RAB11A

Summary

RAB11A (RAB11A, member RAS oncogene family, HGNC:9760) is a protein-coding gene on chromosome 15q22.31, encoding Ras-related protein Rab-11A (P62491). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. It is a selective cancer dependency (DepMap: 20.4% of cell lines).

The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 8766 — RefSeq curated summary.

At a glance

• Gene–disease (curated): neurodevelopmental disorder (Strong, GenCC) — +2 more curated relationships
• GWAS associations: 18
• Clinical variants (ClinVar): 130 total — 1 likely-pathogenic
• Phenotypes (HPO): 1
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 20.4% of screened cell lines
• MANE Select transcript: NM_004663

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9760
Approved symbol	RAB11A
Name	RAB11A, member RAS oncogene family
Location	15q22.31
Locus type	gene with protein product
Status	Approved
Aliases	YL8
Ensembl gene	ENSG00000103769
Ensembl biotype	protein_coding
OMIM	605570
Entrez	8766

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000261890, ENST00000563580, ENST00000564910, ENST00000565075, ENST00000566233, ENST00000567671, ENST00000568850, ENST00000569304, ENST00000569896, ENST00000886505, ENST00000886506, ENST00000886507

RefSeq mRNA: 2 — MANE Select: NM_004663 NM_001206836, NM_004663

CCDS: CCDS10212, CCDS58373

Canonical transcript exons

ENST00000261890 — 5 exons

Exon	Start	End
ENSE00000694763	65879671	65879751
ENSE00001958491	65887701	65891989
ENSE00002628618	65869491	65869625
ENSE00003533937	65877762	65877955
ENSE00003583420	65877332	65877527

Expression profiles

Bgee: expression breadth ubiquitous, 304 present calls, max score 99.62.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 164.4725 / max 1899.8937, expressed in 1827 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147253	115.1727	1826
147254	24.8894	1801
147255	19.4882	1777
147252	1.7236	1127
147246	0.6214	136
147256	0.6057	304
147244	0.4362	182
147257	0.4092	174
147247	0.3275	85
147249	0.3181	68

Top tissues by expression

304 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagus squamous epithelium	UBERON:0006920	99.62	gold quality
gingiva	UBERON:0001828	99.54	gold quality
gingival epithelium	UBERON:0001949	99.54	gold quality
squamous epithelium	UBERON:0006914	99.49	gold quality
epithelium of esophagus	UBERON:0001976	99.48	gold quality
oral cavity	UBERON:0000167	99.47	gold quality
tongue squamous epithelium	UBERON:0006919	99.39	gold quality
pharyngeal mucosa	UBERON:0000355	99.33	gold quality
mammalian vulva	UBERON:0000997	99.25	gold quality
lower esophagus mucosa	UBERON:0035834	99.25	gold quality
esophagus mucosa	UBERON:0002469	99.23	gold quality
amniotic fluid	UBERON:0000173	99.12	gold quality
cortical plate	UBERON:0005343	99.12	gold quality
upper leg skin	UBERON:0004262	99.09	gold quality
right adrenal gland	UBERON:0001233	99.07	gold quality
right adrenal gland cortex	UBERON:0035827	99.05	gold quality
rectum	UBERON:0001052	99.04	gold quality
adrenal tissue	UBERON:0018303	99.03	gold quality
gall bladder	UBERON:0002110	99.00	gold quality
cervix squamous epithelium	UBERON:0006922	99.00	gold quality
mucosa of sigmoid colon	UBERON:0004993	98.99	gold quality
colonic mucosa	UBERON:0000317	98.96	gold quality
penis	UBERON:0000989	98.94	gold quality
skin of leg	UBERON:0001511	98.93	gold quality
skin of abdomen	UBERON:0001416	98.91	gold quality
zone of skin	UBERON:0000014	98.90	gold quality
adult organism	UBERON:0007023	98.87	gold quality
left testis	UBERON:0004533	98.85	gold quality
monocyte	CL:0000576	98.84	gold quality
right testis	UBERON:0004534	98.84	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 9.

Experiment	Marker?	Max mean expression
E-MTAB-6701	yes	46.82
E-HCAD-11	yes	42.96
E-CURD-122	yes	22.06
E-HCAD-1	yes	20.33
E-CURD-46	yes	14.63
E-GEOD-135922	yes	12.49
E-MTAB-8410	yes	11.72
E-GEOD-130148	yes	7.04
E-MTAB-6678	no	3.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, FOS

miRNA regulators (miRDB)

233 targeting RAB11A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3688-3P	99.97	72.02	2834

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 20.4% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 40)

