RAB11B-AS1

Summary

RAB11B-AS1 (RAB11B antisense RNA 1, HGNC:44178) is a long non-coding RNA gene on chromosome 19p13.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44178
Approved symbol	RAB11B-AS1
Name	RAB11B antisense RNA 1
Location	19p13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	MIR4999HG
Ensembl gene	ENSG00000269386
Ensembl biotype	lncRNA
Entrez	100507567
RNAcentral	URS000075D986 — lncRNA, 1034 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 13 lncRNA

ENST00000593581, ENST00000597407, ENST00000597785, ENST00000830917, ENST00000830918, ENST00000830919, ENST00000830920, ENST00000830921, ENST00000830922, ENST00000830923, ENST00000830924, ENST00000830925, ENST00000830926

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000593581 — 3 exons

Exon	Start	End
ENSE00003072854	8376962	8377067
ENSE00004245900	8374363	8374608
ENSE00004245902	8390009	8390685

Expression profiles

Bgee: expression breadth ubiquitous, 227 present calls, max score 87.69.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.6277 / max 76.0398, expressed in 1753 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
178943	2.1821	1340
178941	2.1509	1020
178942	1.3954	806
178944	0.8993	585

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	87.69	gold quality
liver	UBERON:0002107	86.38	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.12	gold quality
spinal cord	UBERON:0002240	84.86	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.83	gold quality
stromal cell of endometrium	CL:0002255	84.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	83.50	gold quality
inferior vagus X ganglion	UBERON:0005363	83.12	gold quality
apex of heart	UBERON:0002098	82.82	gold quality
sural nerve	UBERON:0015488	82.66	gold quality
body of pancreas	UBERON:0001150	82.03	gold quality
epithelium of nasopharynx	UBERON:0001951	81.81	silver quality
subthalamic nucleus	UBERON:0001906	80.96	gold quality
body of stomach	UBERON:0001161	80.88	gold quality
muscle of leg	UBERON:0001383	79.45	gold quality
substantia nigra	UBERON:0002038	79.30	gold quality
sperm	CL:0000019	79.23	silver quality
gastrocnemius	UBERON:0001388	79.03	gold quality
substantia nigra pars reticulata	UBERON:0001966	79.00	silver quality
midbrain	UBERON:0001891	78.98	gold quality
right lobe of thyroid gland	UBERON:0001119	78.83	gold quality
mucosa of paranasal sinus	UBERON:0005030	78.66	silver quality
stomach	UBERON:0000945	78.36	gold quality
left lobe of thyroid gland	UBERON:0001120	78.31	gold quality
pons	UBERON:0000988	78.27	gold quality
medulla oblongata	UBERON:0001896	78.24	silver quality
medial globus pallidus	UBERON:0002477	78.24	gold quality
palpebral conjunctiva	UBERON:0001812	78.05	gold quality
globus pallidus	UBERON:0001875	77.62	gold quality
thyroid gland	UBERON:0002046	77.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.63

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• HIF2-Induced Long Noncoding RNA RAB11B-AS1 Promotes Hypoxia-Mediated Angiogenesis and Breast Cancer Metastasis. (PMID:31900259)
• METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m(6)A-dependent manner. (PMID:35596159)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.