PTMS

Summary

PTMS (parathymosin, HGNC:9629) is a protein-coding gene on chromosome 12p13.31, encoding Parathymosin (P20962). Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

Predicted to enable histone binding activity. Predicted to be involved in negative regulation of apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus.

Source: NCBI Gene 5763 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• Clinical variants (ClinVar): 18 total
• GTEx eGene: eQTL in 9 tissues, sQTL in 17 (q < 0.05)
• Constraint (gnomAD): pLI 0.82 (intermediate), LOEUF 0.63 (unconstrained)
• MANE Select transcript: NM_002824

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9629
Approved symbol	PTMS
Name	parathymosin
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	ParaT
Ensembl gene	ENSG00000159335
Ensembl biotype	protein_coding
OMIM	168440
Entrez	5763

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 protein_coding_CDS_not_defined

MANE Select: ENST00000309083

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 1, TSL 2: 3

ENST00000309083, ENST00000389462, ENST00000538057, ENST00000540667, ENST00000710358, ENST00001136260

RefSeq mRNA: 2 — MANE Select: NM_002824 NM_001330333, NM_002824

CCDS: CCDS81656, CCDS8560

Canonical transcript exons

ENST00000309083 — 5 exons

Exon	Start	End
ENSE00002265104	6770392	6770952
ENSE00003544822	6769603	6769674
ENSE00003621358	6769921	6769999
ENSE00003622130	6770157	6770218
ENSE00004011638	6766363	6766750

Expression profiles

Bgee: expression breadth ubiquitous, 258 present calls, max score 99.96.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 539.0801 / max 4883.5893, expressed in 1824 samples.

Highest expression (Bgee): tendon of biceps brachii, hemisphere of cerebellum, lobe of liver, cerebellar hemisphere, body of uterus.

Genetic regulation across tissues (GTEx eQTL / sQTL)

PTMS is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 9 tissues and its splicing (sQTL) in 17 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 26 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Artery Tibial	sqtl	6.7e-17	-0.39	12:6770036:T:C
Adipose Subcutaneous	sqtl	2.6e-16	-0.38	12:6770036:T:C
Skin Sun Exposed Lower leg	sqtl	9.5e-13	-0.36	12:6768692:A:G
Artery Aorta	sqtl	6.8e-11	-0.43	12:6770036:T:C
Nerve Tibial	sqtl	1.2e-10	-0.41	12:6767122:G:C
Lung	sqtl	1.4e-10	-0.35	12:6770036:T:C
Thyroid	sqtl	2.3e-08	-0.34	12:6770113:A:G
Esophagus Muscularis	sqtl	1.3e-07	-0.29	12:6770036:T:C
Breast Mammary Tissue	sqtl	1.9e-06	-0.35	12:6770036:T:C
Esophagus Mucosa	sqtl	6.2e-06	-0.36	12:6770036:T:C
Cells Cultured fibroblasts	sqtl	8.7e-06	-0.76	12:6769091:G:C
Nerve Tibial	eqtl	2.0e-05	-0.13	12:6767122:G:C
Esophagus Mucosa	eqtl	1.2e-04	+0.13	12:6768692:A:G
Testis	sqtl	5.0e-04	+0.38	12:6770113:A:G
Esophagus Gastroesophageal Junction	sqtl	6.1e-04	-0.27	12:6761697:G:C
Skin Not Sun Exposed Suprapubic	sqtl	8.2e-04	-0.30	12:6759424:C:G
Ovary	sqtl	1.8e-03	-0.59	12:6762933:G:A
Whole Blood	eqtl	4.8e-03	-0.11	12:7694712:C:T
Muscle Skeletal	eqtl	1.1e-02	+0.21	12:5998878:G:A
Adipose Visceral Omentum	eqtl	1.2e-02	+0.52	12:6431511:T:C

FANTOM5 promoters

showing 10 of 21 alternative TSS:

Promoter ID	TPM avg	Samples expressed
123721	413.9223	1820
123725	53.1120	1803
123736	13.0866	1640
123719	11.5472	1652
123723	11.0011	1663
123735	8.7057	1601
123720	6.5985	1708
123737	3.1657	1150
123724	3.1014	1422
123722	3.0520	1290

