PZP

Summary

PZP (PZP alpha-2-macroglobulin like, HGNC:9750) is a protein-coding gene on chromosome 12p13.31, encoding Pregnancy zone protein (P20742). Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism.

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer’s disease patients.

Source: NCBI Gene 5858 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 9 total
• MANE Select transcript: NM_002864

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9750
Approved symbol	PZP
Name	PZP alpha-2-macroglobulin like
Location	12p13.31
Locus type	gene with protein product
Status	Approved
Aliases	CPAMD6
Ensembl gene	ENSG00000126838
Ensembl biotype	protein_coding
OMIM	176420
Entrez	5858

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 5 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000261336, ENST00000535230, ENST00000539983, ENST00000540995, ENST00000543108, ENST00000546116, ENST00000546197, ENST00000882536, ENST00000882537, ENST00000882538, ENST00000882539, ENST00000882540

RefSeq mRNA: 1 — MANE Select: NM_002864 NM_002864

CCDS: CCDS8600

Canonical transcript exons

ENST00000261336 — 36 exons

Exon	Start	End
ENSE00000718195	9202525	9202684
ENSE00001161550	9208259	9208395
ENSE00001634216	9202319	9202371
ENSE00001787679	9203768	9203951
ENSE00001906651	9148840	9148994
ENSE00003463845	9158420	9158576
ENSE00003464013	9157767	9157841
ENSE00003481517	9150644	9150746
ENSE00003487187	9151604	9151672
ENSE00003487326	9149561	9149602
ENSE00003502515	9164133	9164259
ENSE00003503543	9168869	9168974
ENSE00003506354	9152824	9152951
ENSE00003509963	9153125	9153343
ENSE00003511894	9192193	9192256
ENSE00003517149	9159938	9160025
ENSE00003542690	9165139	9165367
ENSE00003543117	9163668	9163789
ENSE00003546727	9169430	9169591
ENSE00003557371	9200364	9200448
ENSE00003576061	9194077	9194238
ENSE00003576388	9200892	9201060
ENSE00003582119	9197012	9197123
ENSE00003605412	9181975	9182117
ENSE00003605673	9180983	9181132
ENSE00003611648	9152220	9152310
ENSE00003616082	9154616	9154839
ENSE00003619196	9157175	9157355
ENSE00003623756	9166052	9166202
ENSE00003633542	9161033	9161116
ENSE00003637346	9192512	9192739
ENSE00003644907	9160314	9160490
ENSE00003647643	9196571	9196685
ENSE00003650351	9162597	9162648
ENSE00003668600	9201327	9201347
ENSE00003673331	9196330	9196439

Expression profiles

Bgee: expression breadth ubiquitous, 178 present calls, max score 93.35.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2279 / max 142.8512, expressed in 24 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129403	0.2028	22
129404	0.0251	6

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	93.35	gold quality
epithelium of bronchus	UBERON:0002031	92.69	gold quality
bronchus	UBERON:0002185	91.66	gold quality
mucosa of paranasal sinus	UBERON:0005030	87.74	gold quality
liver	UBERON:0002107	84.80	gold quality
right lobe of liver	UBERON:0001114	83.98	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.60	gold quality
epithelium of nasopharynx	UBERON:0001951	80.56	gold quality
sperm	CL:0000019	78.86	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	78.75	gold quality
male germ cell	CL:0000015	78.21	silver quality
endothelial cell	CL:0000115	75.30	silver quality
cervix squamous epithelium	UBERON:0006922	74.28	gold quality
apex of heart	UBERON:0002098	74.24	gold quality
nasal cavity epithelium	UBERON:0005384	72.20	silver quality
hair follicle	UBERON:0002073	71.70	gold quality
ileal mucosa	UBERON:0000331	70.80	silver quality
olfactory bulb	UBERON:0002264	68.89	gold quality
type B pancreatic cell	CL:0000169	68.78	gold quality
diaphragm	UBERON:0001103	68.40	gold quality
corpus callosum	UBERON:0002336	68.20	gold quality
tibialis anterior	UBERON:0001385	68.15	silver quality
calcaneal tendon	UBERON:0003701	68.14	gold quality
sural nerve	UBERON:0015488	68.02	gold quality
lung	UBERON:0002048	66.08	gold quality
thymus	UBERON:0002370	66.02	gold quality
nasal cavity mucosa	UBERON:0001826	65.66	gold quality
endometrium epithelium	UBERON:0004811	65.63	gold quality
pancreatic ductal cell	CL:0002079	65.50	silver quality
epithelial cell of pancreas	CL:0000083	65.10	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-6	yes	111.82
E-ANND-3	yes	8.75
E-MTAB-7606	no	126.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting PZP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-122B-5P	99.46	70.81	1457
HSA-MIR-4291	99.20	68.88	2969
HSA-MIR-892C-5P	99.16	70.56	2116
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-5585-5P	97.95	68.80	1024
HSA-MIR-3976	96.67	67.79	1187

