R3HDM2

Summary

R3HDM2 (R3H domain containing 2, HGNC:29167) is a protein-coding gene on chromosome 12q13.3, encoding R3H domain-containing protein 2 (Q9Y2K5).

Enables RNA binding activity. Predicted to be located in nucleus.

Source: NCBI Gene 22864 — RefSeq curated summary.

At a glance

• GWAS associations: 41
• Clinical variants (ClinVar): 115 total
• MANE Select transcript: NM_001394031

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29167
Approved symbol	R3HDM2
Name	R3H domain containing 2
Location	12q13.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1002
Ensembl gene	ENSG00000179912
Ensembl biotype	protein_coding
OMIM	619886
Entrez	22864

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 32 protein_coding, 3 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000347140, ENST00000358907, ENST00000393811, ENST00000402412, ENST00000403821, ENST00000429355, ENST00000441731, ENST00000448732, ENST00000546843, ENST00000547019, ENST00000547262, ENST00000548161, ENST00000551465, ENST00000552428, ENST00000634871, ENST00000878709, ENST00000878710, ENST00000878711, ENST00000878712, ENST00000878713, ENST00000878714, ENST00000878715, ENST00000878716, ENST00000878717, ENST00000938444, ENST00000938445, ENST00000938446, ENST00000938447, ENST00000938448, ENST00000945075, ENST00000945076, ENST00000945077, ENST00000945078, ENST00000945080, ENST00000945081, ENST00000945082, ENST00000945084, ENST00000945085

RefSeq mRNA: 19 — MANE Select: NM_001394031 NM_001330121, NM_001330122, NM_001330123, NM_001351204, NM_001351205, NM_001351206, NM_001351207, NM_001351208, NM_001351209, NM_001351211, NM_001351212, NM_001351213, NM_001351214, NM_001351215, NM_001351216, NM_001351217, NM_001351218, NM_001394031, NM_014925

CCDS: CCDS81703, CCDS81704, CCDS8937, CCDS91709

Canonical transcript exons

ENST00000402412 — 24 exons

Exon	Start	End
ENSE00001413378	57395749	57395818
ENSE00001600262	57310264	57310463
ENSE00001621494	57296411	57296551
ENSE00001672243	57289009	57289040
ENSE00001733477	57297328	57297387
ENSE00003532094	57295399	57295507
ENSE00003547281	57300095	57300181
ENSE00003647704	57303176	57303217
ENSE00003660960	57299352	57299478
ENSE00003678513	57298090	57298168
ENSE00003693661	57292572	57292667
ENSE00003702721	57266731	57266831
ENSE00003703758	57258890	57259059
ENSE00003704043	57255990	57256074
ENSE00003704416	57268922	57269082
ENSE00003705690	57253764	57255113
ENSE00003705703	57268303	57268457
ENSE00003707774	57283824	57284056
ENSE00003708784	57256414	57256511
ENSE00003709217	57280358	57280530
ENSE00003709733	57269752	57269994
ENSE00003709897	57269323	57269449
ENSE00003710695	57257990	57258137
ENSE00003938657	57430720	57431043

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 98.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 21.5841 / max 459.3157, expressed in 1803 samples.

FANTOM5 promoters (15 alternative TSS)

Promoter ID	TPM avg	Samples expressed
131680	13.6792	1772
131679	5.3880	1686
131667	0.7009	363
131662	0.4030	165
131681	0.3675	179
131672	0.3056	61
131677	0.1632	58
131671	0.1517	54
131670	0.1302	46
131676	0.0721	39

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 10	UBERON:0013541	98.55	gold quality
cerebellar vermis	UBERON:0004720	98.42	gold quality
frontal pole	UBERON:0002795	97.71	gold quality
paraflocculus	UBERON:0005351	97.71	gold quality
sural nerve	UBERON:0015488	97.63	gold quality
buccal mucosa cell	CL:0002336	97.15	gold quality
pons	UBERON:0000988	97.06	gold quality
superior surface of tongue	UBERON:0007371	96.96	gold quality
vena cava	UBERON:0004087	96.75	gold quality
middle frontal gyrus	UBERON:0002702	96.73	gold quality
body of tongue	UBERON:0011876	96.60	gold quality
right hemisphere of cerebellum	UBERON:0014890	96.48	gold quality
cortical plate	UBERON:0005343	96.41	gold quality
cerebellar cortex	UBERON:0002129	96.37	gold quality
cerebellar hemisphere	UBERON:0002245	96.35	gold quality
corpus callosum	UBERON:0002336	96.35	gold quality
superior vestibular nucleus	UBERON:0007227	96.34	gold quality
tongue	UBERON:0001723	96.23	gold quality
cerebellum	UBERON:0002037	96.19	gold quality
cardia of stomach	UBERON:0001162	96.11	gold quality
medulla oblongata	UBERON:0001896	96.07	gold quality
trachea	UBERON:0003126	95.97	gold quality
colonic epithelium	UBERON:0000397	95.96	gold quality
diaphragm	UBERON:0001103	95.93	silver quality
saphenous vein	UBERON:0007318	95.93	gold quality
trigeminal ganglion	UBERON:0001675	95.80	gold quality
pharyngeal mucosa	UBERON:0000355	95.74	gold quality
ganglionic eminence	UBERON:0004023	95.73	gold quality
dorsal plus ventral thalamus	UBERON:0001897	95.66	gold quality
CA1 field of hippocampus	UBERON:0003881	95.62	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.53
E-GEOD-109979	no	189.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

