PXN-AS1

Summary

PXN-AS1 (PXN antisense RNA 1, HGNC:44123) is a long non-coding RNA gene on chromosome 12q24.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44123
Approved symbol	PXN-AS1
Name	PXN antisense RNA 1
Location	12q24.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	EyeLinc4
Ensembl gene	ENSG00000255857
Ensembl biotype	lncRNA
Entrez	100506649
RNAcentral	URS000075E544 — lncRNA, 778 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 16 lncRNA

ENST00000535200, ENST00000538804, ENST00000539446, ENST00000542265, ENST00000542314, ENST00000620336, ENST00000664264, ENST00000667017, ENST00000667721, ENST00000684870, ENST00000693683, ENST00000693713, ENST00000702713, ENST00000826986, ENST00000826987, ENST00000826988

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000535200 — 5 exons

Exon	Start	End
ENSE00002266194	120210930	120211106
ENSE00002279375	120209839	120209934
ENSE00002290624	120206545	120206621
ENSE00004238410	120201311	120201426
ENSE00004238412	120212375	120213138

Expression profiles

Bgee: expression breadth ubiquitous, 163 present calls, max score 85.91.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.0642 / max 41.1192, expressed in 1610 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128321	2.4528	1132
128319	2.2976	918
128322	0.6853	414
128320	0.6285	395

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.91	gold quality
mucosa of transverse colon	UBERON:0004991	85.43	gold quality
monocyte	CL:0000576	85.19	gold quality
leukocyte	CL:0000738	85.08	gold quality
islet of Langerhans	UBERON:0000006	84.13	gold quality
sural nerve	UBERON:0015488	84.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.34	gold quality
granulocyte	CL:0000094	83.05	gold quality
rectum	UBERON:0001052	82.42	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.35	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.19	gold quality
lower esophagus mucosa	UBERON:0035834	81.78	gold quality
tibial nerve	UBERON:0001323	81.46	gold quality
right ovary	UBERON:0002118	80.56	gold quality
right uterine tube	UBERON:0001302	80.31	gold quality
adenohypophysis	UBERON:0002196	80.00	gold quality
upper lobe of left lung	UBERON:0008952	79.95	gold quality
gastrocnemius	UBERON:0001388	79.81	gold quality
left ovary	UBERON:0002119	79.71	gold quality
right lobe of liver	UBERON:0001114	79.69	gold quality
muscle of leg	UBERON:0001383	79.65	gold quality
ventricular zone	UBERON:0003053	79.60	gold quality
skin of leg	UBERON:0001511	79.50	gold quality
colonic epithelium	UBERON:0000397	79.35	gold quality
ectocervix	UBERON:0012249	79.25	gold quality
skin of abdomen	UBERON:0001416	79.21	gold quality
left uterine tube	UBERON:0001303	79.18	gold quality
pancreas	UBERON:0001264	78.85	gold quality
spinal cord	UBERON:0002240	78.46	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	78.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	10.72
E-ANND-3	yes	5.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• LncRNA PXN-AS1-L isoform is upregulated in nasopharyngeal carcinoma (NPC) and associated with poor prognosis. PXN-AS1-L promotes NPC cell proliferation, migration, and invasion in vitro, and NPC tumor growth in vivo. PXN-AS1-L directly interacts with SAPCD2 mRNA 3’UTR, and upregulates its mRNA and protein expression. (PMID:31173488)
• PXN-AS1 functioned as a sponge to suppress the expression of miR-3064. (PMID:31488171)
• Upregulation of lncRNA PXN-AS1-L is associated with unfavorable prognosis in patients suffering from glioma. (PMID:31696482)
• SOX9-activated PXN-AS1 promotes the tumorigenesis of glioblastoma by EZH2-mediated methylation of DKK1. (PMID:32329150)
• DDX17-regulated alternative splicing that produced an oncogenic isoform of PXN-AS1 to promote HCC metastasis. (PMID:34626132)
• Upregulation of MAPKAPK5-AS1, PXN-AS1 and URB1-AS1 lncRNAs in non-functioning pituitary adenoma. (PMID:37154079)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.