• mutation impairs a specific subset of Rab11 interactions, possibly those involved in cytoskeleton-based movements driving the slow recycling pathway (PMID:14699104)
• Rab11a, RPL7, and RPL28 showed moderate levels of differential expression in esophageal squamous cell carcinoma (PMID:15188492)
• there is a pivotal role for rab11 in regulating the traffic of a G protein-coupled receptor at the level of the recycling endosome (PMID:15190120)
• an interaction between Rab11 and TPbeta directs TPbeta recycling (PMID:16126723)
• Data suggest that polarization of hepatocytes requires recruitment of rab11a and myosin Vb to intracellular membranes that contain apical ABC transporters and transcytotic markers. (PMID:16214890)
• We conclude that the glutamine residue of Rab11a at position 70 is not strictly essential for GTPase activity of this protein in contrast to Ras and other Rab proteins. (PMID:16473307)
• Results describe the distinct C-terminal binding regions of FIP3 and FIP4 for Rab11 and ARF5/ARF6, and the crystal structure of Rab11 in complex with the Rab11-binding domain (RBD) of FIP3. (PMID:17030804)
• Rab 11 and Arf6 function synergistically in the switch from furrowing to abscission, as well as in the terminal stage of abscission (PMID:17157409)
• CaR is constitutively endocytosed and recycled to the plasma membrane by a Rab11a-dependent mechanism. (PMID:17426287)
• myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells (PMID:17462998)
• Rab11 plays a role in the intracellular trafficking of various types of LG-molecule from the TGN to the cell surface (PMID:17476295)
• These results show that Rab11A and Langerin are required for BG biogenesis, and they illustrate the role played by a Rab GTPase in the formation of a specialized subcompartment within the endocytic-recycling system. (PMID:17538027)
• These data therefore show that (i) Rab11a regulates cell surface abundance of both GLUT4 and FAT/CD36. (PMID:17854769)
• Both phosphorylated and nonphosphorylated MOR internalize via Rab5-dependent pathway after agonist stimulation, and the phosphorylated and nonphosphorylated MORs recycle through distinct vesicular trafficking pathways mediated by Rab4 and Rab11. (PMID:18550774)
• endosomal activation of the PI3K/AKT signaling pathway in response to Gbetagamma trafficking, via its interaction with Rab11, is a relevant step in the mechanism controlling cell survival and proliferation (PMID:18701709)
• Rab11a was expressed in umbrella cells (but not Rab11b or Rab25) and was associated with discoidal/fusiform vesicles, which were dependent on the activity of the Rab11a GTPase for exocytosis. (PMID:18843107)
• Both rab11a and HSP90 appear to be involved in the process of exocytosis of internalized extracellular alpha-synuclein. (PMID:19193894)
• Recycling endosome trafficking to the Golgi complex through a pathway involving Src-family kinases, Cdc42, and Rab11a plays a general role in death signaling by mediating regulated changes in Golgi dynamics. (PMID:19641023)
• A novel mechanism for cellular dysfunction by the HD mutation arising from the inhibition of Rab11 activity and a deficit in vesicle formation at recycling endosomes, is proposed. (PMID:19752198)
• D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment (PMID:19797056)
• Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway. (PMID:19996123)
• Rab11a, FIP3 and DLIC-1 form a ternary complex and DLIC-1 colocalises with endogenous FIP3 and Rab11a in A431 cells. (PMID:20026645)
• Rab11, in its GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward Rab8. (PMID:20308558)
• Results describe the involvement of two Rab GTPases, Rab9 and Rab11, in the trafficking of TRPC6. (PMID:20346379)
• Transmission electron microscopy of thin sections confirmed that Rab11 depletion resulted in significant numbers of abnormally formed virus particles that had failed to pinch off from the plasma membrane. (PMID:20357086)
• Rab11a played a prominent role in recycling of the wild type ss1-adrenergic receptors because dominant negative rab11a inhibited. (PMID:20727405)
• Rab11a is an important regulator of TLR4 and Toll-receptor-associated molecule transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment. (PMID:20933442)
• Rabin8 and Rab11 are associated with the Bardet-Biedl syndrome. (PMID:21273506)
• Rab11a, but not Rab8a, is required for recycling of transferrin in nonpolarized cells. (PMID:21282656)
• The authors propose that influenza virus ribonucleoproteins are routed from the nucleus to the pericentriolar recycling endosome (RE), where they access a Rab11-dependent vesicular transport pathway to the cell periphery. (PMID:21307188)
• Our results uncover a critical host factor with an essential contribution to influenza virus genome delivery and reveal a potential role for RAB11A in the transport of ribonucleoprotein cargo. (PMID:21525351)
• Recycling was accompanied by dephosphorylation of VEGFR-2 between Rab4 and Rab11 vesicles and quantitatively and qualitatively altered signal output. (PMID:21586748)
• Our data suggest a selective role of PICK1 in clustering and reducing the recycling rates of PDZ domain binding partners sorted to the Rab11-dependent recycling pathway. (PMID:22303009)
• Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling steps of langerin from the ERC to the plasma membrane (PMID:22420646)
• miR-141/YWHAG and miR-520e/RAB11A are two potential miRNA/protein target pairs associated with severe obesity. (PMID:22537031)
• TBC1D14 binds activated Rab11 but is not a GAP for Rab11, and loss of Rab11 prevents TBC1D14-induced tubulation of recycling endosomes. (PMID:22613832)
• Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane. (PMID:22685325)
• findings show 2 mother centriole appendage proteins, centriolin and cenexin/ODF2, regulate association of the endosome components Rab11, the Evi5, and the exocyst at the mother centriole (PMID:22981775)
• The potential roles of the Rab11 pathway in the trafficking, assembly and budding steps of negative-strand viruses. (PMID:23176490)
• These findings suggest that Rab11-FIP1 proteins participate in spatially and temporally distinct steps of the recycling process along a complex and dynamic tubular network in which Rab11-FIPs occupy discrete domains. (PMID:23283983)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	rab11a	ENSDARG00000041450
mus_musculus	Rab11a	ENSMUSG00000004771
rattus_norvegicus	Rab11a	ENSRNOG00000011302
drosophila_melanogaster	Rab11	FBGN0015790