Top tissues by expression

showing 100 of 285 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	99.96	gold quality
right hemisphere of cerebellum	UBERON:0014890	99.71	gold quality
right lobe of liver	UBERON:0001114	99.67	gold quality
cerebellar hemisphere	UBERON:0002245	99.65	gold quality
body of uterus	UBERON:0009853	99.63	gold quality
cerebellar cortex	UBERON:0002129	99.59	gold quality
lower esophagus	UBERON:0013473	99.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	99.59	gold quality
ganglionic eminence	UBERON:0004023	99.58	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	99.57	gold quality
muscle layer of sigmoid colon	UBERON:0035805	99.54	gold quality
right ovary	UBERON:0002118	99.53	gold quality
popliteal artery	UBERON:0002250	99.53	gold quality
tibial artery	UBERON:0007610	99.53	gold quality
left ovary	UBERON:0002119	99.52	gold quality
left uterine tube	UBERON:0001303	99.51	gold quality
left coronary artery	UBERON:0001626	99.50	gold quality
descending thoracic aorta	UBERON:0002345	99.50	gold quality
cortical plate	UBERON:0005343	99.50	gold quality
ascending aorta	UBERON:0001496	99.48	gold quality
thoracic aorta	UBERON:0001515	99.48	gold quality
right coronary artery	UBERON:0001625	99.47	gold quality
ventricular zone	UBERON:0003053	99.47	gold quality
aorta	UBERON:0000947	99.43	gold quality
mucosa of stomach	UBERON:0001199	99.43	gold quality
right lung	UBERON:0002167	99.43	gold quality
metanephros cortex	UBERON:0010533	99.42	gold quality
endocervix	UBERON:0000458	99.41	gold quality
nerve	UBERON:0001021	99.37	gold quality
tibial nerve	UBERON:0001323	99.37	gold quality
right frontal lobe	UBERON:0002810	99.31	gold quality
upper lobe of left lung	UBERON:0008952	99.30	gold quality
ectocervix	UBERON:0012249	99.28	gold quality
lower esophagus mucosa	UBERON:0035834	99.26	gold quality
apex of heart	UBERON:0002098	99.22	gold quality
right lobe of thyroid gland	UBERON:0001119	99.18	gold quality
left lobe of thyroid gland	UBERON:0001120	99.18	gold quality
sural nerve	UBERON:0015488	99.14	gold quality
stromal cell of endometrium	CL:0002255	99.12	gold quality
skin of leg	UBERON:0001511	99.12	gold quality
omental fat pad	UBERON:0010414	99.12	gold quality
peritoneum	UBERON:0002358	99.08	gold quality
skin of abdomen	UBERON:0001416	99.06	gold quality
adenohypophysis	UBERON:0002196	99.03	gold quality
minor salivary gland	UBERON:0001830	99.01	gold quality
coronary artery	UBERON:0001621	98.96	gold quality
right atrium auricular region	UBERON:0006631	98.90	gold quality
colonic epithelium	UBERON:0000397	98.83	gold quality
body of stomach	UBERON:0001161	98.79	gold quality
transverse colon	UBERON:0001157	98.76	gold quality
left adrenal gland cortex	UBERON:0035825	98.76	gold quality
left adrenal gland	UBERON:0001234	98.73	gold quality
small intestine Peyer’s patch	UBERON:0003454	98.72	gold quality
right adrenal gland cortex	UBERON:0035827	98.69	gold quality
cingulate cortex	UBERON:0003027	98.68	gold quality
anterior cingulate cortex	UBERON:0009835	98.66	gold quality
right adrenal gland	UBERON:0001233	98.63	gold quality
nucleus accumbens	UBERON:0001882	98.58	gold quality
upper lobe of lung	UBERON:0008948	98.49	gold quality
amygdala	UBERON:0001876	98.33	gold quality
mucosa of transverse colon	UBERON:0004991	98.33	gold quality
esophagus	UBERON:0001043	98.29	gold quality
right uterine tube	UBERON:0001302	98.25	gold quality
cerebellum	UBERON:0002037	98.24	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.11	gold quality
prefrontal cortex	UBERON:0000451	98.02	gold quality
thyroid gland	UBERON:0002046	98.01	gold quality
adrenal cortex	UBERON:0001235	97.82	gold quality
body of pancreas	UBERON:0001150	97.73	gold quality
adipose tissue of abdominal region	UBERON:0007808	97.67	gold quality
tendon	UBERON:0000043	97.66	gold quality
caudate nucleus	UBERON:0001873	97.58	gold quality
gall bladder	UBERON:0002110	97.58	gold quality
stomach	UBERON:0000945	97.51	gold quality
smooth muscle tissue	UBERON:0001135	97.37	gold quality
cardiac atrium	UBERON:0002081	97.32	gold quality
pituitary gland	UBERON:0000007	97.23	gold quality
esophagus mucosa	UBERON:0002469	97.23	gold quality
rectum	UBERON:0001052	97.06	gold quality
putamen	UBERON:0001874	97.00	gold quality
adrenal gland	UBERON:0002369	96.92	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.81	gold quality
heart left ventricle	UBERON:0002084	96.61	gold quality
left testis	UBERON:0004533	96.47	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.41	gold quality
calcaneal tendon	UBERON:0003701	96.37	gold quality
small intestine	UBERON:0002108	96.23	gold quality
fundus of stomach	UBERON:0001160	96.18	gold quality
cardiac ventricle	UBERON:0002082	96.14	gold quality
heart	UBERON:0000948	96.10	gold quality
saliva-secreting gland	UBERON:0001044	96.06	gold quality
subcutaneous adipose tissue	UBERON:0002190	96.04	gold quality
embryo	UBERON:0000922	96.02	gold quality
vagina	UBERON:0000996	95.98	gold quality
ovary	UBERON:0000992	95.91	gold quality
spleen	UBERON:0002106	95.90	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.87	gold quality
right testis	UBERON:0004534	95.86	gold quality
islet of Langerhans	UBERON:0000006	95.70	gold quality
neocortex	UBERON:0001950	95.70	gold quality

