PWAR5

Summary

PWAR5 (Prader Willi/Angelman region RNA 5, HGNC:30090) is a long non-coding RNA gene on chromosome 15q11.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 8123 — RefSeq curated summary.

At a glance

• Gene type: non-coding (TEC) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30090
Approved symbol	PWAR5
Name	Prader Willi/Angelman region RNA 5
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	PAR5, PAR-5
Ensembl gene	ENSG00000279192
Ensembl biotype	TEC
OMIM	600162
Entrez	8123
RNAcentral	URS000075990E — lncRNA, 3373 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 TEC

ENST00000624480

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000624480 — 1 exons

Exon	Start	End
ENSE00003759998	24985053	24988232

Expression profiles

Bgee: expression breadth ubiquitous, 116 present calls, max score 93.19.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5713 / max 379.9191, expressed in 121 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145507	0.3468	74
145508	0.2245	72

Top tissues by expression

116 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.19	gold quality
colonic epithelium	UBERON:0000397	79.89	gold quality
uterine cervix	UBERON:0000002	79.52	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.06	gold quality
corpus callosum	UBERON:0002336	78.22	gold quality
adrenal tissue	UBERON:0018303	77.72	gold quality
calcaneal tendon	UBERON:0003701	76.34	gold quality
sural nerve	UBERON:0015488	71.09	gold quality
skeletal muscle tissue	UBERON:0001134	70.06	gold quality
bone marrow cell	CL:0002092	69.82	gold quality
tonsil	UBERON:0002372	68.44	gold quality
cortical plate	UBERON:0005343	67.65	gold quality
primary visual cortex	UBERON:0002436	67.59	gold quality
bone marrow	UBERON:0002371	65.72	gold quality
kidney	UBERON:0002113	65.45	gold quality
stromal cell of endometrium	CL:0002255	64.32	gold quality
ventricular zone	UBERON:0003053	64.26	gold quality
lung	UBERON:0002048	64.22	gold quality
liver	UBERON:0002107	64.08	gold quality
urinary bladder	UBERON:0001255	63.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	63.88	gold quality
superior frontal gyrus	UBERON:0002661	62.73	gold quality
ganglionic eminence	UBERON:0004023	62.67	gold quality
islet of Langerhans	UBERON:0000006	62.19	gold quality
adult mammalian kidney	UBERON:0000082	61.29	gold quality
muscle of leg	UBERON:0001383	60.57	gold quality
endometrium	UBERON:0001295	60.46	gold quality
pancreas	UBERON:0001264	59.62	gold quality
gastrocnemius	UBERON:0001388	59.35	gold quality
testis	UBERON:0000473	59.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The present findings confirm that genetic abnormalities of the 15q11-q13 region are an important cause of Autistic spectrum disorder, accounting for approximately 1% of cases (PMID:19278672)
• in vitro restoration of PAR5 expression inhibited human glioma cell proliferation, invasion and migration by binding to EZH2 and regulating oncogene expression. This finding may provide a therapeutic approach for the future treatment of glioma (PMID:29048683)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.