PWRN1

Summary

PWRN1 (Prader-Willi region non-protein coding RNA 1, HGNC:33235) is a long non-coding RNA gene on chromosome 15q11.2.

This gene is located in the Prader-Willi syndrome (PWS) region of chromosome 15, which is known to undergo imprinting. The transcript is believed to be non-coding. It is bi-allelically expressed in testis and kidney, but mono-allelically expressed from the paternal allele in brain. This gene is poly-adenylated and is known to undergo alternative splicing. Transcript variants may represent part of a complex imprinting center-SNURF-SNRPN transcription unit. The contribution of this gene to the PWS phenotype is unknown, but it has been suggested that it may play a role in establishing paternal imprinting in the PWS region, perhaps by maintaining the paternal allele in an open chromatin configuration.

Source: NCBI Gene 791114 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33235
Approved symbol	PWRN1
Name	Prader-Willi region non-protein coding RNA 1
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00198, LOHAN1
Ensembl gene	ENSG00000259905
Ensembl biotype	lncRNA
OMIM	611215
Entrez	791114
RNAcentral	URS000075E11D — lncRNA, 1451 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 57 — 57 lncRNA

ENST00000561964, ENST00000562244, ENST00000562501, ENST00000564898, ENST00000565241, ENST00000565295, ENST00000565512, ENST00000565893, ENST00000566676, ENST00000566797, ENST00000567647, ENST00000568019, ENST00000568045, ENST00000568541, ENST00000568609, ENST00000569908, ENST00000570105, ENST00000650789, ENST00000650803, ENST00000650870, ENST00000650918, ENST00000651067, ENST00000651215, ENST00000651227, ENST00000651552, ENST00000651558, ENST00000651815, ENST00000652025, ENST00000652139, ENST00000652316, ENST00000652526, ENST00000652735, ENST00000655991, ENST00000657427, ENST00000657530, ENST00000660084, ENST00000660695, ENST00000661140, ENST00000661593, ENST00000661753, ENST00000661971, ENST00000662084, ENST00000663242, ENST00000663548, ENST00000663854, ENST00000665535, ENST00000666127, ENST00000666311, ENST00000667431, ENST00000667702, ENST00000668025, ENST00000668898, ENST00000669607, ENST00000669731, ENST00000669910, ENST00000670594, ENST00000670841

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000561964 — 3 exons

Exon	Start	End
ENSE00002589977	24274791	24275015
ENSE00002608415	24257117	24257257
ENSE00002622836	24235078	24235159

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 97.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0057 / max 4.5096, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145482	0.0057	3

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	97.01	gold quality
right testis	UBERON:0004534	96.76	gold quality
sperm	CL:0000019	93.58	gold quality
testis	UBERON:0000473	93.27	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.63	gold quality
adrenal tissue	UBERON:0018303	91.62	gold quality
right uterine tube	UBERON:0001302	90.32	gold quality
body of pancreas	UBERON:0001150	87.17	gold quality
left lobe of thyroid gland	UBERON:0001120	86.49	gold quality
right lobe of thyroid gland	UBERON:0001119	85.17	gold quality
thyroid gland	UBERON:0002046	84.03	gold quality
left ovary	UBERON:0002119	83.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.23	gold quality
adenohypophysis	UBERON:0002196	82.23	gold quality
pituitary gland	UBERON:0000007	81.72	gold quality
metanephros cortex	UBERON:0010533	79.40	gold quality
right ovary	UBERON:0002118	79.18	gold quality
bone marrow cell	CL:0002092	78.81	gold quality
cortical plate	UBERON:0005343	78.47	gold quality
nucleus accumbens	UBERON:0001882	78.26	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.12	gold quality
pancreas	UBERON:0001264	77.58	gold quality
ovary	UBERON:0000992	76.94	gold quality
hypothalamus	UBERON:0001898	76.17	gold quality
caudate nucleus	UBERON:0001873	75.69	gold quality
putamen	UBERON:0001874	75.65	gold quality
colonic epithelium	UBERON:0000397	75.31	gold quality
spinal cord	UBERON:0002240	74.81	gold quality
ganglionic eminence	UBERON:0004023	73.17	gold quality
adult mammalian kidney	UBERON:0000082	73.13	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-GEOD-131882	yes	4659.12
E-CURD-119	yes	2180.91
E-ANND-3	yes	10.75
E-HCAD-25	yes	9.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• PWRN1 gene is imprinted, with monoallelic expression from the paternal allele in fetal brain, but biallelic expression in testis and kidney. (PMID:17337158)
• Microarray analysis reveals that lncRNA PWRN1-209 promotes human bone marrow mesenchymal stem cell osteogenic differentiation on microtopography titanium surface in vitro. (PMID:32447825)
• Long noncoding RNA PWRN1 is lowly expressed in osteosarcoma and modulates cancer proliferation and migration by targeting hsa-miR-214-5p. (PMID:32870579)
• LncRNA PWRN1 inhibits the progression of hepatocellular carcinoma by activating PKM2 activity. (PMID:38218456)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.