PYDC5

Summary

PYDC5 (pyrin domain containing 5, HGNC:53781) is a protein-coding gene on chromosome 1q23.1, encoding Pyrin domain-containing protein 5 (W6CW81). Functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2.

Involved in cellular response to interferon-beta; cellular response to virus; and negative regulation of AIM2 inflammasome complex assembly.

Source: NCBI Gene 107181291 — RefSeq curated summary.

At a glance

• MANE Select transcript: NM_001320010

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53781
Approved symbol	PYDC5
Name	pyrin domain containing 5
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	POP3
Ensembl gene	ENSG00000289721
Ensembl biotype	protein_coding
Entrez	107181291

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000696987

RefSeq mRNA: 1 — MANE Select: NM_001320010 NM_001320010

CCDS: CCDS91078

Canonical transcript exons

ENST00000696987 — 1 exons

Exon	Start	End
ENSE00003969202	158999971	159002751

Expression profiles

Top tissues by expression

0 total, by Bgee expression score (0-100, higher = more expressed):

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Pyrin domain-containing protein 5 — W6CW81 (reviewed: W6CW81)

Alternative names: Pyrin domain-only protein 3

All UniProt accessions (1): W6CW81

UniProt curated annotations — full annotation on UniProt →

Function. Functions as an inhibitor of DNA virus-induced activation of AIM2-like receptors (ALR) inflammasome through interaction with AIM2.

Subunit / interactions. Interacts with AIM2; disrupts assembly of the ALR inflammasome complex. Interacts with IFI16. Interacts with NLRP3.

Tissue specificity. Expressed in monocytic cell lines and primary macrophages but not in B or T cells.

Induction. Up-regulated in response to IFNB1 or virus infection.

RefSeq proteins (1): NP_001306939* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004020	DAPIN	Domain
IPR011029	DEATH-like_dom_sf	Homologous_superfamily

UniProt features (2 total): chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-W6CW81-F1	53.59	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 43 (showing top): GOBP_NEGATIVE_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_CELLULAR_RESPONSE_TO_VIRUS, GOBP_INFLAMMATORY_RESPONSE, GOBP_RESPONSE_TO_PEPTIDE, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GOBP_RESPONSE_TO_INTERFERON_BETA, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_COMPONENT_ORGANIZATION, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_REGULATION_OF_PROTEIN_CONTAINING_COMPLEX_ASSEMBLY, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_BIOTIC_STIMULUS, GOBP_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS

GO Biological Process (7): inflammatory response (GO:0006954), negative regulation of protein-containing complex assembly (GO:0031333), cellular response to interferon-beta (GO:0035458), cellular response to virus (GO:0098586), negative regulation of AIM2 inflammasome complex assembly (GO:0140972), regulation of innate immune response (GO:0045088), cellular response to cytokine stimulus (GO:0071345)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
defense response	1
regulation of protein-containing complex assembly	1
negative regulation of cellular component organization	1
protein-containing complex assembly	1
response to interferon-beta	1
cellular response to cytokine stimulus	1
response to virus	1
negative regulation of protein-containing complex assembly	1
AIM2 inflammasome complex assembly	1
regulation of AIM2 inflammasome complex assembly	1
negative regulation of inflammasome-mediated signaling pathway	1
regulation of response to biotic stimulus	1
regulation of defense response	1
regulation of response to external stimulus	1
innate immune response	1
regulation of immune response	1
response to cytokine	1
binding	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A7H0DN66, A0A7H0DNG7, O14278, O36397, O42654, O92277, P03207, P0C722, P0C723, P0CAA1, P0DSV9, P0DSW0, P21089, P24438, P24651, P24772, P37588, P52361, P52469, P52474, P52548, P55794, Q00732, Q01032, Q03956, Q0VD34, Q10095, Q11115, Q18LD2, Q2HR83, Q568Z9, Q5MKM1, Q5R4I8, Q5UNU6, Q69550, Q80A33, Q86197, Q8IRS9, Q8IRT0, Q8K0S0

Diamond homologs: D0QMC3, O14862, O35368, P0DOV1, P0DOV2, P41218, Q16666, Q504N7, Q5RD14, Q6K0P9, Q8BV49, Q8CGE8, Q8SPH9, Q91VJ1, Q9R002, W6CW81

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000931902 (1:159001363 G>A), RS1001584597 (1:159000817 GTGGATCCCTCATGAATGGCTCAGTGCCA>G), RS1001814147 (1:159000613 A>C,G), RS1002195245 (1:158999648 T>G), RS1004142061 (1:159003957 G>A,C), RS1004533630 (1:159000481 T>C), RS1004590798 (1:159000235 C>G), RS1004996565 (1:159001818 C>T), RS1006209138 (1:159002200 A>G), RS1006281252 (1:159001874 G>T), RS1007229026 (1:159003760 A>T), RS1007280098 (1:159003944 G>A), RS1007940535 (1:159000868 C>A), RS1008741715 (1:159004695 GA>G,GAA), RS1010233220 (1:159000940 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.