PTPRG-AS1

Summary

PTPRG-AS1 (PTPRG antisense RNA 1, HGNC:44638) is a long non-coding RNA gene on chromosome 3p14.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44638
Approved symbol	PTPRG-AS1
Name	PTPRG antisense RNA 1
Location	3p14.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241472
Ensembl biotype	lncRNA
Entrez	100506994
RNAcentral	URS000075E7B9 — lncRNA, 2690 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 88 — 87 lncRNA, 1 retained_intron

ENST00000462497, ENST00000466893, ENST00000469148, ENST00000474795, ENST00000475371, ENST00000479018, ENST00000479588, ENST00000490916, ENST00000495542, ENST00000498655, ENST00000652936, ENST00000652980, ENST00000653279, ENST00000660182, ENST00000661510, ENST00000662235, ENST00000664200, ENST00000664757, ENST00000664758, ENST00000665590, ENST00000665832, ENST00000668824, ENST00000669426, ENST00000669571, ENST00000670193, ENST00000670263, ENST00000700780, ENST00000701063, ENST00000701508, ENST00000701712, ENST00000701777, ENST00000702680, ENST00000703249, ENST00000817057, ENST00000817058, ENST00000817059, ENST00000817060, ENST00000817061, ENST00000817062, ENST00000817063, ENST00000817064, ENST00000817065, ENST00000817066, ENST00000817067, ENST00000817068, ENST00000817069, ENST00000817070, ENST00000817071, ENST00000817072, ENST00000817073, ENST00000817074, ENST00000817075, ENST00000817076, ENST00000817077, ENST00000817078, ENST00000817079, ENST00000817080, ENST00000817081, ENST00000817082, ENST00000817083, ENST00000817084, ENST00000817085, ENST00000817086, ENST00000817087, ENST00000817088, ENST00000817089, ENST00000817090, ENST00000817091, ENST00000817092, ENST00000817093, ENST00000817094, ENST00000817095, ENST00000817096, ENST00000817097, ENST00000817098, ENST00000817099, ENST00000817100, ENST00000817101, ENST00000817102, ENST00000817103, ENST00000817104, ENST00000817105, ENST00000817106, ENST00000817107, ENST00000817108, ENST00000817109, ENST00000817110, ENST00000817111

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000462497 — 4 exons

Exon	Start	End
ENSE00001809437	62318866	62318923
ENSE00001822401	62261825	62264142
ENSE00001937426	62317808	62317900
ENSE00004220481	62317106	62317192

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 88.96.

FANTOM5 (CAGE): breadth broad, TPM avg 2.7417 / max 102.7830, expressed in 763 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
42793	2.2813	618
42794	0.4604	268

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	88.96	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.36	gold quality
colonic epithelium	UBERON:0000397	85.11	gold quality
right testis	UBERON:0004534	81.88	gold quality
left testis	UBERON:0004533	81.41	gold quality
testis	UBERON:0000473	80.05	gold quality
cortical plate	UBERON:0005343	79.49	gold quality
sural nerve	UBERON:0015488	77.76	gold quality
ganglionic eminence	UBERON:0004023	77.55	gold quality
ventricular zone	UBERON:0003053	77.33	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	71.10	gold quality
tendon	UBERON:0000043	70.64	gold quality
bone marrow cell	CL:0002092	69.79	gold quality
prefrontal cortex	UBERON:0000451	69.24	gold quality
spinal cord	UBERON:0002240	68.83	gold quality
anterior cingulate cortex	UBERON:0009835	68.65	gold quality
popliteal artery	UBERON:0002250	68.57	gold quality
tibial artery	UBERON:0007610	68.52	gold quality
islet of Langerhans	UBERON:0000006	67.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.90	gold quality
amygdala	UBERON:0001876	66.73	gold quality
aorta	UBERON:0000947	66.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.88	gold quality
tibial nerve	UBERON:0001323	65.86	gold quality
neocortex	UBERON:0001950	65.84	gold quality
right frontal lobe	UBERON:0002810	65.46	gold quality
frontal cortex	UBERON:0001870	65.26	gold quality
corpus callosum	UBERON:0002336	64.80	gold quality
stromal cell of endometrium	CL:0002255	64.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.74

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Overexpression of long noncoding RNA PTPRG-AS1 is associated with poor prognosis in epithelial ovarian cancer. (PMID:32844927)
• Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4. (PMID:33174523)
• Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma. (PMID:34767727)
• Long non-coding RNA PTPRG-AS1/microRNA-124-3p regulates radiosensitivity of nasopharyngeal carcinoma via the LIM Homeobox 2-dependent Notch pathway through competitive endogenous RNA mechanism. (PMID:35300558)
• POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis. (PMID:38318853)
• Mechanism of HOXA10 in nasopharyngeal carcinoma cell proliferation through the PTPRG-AS1/USP1 axis. (PMID:39445487)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.