Single-cell (SCXA)

Detected in 17 experiment(s), a significant marker in 11.

Experiment	Marker?	Max mean expression
E-MTAB-8495	yes	524.30
E-MTAB-5061	yes	265.05
E-HCAD-1	yes	77.98
E-MTAB-6701	yes	45.54
E-GEOD-134144	yes	36.33
E-MTAB-10553	yes	29.19
E-CURD-122	yes	21.21
E-CURD-88	yes	12.00
E-ANND-3	yes	11.21
E-GEOD-125970	yes	10.31
E-CURD-46	yes	9.98
E-MTAB-10662	no	2316.75
E-MTAB-10485	no	1839.86
E-MTAB-10018	no	1508.24
E-MTAB-10283	no	673.49

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 80 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Basal ganglia	tissue	386.0	low
Putamen	tissue	351.5
Cerebral cortex	tissue	343.5	medium
Temporal cortex	tissue	343.5
Somatosensory cortex	tissue	338.8
Cerebellum	tissue	338.2	high
Prefrontal cortex	tissue	335.3
Hippocampal formation	tissue	326.0
Entorhinal cortex	tissue	326.0
Motor cortex	tissue	320.2
Occipital cortex	tissue	317.3
Retrosplenial and cingulate cortex	tissue	297.3
Ventral forebrain	tissue	280.9
Liver	tissue	277.2	medium
Retrosplenial cortex	tissue	276.3
Hippocampus	tissue	276.2	low
Insular cortex	tissue	273.7
Postcentral gyrus	tissue	271.8
Septum	tissue	252.1
Amygdala	tissue	239.3
Nucleus accumbens	tissue	236.6
Olfactory bulb	tissue	227.7
Thalamus	tissue	221.1
Superior colliculi	tissue	204.8
Vagina	tissue	187.5	high
Pons	tissue	179.3
Hypothalamus	tissue	167.4
Midbrain	tissue	167.3
Caudate putamen	tissue	164.2
Choroid plexus	tissue	163.3
Frontal cortex	tissue	157.4
Substantia nigra	tissue	146.3
Spinal cord	tissue	139.8
Medulla oblongata	tissue	124.4
Pituitary gland	tissue	120.2
Ovary	tissue	117.9	medium
Periaqueductal gray	tissue	108.8
Prostate	tissue	102.7	medium
Adipose tissue	tissue	93.5	high
Smooth muscle	tissue	92.2	medium
Endometrium 1	tissue	89.7	high
Locus coeruleus	tissue	88.6
Seminal vesicle	tissue	81.9	medium
Parathyroid gland	tissue	77.5	medium
Corpus callosum	tissue	76.6
Lung	tissue	64.6	medium
Retina	tissue	60.0
Cervix	tissue	56.7	medium
Kidney	tissue	56.2	medium
Skin 1	tissue	55.1	medium
Skeletal muscle	tissue	52.8	medium
Fallopian tube	tissue	52.2	not detected
Adrenal gland	tissue	49.6	low
Small intestine	tissue	48.9	not detected
Placenta	tissue	46.5	high
Colon	tissue	45.0	medium
Salivary gland	tissue	42.2	medium
Spleen	tissue	41.7	low
Urinary bladder	tissue	41.2	low
Breast	tissue	39.2	high