Literature-anchored findings (GeneRIF, showing 11)

• Differential binding to ldl receptor related protein (PMID:11811950)
• A new purification methodology was used on the C-terminal peptide fragment of PZP. (PMID:17257854)
• Quantitative measurements using a multiple reaction monitoring assay showed a significant increase in plasma pregnancy-zone protein in presymptomatic Alzheimer disease compared with controls (PMID:21879768)
• The data of this study link the finding of elevated serum PZP levels with the characteristic Alzheimer’s Disease pathology and identify PZP as a novel component in Alzheimer’s Disease. (PMID:25737043)
• Inflammation-associated LRG and PZP may be novel biomarkers of early-onset myocardial infarction (PMID:30411527)
• stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide (PMID:30850528)
• Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF-beta/SMAD signaling. (PMID:33057846)
• Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA). (PMID:33388716)
• Hypermethylation of the PZP gene is associated with hepatocellular carcinoma cell proliferation, invasion and migration. (PMID:33471436)
• The Pregnancy Zone Protein (PZP) is significantly downregulated in the placenta of preeclampsia and HELLP syndrome patients. (PMID:35843132)
• High-Level Secretion of Pregnancy Zone Protein Is a Novel Biomarker of DNA Damage-Induced Senescence and Promotes Spontaneous Senescence. (PMID:37831546)

Cross-species orthologs

26 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:dkey-46g23.5	ENSDARG00000008835
danio_rerio	si:dkey-52d15.3	ENSDARG00000041645
danio_rerio	si:dkey-105h12.2	ENSDARG00000041685
danio_rerio	a2ml	ENSDARG00000056314
danio_rerio	zgc:171426	ENSDARG00000074764
danio_rerio	zgc:165518	ENSDARG00000075737
danio_rerio	zgc:165453	ENSDARG00000078183
danio_rerio	si:ch211-212c13.8	ENSDARG00000078757
danio_rerio	si:ch211-212c13.10	ENSDARG00000093199
danio_rerio	a2ml2	ENSDARG00000097105
		ENSDARG00000100979
danio_rerio	zgc:171445	ENSDARG00000115205
danio_rerio	si:dkey-46g23.2	ENSDARG00000115817
danio_rerio	si:dkey-46g23.3	ENSDARG00000116005
mus_musculus	Mug2	ENSMUSG00000030131
mus_musculus	Mug1	ENSMUSG00000059908
mus_musculus	Gm7298	ENSMUSG00000108022
rattus_norvegicus	Cpamd8	ENSRNOG00000065350
rattus_norvegicus	Mug1l1	ENSRNOG00000070375
rattus_norvegicus		ENSRNOG00000075610
rattus_norvegicus		ENSRNOG00000091232
drosophila_melanogaster	Tep4	FBGN0041180
drosophila_melanogaster	Tep3	FBGN0041181
drosophila_melanogaster	Tep2	FBGN0041182
drosophila_melanogaster	Tep1	FBGN0041183
caenorhabditis_elegans	tep-1	WBGENE00013969

Paralogs (8): C5 (ENSG00000106804), C3 (ENSG00000125730), CD109 (ENSG00000156535), CPAMD8 (ENSG00000160111), A2ML1 (ENSG00000166535), A2M (ENSG00000175899), C4B (ENSG00000224389), C4A (ENSG00000244731)

Protein

Protein identifiers

Pregnancy zone protein — P20742 (reviewed: P20742)

Alternative names: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

All UniProt accessions (2): P20742, F5GXY0

UniProt curated annotations — full annotation on UniProt →

Function. Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ‘bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Subunit / interactions. Homotetramer, which consists of two pairs of disulfide-linked chains.

