PUM3

Summary

PUM3 (pumilio RNA binding family member 3, HGNC:29676) is a protein-coding gene on chromosome 9p24.2, encoding Pumilio homolog 3 (Q15397). Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress.

Enables RNA binding activity. Predicted to be involved in regulation of translation. Located in chromosome; endoplasmic reticulum; and nuclear lumen.

Source: NCBI Gene 9933 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 151 total — 1 pathogenic
• MANE Select transcript: NM_014878

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29676
Approved symbol	PUM3
Name	pumilio RNA binding family member 3
Location	9p24.2
Locus type	gene with protein product
Status	Approved
Aliases	XTP5, PEN, PUF6, hPUF-A, HA-8, Puf-A
Ensembl gene	ENSG00000080608
Ensembl biotype	protein_coding
OMIM	609960
Entrez	9933

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 26 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000382032, ENST00000397885, ENST00000469168, ENST00000490444, ENST00000861028, ENST00000861029, ENST00000861030, ENST00000861031, ENST00000861032, ENST00000861033, ENST00000861034, ENST00000861035, ENST00000861036, ENST00000922205, ENST00000922206, ENST00000922207, ENST00000922208, ENST00000922209, ENST00000922210, ENST00000922211, ENST00000922212, ENST00000922213, ENST00000922214, ENST00000922215, ENST00000922216, ENST00000922217, ENST00000954334, ENST00000954335, ENST00000954336

RefSeq mRNA: 1 — MANE Select: NM_014878 NM_014878

CCDS: CCDS6448

Canonical transcript exons

ENST00000397885 — 18 exons

Exon	Start	End
ENSE00000686730	2810344	2810431
ENSE00000813087	2807814	2807904
ENSE00000982079	2831251	2831344
ENSE00000982080	2830962	2831028
ENSE00000982081	2829774	2829948
ENSE00000982082	2828675	2828778
ENSE00000982083	2827073	2827151
ENSE00000982085	2823781	2823834
ENSE00000982086	2820018	2820098
ENSE00000982087	2812220	2812362
ENSE00000982088	2811361	2811583
ENSE00001028345	2833357	2833432
ENSE00001088952	2824717	2824815
ENSE00001530665	2844045	2844095
ENSE00001596518	2837180	2837401
ENSE00001603827	2834031	2834166
ENSE00001784806	2838426	2838517
ENSE00001914286	2804152	2804463

Expression profiles

Bgee: expression breadth ubiquitous, 264 present calls, max score 94.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.1351 / max 875.5705, expressed in 1777 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99749	26.1351	1777

Top tissues by expression

284 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.70	gold quality
calcaneal tendon	UBERON:0003701	92.83	gold quality
mucosa of transverse colon	UBERON:0004991	92.29	gold quality
esophagus mucosa	UBERON:0002469	92.26	gold quality
lower esophagus mucosa	UBERON:0035834	91.85	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	91.83	gold quality
metanephros cortex	UBERON:0010533	91.45	gold quality
peritoneum	UBERON:0002358	91.31	gold quality
omental fat pad	UBERON:0010414	91.31	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.04	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	91.04	gold quality
left ovary	UBERON:0002119	91.00	gold quality
adipose tissue of abdominal region	UBERON:0007808	90.62	gold quality
minor salivary gland	UBERON:0001830	90.60	gold quality
body of pancreas	UBERON:0001150	90.44	gold quality
right ovary	UBERON:0002118	90.38	gold quality
upper lobe of left lung	UBERON:0008952	90.22	gold quality
left uterine tube	UBERON:0001303	90.20	gold quality
mouth mucosa	UBERON:0003729	89.96	gold quality
rectum	UBERON:0001052	89.85	gold quality
esophagus	UBERON:0001043	89.75	gold quality
ventricular zone	UBERON:0003053	89.67	gold quality
skin of abdomen	UBERON:0001416	89.54	gold quality
tonsil	UBERON:0002372	89.49	gold quality
sural nerve	UBERON:0015488	89.43	gold quality
left adrenal gland cortex	UBERON:0035825	89.39	gold quality
upper lobe of lung	UBERON:0008948	89.38	gold quality
ovary	UBERON:0000992	89.28	gold quality
islet of Langerhans	UBERON:0000006	89.11	gold quality
right adrenal gland	UBERON:0001233	89.05	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-4850	no	3179.70
E-MTAB-6142	no	218.07
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