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — Blood vessel (369.1), Dorsal hippocampus (319.8), Ventral hippocampus (310.0), Hippocampus, CA1 (306.5), Corticomedial amygdala (300.2).

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

1 targets:

Target	Regulation
NR3C1	Activation

Functional genomics

gnomAD constraint: pLI 0.821, LOEUF 0.627, missense Z 1 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000309083 — one region, missense o/e 0.75.

Cross-species orthologs

0 orthologs

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1916452) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 12 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal behavior	2
hyperactivity	1
decreased exploration in new environment	1
increased circulating phosphate level	1
premature death	1
neurodegeneration	1
decreased grip strength	1
preweaning lethality, incomplete penetrance	1
decreased urine magnesium level	1
impaired spatial learning	1
brain atrophy	1
decreased thigmotaxis	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Rattus norvegicus	P04550	99.0%	Diamond
Mus musculus	Q9D0J8	99.0%	Diamond
Bos taurus	P08814	92.2%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
GPR162	protein-coding	27239
LAG3	protein-coding	3902
CD4	protein-coding	920
MLF2	protein-coding	8079
PIANP	protein-coding	196500
COPS7A	protein-coding	50813

Protein

Protein identifiers

Parathymosin — P20962 (reviewed: P20962)

All UniProt accessions (4): P20962, A0A158RFU3, A0AA34QVV1, F5GXR3

UniProt curated annotations — full annotation on UniProt →

Function. Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections.

Similarity. Belongs to the pro/parathymosin family.

RefSeq proteins (2): NP_001317262, NP_002815* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004931	Pro/parathymosin	Family

Pfam: PF03247

UniProt features (13 total): modified residue 8, compositionally biased region 2, initiator methionine 1, chain 1, region of interest 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P20962-F1	62.03	0.00

Human Protein Atlas

Protein class: Predicted intracellular proteins, Essential proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoli; nucleoli rim; nucleoplasm

Antibody reliability (HPA): IH approved · IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8)

Type	Positions
N6-acetyllysine	15, 92, 4
Phosphothreonine	52
N-acetylserine	2
Phosphoserine	2, 5, 13

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 225 (showing top): GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GGGTGGRR_PAX4_03, COUP_01, NFKB_C, IRF7_01, MODULE_75, HNF4_DR1_Q3, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, HNF4_01, TGANTCA_AP1_C, GATA1_03, PU1_Q6, MYB_Q3, LXR_Q3

GO Biological Process (4): immune system process (GO:0002376), DNA replication (GO:0006260), negative regulation of apoptotic process (GO:0043066), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (1): histone binding (GO:0042393)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

11 GO namespaces:

Category	Terms
biological_process	1
DNA metabolic process	1
DNA biosynthetic process	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
protein binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

IntAct

Human interaction partners of PTMS in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

8 partners by confidence:

Partner	Interaction type	MIscore	Records
PARP2	adp ribosylation reaction	0.440	1
SDCBP2	physical association	0.370	1
GET4	physical association	0.000	1
MYB	physical association	0.000	1
RXRB	physical association	0.000	1
SCHIP1	physical association	0.000	1
SMAD2	physical association	0.000	1
ZNF24	physical association	0.000	1

