PWWP2A

Summary

PWWP2A (PWWP domain containing 2A, HGNC:29406) is a protein-coding gene on chromosome 5q33.3, encoding PWWP domain-containing protein 2A (Q96N64). Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes.

Enables NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Involved in chromatin remodeling. Located in nucleus.

Source: NCBI Gene 114825 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 114 total — 1 likely-pathogenic
• Cancer driver (intOGen): loss-of-function (tumor-suppressor-like) across 1 cancer types
• MANE Select transcript: NM_001130864

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29406
Approved symbol	PWWP2A
Name	PWWP domain containing 2A
Location	5q33.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1935
Ensembl gene	ENSG00000170234
Ensembl biotype	protein_coding
OMIM	617823
Entrez	114825

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 4 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000307063, ENST00000456329, ENST00000520662, ENST00000521424, ENST00000523662, ENST00000524050, ENST00000934498

RefSeq mRNA: 6 — MANE Select: NM_001130864 NM_001130864, NM_001267035, NM_001349733, NM_001349734, NM_001349735, NM_052927

CCDS: CCDS47331, CCDS47332, CCDS58990

Canonical transcript exons

ENST00000307063 — 2 exons

Exon	Start	End
ENSE00001671969	160091339	160094065
ENSE00003843828	160118805	160119450

Expression profiles

Bgee: expression breadth ubiquitous, 254 present calls, max score 92.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.5206 / max 117.4308, expressed in 1705 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
64616	7.5206	1705

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ileal mucosa	UBERON:0000331	92.75	gold quality
endothelial cell	CL:0000115	91.49	gold quality
corpus callosum	UBERON:0002336	89.93	gold quality
calcaneal tendon	UBERON:0003701	89.20	gold quality
colonic epithelium	UBERON:0000397	88.24	gold quality
thymus	UBERON:0002370	88.12	gold quality
monocyte	CL:0000576	87.91	gold quality
leukocyte	CL:0000738	87.83	gold quality
tibialis anterior	UBERON:0001385	87.40	silver quality
ventricular zone	UBERON:0003053	87.17	gold quality
cerebellum	UBERON:0002037	86.57	gold quality
visceral pleura	UBERON:0002401	86.50	gold quality
cerebellar cortex	UBERON:0002129	86.34	gold quality
cerebellar hemisphere	UBERON:0002245	86.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.20	gold quality
cerebellar vermis	UBERON:0004720	86.00	gold quality
rectum	UBERON:0001052	85.68	gold quality
ganglionic eminence	UBERON:0004023	85.64	gold quality
embryo	UBERON:0000922	85.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	85.04	gold quality
bone marrow cell	CL:0002092	84.93	gold quality
upper arm skin	UBERON:0004263	84.90	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.89	gold quality
cortical plate	UBERON:0005343	84.85	gold quality
granulocyte	CL:0000094	84.37	gold quality
uterine cervix	UBERON:0000002	84.20	gold quality
adrenal tissue	UBERON:0018303	84.19	gold quality
parietal pleura	UBERON:0002400	84.12	gold quality
pylorus	UBERON:0001166	83.60	gold quality
deltoid	UBERON:0001476	83.47	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.54

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting PWWP2A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-511-3P	99.99	68.85	1467
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-548AG	99.77	69.25	1492
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-548AI	99.69	69.24	1494
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-570-5P	99.69	69.24	1494
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-6853-3P	99.36	70.79	1558
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-3190-5P	98.87	64.89	1345
HSA-MIR-6501-3P	98.71	67.45	1480
HSA-MIR-6796-3P	98.68	65.49	689
HSA-MIR-4768-3P	98.16	66.02	2330
HSA-MIR-4275	97.96	68.42	1549

Literature-anchored findings (GeneRIF, showing 4)

• Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link between H2A.Z, chromosome segregation, and organ development. (PMID:28645917)
• Study in HeLa, HEK293F, and mouse embryonic stem cells reveal that loss of PWWP2A/B leads to increases in histone acetylation predominantly at highly expressed genes, accompanied by decreases in Pol II elongation. Collectively, these findings suggest a role for PWWP2A/B in regulating transcription through the fine-tuning of histone acetylation dynamics at actively transcribed genes. (PMID:30228260)
• PWWP2A is a complex chromatin-binding protein that serves to direct the deacetylase complex M1HR to H2A.Z-containing chromatin, thereby promoting changes in histone acetylation levels.PWWP2A’s internal region binds H2A.Z nucleosomes and DNA. (PMID:30327463)
• It has been shown that dysregulation of the circular RNA PWWP2A-miR-579 axis is involved in dexamethasone-induced cytotoxicity in human osteoblasts. (PMID:31376935)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	pwwp2a	ENSDARG00000075526
danio_rerio		ENSDARG00000114922
mus_musculus	Pwwp2a	ENSMUSG00000044950
rattus_norvegicus	Pwwp2a	ENSRNOG00000003936

Paralogs (4): DNMT3B (ENSG00000088305), DNMT3A (ENSG00000119772), DNMT3L (ENSG00000142182), PWWP2B (ENSG00000171813)

Protein

Protein identifiers

PWWP domain-containing protein 2A — Q96N64 (reviewed: Q96N64)

All UniProt accessions (3): Q96N64, H0YB44, H0YC06

UniProt curated annotations — full annotation on UniProt →

Function. Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes. Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z. Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation. Essential for proper mitosis progression.