21 targeting PUM3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-6083	99.47	68.73	2393
HSA-MIR-410-3P	99.27	69.98	2457
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-4773	98.35	67.30	1710
HSA-MIR-6502-3P	97.86	65.43	569

Literature-anchored findings (GeneRIF, showing 2)

• Results indicate that mismatches in minor H antigens HA-8 (KIAA0020) and ACC-1 (BCL2A1) predisposed to chronic graft-versus-host disease (GvHD). (PMID:23480177)
• Phosphorylation of PUF-A/PUM3 on Y259 modulates PUF-A stability and cell proliferation. (PMID:34407138)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	pum3	ENSDARG00000087779
mus_musculus	Pum3	ENSMUSG00000041360
rattus_norvegicus	Pum3	ENSRNOG00000012574
rattus_norvegicus	Pum3l1	ENSRNOG00000048356
drosophila_melanogaster	peng	FBGN0015527
caenorhabditis_elegans		WBGENE00014165

Protein

Protein identifiers

Pumilio homolog 3 — Q15397 (reviewed: Q15397)

Alternative names: HBV X-transactivated gene 5 protein, HBV XAg-transactivated protein 5, Minor histocompatibility antigen HA-8

All UniProt accessions (2): Q15397, S4R3K8

UniProt curated annotations — full annotation on UniProt →

Function. Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells.

Subunit / interactions. Interacts with PARP1 (via catalytic domain).

Subcellular location. Nucleus. Nucleolus. Nucleoplasm. Chromosome.

Tissue specificity. Widely expressed.

Domain organisation. The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen. A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.

Polymorphism. The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.

RefSeq proteins (1): NP_055693* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001313	Pumilio_RNA-bd_rpt	Repeat
IPR011989	ARM-like	Homologous_superfamily
IPR012959	CPL_dom	Domain
IPR016024	ARM-type_fold	Homologous_superfamily
IPR033133	PUM-HD	Domain
IPR040059	PUM3	Family

Pfam: PF08144

UniProt features (82 total): helix 45, repeat 11, turn 8, sequence variant 6, compositionally biased region 3, region of interest 2, strand 2, chain 1, domain 1, short sequence motif 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
4WZR	X-RAY DIFFRACTION	2.15
4WZW	X-RAY DIFFRACTION	2.95

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15397-F1	85.19	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 33

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 203 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, TAKADA_GASTRIC_CANCER_COPY_NUMBER_DN, PUJANA_CHEK2_PCC_NETWORK, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, SCHUHMACHER_MYC_TARGETS_UP, ONKEN_UVEAL_MELANOMA_UP, MYOD_01, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, YANG_BREAST_CANCER_ESR1_DN, BILD_E2F3_ONCOGENIC_SIGNATURE

GO Biological Process (2): regulation of translation (GO:0006417), regulation of protein ADP-ribosylation (GO:0010835)

GO Molecular Function (4): DNA binding (GO:0003677), RNA binding (GO:0003723), mRNA binding (GO:0003729), protein binding (GO:0005515)

GO Cellular Component (5): nucleoplasm (GO:0005654), chromosome (GO:0005694), nucleolus (GO:0005730), endoplasmic reticulum (GO:0005783), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
nucleic acid binding	2
nuclear lumen	2
intracellular membraneless organelle	2
intracellular membrane-bounded organelle	2
translation	1
post-transcriptional regulation of gene expression	1
regulation of protein metabolic process	1
regulation of transferase activity	1
NAD+-protein mono-ADP-ribosyltransferase activity	1
RNA binding	1
binding	1
cellular anatomical structure	1
cytoplasm	1
endomembrane system	1

Protein interactions and networks

STRING

2098 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PUM3	EIF5B	O60841	723
PUM3	NOP9	Q86U38	678
PUM3	HLA-A	P01891	678
PUM3	NME2	P22392	621
PUM3	NSA2	O95478	562
PUM3	RPF2	Q9H7B2	526
PUM3	PUM1	Q14671	515
PUM3	PUM2	Q8TB72	500
PUM3	DDX27	Q96GQ7	475
PUM3	ARHGAP45	Q92619	470
PUM3	COX17	Q14061	462
PUM3	SURF6	O75683	455
PUM3	GNL2	Q13823	452
PUM3	TMEM209	Q96SK2	443
PUM3	PNO1	Q9NRX1	440

IntAct

256 interactions, top by confidence:

A	B	Type	Score
MED23	MED19	psi-mi:“MI:2364”(proximity)	0.770
SRP68	SRP72	psi-mi:“MI:0914”(association)	0.730
RPL10A	RRP8	psi-mi:“MI:0914”(association)	0.640
RPL14	RRP8	psi-mi:“MI:0914”(association)	0.640
H1-1	RRP8	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NOL12	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	NVL	psi-mi:“MI:0914”(association)	0.610
MAGEB10	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-6	ZNF724	psi-mi:“MI:0914”(association)	0.530
RBM34	NVL	psi-mi:“MI:0914”(association)	0.530
H1-4	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
ILF2	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
RPL37A	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MACROH2A2	PPM1G	psi-mi:“MI:0914”(association)	0.530
PRR11	NVL	psi-mi:“MI:0914”(association)	0.530
MAK16	NVL	psi-mi:“MI:0914”(association)	0.530
ZNF71	NVL	psi-mi:“MI:0914”(association)	0.530
RPL30	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL8	RRP8	psi-mi:“MI:0914”(association)	0.530
RPL18A	RRP8	psi-mi:“MI:0914”(association)	0.530
PUM3	RRP8	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530

BioGRID (392): KIAA0020 (Affinity Capture-RNA), KIAA0020 (Affinity Capture-RNA), KIAA0020 (Affinity Capture-RNA), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS), KIAA0020 (Affinity Capture-MS)

ESM2 similar proteins: A1Z3X3, A2AT37, A4GWN3, A5PKE4, B0UYI1, B2GV38, O08848, O35841, O43395, O75031, P49754, Q08CZ0, Q15397, Q15650, Q2HJ41, Q2T9K6, Q3UBZ5, Q5EAQ1, Q5KU39, Q5R5F1, Q5R644, Q5RCR8, Q5RE03, Q5U3V9, Q5VZK9, Q5XIC7, Q5ZJ85, Q5ZKG8, Q5ZMW3, Q676U5, Q6GLK9, Q6GMH0, Q6NYU2, Q7Z3V4, Q80UM3, Q80YQ8, Q8BHL5, Q8BM39, Q8R2M0, Q8WV92

Diamond homologs: Q09622, Q15397, Q562C7, Q9LRZ3, Q8BKS9, X1WGX5, Q04373, Q9UU76

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
“Cap-binding complex”	“down-regulates quantity by repression”	PUM3	“post transcriptional regulation”

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 188 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	6	35.4×	3e-07
Peptide chain elongation	24	26.7×	3e-26
Viral mRNA Translation	24	26.7×	3e-26
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	24	26.4×	3e-26
Selenocysteine synthesis	24	25.3×	6e-26
Eukaryotic Translation Termination	24	25.3×	6e-26
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	24	24.8×	9e-26
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	24	24.8×	9e-26

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of DNA recombination	7	47.1×	1e-08
chromosome condensation	7	35.3×	8e-08
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	5	28.0×	5e-05
cytoplasmic translation	25	27.7×	9e-27
ribosomal large subunit biogenesis	8	21.2×	3e-07
positive regulation of viral genome replication	5	17.4×	4e-04
translation	25	15.4×	4e-20
rRNA processing	18	15.3×	4e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

151 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	117
Likely benign	3
Benign	3

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
563675	GRCh37/hg19 9p24.3-23(chr9:203861-9306658)x1	Pathogenic

SpliceAI

2698 predictions. Top by Δscore:

Variant	Effect	Δscore
9:2804464:C:CC	acceptor_gain	1.0000
9:2806445:T:C	acceptor_gain	1.0000
9:2811605:G:GC	acceptor_gain	1.0000
9:2811608:T:TC	acceptor_gain	1.0000
9:2811624:C:CT	acceptor_gain	1.0000
9:2823836:T:C	acceptor_gain	1.0000
9:2827071:A:AC	donor_gain	1.0000
9:2827072:C:CC	donor_gain	1.0000
9:2827072:CTGAT:C	donor_gain	1.0000
9:2828673:A:AC	donor_gain	1.0000
9:2828674:C:CC	donor_gain	1.0000
9:2828779:C:CC	acceptor_gain	1.0000
9:2829760:T:TA	donor_gain	1.0000
9:2829770:TCAC:T	donor_loss	1.0000
9:2829771:CACCT:C	donor_loss	1.0000
9:2829808:T:TA	donor_gain	1.0000
9:2829944:TACTT:T	acceptor_gain	1.0000
9:2829946:CTT:C	acceptor_gain	1.0000
9:2829946:CTTC:C	acceptor_loss	1.0000
9:2829947:TT:T	acceptor_gain	1.0000
9:2829947:TTCTA:T	acceptor_loss	1.0000
9:2829948:TC:T	acceptor_loss	1.0000
9:2829949:C:A	acceptor_loss	1.0000
9:2829949:C:CC	acceptor_gain	1.0000
9:2829950:T:G	acceptor_loss	1.0000
9:2829954:C:CT	acceptor_gain	1.0000
9:2829956:C:CT	acceptor_gain	1.0000
9:2829957:A:T	acceptor_gain	1.0000
9:2829959:C:CT	acceptor_gain	1.0000
9:2829961:C:CT	acceptor_gain	1.0000

