	Effect	Δscore
17:42970283:ACTT:A	donor_loss	1.0000
17:42970284:CTT:C	donor_loss	1.0000
17:42970285:TTA:T	donor_loss	1.0000
17:42970286:TACA:T	donor_loss	1.0000
17:42970287:A:AC	donor_gain	1.0000
17:42970287:A:C	donor_loss	1.0000
17:42970287:ACAT:A	donor_gain	1.0000
17:42970287:ACATC:A	donor_gain	1.0000
17:42970288:C:CA	donor_gain	1.0000
17:42970288:CA:C	donor_gain	1.0000
17:42970288:CAT:C	donor_gain	1.0000
17:42970288:CATC:C	donor_gain	1.0000
17:42970288:CATCC:C	donor_gain	1.0000
17:42971601:TCTCA:T	donor_loss	1.0000
17:42971602:CTCA:C	donor_loss	1.0000
17:42971603:TCAC:T	donor_loss	1.0000
17:42971604:CACC:C	donor_loss	1.0000
17:42971605:ACC:A	donor_loss	1.0000
17:42971606:CCT:C	donor_gain	1.0000
17:42971693:CTGG:C	acceptor_gain	1.0000
17:42971697:C:CC	acceptor_gain	1.0000
17:42970283:A:AC	donor_gain	0.9900
17:42970284:C:CC	donor_gain	0.9900
17:42970290:T:TA	donor_gain	0.9900
17:42970341:AGCTA:A	acceptor_loss	0.9900
17:42970342:GCTAG:G	acceptor_loss	0.9900
17:42970343:C:CA	acceptor_loss	0.9900
17:42970343:C:CC	acceptor_gain	0.9900
17:42971694:TGG:T	acceptor_gain	0.9900
17:42971695:GG:G	acceptor_gain	0.9900

AlphaMissense

1059 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000486057 (17:42969096 G>A,C), RS1000800008 (17:42978547 G>C), RS1000912538 (17:42969350 T>G), RS1001207723 (17:42974655 C>A,T), RS1001344922 (17:42974240 G>C), RS1001570091 (17:42974079 C>T), RS1001762427 (17:42981583 C>T), RS1002173208 (17:42967735 G>A), RS1002235083 (17:42972895 G>A), RS1002315650 (17:42971127 G>A), RS1002349528 (17:42972653 G>A), RS1002470277 (17:42980203 T>C,G), RS1002938011 (17:42981733 C>A,T), RS1002975150 (17:42975770 G>A,C), RS1003015025 (17:42981975 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
beta-lapachone	decreases expression, increases expression	1
abrine	increases expression	1
Doxorubicin	decreases expression	1
Smoke	increases expression	1
Triclosan	decreases expression	1
S-Nitrosoglutathione	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.