Subunit / interactions. Component of a MTA1-specific subcomplex of the NuRD complex (M1HR), composed of PWWP2A, MTA1/2, HDAC1/2, and RBBP4/7 but does not contain CHD4 and MBD3. Interacts with MTA1; the interaction mediates the association of PWWP2A with the M1HR complex. Interacts with H2A.Z/H2AZ1. Interacts (via PWWP domain) with histone H3 trimethylated at ‘Lys-36’ (H3K36me3). Does not interact with CHD4 and MBD3. Interacts with MTA1 and with HDAC1 in a MTA1-dependent manner. Does not interact with CHD4 and MBD3. Interacts with MTA1 and with HDAC1 in a MTA1-dependent manner. Does not interact with CHD4 and MBD3.

Subcellular location. Nucleus.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96N64-1	1	yes
Q96N64-2	2
Q96N64-3	3

RefSeq proteins (6): NP_001124336, NP_001253964, NP_001336662, NP_001336663, NP_001336664, NP_443159 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000313	PWWP_dom	Domain

Pfam: PF00855

UniProt features (32 total): compositionally biased region 10, region of interest 7, modified residue 4, splice variant 4, mutagenesis site 3, chain 1, domain 1, cross-link 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96N64-F1	58.44	0.17

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 81, 102, 116, 119, 208

Mutagenesis-validated functional residues (3):

Position	Phenotype
666	no effect on interaction with h3k36me3.
669	loss of interaction with h3k36me3.
695	loss of interaction with h3k36me3.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9937850	NuRD complex assembly

MSigDB gene sets: 136 (showing top): GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_DNA_TEMPLATED_TRANSCRIPTION_INITIATION, GOBP_TRANSCRIPTION_INITIATION_AT_RNA_POLYMERASE_II_PROMOTER, GOBP_CHROMATIN_REMODELING, GOBP_POSITIVE_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, GOBP_REGULATION_OF_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, GOMF_CHROMATIN_BINDING, GOMF_HISTONE_BINDING, GOBP_DNA_TEMPLATED_TRANSCRIPTION_ELONGATION, KYNG_NORMAL_AGING_DN, KYNG_WERNER_SYNDROM_DN, GOBP_POSITIVE_REGULATION_OF_TRANSCRIPTION_BY_RNA_POLYMERASE_II, GOMF_PROTEIN_CONTAINING_COMPLEX_BINDING, ARNT2_TARGET_GENES, ASH1L_TARGET_GENES

GO Biological Process (3): regulation of transcriptional start site selection at RNA polymerase II promoter (GO:0001178), chromatin remodeling (GO:0006338), positive regulation of transcription elongation by RNA polymerase II (GO:0032968)

GO Molecular Function (5): chromatin binding (GO:0003682), histone binding (GO:0042393), NuRD complex binding (GO:0120325), histone H3K36me3 reader activity (GO:0140003), protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
CHD3, CHD4, CHD5 subfamily	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
transcriptional start site selection at RNA polymerase II promoter	1
regulation of transcription, start site selection	1
regulation of transcription initiation by RNA polymerase II	1
chromatin organization	1
transcription elongation by RNA polymerase II	1
positive regulation of DNA-templated transcription, elongation	1
regulation of transcription elongation by RNA polymerase II	1
positive regulation of transcription by RNA polymerase II	1
protein binding	1
protein-containing complex binding	1
histone H3 reader activity	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

610 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PWWP2A	C11orf16	Q9NQ32	678
PWWP2A	H2AZ1	P0C0S5	666
PWWP2A	RBBP4	P31149	585
PWWP2A	ZCCHC8	Q6NZY4	549
PWWP2A	PPFIBP1	Q86W92	522
PWWP2A	C16orf87	Q6PH81	498
PWWP2A	PHF14	O94880	486
PWWP2A	SHTN1	A0MZ66	416
PWWP2A	BAHD1	Q8TBE0	389
PWWP2A	ZNF296	Q8WUU4	386
PWWP2A	CHD3	Q12873	370
PWWP2A	ZNF215	Q9UL58	365
PWWP2A	GATAD2A	Q86YP4	353
PWWP2A	HMGXB3	Q12766	345
PWWP2A	G3V325	G3V325	339