Paralogs (68): RAB27B (ENSG00000041353), RAB27A (ENSG00000069974), RAB7A (ENSG00000075785), RABL2B (ENSG00000079974), RAB21 (ENSG00000080371), RAB10 (ENSG00000084733), RAB18 (ENSG00000099246), RAB36 (ENSG00000100228), IFT27 (ENSG00000100360), RAB40AL (ENSG00000102128), RAB2A (ENSG00000104388), RAB3D (ENSG00000105514), RAB3A (ENSG00000105649), RAB5C (ENSG00000108774), RAB34 (ENSG00000109113), RAB5B (ENSG00000111540), RAB35 (ENSG00000111737), RAB23 (ENSG00000112210), DNAJC27 (ENSG00000115137), RAB29 (ENSG00000117280), RAB32 (ENSG00000118508), RAB14 (ENSG00000119396), RAB9B (ENSG00000123570), RAB9A (ENSG00000123595), RAB38 (ENSG00000123892), RAB22A (ENSG00000124209), RAB17 (ENSG00000124839), RAB2B (ENSG00000129472), RAB25 (ENSG00000132698), RAB33A (ENSG00000134594), RAB30 (ENSG00000137502), RAB1A (ENSG00000138069), RAB20 (ENSG00000139832), RAB15 (ENSG00000139998), RAB40B (ENSG00000141542), RAB13 (ENSG00000143545), RABL2A (ENSG00000144134), RAB5A (ENSG00000144566), RAB19 (ENSG00000146955), RAB41 (ENSG00000147127)

Protein

Protein identifiers

Ras-related protein Rab-11A — P62491 (reviewed: P62491)

Alternative names: YL8

All UniProt accessions (5): P62491, B4DQU5, H3BMH2, H3BN38, H3BSC1

UniProt curated annotations — full annotation on UniProt →

Function. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling. Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44. Also interacts with RABL3 to promote ciliary vesicle formation.

Subunit / interactions. Interacts (GTP-bound form) with RAB11FIPs (via their C-termini) including RAB11FIP1, RAB11FIP2, RAB11FIP3, RAB11FIP4 and RAB11FIP5 effectors. Interacts with RAB11FIP5 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP-dependent manner. Forms a complex with RAB11FIP3 and dynein intermediate chain DYNC1LI1; the interaction between RAB11A1 and RAB11FIP3 is direct; the complex regulates endocytic trafficking. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with STXBP6. Interacts with VIPAS39. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. May interact with TBC1D14. Interacts with UNC119; in a cell cycle-dependent manner. GDP-bound and nucleotide-free forms interact with SH3BP5. Interacts (GDP-bound form) with KIF5A in a ZFYVE27-dependent manner. Interacts (GDP-bound form) with RELCH. Found in a complex composed of RELCH, OSBP1 and RAB11A. Interacts with TBC1D12. Interacts with DEF6. Interacts with VPS33B. Interacts with ATP9A. Forms a heterotetramer with RAB11FIP3; the GTP-bound form is preferred for binding. Forms a complex with Rabin8/RAB3IP and RAB11FIP3, probably a heterohexamer with two of each protein subunit, where Rabin8/RAB3IP and RAB11FIP3 simultaneously bind to RAB11A; the complex promotes preciliary trafficking and cilia growth. Forms a complex containing RAB11A, ASAP1, Rabin8/RAB3IP, RAP11FIP3 and ARF4; the complex promotes preciliary trafficking; the complex binds to RHO in photoreceptor cells and promotes RHO ciliary transport. Interacts (GTP-bound form) with WDR44; the interaction prevents RAB11A-RAB3IP-RAB11FIP3 complex formation. Interacts with SH3TC2. Interacts (GTP-bound) with RABL3 (GDP-bound); the interaction stabilizes RABL3 and regulates ciliary vesicle formation during early ciliogenesis.