76 targeting R3HDM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-300	99.92	71.76	2856

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	r3hdm2	ENSDARG00000102610
mus_musculus	R3hdm2	ENSMUSG00000025404
rattus_norvegicus	R3hdm2	ENSRNOG00000007801

Paralogs (2): R3HDM1 (ENSG00000048991), ARPP21 (ENSG00000172995)

Protein

Protein identifiers

R3H domain-containing protein 2 — Q9Y2K5 (reviewed: Q9Y2K5)

All UniProt accessions (7): Q9Y2K5, A0A0U1RRA6, B5MCG9, B5MCU0, C9J7N6, H0YIX9, H7C0E9

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Nucleus.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y2K5-1	1	yes
Q9Y2K5-2	2
Q9Y2K5-3	3

RefSeq proteins (19): NP_001317050, NP_001317051, NP_001317052, NP_001338133, NP_001338134, NP_001338135, NP_001338136, NP_001338137, NP_001338138, NP_001338140, NP_001338141, NP_001338142, NP_001338143, NP_001338144, NP_001338145, NP_001338146, NP_001338147, NP_001380960, NP_055740 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001374	R3H_dom	Domain
IPR024771	SUZ	Domain
IPR036867	R3H_dom_sf	Homologous_superfamily
IPR051937	R3H_domain_containing	Family

Pfam: PF01424

UniProt features (46 total): compositionally biased region 13, modified residue 9, region of interest 7, splice variant 4, helix 4, strand 3, domain 2, chain 1, sequence variant 1, sequence conflict 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1WHR	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y2K5-F1	49.08	0.11

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 37, 143, 330, 333, 349, 853, 855, 856, 860

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 121 (showing top): RORA1_01, TGACCTY_ERR1_Q2, WTGAAAT_UNKNOWN, TGIF_01, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN, NKX22_01, FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN, VDR_Q3, FOXJ2_02, PIT1_Q6, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MODULE_95, YNGTTNNNATT_UNKNOWN, AR_01, TGGAAA_NFAT_Q4_01

GO Biological Process (0):

GO Molecular Function (3): RNA binding (GO:0003723), nucleic acid binding (GO:0003676), protein binding (GO:0005515)

GO Cellular Component (1): nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	2
nucleic acid binding	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

798 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
R3HDM2	INHBC	P55103	581
R3HDM2	ZSCAN30	Q86W11	560
R3HDM2	SLC17A1	Q14916	493
R3HDM2	RIPOR1	Q6ZS17	485
R3HDM2	SLC22A11	Q9NSA0	451
R3HDM2	PDZK1	Q5T2W1	433
R3HDM2	ZSCAN23	Q3MJ62	431
R3HDM2	ARL17B	I3L3L1	417
R3HDM2	CFAP54	Q96N23	413
R3HDM2	CARMIL1	Q5VZK9	405
R3HDM2	ARL17A	Q8IVW1	400
R3HDM2	CWH43	Q9H720	399
R3HDM2	SLC2A9	Q9NRM0	396
R3HDM2	GPN3	Q9UHW5	388
R3HDM2	SYTL3	Q4VX76	384

IntAct

75 interactions, top by confidence:

A	B	Type	Score
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
R3HDM2	MEI4	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-1	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP12-3	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP1-3	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP4-12	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
NOTCH2NLC	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRT31	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRT34	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
ADAMTSL4	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-7	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
SPRY3	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
TRIM42	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP13-3	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
MEI4	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
INCA1	R3HDM2	psi-mi:“MI:0915”(physical association)	0.560
YWHAQ	IGLC7	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
PKM	R3HDM2	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
YWHAB	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
YWHAG	C1orf226	psi-mi:“MI:0914”(association)	0.350
YWHAB	BRAF	psi-mi:“MI:0914”(association)	0.350
YWHAE	DEPDC5	psi-mi:“MI:0914”(association)	0.350
YWHAG	BRAF	psi-mi:“MI:0914”(association)	0.350

BioGRID (169): R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid), FAM168A (Two-hybrid), KRTAP3-2 (Two-hybrid), C1orf94 (Two-hybrid), KRTAP10-8 (Two-hybrid), KRTAP10-3 (Two-hybrid), NOTCH2NL (Two-hybrid), R3HDM2 (Affinity Capture-MS), R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid), R3HDM2 (Two-hybrid)

ESM2 similar proteins: A0A3Q7JC00, A0JM64, A0JNC2, A2VE44, A4IHD9, B2C6R6, B5DE09, B8BCZ8, E7F1H9, F4JT98, O09000, O57539, P78364, Q0WVM7, Q15596, Q17BA4, Q2NLB0, Q3TCX3, Q5RDA3, Q5TP13, Q5ZL54, Q61026, Q64028, Q6GP15, Q6K271, Q6NS15, Q6PEH8, Q71SY5, Q7XYY2, Q7ZVN7, Q80TM6, Q8C7E9, Q8CHY6, Q8HXM1, Q8IZL2, Q8VCB2, Q8W234, Q90WJ3, Q924H2, Q940A7

Diamond homologs: A0JNC2, Q15032, Q80TM6, Q8MSX1, Q9DCB4, Q9UBL0, Q9Y2K5, Q5R6X9, Q7M2N1

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 39 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	6	182.7×	2e-11
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	6	161.2×	3e-11
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	6	161.2×	3e-11
Activation of BH3-only proteins	6	119.2×	2e-10
RHO GTPases activate PKNs	6	76.1×	2e-09
Intrinsic Pathway for Apoptosis	6	70.3×	3e-09
SARS-CoV-1-host interactions	6	42.2×	8e-08
Apoptosis	6	40.3×	9e-08

GO biological processes:

GO term	Partners	Fold	FDR
protein targeting	5	63.2×	3e-06
intracellular protein localization	6	21.7×	3e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

115 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

5683 predictions. Top by Δscore:

Variant	Effect	Δscore
12:57254999:T:TA	donor_gain	1.0000
12:57255114:C:CC	acceptor_gain	1.0000
12:57256102:CCCA:C	acceptor_gain	1.0000
12:57256105:A:C	acceptor_gain	1.0000
12:57258043:AGT:A	donor_gain	1.0000
12:57258885:CTCA:C	donor_loss	1.0000
12:57258887:CA:C	donor_loss	1.0000
12:57258888:A:AC	donor_gain	1.0000
12:57258888:ACCTG:A	donor_loss	1.0000
12:57258889:C:CC	donor_gain	1.0000
12:57258889:C:CT	donor_loss	1.0000
12:57259055:CACTC:C	acceptor_gain	1.0000
12:57259057:CTC:C	acceptor_gain	1.0000
12:57259058:TCC:T	acceptor_loss	1.0000
12:57259060:C:CC	acceptor_gain	1.0000
12:57259060:CT:C	acceptor_loss	1.0000
12:57268371:T:TA	donor_gain	1.0000
12:57268866:T:A	donor_gain	1.0000
12:57268920:A:AC	donor_gain	1.0000
12:57268921:C:CC	donor_gain	1.0000
12:57268945:A:AC	donor_gain	1.0000
12:57268946:C:CC	donor_gain	1.0000
12:57280353:CTCA:C	donor_loss	1.0000
12:57280354:TCA:T	donor_loss	1.0000
12:57280355:CA:C	donor_loss	1.0000
12:57280355:CACCT:C	donor_loss	1.0000
12:57280356:ACC:A	donor_loss	1.0000
12:57280357:C:A	donor_loss	1.0000
12:57284052:TCCCC:T	acceptor_gain	1.0000
12:57284053:CCCCC:C	acceptor_gain	1.0000