BioGRID (98 interactions; top human partners by supporting records): NR3C1 (Proximity Label-MS; 3 records), CREBBP (Affinity Capture-Western; 2 records), EP300 (Affinity Capture-Western; 2 records), HSPE1 (Affinity Capture-MS; 2 records), PTMA (Affinity Capture-MS; 2 records), SOD1 (Affinity Capture-MS; 2 records), ACTC1 (Affinity Capture-MS), ADSS (Co-fractionation), AGRN (Affinity Capture-MS), AKT3 (Affinity Capture-MS), ANP32A (Affinity Capture-MS), ANP32B (Affinity Capture-MS), ANXA5 (Affinity Capture-MS), APP (Reconstituted Complex), ATPIF1 (Affinity Capture-MS)

SIGNOR signaling

3 signaling interactions:

A	Effect	B	Mechanism
PTMS	“up-regulates quantity by expression”	NR3C1	“transcriptional regulation”
PTMS	“up-regulates activity”	EP300	binding
PTMS	“up-regulates activity”	NCOA1	binding

Disease & clinical

Genetic variants

Variant evidence for PTMS: 18 ClinVar records (0 pathogenic / likely pathogenic).

ClinVar

18 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	5
Likely benign	1
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 26 predictions of 400):

Position(s)	Effect	Δscore	Sites
12:6769601–6769602	acceptor_loss	1.0000	3
12:6769648	donor_gain	1.0000
12:6769660	donor_gain	1.0000
12:6769675–6769676	donor_loss	1.0000	2
12:6769920	acceptor_loss	1.0000	2
12:6769989–6769990	donor_gain	1.0000	2
12:6770000–6770001	donor_loss	1.0000	5
12:6770216	donor_gain	1.0000
12:6770390–6770391	acceptor_loss	1.0000	4
12:6766751–6766752	donor_loss	0.9900	5

AlphaMissense

224 missense substitutions predicted likely pathogenic (of 676 scored), across 65 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
N98	8	0.828	0.954
N43	8	0.812	0.962
D16	8	0.787	0.923
K95	6	0.960	0.979
G99	6	0.924	0.987
K92	6	0.922	0.977
K20	6	0.890	0.949
K18	6	0.872	0.965
K80	6	0.861	0.953
K21	6	0.858	0.948
T96	6	0.848	0.975
G44	6	0.843	0.950
K34	6	0.814	0.930
K31	6	0.806	0.926
D90	6	0.747	0.888
R93	5	0.873	0.951
R81	5	0.855	0.932
K35	5	0.809	0.878
K15	5	0.756	0.893
K27	5	0.745	0.826

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Disease associations

OMIM: gene MIM:168440 | disease phenotypes:

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066490 (SINGLE PROTEIN)

PharmGKB: 1 entry (CPIC guideline: no)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.41	Kd	39.4	nM	CHEMBL3752910
7.41	ED50	39.4	nM	CHEMBL3752910

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(1-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149920: Binding affinity to human PTMS incubated for 45 mins by Kinobead based pull down assay	kd	0.0394	uM

CTD chemical–gene interactions

56 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	increases expression, affects cotreatment	3
Benzo(a)pyrene	decreases expression, increases methylation	3
Particulate Matter	increases expression, affects cotreatment, decreases expression, increases abundance	3
bisphenol A	affects expression, decreases expression	2
sodium arsenite	affects methylation, increases expression	2
Air Pollutants	increases abundance, increases expression, decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	decreases expression	2
Cadmium Chloride	increases expression	2
UF010 compound	increases acetylation	1
FR900359	increases phosphorylation	1
bisphenol F	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
lead acetate	increases expression	1
beta-lapachone	decreases expression	1
cobaltous chloride	decreases expression	1
butyraldehyde	decreases expression	1
cupric chloride	increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluoro-n-nonanoic acid	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
(+)-JQ1 compound	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Temozolomide	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652962	Binding	Binding affinity to human PTMS incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — *ChemMedChem*

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.

Predicted chemistry — Sugi Predict

The predicted patent-compound landscape for PTMS across ~30M SureChEMBL compounds — explore on Sugi Predict.