PWAR4

Summary

PWAR4 (Prader Willi/Angelman region RNA 4, HGNC:29998) is a long non-coding RNA gene on chromosome 15q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 347745 — RefSeq curated summary.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29998
Approved symbol	PWAR4
Name	Prader Willi/Angelman region RNA 4
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PAR4, PAR-4
Entrez	347745
RNAcentral	URS000075BB19 — lncRNA, 342 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000111979 (15:25210619 G>A,C,T), RS1000672100 (15:25209772 C>T), RS1002456590 (15:25211599 C>T), RS1002482850 (15:25211354 G>A), RS1003458804 (15:25212477 T>C,G), RS1004511777 (15:25211059 C>G), RS1005461828 (15:25212076 C>T), RS1006928516 (15:25210804 C>A), RS1007294870 (15:25209925 T>C), RS1009210420 (15:25209909 C>T), RS1009222603 (15:25210367 G>A,C,T), RS1010266732 (15:25210591 G>A), RS1010915369 (15:25212399 C>T), RS1011662778 (15:25211381 GCC>G), RS1012773518 (15:25211899 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aflatoxin B2	increases methylation	1
Benzo(a)pyrene	affects methylation	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.