AlphaMissense

6540 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:57254831:A:T	L958H	1.000
12:57254837:A:G	F956S	1.000
12:57254879:G:T	A942D	1.000
12:57254897:A:G	F936S	1.000
12:57254903:G:T	A934D	1.000
12:57254924:G:T	A927D	1.000
12:57255007:C:A	W899C	1.000
12:57255007:C:G	W899C	1.000
12:57255008:C:G	W899S	1.000
12:57255009:A:G	W899R	1.000
12:57255009:A:T	W899R	1.000
12:57255035:A:G	L890P	1.000
12:57255057:C:G	A883P	1.000
12:57255083:A:G	L874P	1.000
12:57255083:A:T	L874H	1.000
12:57255098:A:G	L869P	1.000
12:57283903:G:C	F350L	1.000
12:57283903:G:T	F350L	1.000
12:57283905:A:G	F350L	1.000
12:57283906:G:C	S349R	1.000
12:57283906:G:T	S349R	1.000
12:57283908:T:G	S349R	1.000
12:57283915:T:A	K346N	1.000
12:57283915:T:G	K346N	1.000
12:57283916:T:A	K346I	1.000
12:57283963:G:C	S330R	1.000
12:57283963:G:T	S330R	1.000
12:57283965:T:G	S330R	1.000
12:57283971:A:G	W328R	1.000
12:57283971:A:T	W328R	1.000

dbSNP variants (sampled 300 via entrez): RS1000024056 (12:57342460 A>T), RS1000026389 (12:57309302 A>C), RS1000080453 (12:57302125 A>C), RS1000084620 (12:57419230 G>A), RS1000086461 (12:57306761 T>A,C), RS1000123137 (12:57391865 T>C), RS1000134788 (12:57390958 G>A), RS1000135066 (12:57349795 C>T), RS1000160158 (12:57331322 T>C), RS1000161380 (12:57277293 C>T), RS1000177468 (12:57424159 T>C), RS1000203875 (12:57335434 C>T), RS1000219832 (12:57269098 G>A), RS1000220289 (12:57280105 T>A), RS1000226320 (12:57327675 G>A)

Disease associations

OMIM: gene MIM:619886 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

41 associations (top):

Study	Trait	p-value
GCST000818_9	Urate levels	2.000000e-11
GCST002539_15	Schizophrenia	2.000000e-12
GCST002829_23	Urate levels in overweight individuals	2.000000e-07
GCST002829_35	Urate levels in overweight individuals	4.000000e-08
GCST004292_54	Glomerular filtration rate (creatinine)	2.000000e-07
GCST004521_233	Autism spectrum disorder or schizophrenia	4.000000e-10
GCST006613_49	Triglycerides	9.000000e-13
GCST006803_97	Schizophrenia	3.000000e-11
GCST007576_241	Chronotype	2.000000e-09
GCST007876_5	Estimated glomerular filtration rate	2.000000e-08
GCST008058_71	Estimated glomerular filtration rate	9.000000e-25
GCST008059_52	Estimated glomerular filtration rate	1.000000e-26
GCST008062_61	Blood urea nitrogen levels	3.000000e-17
GCST008070_35	HDL cholesterol levels	3.000000e-09
GCST008070_84	HDL cholesterol levels	2.000000e-09
GCST008074_119	Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	5.000000e-12
GCST008074_145	Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	5.000000e-12
GCST008075_104	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	7.000000e-19
GCST008075_34	HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df)	8.000000e-19
GCST008083_162	Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	5.000000e-13
GCST008083_95	Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	2.000000e-13
GCST008084_227	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	1.000000e-20
GCST008084_45	HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df)	1.000000e-20
GCST008085_142	HDL cholesterol levels in current drinkers	2.000000e-12
GCST008085_23	HDL cholesterol levels in current drinkers	1.000000e-12
GCST008158_113	Body mass index	3.000000e-06
GCST008747_75	Estimated glomerular filtration rate	4.000000e-15
GCST008916_2	Asthma	2.000000e-08
GCST008971_117	Urate levels	7.000000e-65
GCST010002_217	Refractive error	6.000000e-174

EFO canonical traits (13, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0004530	triglyceride measurement
EFO:0008328	chronotype measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004329	alcohol drinking
EFO:0004340	body mass index
EFO:0004509	hemoglobin measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004615	apolipoprotein B measurement
EFO:0009819	comparative body size at age 10, self-reported
EFO:0004348	hematocrit
EFO:0005091	monocyte count
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression	4
Benzo(a)pyrene	decreases expression	3
bisphenol F	increases expression, affects cotreatment, decreases methylation	2
Aflatoxin B1	affects expression, decreases methylation	2
aristolochic acid I	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
bufotalin	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
beta-lapachone	decreases expression	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	decreases methylation	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	decreases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases expression	1
Arsenic	affects methylation	1
Atrazine	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Caffeine	affects phosphorylation	1
Coumestrol	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.