PWAR1

Summary

PWAR1 (Prader Willi/Angelman region RNA 1, HGNC:30089) is a long non-coding RNA gene on chromosome 15q11.2.

At a glance

• Gene type: non-coding (TEC) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30089
Approved symbol	PWAR1
Name	Prader Willi/Angelman region RNA 1
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PAR1, PAR-1
Ensembl gene	ENSG00000279050
Ensembl biotype	TEC
OMIM	600161
Entrez	145624
RNAcentral	URS0000759FB4 — lncRNA, 2412 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 TEC

ENST00000624188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624188 — 1 exons

Exon	Start	End
ENSE00003756614	25135642	25138055

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 86.23.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.23	gold quality
skeletal muscle tissue	UBERON:0001134	64.98	silver quality
muscle of leg	UBERON:0001383	60.54	gold quality
ganglionic eminence	UBERON:0004023	60.53	gold quality
primary visual cortex	UBERON:0002436	57.52	gold quality
hindlimb stylopod muscle	UBERON:0004252	57.03	silver quality
right lobe of thyroid gland	UBERON:0001119	51.80	gold quality
thyroid gland	UBERON:0002046	50.64	gold quality
prefrontal cortex	UBERON:0000451	50.49	gold quality
superior frontal gyrus	UBERON:0002661	50.47	gold quality
left lobe of thyroid gland	UBERON:0001120	50.35	gold quality
corpus callosum	UBERON:0002336	49.79	silver quality
kidney	UBERON:0002113	49.77	silver quality
frontal cortex	UBERON:0001870	49.27	silver quality
liver	UBERON:0002107	48.72	silver quality
right hemisphere of cerebellum	UBERON:0014890	48.16	silver quality
right frontal lobe	UBERON:0002810	47.82	gold quality
islet of Langerhans	UBERON:0000006	47.26	silver quality
urinary bladder	UBERON:0001255	46.50	gold quality
cerebellar hemisphere	UBERON:0002245	46.49	silver quality
multicellular organism	UBERON:0000468	46.46	gold quality
lung	UBERON:0002048	46.10	silver quality
right lobe of liver	UBERON:0001114	45.81	silver quality
heart left ventricle	UBERON:0002084	45.63	gold quality
brain	UBERON:0000955	45.32	gold quality
lymph node	UBERON:0000029	45.00	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	44.77	silver quality
left coronary artery	UBERON:0001626	44.47	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	44.37	silver quality
right adrenal gland cortex	UBERON:0035827	44.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Compromised PAR1 Activation-A Cause for Bleeding in XMEN? (PMID:36720253)
• Association between Polymorphism of Genes IL-1A, NFKB1, PAR1, TP53, and UCP2 and Susceptibility to Non-Small Cell Lung Cancer in the Brazilian Amazon. (PMID:36833388)
• HepPar1 and GATA-3 Expression in Neuroendocrine Neoplasms: A Potential Trap for Pathologic Diagnosis: Erratum. (PMID:38224134)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.