PWRN2

Summary

PWRN2 (Prader-Willi region non-protein coding RNA 2, HGNC:33236) is a long non-coding RNA gene on chromosome 15q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33236
Approved symbol	PWRN2
Name	Prader-Willi region non-protein coding RNA 2
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	NCRNA00199
Ensembl gene	ENSG00000260551
Ensembl biotype	lncRNA
OMIM	611217
Entrez	791115
RNAcentral	URS00001BCC5D — lncRNA, 4295 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000566245, ENST00000567246, ENST00000567854

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000566245 — 2 exons

Exon	Start	End
ENSE00002587134	24169773	24169874
ENSE00002590322	24162754	24163282

Expression profiles

Bgee: expression breadth ubiquitous, 102 present calls, max score 86.40.

Top tissues by expression

200 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	86.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.03	gold quality
left testis	UBERON:0004533	83.44	gold quality
right testis	UBERON:0004534	82.94	gold quality
testis	UBERON:0000473	80.85	gold quality
epithelium of nasopharynx	UBERON:0001951	73.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.88	gold quality
superficial temporal artery	UBERON:0001614	70.11	gold quality
mucosa of paranasal sinus	UBERON:0005030	70.08	gold quality
germinal epithelium of ovary	UBERON:0001304	69.35	gold quality
buccal mucosa cell	CL:0002336	65.39	gold quality
lateral globus pallidus	UBERON:0002476	64.32	silver quality
nasal cavity epithelium	UBERON:0005384	64.06	gold quality
lower lobe of lung	UBERON:0008949	63.46	silver quality
vena cava	UBERON:0004087	63.38	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	63.21	gold quality
corpus callosum	UBERON:0002336	62.89	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	62.83	gold quality
adrenal tissue	UBERON:0018303	62.05	gold quality
gingival epithelium	UBERON:0001949	62.01	gold quality
subthalamic nucleus	UBERON:0001906	61.57	gold quality
quadriceps femoris	UBERON:0001377	61.55	gold quality
vastus lateralis	UBERON:0001379	61.46	gold quality
upper lobe of lung	UBERON:0008948	59.65	silver quality
mammary duct	UBERON:0001765	59.11	gold quality
amniotic fluid	UBERON:0000173	58.79	gold quality
gingiva	UBERON:0001828	58.44	gold quality
monocyte	CL:0000576	58.24	gold quality
cerebellar hemisphere	UBERON:0002245	58.21	gold quality
ventral tegmental area	UBERON:0002691	58.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.92

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Prader-Willi region nonprotein coding RNA 2 (PWRN2) was found to be associated with oocyte nuclear maturation in patients with polycystic ovary syndrome (PCOS) in contrast to that in normal patients. (PMID:30075721)
• LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis. (PMID:33090407)
• Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration. (PMID:33340764)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.