PWRN4

Summary

PWRN4 (Prader-Willi region non-protein coding RNA 4, HGNC:49130) is a long non-coding RNA gene on chromosome 15q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49130
Approved symbol	PWRN4
Name	Prader-Willi region non-protein coding RNA 4
Location	15q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC01084
Ensembl gene	ENSG00000260232
Ensembl biotype	lncRNA
Entrez	105370731
RNAcentral	URS00007E365A — lncRNA, 618 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000563016, ENST00000652183, ENST00000657402, ENST00000661343, ENST00000663429, ENST00000663707, ENST00000688986, ENST00000724246, ENST00000724247, ENST00000724248, ENST00000724249, ENST00000724250, ENST00000724251, ENST00000724252, ENST00000724253, ENST00000724254

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563016 — 4 exons

Exon	Start	End
ENSE00002581783	23979071	23979211
ENSE00002591999	23976147	23976243
ENSE00002606040	24003338	24003435
ENSE00002615972	23975172	23975255

Expression profiles

Bgee: expression breadth broad, 92 present calls, max score 83.60.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4649 / max 87.5582, expressed in 117 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
145479	0.4649	117

Top tissues by expression

92 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	75.60	gold quality
adrenal tissue	UBERON:0018303	72.12	gold quality
pituitary gland	UBERON:0000007	69.41	gold quality
testis	UBERON:0000473	64.35	gold quality
adenohypophysis	UBERON:0002196	64.26	gold quality
left testis	UBERON:0004533	63.87	gold quality
right testis	UBERON:0004534	63.17	gold quality
ventricular zone	UBERON:0003053	63.11	gold quality
corpus callosum	UBERON:0002336	62.35	gold quality
ganglionic eminence	UBERON:0004023	59.85	gold quality
nucleus accumbens	UBERON:0001882	59.76	gold quality
putamen	UBERON:0001874	58.79	gold quality
caudate nucleus	UBERON:0001873	58.65	gold quality
monocyte	CL:0000576	58.48	gold quality
islet of Langerhans	UBERON:0000006	57.02	gold quality
cortical plate	UBERON:0005343	56.98	silver quality
hypothalamus	UBERON:0001898	56.97	gold quality
superior frontal gyrus	UBERON:0002661	55.29	gold quality
brain	UBERON:0000955	54.58	gold quality
muscle tissue	UBERON:0002385	54.45	gold quality
pancreas	UBERON:0001264	53.94	gold quality
endometrium	UBERON:0001295	53.34	gold quality
prefrontal cortex	UBERON:0000451	53.24	gold quality
multicellular organism	UBERON:0000468	52.88	gold quality
body of pancreas	UBERON:0001150	52.16	gold quality
lung	UBERON:0002048	51.44	gold quality
primary visual cortex	UBERON:0002436	51.17	gold quality
blood	UBERON:0000178	51.00	gold quality
fundus of stomach	UBERON:0001160	50.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.73

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.