AlphaMissense

4303 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:2823826:T:A	K381N	0.999
9:2823826:T:G	K381N	0.999
9:2823829:C:A	R380S	0.999
9:2823829:C:G	R380S	0.999
9:2824717:C:A	K378N	0.999
9:2824717:C:G	K378N	0.999
9:2823827:T:A	K381I	0.998
9:2823828:T:C	K381E	0.998
9:2823830:C:A	R380M	0.998
9:2823830:C:G	R380T	0.998
9:2831320:G:T	R181S	0.998
9:2834034:C:G	R146T	0.998
9:2823814:T:A	K385N	0.997
9:2823814:T:G	K385N	0.997
9:2823815:T:A	K385I	0.997
9:2823816:T:C	K385E	0.997
9:2824727:C:T	G375D	0.997
9:2824760:C:T	G364D	0.997
9:2831319:C:G	R181P	0.997
9:2831332:G:C	H177D	0.997
9:2834033:T:A	R146S	0.997
9:2834033:T:G	R146S	0.997
9:2834047:A:G	W142R	0.997
9:2834047:A:T	W142R	0.997
9:2820049:T:C	D413G	0.996
9:2820050:C:G	D413H	0.996
9:2824719:T:C	K378E	0.996
9:2829838:G:T	A263D	0.996
9:2830983:A:T	V219D	0.996
9:2831009:A:C	S210R	0.996

dbSNP variants (sampled 300 via entrez): RS1000041588 (9:2840647 C>T), RS1000057532 (9:2835835 T>C), RS1000071404 (9:2804641 A>G), RS1000100594 (9:2837806 T>C), RS1000134480 (9:2824130 C>T), RS1000166631 (9:2839149 C>T), RS1000222758 (9:2842197 G>A), RS1000295043 (9:2814893 G>A,C), RS1000302035 (9:2810153 C>G), RS1000364099 (9:2820026 T>A,G), RS1000388103 (9:2815173 T>A), RS1000429986 (9:2835608 G>A), RS1000467686 (9:2823047 T>C), RS1000474777 (9:2837505 C>A,T), RS1000540782 (9:2822864 T>A,C)

Disease associations

OMIM: gene MIM:609960 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST001762_367	Obesity-related traits	9.000000e-06
GCST001762_499	Obesity-related traits	1.000000e-06
GCST002039_5	Blood trace element (Se levels)	3.000000e-06
GCST002187_8	Systolic blood pressure in sickle cell anemia	8.000000e-06
GCST005839_13	Depression	2.000000e-08
GCST006041_17	Major depressive disorder	4.000000e-08
GCST008161_71	Waist circumference adjusted for body mass index	7.000000e-06
GCST009391_1188	Metabolite levels	4.000000e-06
GCST011703_91	Smoking initiation	2.000000e-08

EFO canonical traits (6, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure
EFO:0004344	birth weight
EFO:0006335	systolic blood pressure
EFO:0007789	BMI-adjusted waist circumference
EFO:0021575	adipic acid measurement
EFO:0005670	smoking initiation

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tretinoin	decreases expression	4
bisphenol A	affects cotreatment, affects methylation, decreases expression	3
Benzo(a)pyrene	decreases expression, affects methylation	3
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
dicrotophos	decreases expression	1
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
decabromobiphenyl ether	decreases expression	1
sodium arsenite	decreases expression	1
tetrabromobisphenol A	decreases expression	1
nickel sulfate	decreases expression	1
perfluoro-n-nonanoic acid	increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Fulvestrant	affects cotreatment, affects methylation	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylstilbestrol	increases expression	1
Dimethyl Sulfoxide	affects expression	1
Doxorubicin	decreases expression	1
Estradiol	increases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, increases expression	1
Nickel	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_ZD04	Mel 05.18	Cancer cell line	Male
CVCL_ZD05	Mel 06.07	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.