Subcellular location. Cell membrane. Endosome membrane. Recycling endosome membrane. Cleavage furrow. Cytoplasmic vesicle. Phagosome membrane. Golgi apparatus membrane. Golgi apparatus. trans-Golgi network. Cytoplasmic vesicle membrane. Cell projection. Cilium.

Post-translational modifications. (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3.

Activity regulation. Regulated by guanine nucleotide exchange factors (GEFs) including SH3BP5, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation.

Domain organisation. Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.

Similarity. Belongs to the small GTPase superfamily. Rab family.

Isoforms (2)

UniProt ID	Names	Canonical?
P62491-1	1	yes
P62491-2	2

RefSeq proteins (2): NP_001193765, NP_004654* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR005225	Small_GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR050209	Rab_GTPases_membrane_traffic	Family

Pfam: PF00071

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (65 total): binding site 21, mutagenesis site 14, strand 8, helix 8, region of interest 3, modified residue 2, lipid moiety-binding region 2, turn 2, initiator methionine 1, chain 1, propeptide 1, glycosylation site 1, splice variant 1

Structure

Experimental structures (PDB)

30 structures.

PDB	Method	Resolution (Å)
1OIX	X-RAY DIFFRACTION	1.7
2D7C	X-RAY DIFFRACTION	1.75
2HV8	X-RAY DIFFRACTION	1.86
1OIV	X-RAY DIFFRACTION	1.98
1YZK	X-RAY DIFFRACTION	2
4C4P	X-RAY DIFFRACTION	2
1OIW	X-RAY DIFFRACTION	2.05
5JCZ	X-RAY DIFFRACTION	2.06
6IY1	X-RAY DIFFRACTION	2.11
4LX0	X-RAY DIFFRACTION	2.19
5EZ5	X-RAY DIFFRACTION	2.4
2GZD	X-RAY DIFFRACTION	2.44
2GZH	X-RAY DIFFRACTION	2.47
4LWZ	X-RAY DIFFRACTION	2.55
4UJ5	X-RAY DIFFRACTION	2.6
5C46	X-RAY DIFFRACTION	2.65
4D0L	X-RAY DIFFRACTION	2.94
4UJ3	X-RAY DIFFRACTION	3
8VOF	X-RAY DIFFRACTION	3
6DJL	X-RAY DIFFRACTION	3.1
5C4G	X-RAY DIFFRACTION	3.2
5EUQ	X-RAY DIFFRACTION	3.2
5FBR	X-RAY DIFFRACTION	3.28
5FBV	X-RAY DIFFRACTION	3.29
5FBL	X-RAY DIFFRACTION	3.37
5FBW	X-RAY DIFFRACTION	3.49
5FBQ	X-RAY DIFFRACTION	3.79
6IXV	X-RAY DIFFRACTION	3.8
4UJ4	X-RAY DIFFRACTION	4.2
4D0M	X-RAY DIFFRACTION	6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P62491-F1	87.43	0.69

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (21): 24; 25; 25; 26; 37; 38; 40; 42; 43; 43; 66; 69 …

Post-translational modifications (4): 2, 213, 212, 213

Glycosylation sites (1): 4

Mutagenesis-validated functional residues (14):

Position	Phenotype
13	abolishes sh3bp5-mediated guanine nucleotide exchange.
22	impairs protein folding.
24	impairs protein folding and decreases affinity for guanine nucleotides.
25	dominant-negative mutant (gdp-bound form). induces increased number of binucleated cells, indicating defects in cytokine
36	nearly abolishes sh3bp5-mediated guanine nucleotide exchange.
38	decreases sh3bp5-mediated guanine nucleotide exchange.
38	nearly abolishes sh3bp5-mediated guanine nucleotide exchange.
40	nearly abolishes sh3bp5-mediated guanine nucleotide exchange.
41	mildly decreases sh3bp5-mediated guanine nucleotide exchange.
41	abolishes sh3bp5-mediated guanine nucleotide exchange.
44	abolishes sh3bp5-mediated guanine nucleotide exchange.
70	constitutively active mutant (gtp-bound form). decreases gtpase activity. disrupts the trafficking of cdh1 to the plasma
82	decreases sh3bp5-mediated guanine nucleotide exchange.
154	impairs protein folding.