Subcellular location. Secreted.

Tissue specificity. Plasma. Prominent constituent of late-pregnancy sera.

Similarity. Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.

Isoforms (2)

UniProt ID	Names	Canonical?
P20742-1	1	yes
P20742-2	2

RefSeq proteins (1): NP_002855* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001599	Macroglobln_a2	Domain
IPR002890	MG2	Domain
IPR008930	Terpenoid_cyclase/PrenylTrfase	Homologous_superfamily
IPR009048	A-macroglobulin_rcpt-bd	Domain
IPR010916	TonB_box_CS	Conserved_site
IPR011625	A2M_N_BRD	Domain
IPR011626	Alpha-macroglobulin_TED	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR019742	MacrogloblnA2_CS	Conserved_site
IPR036595	A-macroglobulin_rcpt-bd_sf	Homologous_superfamily
IPR040839	MG4	Domain
IPR041555	MG3	Domain
IPR041813	A2M_TED	Domain
IPR047565	Alpha-macroglob_thiol-ester_cl	Conserved_site
IPR050473	A2M/Complement_sys	Family

Pfam: PF00207, PF01835, PF07677, PF07678, PF07703, PF17789, PF17791

UniProt features (26 total): glycosylation site 10, sequence variant 8, splice variant 3, signal peptide 1, chain 1, cross-link 1, region of interest 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P20742-F1	81.87	0.29

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 978–981

Glycosylation sites (10): 932, 997, 1430, 54, 69, 246, 392, 406, 753, 875

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 63 (showing top): MODULE_379, BLALOCK_ALZHEIMERS_DISEASE_UP, HSIAO_LIVER_SPECIFIC_GENES, CAIRO_HEPATOBLASTOMA_DN, GOBP_MULTI_MULTICELLULAR_ORGANISM_PROCESS, BROWN_MYELOID_CELL_DEVELOPMENT_UP, MODULE_242, ZHONG_SECRETOME_OF_LUNG_CANCER_AND_ENDOTHELIUM, MODULE_104, GOCC_BLOOD_MICROPARTICLE, GOMF_PEPTIDASE_REGULATOR_ACTIVITY, BOCHKIS_FOXA2_TARGETS, GOMF_PROTEASE_BINDING, GOMF_SERINE_TYPE_ENDOPEPTIDASE_INHIBITOR_ACTIVITY, GOMF_ENZYME_INHIBITOR_ACTIVITY

GO Biological Process (1): female pregnancy (GO:0007565)

GO Molecular Function (4): protease binding (GO:0002020), endopeptidase inhibitor activity (GO:0004866), serine-type endopeptidase inhibitor activity (GO:0004867), peptidase inhibitor activity (GO:0030414)

GO Cellular Component (5): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615), extracellular exosome (GO:0070062), blood microparticle (GO:0072562), extracellular matrix (GO:0031012)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
multi-organism reproductive process	1
multi-multicellular organism process	1
enzyme binding	1
endopeptidase activity	1
peptidase inhibitor activity	1
endopeptidase regulator activity	1
serine-type endopeptidase activity	1
endopeptidase inhibitor activity	1
enzyme inhibitor activity	1
peptidase activity	1
peptidase regulator activity	1
extracellular vesicle	1
extracellular region	1
external encapsulating structure	1

Protein interactions and networks

STRING

874 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
PZP	CTRB2	Q6GPI1	822
PZP	CTRB1	P17538	755
PZP	SERPINF2	P08697	585
PZP	BRPF1	P55201	571
PZP	FGG	P02679	494
PZP	FGA	P02671	466
PZP	FN1	P02751	461
PZP	MEAF6	Q9HAF1	450
PZP	MMP9	P14780	449
PZP	SHBG	P04278	446
PZP	PAEP	P09466	446
PZP	SERPINF1	P36955	422
PZP	ADH4	P08319	412
PZP	KLK7	P49862	405
PZP	MLLT10	P55197	400