IntAct

47 interactions, top by confidence:

A	B	Type	Score
HDAC1	CDK2AP1	psi-mi:“MI:0914”(association)	0.840
HDAC1	PWWP2A	psi-mi:“MI:0403”(colocalization)	0.830
PWWP2A	HDAC1	psi-mi:“MI:0915”(physical association)	0.830
RBBP4	CDK2AP1	psi-mi:“MI:0914”(association)	0.790
HDAC1	TNRC18	psi-mi:“MI:0914”(association)	0.790
HDAC1	ZNF609	psi-mi:“MI:0914”(association)	0.730
RBBP7	HAT1	psi-mi:“MI:0914”(association)	0.730
P4HA3	FAM171A2	psi-mi:“MI:0914”(association)	0.640
PWWP2A	H2BC21	psi-mi:“MI:0915”(physical association)	0.560
RBBP4	TNRC18	psi-mi:“MI:0914”(association)	0.530
RBBP7	EPOP	psi-mi:“MI:0914”(association)	0.530
PWWP2A	COX4I1	psi-mi:“MI:0915”(physical association)	0.400
PWWP2A	BANF1	psi-mi:“MI:0915”(physical association)	0.400
PWWP2A	H2BC12L	psi-mi:“MI:0915”(physical association)	0.400
PWWP2A	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
Kif20a	TNRC18	psi-mi:“MI:0914”(association)	0.350
THOC1	TARS3	psi-mi:“MI:0914”(association)	0.350
Set	ZKSCAN1	psi-mi:“MI:0914”(association)	0.350
Mta1	MTA3	psi-mi:“MI:0914”(association)	0.350
HDAC1	TRAK1	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CCP110	A2ML1	psi-mi:“MI:0914”(association)	0.350
CCP110	KIF2A	psi-mi:“MI:0914”(association)	0.350
H1-0	SMARCA5	psi-mi:“MI:0914”(association)	0.350

BioGRID (93): PWWP2A (Proximity Label-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-RNA), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PWWP2A (Affinity Capture-MS), PLEKHF2 (Two-hybrid), PWWP2A (Proximity Label-MS), PWWP2A (Proximity Label-MS)

ESM2 similar proteins: A0A1L8GR68, A2CG63, E9Q9M8, F7AQ22, G3V8T1, O75152, O75376, P49140, P51826, P97432, Q13625, Q14596, Q17R98, Q1LY51, Q3TYA6, Q4KKX4, Q4LE39, Q4R6F6, Q501R9, Q505G8, Q5F3Z9, Q5HYC2, Q5RC94, Q5XJV7, Q60974, Q68FE8, Q69Z61, Q6A098, Q6NXK2, Q6NZF1, Q6PJT7, Q6ZNC4, Q86YI8, Q8BFU3, Q8BJ05, Q8CCH7, Q8CG79, Q8CHY6, Q8K2W6, Q8ND24

Diamond homologs: A0A1L8GR68, E9Q9M8, F7AQ22, O88508, Q1LZ53, Q4W5Z4, Q69Z61, Q6NUJ5, Q96N64, Q9FNE4, Q9UBC3, Q9Y6K1, O88509, Q923W4, Q9JMG7, Q9Y3E1, P00476, P09915, P0DOY1, P34906, Q10SU5, Q1LZ50, Q2RBJ4, Q9CWR8, Q9LXE5, Q9M548, Q9UJW3, Q9MA56, A4FUF0, F4K4D6, Q49A26, Q562D5, Q5R7T2, Q5RKH0, Q5RKN4, Q5ZLS7, Q922P9, Q9LK91, Q9LYZ0, Q9SF36

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 50 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	5	56.0×	7e-07
NuRD complex assembly	10	41.5×	6e-12
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	9	40.3×	6e-11
Interaction of NuRD complexes with transcription factors	10	37.3×	9e-12
RNA Polymerase I Transcription Initiation	5	32.9×	8e-06
Deposition of new CENPA-containing nucleosomes at the centromere	7	32.7×	5e-08
PRC2 methylates histones and DNA	7	31.4×	6e-08
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)	9	31.2×	5e-10

GO biological processes:

GO term	Partners	Fold	FDR
regulation of stem cell differentiation	5	87.0×	4e-07
heterochromatin formation	5	29.0×	5e-05
nucleosome assembly	7	22.3×	3e-06
chromatin remodeling	7	11.6×	1e-04
chromatin organization	5	11.3×	2e-03

Disease & clinical

Cancer significance

From intOGen — cancer-driver classification: loss-of-function (tumor-suppressor-like) across 1 cancer types — STAD.