Function

Pathways and Gene Ontology

Reactome pathways

6 pathways

ID	Pathway
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-432040	Vasopressin regulates renal water homeostasis via Aquaporins
R-HSA-5620912	Anchoring of the basal body to the plasma membrane
R-HSA-5620916	VxPx cargo-targeting to cilium
R-HSA-8854214	TBC/RABGAPs
R-HSA-8873719	RAB geranylgeranylation

MSigDB gene sets: 546 (showing top): GOBP_MITOTIC_CYTOKINESIS, RNGTGGGC_UNKNOWN, GOBP_CHROMOSOME_ORGANIZATION, MODULE_52, GOBP_PROTEIN_LOCALIZATION_TO_CYTOSKELETON, GOBP_CYTOPLASMIC_MICROTUBULE_ORGANIZATION, GOBP_PIGMENT_GRANULE_LOCALIZATION, GOBP_ENDOSOME_ORGANIZATION, GOBP_VESICLE_LOCALIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_REGULATION_OF_NEURONAL_SYNAPTIC_PLASTICITY, GOBP_VESICLE_ORGANIZATION, GOBP_PROTEIN_LOCALIZATION_TO_CILIUM, GOBP_CHROMOSOME_LOCALIZATION, GOBP_CELL_CYCLE_PHASE_TRANSITION

GO Biological Process (42): exocytosis (GO:0006887), mitotic metaphase chromosome alignment (GO:0007080), positive regulation of epithelial cell migration (GO:0010634), positive regulation of G2/M transition of mitotic cell cycle (GO:0010971), vesicle-mediated transport (GO:0016192), astral microtubule organization (GO:0030953), neuron projection development (GO:0031175), melanosome transport (GO:0032402), regulation of cytokinesis (GO:0032465), protein localization to cell surface (GO:0034394), multivesicular body assembly (GO:0036258), Golgi to plasma membrane protein transport (GO:0043001), regulation of long-term neuronal synaptic plasticity (GO:0048169), plasma membrane to endosome transport (GO:0048227), regulation of protein transport (GO:0051223), establishment of vesicle localization (GO:0051650), regulation of vesicle-mediated transport (GO:0060627), obsolete early endosome to recycling endosome transport (GO:0061502), protein localization to cilium (GO:0061512), protein transmembrane transport (GO:0071806), establishment of protein localization to organelle (GO:0072594), protein localization to plasma membrane (GO:0072659), establishment of protein localization to membrane (GO:0090150), mitotic spindle assembly (GO:0090307), neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887), vesicle-mediated transport in synapse (GO:0099003), synaptic vesicle endosomal processing (GO:0099532), amyloid-beta clearance by transcytosis (GO:0150093), regulation of cilium assembly (GO:1902017), obsolete regulation of early endosome to recycling endosome transport (GO:1902954), positive regulation of protein localization to plasma membrane (GO:1903078), positive regulation of mitotic cytokinetic process (GO:1903438), regulation of protein localization to centrosome (GO:1904779), exosomal secretion (GO:1990182), regulation of endocytic recycling (GO:2001135), mitotic cytokinesis (GO:0000281), obsolete vesicle docking involved in exocytosis (GO:0006904), microtubule-based movement (GO:0007018), protein transport (GO:0015031), positive regulation of cilium assembly (GO:0045724)

GO Molecular Function (10): GTPase activity (GO:0003924), G protein activity (GO:0003925), GTP binding (GO:0005525), microtubule binding (GO:0008017), syntaxin binding (GO:0019905), myosin V binding (GO:0031489), dynein light intermediate chain binding (GO:0051959), nucleotide binding (GO:0000166), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (33): Golgi membrane (GO:0000139), spindle pole (GO:0000922), multivesicular body (GO:0005771), Golgi apparatus (GO:0005794), trans-Golgi network (GO:0005802), centrosome (GO:0005813), centriole (GO:0005814), cytosol (GO:0005829), transport vesicle (GO:0030133), cytoplasmic vesicle membrane (GO:0030659), endocytic vesicle membrane (GO:0030666), synaptic vesicle membrane (GO:0030672), cytoplasmic vesicle (GO:0031410), vesicle (GO:0031982), cleavage furrow (GO:0032154), trans-Golgi network membrane (GO:0032588), protein-containing complex (GO:0032991), phagocytic vesicle (GO:0045335), recycling endosome (GO:0055037), recycling endosome membrane (GO:0055038), extracellular exosome (GO:0070062), Schaffer collateral - CA1 synapse (GO:0098685), presynaptic endosome (GO:0098830), postsynaptic recycling endosome (GO:0098837), glutamatergic synapse (GO:0098978), cytoplasm (GO:0005737), endosome (GO:0005768), kinetochore microtubule (GO:0005828), plasma membrane (GO:0005886), endosome membrane (GO:0010008), endomembrane system (GO:0012505), membrane (GO:0016020), pseudopodium membrane (GO:0031260)

Reactome top-level categories

Rollup of top-6 pathways:

Category	Pathways
Membrane Trafficking	1
Aquaporin-mediated transport	1
Assembly of the 9+0 primary cilium	1
Cargo trafficking to the periciliary membrane	1
Rab regulation of trafficking	1
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
vesicle-mediated transport	3
protein transport	3
cytoplasm	3
regulation of transport	2
bounding membrane of organelle	2
cellular anatomical structure	2
endomembrane system	2
microtubule organizing center	2
cytoplasmic vesicle	2
endocytic vesicle	2
secretion by cell	1
vesicle fusion to plasma membrane	1
mitotic sister chromatid segregation	1
mitotic cell cycle	1
metaphase chromosome alignment	1
mitotic cell cycle process	1
epithelial cell migration	1
regulation of epithelial cell migration	1
positive regulation of cell migration	1
G2/M transition of mitotic cell cycle	1
regulation of G2/M transition of mitotic cell cycle	1
positive regulation of mitotic cell cycle phase transition	1
positive regulation of cell cycle G2/M phase transition	1
transport	1
cellular process	1
spindle organization	1
cytoplasmic microtubule organization	1
neuron development	1
plasma membrane bounded cell projection organization	1
melanosome localization	1
establishment of melanosome localization	1
pigment granule transport	1
cytokinesis	1
regulation of cell cycle process	1
regulation of cell division	1
intracellular protein localization	1
multivesicular body organization	1
organelle assembly	1
Golgi to plasma membrane transport	1
establishment of protein localization to plasma membrane	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

167 interactions, top by confidence:

A	B	Type	Score
RAB11FIP2	RAB11A	psi-mi:“MI:0407”(direct interaction)	0.960
RAB11A	RAB11FIP2	psi-mi:“MI:2364”(proximity)	0.960
RAB11A	RAB11FIP2	psi-mi:“MI:0915”(physical association)	0.960
RAB11FIP2	RAB11A	psi-mi:“MI:0915”(physical association)	0.960
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
RAB11FIP3	RAB11A	psi-mi:“MI:0915”(physical association)	0.860
RAB11A	RAB11FIP3	psi-mi:“MI:0915”(physical association)	0.860
RAB11A	RAB11FIP3	psi-mi:“MI:0407”(direct interaction)	0.860
RAB11A	RAB11FIP3	psi-mi:“MI:0914”(association)	0.860
RAB11FIP3	RAB11A	psi-mi:“MI:0914”(association)	0.860
RAB11FIP3	RAB11A	psi-mi:“MI:0407”(direct interaction)	0.860
RAB11A	RAB11FIP5	psi-mi:“MI:0915”(physical association)	0.840
RAB11A	EVI5	psi-mi:“MI:0914”(association)	0.800
EVI5	RAB11A	psi-mi:“MI:0915”(physical association)	0.800

BioGRID (1210): RAB11FIP2 (Reconstituted Complex), RAB11A (Affinity Capture-Western), RAB11A (Two-hybrid), ARHGDIA (Co-fractionation), NUTF2 (Co-fractionation), RAB11A (Co-fractionation), RAB11A (Co-fractionation), RAB11A (Co-fractionation), RAB11A (Co-fractionation), RAB5A (Co-fractionation), RAB5B (Co-fractionation), RAB5C (Co-fractionation), RAB7A (Co-fractionation), RAB11A (Affinity Capture-MS), RAB11A (Reconstituted Complex)

ESM2 similar proteins: E2RQ15, O01803, O04486, O23561, O35509, P17610, P19892, P22129, P25766, P28185, P28187, P36412, P46638, P62490, P62491, P62492, P62493, P62494, Q01111, Q15907, Q1PEX3, Q2TA29, Q39222, Q39434, Q39572, Q3MHP2, Q40191, Q40193, Q40195, Q40520, Q40522, Q40523, Q40723, Q52NJ1, Q58DW6, Q5R9M7, Q5ZJN2, Q96283, Q9FE79, Q9FGK5

Diamond homologs: A5D7F5, A8HN58, E2RQ15, M0RC99, O01803, O04486, O14966, O35509, O35963, O49513, O80501, P01123, P17608, P18066, P19892, P20339, P22129, P25766, P28185, P29687, P31583, P34143, P35278, P36862, P40393, P46629, P46638, P51146, P51147, P51148, P57735, P61017, P61018, P61020, P61021, P61271, P62490, P62491, P62492, P62493

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
PRKCA	unknown	RAB11A	phosphorylation
PRKCB	unknown	RAB11A	phosphorylation
PRKCE	unknown	RAB11A	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 117 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
MyD88 cascade initiated on plasma membrane	5	12.6×	6e-03
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	5	11.8×	6e-03
MyD88 dependent cascade initiated on endosome	5	11.8×	6e-03
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	9	10.8×	4e-05
Extra-nuclear estrogen signaling	5	10.5×	8e-03
PIP3 activates AKT signaling	11	9.1×	2e-05
Clathrin-mediated endocytosis	7	7.4×	6e-03

GO biological processes:

GO term	Partners	Fold	FDR
memory	5	9.2×	1e-02
endocytosis	8	7.7×	2e-03
neuron projection development	6	7.4×	9e-03
vesicle-mediated transport	7	6.8×	6e-03
protein transport	11	4.9×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

130 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	50
Likely benign	58
Benign	8

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2430281	NM_004663.5(RAB11A):c.335A>G (p.His112Arg)	Likely pathogenic

SpliceAI

2759 predictions. Top by Δscore:

Variant	Effect	Δscore
15:65729245:CATCT:C	acceptor_gain	1.0000
15:65729249:T:TC	acceptor_gain	1.0000
15:65729525:GATAC:G	donor_loss	1.0000
15:65729526:ATAC:A	donor_loss	1.0000
15:65729527:TACT:T	donor_loss	1.0000
15:65729528:AC:A	donor_loss	1.0000
15:65729529:CTCAC:C	donor_loss	1.0000
15:65729530:TC:T	donor_loss	1.0000
15:65729531:CACA:C	donor_loss	1.0000
15:65729532:A:AC	donor_gain	1.0000
15:65729532:A:C	donor_loss	1.0000
15:65729533:C:CA	donor_gain	1.0000
15:65729533:CA:C	donor_gain	1.0000
15:65729533:CAG:C	donor_gain	1.0000
15:65729533:CAGA:C	donor_gain	1.0000
15:65729676:CCA:C	acceptor_gain	1.0000
15:65729677:CA:C	acceptor_gain	1.0000
15:65729677:CAC:C	acceptor_gain	1.0000
15:65729679:C:CC	acceptor_gain	1.0000
15:65729688:C:CT	acceptor_gain	1.0000
15:65731701:C:CC	acceptor_gain	1.0000
15:65731713:T:C	acceptor_gain	1.0000
15:65731713:T:TC	acceptor_gain	1.0000
15:65732820:T:C	acceptor_gain	1.0000
15:65737705:A:AC	donor_gain	1.0000
15:65737706:C:CC	donor_gain	1.0000
15:65737768:T:TA	donor_gain	1.0000
15:65737849:T:TA	donor_gain	1.0000
15:65737850:C:A	donor_gain	1.0000
15:65738871:TAGGC:T	acceptor_gain	1.0000

AlphaMissense

1414 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
15:65877338:T:C	L16P	1.000
15:65877343:G:A	G18R	1.000
15:65877343:G:C	G18R	1.000
15:65877344:G:A	G18E	1.000
15:65877344:G:T	G18V	1.000
15:65877358:G:A	G23R	1.000
15:65877358:G:C	G23R	1.000
15:65877359:G:A	G23E	1.000
15:65877359:G:T	G23V	1.000
15:65877361:A:C	K24Q	1.000
15:65877362:A:T	K24M	1.000
15:65877363:G:C	K24N	1.000
15:65877363:G:T	K24N	1.000
15:65877365:G:T	S25I	1.000
15:65877371:T:C	L27P	1.000
15:65877374:T:C	L28P	1.000
15:65877380:G:C	R30P	1.000
15:65877397:T:C	F36L	1.000
15:65877398:T:C	F36S	1.000
15:65877399:T:A	F36L	1.000
15:65877399:T:G	F36L	1.000
15:65877419:C:T	T43I	1.000
15:65877422:T:A	I44N	1.000
15:65877424:G:A	G45R	1.000
15:65877424:G:C	G45R	1.000
15:65877425:G:A	G45E	1.000
15:65877433:T:C	F48L	1.000
15:65877434:T:C	F48S	1.000
15:65877434:T:G	F48C	1.000
15:65877435:T:A	F48L	1.000

dbSNP variants (sampled 300 via entrez): RS1000100561 (15:65870114 C>A,G,T), RS1000132479 (15:65889407 T>C), RS1000171212 (15:65892461 C>T), RS1000173967 (15:65889884 G>A), RS1000394359 (15:65885054 C>T), RS1000536367 (15:65870349 C>T), RS1000731899 (15:65886616 A>G), RS1000793826 (15:65882842 C>A), RS1000869190 (15:65874546 G>A), RS1000905158 (15:65878409 C>T), RS1000952111 (15:65878160 A>G), RS1001136329 (15:65871934 T>G), RS1001175305 (15:65891619 C>T), RS1001398117 (15:65884452 G>T), RS1001430362 (15:65869333 G>A)

Disease associations

OMIM: gene MIM:605570 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
neurodevelopmental disorder	Strong	Autosomal dominant
autosomal dominant non-syndromic intellectual disability	Supportive	Autosomal dominant

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
complex neurodevelopmental disorder with motor features	Moderate	AD

Mondo (3): precocious puberty in female (MONDO:0018561), neurodevelopmental disorder (MONDO:0700092), autosomal dominant non-syndromic intellectual disability (MONDO:0015802)

Orphanet (1): Rare precocious puberty in female (Orphanet:435561)

HPO phenotypes

1 total (1 of 1 shown, HPO-id order):

HPO	Term
HP:0010465	Precocious puberty in females

GWAS associations

18 associations (top):