IntAct

15 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
DEFA6	EXTL3	psi-mi:“MI:0914”(association)	0.530
PZP	VDAC2	psi-mi:“MI:0915”(physical association)	0.400
PZP	A2M	psi-mi:“MI:0915”(physical association)	0.400
TUBGCP4	PZP	psi-mi:“MI:0914”(association)	0.350
TMEM248	PKD2	psi-mi:“MI:0914”(association)	0.350
MAPT	LANCL1	psi-mi:“MI:0914”(association)	0.350
MAPT	NCAN	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
rep	DDX3X	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
CCL18	PZP	psi-mi:“MI:0914”(association)	0.350

BioGRID (24): PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), VDAC2 (Proximity Label-MS), PZP (Reconstituted Complex), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS), A2M (Affinity Capture-MS), TGFB1 (Reconstituted Complex), TGFB2 (Reconstituted Complex), PZP (Affinity Capture-MS), PZP (Affinity Capture-MS)

ESM2 similar proteins: A0AAQ4VMX2, A6X935, A8K2U0, I2C090, P01023, P01029, P01030, P01031, P06238, P06684, P06756, P08649, P08650, P0C0L4, P0C0L5, P14046, P19069, P19827, P20740, P20742, P24063, P28665, P28666, P43406, P61625, P79263, P80746, P97278, P98093, Q03626, Q06274, Q0VCM5, Q14624, Q29052, Q3T052, Q3UU35, Q5R4N8, Q61702, Q61838, Q63041

Diamond homologs: A8K2U0, P01023, P06238, P14046, P20739, P20740, P20742, P28665, P28666, Q03626, Q3UU35, Q5R4N8, Q61838, Q63041, Q6GQT1, Q6IE52, Q6ZMU1, Q7SIH1, P20738, Q6IE37, C9XI63, P20737, Q6YHK3, Q8IZJ3, Q8R422, Q9GYW4, P23667, Q8YM40, A0AAQ4VMX2, A0RZC6, P01024, P01026, P01029, P01030, P08649, P0C0L4, P0C0L5, P19069, Q0ZZJ6

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
MMP9	“down-regulates quantity by destabilization”	PZP	cleavage
MMP2	“down-regulates quantity by destabilization”	PZP	cleavage
PZP	“down-regulates activity”	MMP9	binding
PZP	“down-regulates activity”	MMP2	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

9 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	3
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

4466 predictions. Top by Δscore:

Variant	Effect	Δscore
12:9150639:CTCA:C	donor_loss	1.0000
12:9150640:TCAC:T	donor_loss	1.0000
12:9150641:CACC:C	donor_loss	1.0000
12:9150642:A:T	donor_loss	1.0000
12:9150643:C:CA	donor_loss	1.0000
12:9150643:CCTGT:C	donor_gain	1.0000
12:9150742:GTCAC:G	acceptor_gain	1.0000
12:9150743:TCAC:T	acceptor_gain	1.0000
12:9150744:CAC:C	acceptor_gain	1.0000
12:9150744:CACC:C	acceptor_gain	1.0000
12:9150745:AC:A	acceptor_gain	1.0000
12:9150746:CC:C	acceptor_gain	1.0000
12:9150746:CCTGA:C	acceptor_loss	1.0000
12:9150747:C:CC	acceptor_gain	1.0000
12:9150747:CTGA:C	acceptor_loss	1.0000
12:9152311:C:CC	acceptor_gain	1.0000
12:9152818:TCTTA:T	donor_loss	1.0000
12:9152819:CTTA:C	donor_loss	1.0000
12:9152820:TTAC:T	donor_loss	1.0000
12:9152821:TACCT:T	donor_loss	1.0000
12:9152822:A:AC	donor_gain	1.0000
12:9152823:C:A	donor_loss	1.0000
12:9152823:C:CC	donor_gain	1.0000
12:9152947:GATGT:G	acceptor_gain	1.0000
12:9152948:ATGT:A	acceptor_gain	1.0000
12:9152949:TGT:T	acceptor_gain	1.0000
12:9152952:C:A	acceptor_loss	1.0000
12:9152952:C:CC	acceptor_gain	1.0000
12:9152954:G:C	acceptor_gain	1.0000
12:9157765:A:AC	donor_gain	1.0000