Clinical variants and AI predictions

ClinVar

114 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	98
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
402170	NM_003314.3(TTC1):c.784T>G (p.Phe262Val)	Likely pathogenic

SpliceAI

1047 predictions. Top by Δscore:

Variant	Effect	Δscore
5:160064931:GGTAA:G	acceptor_gain	1.0000
5:160065006:G:GT	donor_gain	1.0000
5:160094061:CAAAC:C	acceptor_gain	1.0000
5:160094063:AAC:A	acceptor_gain	1.0000
5:160094064:ACC:A	acceptor_loss	1.0000
5:160094065:CCTT:C	acceptor_gain	1.0000
5:160094066:C:CC	acceptor_gain	1.0000
5:160094067:T:C	acceptor_gain	1.0000
5:160094068:T:C	acceptor_gain	1.0000
5:160094068:T:TC	acceptor_gain	1.0000
5:160094077:A:AC	acceptor_gain	1.0000
5:160094077:A:C	acceptor_gain	1.0000
5:160108543:A:AC	donor_gain	1.0000
5:160108544:C:CC	donor_gain	1.0000
5:160108544:CTG:C	donor_gain	1.0000
5:160113226:C:CT	donor_gain	1.0000
5:160113232:T:A	donor_gain	1.0000
5:160117827:A:AC	donor_gain	1.0000
5:160117828:C:CC	donor_gain	1.0000
5:160117831:ATAAG:A	donor_gain	1.0000
5:160118801:GTAC:G	donor_loss	1.0000
5:160118802:TAC:T	donor_loss	1.0000
5:160118803:ACCT:A	donor_loss	1.0000
5:160064926:TTACA:T	acceptor_loss	0.9900
5:160064927:TACAG:T	acceptor_loss	0.9900
5:160064928:ACAGG:A	acceptor_loss	0.9900
5:160064929:CAGG:C	acceptor_loss	0.9900
5:160064930:A:AG	acceptor_gain	0.9900
5:160064930:A:C	acceptor_loss	0.9900
5:160064931:G:C	acceptor_loss	0.9900

AlphaMissense

4920 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:160092444:C:G	A736P	1.000
5:160092446:G:T	A735E	1.000
5:160092447:C:G	A735P	1.000
5:160092458:G:T	A731D	1.000
5:160092465:G:T	R729S	1.000
5:160092467:T:C	Y728C	1.000
5:160092468:A:C	Y728D	1.000
5:160092468:A:G	Y728H	1.000
5:160092474:C:G	G726R	1.000
5:160092478:T:A	R724S	1.000
5:160092478:T:G	R724S	1.000
5:160092490:A:C	F720L	1.000
5:160092490:A:T	F720L	1.000
5:160092491:A:G	F720S	1.000
5:160092492:A:G	F720L	1.000
5:160092502:G:C	F716L	1.000
5:160092502:G:T	F716L	1.000
5:160092503:A:G	F716S	1.000
5:160092504:A:G	F716L	1.000
5:160092514:A:C	F712L	1.000
5:160092514:A:T	F712L	1.000
5:160092515:A:G	F712S	1.000
5:160092516:A:G	F712L	1.000
5:160092545:G:A	S702F	1.000
5:160092562:A:C	F696L	1.000
5:160092562:A:T	F696L	1.000
5:160092563:A:G	F696S	1.000
5:160092564:A:G	F696L	1.000
5:160092565:C:A	W695C	1.000
5:160092565:C:G	W695C	1.000

dbSNP variants (sampled 300 via entrez): RS1000020090 (5:160104096 C>G), RS1000057963 (5:160095008 A>C), RS1000077920 (5:160066201 C>A,G,T), RS1000093511 (5:160044196 A>G), RS1000109032 (5:160050858 T>C), RS1000124473 (5:160044643 G>A,T), RS1000149685 (5:160087659 C>A), RS1000212147 (5:160088261 G>A), RS1000304433 (5:160082009 T>C), RS1000357346 (5:160082235 G>A,C), RS1000423761 (5:160116989 G>A), RS1000461035 (5:160046045 A>G), RS1000503008 (5:160089247 A>G), RS1000512100 (5:160047955 T>C), RS1000564017 (5:160087903 T>C,G)

Disease associations

OMIM: gene MIM:617823 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases expression, affects expression	5
trichostatin A	affects cotreatment, decreases expression	3
Benzo(a)pyrene	increases expression, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
FR900359	affects phosphorylation	1
bisphenol F	affects cotreatment, decreases expression	1
TAK-243	decreases sumoylation	1
2-butenal	decreases expression	1
CGP 52608	increases reaction, affects binding	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Caffeine	decreases phosphorylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	increases expression	1
Phthalic Acids	increases methylation	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	decreases expression, affects cotreatment	1
Cyclosporine	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.