PURPL

Summary

PURPL (p53 upregulated regulator of p53 levels, HGNC:48995) is a long non-coding RNA gene on chromosome 5p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48995
Approved symbol	PURPL
Name	p53 upregulated regulator of p53 levels
Location	5p14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC643401, RP11-46C20.1
Ensembl gene	ENSG00000250337
Ensembl biotype	lncRNA
Entrez	643401
RNAcentral	URS000075D3F5 — lncRNA, 1120 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 129 — 129 lncRNA

ENST00000503107, ENST00000505775, ENST00000510165, ENST00000512067, ENST00000514255, ENST00000514844, ENST00000650981, ENST00000651409, ENST00000652841, ENST00000653835, ENST00000654039, ENST00000655107, ENST00000655438, ENST00000656783, ENST00000657173, ENST00000657375, ENST00000657424, ENST00000658312, ENST00000659077, ENST00000659489, ENST00000659860, ENST00000660307, ENST00000660639, ENST00000661698, ENST00000664501, ENST00000664566, ENST00000665451, ENST00000667264, ENST00000667420, ENST00000667624, ENST00000668103, ENST00000668406, ENST00000669423, ENST00000670554, ENST00000670840, ENST00000686605, ENST00000687778, ENST00000688783, ENST00000690628, ENST00000700779, ENST00000710958, ENST00000710961, ENST00000710962, ENST00000710963, ENST00000710964, ENST00000710965, ENST00000710966, ENST00000710967, ENST00000710968, ENST00000710969, ENST00000710970, ENST00000710971, ENST00000710972, ENST00000710999, ENST00000711000, ENST00000711001, ENST00000711002, ENST00000711003, ENST00000711004, ENST00000711005, ENST00000711006, ENST00000711007, ENST00000711008, ENST00000711009, ENST00000711010, ENST00000711011, ENST00000711012, ENST00000711013, ENST00000711014, ENST00000711015, ENST00000711016, ENST00000711017, ENST00000711018, ENST00000711019, ENST00000711020, ENST00000711021, ENST00000711022, ENST00000711023, ENST00000711024, ENST00000711025, ENST00000711026, ENST00000711027, ENST00000711028, ENST00000711029, ENST00000711030, ENST00000711031, ENST00000711032, ENST00000711033, ENST00000711034, ENST00000711035, ENST00000711036, ENST00000711038, ENST00000711039, ENST00000711040, ENST00000711041, ENST00000711042, ENST00000711043, ENST00000711044, ENST00000711045, ENST00000711047, ENST00000711051, ENST00000711052, ENST00000711053, ENST00000711054, ENST00000711055, ENST00000711056, ENST00000711057, ENST00000711058, ENST00000711059, ENST00000711062, ENST00000711064, ENST00000711065, ENST00000711066, ENST00000711067, ENST00000711068, ENST00000711069, ENST00000711070, ENST00000711071, ENST00000711072, ENST00000711073, ENST00000711074, ENST00000711075, ENST00000711076, ENST00000711077, ENST00000711078, ENST00000711293, ENST00000839279, ENST00000839280, ENST00000839281

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503107 — 4 exons

Exon	Start	End
ENSE00004014250	27475535	27475695
ENSE00004014309	27482412	27482566
ENSE00004014338	27484926	27488783
ENSE00004014434	27472284	27472519

Expression profiles

Bgee: expression breadth ubiquitous, 144 present calls, max score 81.38.

FANTOM5 (CAGE): breadth broad, TPM avg 12.8109 / max 979.2260, expressed in 630 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
55929	11.8856	587
55928	0.2341	47
55930	0.2173	108
55933	0.1893	59
55934	0.1207	55
55931	0.0851	47
55932	0.0789	37

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.38	gold quality
colonic epithelium	UBERON:0000397	80.06	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	76.07	gold quality
stromal cell of endometrium	CL:0002255	75.59	gold quality
calcaneal tendon	UBERON:0003701	70.05	gold quality
apex of heart	UBERON:0002098	67.86	gold quality
body of pancreas	UBERON:0001150	65.76	gold quality
ventricular zone	UBERON:0003053	65.71	gold quality
right lobe of liver	UBERON:0001114	64.47	gold quality
ectocervix	UBERON:0012249	62.34	gold quality
cortical plate	UBERON:0005343	61.85	gold quality
pancreas	UBERON:0001264	61.35	gold quality
sural nerve	UBERON:0015488	61.04	silver quality
hindlimb stylopod muscle	UBERON:0004252	60.87	gold quality
ganglionic eminence	UBERON:0004023	59.58	gold quality
tendon	UBERON:0000043	59.44	gold quality
endocervix	UBERON:0000458	59.17	gold quality
vagina	UBERON:0000996	58.71	gold quality
ascending aorta	UBERON:0001496	58.04	gold quality
uterine cervix	UBERON:0000002	58.01	gold quality
thoracic aorta	UBERON:0001515	57.62	gold quality
monocyte	CL:0000576	57.32	gold quality
metanephros cortex	UBERON:0010533	57.19	gold quality
aorta	UBERON:0000947	56.61	gold quality
tibial artery	UBERON:0007610	56.05	gold quality
popliteal artery	UBERON:0002250	56.01	gold quality
heart left ventricle	UBERON:0002084	55.56	gold quality
left coronary artery	UBERON:0001626	55.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	55.38	gold quality
cortex of kidney	UBERON:0001225	55.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.04

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Silencing of PURPL inhibited liver cancer cells proliferation, blocked cell cycle progression, and promoted apoptosis. Most importantly, PURPL expression was negatively correlated with p53 mRNA expression. (PMID:31059022)
• High PURPL expression is associated with gastric cancer. (PMID:31606380)
• Long non-coding RNA p53 upregulated regulator of p53 levels (PURPL) promotes the development of gastric cancer. (PMID:35012438)
• LINC01021 maintains tumorigenicity by enhancing N6-methyladenosine reader IMP2 dependent stabilization of MSX1 and JARID2: implication in colorectal cancer. (PMID:35173309)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.