AlphaMissense

9663 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:9154628:G:C	F1254L	0.995
12:9154628:G:T	F1254L	0.995
12:9154630:A:G	F1254L	0.995
12:9165315:A:G	W771R	0.992
12:9165315:A:T	W771R	0.992
12:9153343:C:G	D1259H	0.989
12:9159973:A:C	F1034L	0.989
12:9159973:A:T	F1034L	0.989
12:9159975:A:G	F1034L	0.989
12:9160417:G:C	N982K	0.989
12:9160417:G:T	N982K	0.989
12:9165313:C:A	W771C	0.989
12:9165313:C:G	W771C	0.989
12:9153330:G:T	A1263D	0.986
12:9159979:G:C	S1032R	0.986
12:9159979:G:T	S1032R	0.986
12:9159981:T:G	S1032R	0.986
12:9160010:A:G	L1022P	0.986
12:9160420:C:A	Q981H	0.986
12:9160420:C:G	Q981H	0.986
12:9166077:A:G	W745R	0.986
12:9166077:A:T	W745R	0.986
12:9200909:A:G	F218S	0.985
12:9160424:T:A	E980V	0.984
12:9153322:C:G	A1266P	0.983
12:9158542:C:G	A1058P	0.983
12:9158574:A:G	L1047P	0.983
12:9166069:C:A	W747C	0.983
12:9166069:C:G	W747C	0.983
12:9153327:A:G	L1264P	0.982

dbSNP variants (sampled 300 via entrez): RS1000045190 (12:9173936 C>A), RS1000129083 (12:9176739 T>A), RS1000187059 (12:9167587 G>A), RS1000319959 (12:9167336 C>G), RS1000489480 (12:9160970 C>T), RS1000511005 (12:9180324 A>C), RS1000570468 (12:9142575 T>C), RS1000589153 (12:9154393 G>A,C), RS1000602593 (12:9199696 A>G), RS1000633611 (12:9199361 A>G), RS1000763302 (12:9194654 C>T), RS1000802251 (12:9173635 G>T), RS1000849216 (12:9206017 C>T), RS1000860424 (12:9179028 G>A,C), RS1000994902 (12:9172896 C>T)

Disease associations

OMIM: gene MIM:176420 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST000767_1	Non-alcoholic fatty liver disease histology (AST)	1.000000e-06
GCST001762_79	Obesity-related traits	9.000000e-06
GCST003997_15	Myopia	4.000000e-12
GCST006291_40	Spherical equivalent or myopia (age of diagnosis)	4.000000e-12
GCST006427_26	Depression in smokers	7.000000e-07
GCST010002_207	Refractive error	1.000000e-40
GCST010204_125	Low density lipoprotein cholesterol levels	5.000000e-12
GCST010396_120	Gut microbiota (bacterial taxa, hurdle binary method)	7.000000e-07

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005189	respiratory quotient
EFO:0004847	age at onset
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	2
bisphenol A	decreases methylation	1
sodium arsenite	decreases expression	1
chromium hexavalent ion	increases expression	1
licochalcone B	decreases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Cadmium	affects binding	1
Carmustine	decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Estradiol	decreases expression	1
Ivermectin	decreases expression	1
Lead	affects binding	1
Nickel	affects binding	1
Ozone	affects expression, increases abundance	1
Phenobarbital	affects expression	1
Phthalic Acids	increases methylation	1
Tobacco Smoke Pollution	decreases expression	1
Valproic Acid	decreases expression	1
Zinc	affects binding	1
8-Bromo Cyclic Adenosine Monophosphate	increases expression	1
Aflatoxin B1	decreases expression, decreases methylation	1
Palmitic Acid	decreases expression	1
Copper Sulfate	decreases expression	1
Genistein	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.