Study	Trait	p-value
GCST004601_176	Red blood cell count	5.000000e-17
GCST004602_212	Mean corpuscular volume	3.000000e-49
GCST004602_213	Mean corpuscular volume	1.000000e-52
GCST004615_100	Hemoglobin concentration	5.000000e-09
GCST004630_161	Mean corpuscular hemoglobin	8.000000e-18
GCST004630_162	Mean corpuscular hemoglobin	8.000000e-76
GCST005992_19	Mean corpuscular hemoglobin concentration	8.000000e-11
GCST005993_11	Mean corpuscular hemoglobin	4.000000e-28
GCST006011_43	Mean corpuscular volume	3.000000e-21
GCST90002384_385	Hemoglobin	1.000000e-12
GCST90002390_417	Mean corpuscular hemoglobin	1.000000e-36
GCST90002392_430	Mean corpuscular volume	1.000000e-28
GCST90002393_607	Monocyte count	3.000000e-18
GCST90002397_261	Mean spheric corpuscular volume	7.000000e-12
GCST90002398_285	Neutrophil count	4.000000e-16
GCST90002399_366	Neutrophil percentage of white cells	5.000000e-17
GCST90002405_339	Reticulocyte count	1.000000e-10
GCST90002406_388	Reticulocyte fraction of red cells	1.000000e-20

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0004509	hemoglobin measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0005091	monocyte count
EFO:0004833	neutrophil count
EFO:0007990	neutrophil percentage of leukocytes
EFO:0007986	reticulocyte count

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D065886	Neurodevelopmental Disorders	F03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL5291509 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression	1
pyrogallol 1,3-dimethyl ether	affects cotreatment, affects localization, increases expression	1
methylparaben	decreases expression	1
sodium arsenite	increases abundance, decreases expression	1
ochratoxin A	affects binding	1
ochratoxin B	affects binding	1
ICG 001	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Atrazine	decreases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	increases expression	1
Fluorouracil	decreases expression	1
Furaldehyde	affects cotreatment, affects localization, decreases expression	1
Gold	decreases expression	1
Melitten	affects cotreatment, decreases localization	1
Sodium Chloride	affects cotreatment, affects localization, decreases expression, increases expression	1
Tretinoin	decreases expression	1
Zinc	decreases expression	1
1-Methyl-4-phenylpyridinium	affects expression	1
Aflatoxin B1	decreases methylation	1
Antirheumatic Agents	decreases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5223841	Binding	Inhibition of Rab11A in human HeLa cells assessed as inhibition of Rab11A prenylation	Targeting Small GTPases and Their Prenylation in Diabetes Mellitus. — J Med Chem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7Z3	Ubigene A-549 RAB11A KO	Cancer cell line	Male

Clinical trials (associated diseases)

202 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04586348	PHASE4	UNKNOWN	Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115	PHASE4	UNKNOWN	Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02559102	PHASE3	COMPLETED	Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079	PHASE3	COMPLETED	Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480	PHASE3	RECRUITING	Reducing Missed Appointments
NCT07377032	PHASE3	RECRUITING	TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT02909959	PHASE2	COMPLETED	Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348	PHASE2	RECRUITING	Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372	PHASE2	COMPLETED	Safety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191	PHASE1	COMPLETED	NeuroModulation Technique Treatment of Autism
NCT04475848	PHASE1	COMPLETED	A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398	PHASE1	COMPLETED	IAMA-6 Oral Dose Study in Healthy Adults
NCT01783041	PHASE2/PHASE3	COMPLETED	Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385	PHASE2/PHASE3	RECRUITING	Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098	EARLY_PHASE1	NOT_YET_RECRUITING	Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783	Not specified	COMPLETED	CYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504	Not specified	RECRUITING	Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784	Not specified	UNKNOWN	High Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791	Not specified	COMPLETED	Nutrition and Pregnancy Intervention Study
NCT01942525	Not specified	UNKNOWN	Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170	Not specified	COMPLETED	Etiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649	Not specified	ACTIVE_NOT_RECRUITING	Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191	Not specified	TERMINATED	Biomarkers, Neurodevelopment and Preterm Infants
NCT02690675	Not specified	COMPLETED	Iron Supplement Effect on Child Development
NCT02694003	Not specified	COMPLETED	Better Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894	Not specified	COMPLETED	Family Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674	Not specified	UNKNOWN	Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157	Not specified	COMPLETED	Analyzing Retinal Microanatomy in ROP
NCT02898298	Not specified	COMPLETED	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
NCT02912780	Not specified	UNKNOWN	Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
NCT03023293	Not specified	COMPLETED	n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
NCT03023644	Not specified	COMPLETED	Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
NCT03032991	Not specified	UNKNOWN	Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
NCT03088189	Not specified	TERMINATED	Effect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring
NCT03096028	Not specified	COMPLETED	Developmental Origins of Mental Health Disorders
NCT03148782	Not specified	COMPLETED	Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase
NCT03172104	Not specified	COMPLETED	Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age
NCT03222375	Not specified	RECRUITING	SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
NCT03229928	Not specified	COMPLETED	Clinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge
NCT03232489	Not specified	UNKNOWN	Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice