RAB24

Summary

RAB24 (RAB24, member RAS oncogene family, HGNC:9765) is a protein-coding gene on chromosome 5q35.3, encoding Ras-related protein Rab-24 (Q969Q5). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.

RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).

Source: NCBI Gene 53917 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 5 total
• MANE Select transcript: NM_001031677

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9765
Approved symbol	RAB24
Name	RAB24, member RAS oncogene family
Location	5q35.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000169228
Ensembl biotype	protein_coding
OMIM	612415
Entrez	53917

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 5 retained_intron

ENST00000303251, ENST00000303270, ENST00000393610, ENST00000393611, ENST00000471466, ENST00000478234, ENST00000495458, ENST00000504395, ENST00000512758, ENST00000889061, ENST00000921245, ENST00000946229

RefSeq mRNA: 2 — MANE Select: NM_001031677 NM_001031677, NM_130781

CCDS: CCDS34300

Canonical transcript exons

ENST00000303251 — 8 exons

Exon	Start	End
ENSE00001408244	177301198	177301807
ENSE00001829843	177303172	177303719
ENSE00003476005	177302752	177302830
ENSE00003496636	177301925	177301987
ENSE00003510373	177303009	177303077
ENSE00003604684	177302577	177302644
ENSE00003638446	177302397	177302496
ENSE00003640949	177302128	177302178

Expression profiles

Bgee: expression breadth ubiquitous, 140 present calls, max score 98.42.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.6751 / max 196.1752, expressed in 1798 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
65070	12.3288	1798
65071	0.5929	367
65069	0.4557	169
65068	0.1515	55
65067	0.1461	60

Top tissues by expression

140 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.42	gold quality
monocyte	CL:0000576	97.81	gold quality
blood	UBERON:0000178	97.58	gold quality
leukocyte	CL:0000738	97.51	gold quality
spleen	UBERON:0002106	96.18	gold quality
body of pancreas	UBERON:0001150	96.08	gold quality
pituitary gland	UBERON:0000007	95.69	gold quality
lower esophagus mucosa	UBERON:0035834	95.60	gold quality
adenohypophysis	UBERON:0002196	95.33	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.92	gold quality
cerebellar hemisphere	UBERON:0002245	94.62	gold quality
cerebellum	UBERON:0002037	94.55	gold quality
cerebellar cortex	UBERON:0002129	94.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	94.05	gold quality
right frontal lobe	UBERON:0002810	93.93	gold quality
esophagus mucosa	UBERON:0002469	93.75	gold quality
skin of abdomen	UBERON:0001416	93.58	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	93.57	gold quality
pancreas	UBERON:0001264	93.37	gold quality
frontal cortex	UBERON:0001870	93.31	gold quality
zone of skin	UBERON:0000014	93.22	gold quality
left adrenal gland cortex	UBERON:0035825	93.19	gold quality
anterior cingulate cortex	UBERON:0009835	93.13	gold quality
skin of leg	UBERON:0001511	93.11	gold quality
right adrenal gland	UBERON:0001233	93.09	gold quality
minor salivary gland	UBERON:0001830	93.05	gold quality
prefrontal cortex	UBERON:0000451	93.02	gold quality
cerebral cortex	UBERON:0000956	92.94	gold quality
right adrenal gland cortex	UBERON:0035827	92.94	gold quality
left adrenal gland	UBERON:0001234	92.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

13 targeting RAB24, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-4751	98.80	64.95	525
HSA-MIR-3166	98.24	66.63	1223
HSA-MIR-615-5P	98.10	63.76	591
HSA-MIR-4690-3P	97.02	64.72	981
HSA-MIR-5685	97.02	64.34	1004
HSA-MIR-6854-5P	96.77	65.96	848

Literature-anchored findings (GeneRIF, showing 3)

• Rab24 modulates several mitotic events, including chromosome segregation and cytokinesis, perhaps through the interaction with microtubules (PMID:23387408)
• Our work provides new insights into the molecular function of Rab24 in the last steps of the endosomal degradative pathway. (PMID:27550070)
• Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity. (PMID:32694843)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rab24	ENSDARG00000054032
mus_musculus	Rab24	ENSMUSG00000034789
rattus_norvegicus	Rab24	ENSRNOG00000016539

Paralogs (68): RAB27B (ENSG00000041353), RAB27A (ENSG00000069974), RAB7A (ENSG00000075785), RABL2B (ENSG00000079974), RAB21 (ENSG00000080371), RAB10 (ENSG00000084733), RAB18 (ENSG00000099246), RAB36 (ENSG00000100228), IFT27 (ENSG00000100360), RAB40AL (ENSG00000102128), RAB11A (ENSG00000103769), RAB2A (ENSG00000104388), RAB3D (ENSG00000105514), RAB3A (ENSG00000105649), RAB5C (ENSG00000108774), RAB34 (ENSG00000109113), RAB5B (ENSG00000111540), RAB35 (ENSG00000111737), RAB23 (ENSG00000112210), DNAJC27 (ENSG00000115137), RAB29 (ENSG00000117280), RAB32 (ENSG00000118508), RAB14 (ENSG00000119396), RAB9B (ENSG00000123570), RAB9A (ENSG00000123595), RAB38 (ENSG00000123892), RAB22A (ENSG00000124209), RAB17 (ENSG00000124839), RAB2B (ENSG00000129472), RAB25 (ENSG00000132698), RAB33A (ENSG00000134594), RAB30 (ENSG00000137502), RAB1A (ENSG00000138069), RAB20 (ENSG00000139832), RAB15 (ENSG00000139998), RAB40B (ENSG00000141542), RAB13 (ENSG00000143545), RABL2A (ENSG00000144134), RAB5A (ENSG00000144566), RAB19 (ENSG00000146955)

Protein

Protein identifiers

Ras-related protein Rab-24 — Q969Q5 (reviewed: Q969Q5)

All UniProt accessions (3): Q969Q5, D6RFW3, F8W8H5

UniProt curated annotations — full annotation on UniProt →

Function. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction.

Subunit / interactions. Interacts with ZFYVE20. Does not interact with the GDP dissociation inhibitors ARHGDIA and ARHGDIB.

Subcellular location. Cytoplasm. Cytosol. Membrane. Cytoplasmic vesicle. Autophagosome membrane. Perinuclear region. Cytoskeleton. Spindle.

Post-translational modifications. Prenylated; prenylation is required for RAB24 localization to autophagosomes. Isoprenylation is inefficient compared to other Rab family members. Phosphorylated at Tyr-17 and Tyr-172. Cytosolic pool of RAB24 is more phosphorylated than the membrane-associated pool.

Activity regulation. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs).

Domain organisation. Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.

Induction. By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into postmitotic neurons (NTN2) (at protein level).

Miscellaneous. The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP.

Similarity. Belongs to the small GTPase superfamily. Rab family.

RefSeq proteins (2): NP_001026847, NP_570137 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR005225	Small_GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR041828	Rab24	Family

Pfam: PF00071

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (21 total): binding site 11, sequence conflict 3, region of interest 2, modified residue 2, lipid moiety-binding region 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969Q5-F1	89.20	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (11): 66; 121; 123; 156; 19; 20; 21; 21; 40; 40; 63

Post-translational modifications (4): 17, 172, 200, 201

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-8873719	RAB geranylgeranylation

MSigDB gene sets: 151 (showing top): ATF_B, RNGTGGGC_UNKNOWN, GOBP_ATTACHMENT_OF_SPINDLE_MICROTUBULES_TO_KINETOCHORE, REACTOME_INNATE_IMMUNE_SYSTEM, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOCC_VACUOLAR_MEMBRANE, GOCC_SECRETORY_GRANULE, GOBP_CHROMOSOME_LOCALIZATION, GOBP_OOGENESIS, IVANOVA_HEMATOPOIESIS_MATURE_CELL, CAGCTG_AP4_Q5, CREB_Q4, GOBP_ANATOMICAL_STRUCTURE_MATURATION, GOBP_ORGANELLE_FISSION, GOBP_CELL_MATURATION

GO Biological Process (6): oocyte maturation (GO:0001556), intracellular protein transport (GO:0006886), autophagy (GO:0006914), attachment of spindle microtubules to kinetochore (GO:0008608), meiotic nuclear division (GO:0140013), protein transport (GO:0015031)

GO Molecular Function (7): GTPase activity (GO:0003924), G protein activity (GO:0003925), GTP binding (GO:0005525), metal ion binding (GO:0046872), nucleotide binding (GO:0000166), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (16): autophagosome membrane (GO:0000421), mitochondrion (GO:0005739), endosome (GO:0005768), autophagosome (GO:0005776), spindle (GO:0005819), cytosol (GO:0005829), plasma membrane (GO:0005886), endomembrane system (GO:0012505), endocytic vesicle (GO:0030139), secretory granule membrane (GO:0030667), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), cytoskeleton (GO:0005856), membrane (GO:0016020), organelle membrane (GO:0031090), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
cytoplasm	4
intracellular protein localization	2
cytoplasmic vesicle	2
vacuole	2
intracellular membraneless organelle	2
membrane	2
developmental process involved in reproduction	1
cell maturation	1
oocyte development	1
protein transport	1
intracellular transport	1
catabolic process	1
transmembrane transport	1
process utilizing autophagic mechanism	1
microtubule binding	1
cell cycle process	1
metaphase chromosome alignment	1
nuclear division	1
meiotic cell cycle	1
meiotic cell cycle process	1
transport	1
establishment of protein localization	1
ribonucleoside triphosphate phosphatase activity	1
GTPase activity	1
molecular function regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
cation binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
vacuolar membrane	1
autophagosome	1
intracellular membrane-bounded organelle	1
endomembrane system	1
microtubule cytoskeleton	1
cell periphery	1
plasma membrane	1

Protein interactions and networks

STRING

1330 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RAB24	GABARAP	O95166	654
RAB24	RBSN	Q9H1K0	588
RAB24	ATG4C	Q96DT6	557
RAB24	ATG7	O95352	527
RAB24	SMCR8	Q8TEV9	522
RAB24	ATG16L2	Q8NAA4	511
RAB24	BECN1	Q14457	510
RAB24	LAMP2	P13473	494
RAB24	SEL1L	Q9UBV2	493
RAB24	NR3C1	P04150	490
RAB24	RABL3	Q5HYI8	458
RAB24	HSPA4	P34932	454
RAB24	ATG16L1	Q676U5	449
RAB24	ATG5	Q9H1Y0	448
RAB24	ATG4D	Q86TL0	442

IntAct

23 interactions, top by confidence:

A	B	Type	Score
GDI1	RAB4A	psi-mi:“MI:0914”(association)	0.820
RAB24	GDI2	psi-mi:“MI:0915”(physical association)	0.710
GAMT	RAB24	psi-mi:“MI:0915”(physical association)	0.560
SFXN5	TOMM40	psi-mi:“MI:0914”(association)	0.530
RAB24	SMCR8	psi-mi:“MI:0915”(physical association)	0.400
COQ9	NDUFS8	psi-mi:“MI:0914”(association)	0.350
RAB24	KRT36	psi-mi:“MI:0914”(association)	0.350
GDI1	U2SURP	psi-mi:“MI:0914”(association)	0.350
GDI2	SGTA	psi-mi:“MI:0914”(association)	0.350
FIS1	QSOX1	psi-mi:“MI:0914”(association)	0.350
GDI1	NADK	psi-mi:“MI:0914”(association)	0.350
LYRM4	UBA1	psi-mi:“MI:0914”(association)	0.350
RAB24	UBA1	psi-mi:“MI:0914”(association)	0.350
RAB24	AIP	psi-mi:“MI:0914”(association)	0.350
MTCH2	IPO5	psi-mi:“MI:0914”(association)	0.350
SLC1A2	UBXN8	psi-mi:“MI:0914”(association)	0.350
SLC38A8	ILVBL	psi-mi:“MI:0914”(association)	0.350
SPNS1	ACADS	psi-mi:“MI:0914”(association)	0.350
BIN1	RAB24	psi-mi:“MI:0915”(physical association)	0.000
GAMT	RAB24	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (45): RAB24 (Affinity Capture-MS), RAB24 (Affinity Capture-MS), RAB24 (Protein-RNA), RAB24 (Two-hybrid), RAB24 (Affinity Capture-MS), RAB24 (Proximity Label-MS), RAB24 (Proximity Label-MS), RAB24 (Proximity Label-MS), RAB24 (Affinity Capture-MS), ELP2 (Affinity Capture-MS), RAB24 (Affinity Capture-MS), RAB24 (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), UBA1 (Affinity Capture-MS), CHML (Affinity Capture-MS)

ESM2 similar proteins: A2VE14, A5D9H7, B2GV54, B9EKX1, D0RB01, F1M625, F1NBL0, O35684, O54760, O54761, O60242, O60656, O75317, P13591, P31836, P35237, P35290, P62068, P62069, P69849, Q3UQ28, Q3ZCW2, Q4R3G2, Q5JPE7, Q5NVN7, Q5R5K6, Q5R899, Q5RBQ4, Q5RKN4, Q5T4D3, Q5VU57, Q5ZHQ2, Q5ZIN0, Q6ZW05, Q80ZF8, Q8BLF1, Q8BUV3, Q90935, Q90W79, Q969Q5

Diamond homologs: A6QR46, C8VQY7, M0RC99, O01803, O04486, O18334, O80501, P11620, P17608, P17610, P18066, P20339, P20340, P25228, P25766, P29687, P31582, P31583, P34142, P34143, P34213, P35278, P35279, P35282, P35285, P35286, P35290, P35292, P35294, P36017, P36018, P36019, P36586, P41925, P51147, P51148, P51153, P51154, P51996, P55745

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

5 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1253 predictions. Top by Δscore:

Variant	Effect	Δscore
5:177302395:A:AC	donor_gain	1.0000
5:177302396:C:CC	donor_gain	1.0000
5:177302396:CTGT:C	donor_gain	1.0000
5:177302406:A:AC	donor_gain	1.0000
5:177302417:T:TA	donor_gain	1.0000
5:177302492:CAGCC:C	acceptor_gain	1.0000
5:177302495:CC:C	acceptor_gain	1.0000
5:177302496:CC:C	acceptor_gain	1.0000
5:177302496:CCTGA:C	acceptor_loss	1.0000
5:177302497:C:CG	acceptor_loss	1.0000
5:177302654:CGGCA:C	acceptor_gain	1.0000
5:177302655:G:T	acceptor_gain	1.0000
5:177302657:C:CT	acceptor_gain	1.0000
5:177302658:A:AC	acceptor_gain	1.0000
5:177302658:A:C	acceptor_gain	1.0000
5:177302661:C:CT	acceptor_gain	1.0000
5:177303003:ACTT:A	donor_loss	1.0000
5:177303005:TTA:T	donor_loss	1.0000
5:177303006:T:TG	donor_loss	1.0000
5:177303007:A:AC	donor_gain	1.0000
5:177303007:AC:A	donor_gain	1.0000
5:177303008:C:CC	donor_gain	1.0000
5:177303008:CC:C	donor_gain	1.0000
5:177303074:TGGT:T	acceptor_gain	1.0000
5:177303075:GGTCT:G	acceptor_loss	1.0000
5:177303077:TCTGC:T	acceptor_loss	1.0000
5:177303078:C:CC	acceptor_gain	1.0000
5:177303078:CTG:C	acceptor_loss	1.0000
5:177303079:T:G	acceptor_loss	1.0000
5:177303084:C:CT	acceptor_gain	1.0000

AlphaMissense

1343 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:177302756:G:C	C87W	1.000
5:177302829:T:A	D63V	1.000
5:177302829:T:C	D63G	1.000
5:177302829:T:G	D63A	1.000
5:177302830:C:G	D63H	1.000
5:177303011:A:G	W62R	1.000
5:177303011:A:T	W62R	1.000
5:177303060:G:C	F45L	1.000
5:177303060:G:T	F45L	1.000
5:177303062:A:G	F45L	1.000
5:177303227:G:A	T21I	1.000
5:177302147:G:C	S155R	0.999
5:177302147:G:T	S155R	0.999
5:177302149:T:G	S155R	0.999
5:177302151:G:A	S154F	0.999
5:177302467:C:A	K121N	0.999
5:177302467:C:G	K121N	0.999
5:177302474:C:T	G119D	0.999
5:177302476:A:C	C118W	0.999
5:177302477:C:T	C118Y	0.999
5:177302478:A:G	C118R	0.999
5:177302757:C:T	C87Y	0.999
5:177302758:A:G	C87R	0.999
5:177302760:A:T	V86D	0.999
5:177302766:G:T	A84D	0.999
5:177302820:C:T	G66D	0.999
5:177302821:C:A	G66C	0.999
5:177302821:C:G	G66R	0.999
5:177302828:G:C	D63E	0.999
5:177302828:G:T	D63E	0.999

dbSNP variants (sampled 300 via entrez): RS1000945330 (5:177303274 G>A,T), RS1001397878 (5:177302923 G>A,C), RS1001998859 (5:177301298 T>A,C,G), RS1002825693 (5:177304318 G>A), RS1003185797 (5:177304838 C>T), RS1005115063 (5:177303617 C>A,G,T), RS1005474200 (5:177303724 A>G), RS1006074211 (5:177302341 T>C), RS1006386330 (5:177303905 G>A,C,T), RS1007621991 (5:177305174 G>A), RS1008296955 (5:177302393 C>G), RS1008634203 (5:177303752 G>A,C), RS1009299043 (5:177301067 C>T), RS1010266450 (5:177304610 C>T), RS1010648481 (5:177304297 G>A,T)

Disease associations

OMIM: gene MIM:612415 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST005956_15	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_13	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-07
GCST005962_42	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	1.000000e-08
GCST007293_138	Body fat distribution (arm fat ratio)	1.000000e-08
GCST007293_79	Body fat distribution (arm fat ratio)	2.000000e-11
GCST007293_97	Body fat distribution (arm fat ratio)	2.000000e-10
GCST007294_102	Body fat distribution (trunk fat ratio)	2.000000e-10
GCST007294_155	Body fat distribution (trunk fat ratio)	4.000000e-09
GCST007485_3	Anthropometric traits	3.000000e-67
GCST007490_8	Anthropometric traits (multi-trait analysis)	2.000000e-36
GCST007640_1	Narrowest width of the femoral neck	2.000000e-08
GCST90020029_1507	Waist circumference adjusted for body mass index	6.000000e-12

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004341	body fat distribution
EFO:0004324	body weights and measures
EFO:0004511	femoral neck bone geometry
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	2
Cyclosporine	increases expression	2
triphenyl phosphate	affects expression	1
sodium arsenate	decreases expression, increases abundance	1
perfluorooctanoic acid	increases expression	1
beta-methylcholine	affects expression	1
mitomycin C-DNA adduct	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Arsenic Trioxide	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Cisplatin	affects cotreatment, increases expression	1
Coumestrol	decreases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Mustard Gas	increases expression	1
Ozone	affects expression, increases abundance	1
Phenolsulfonphthalein	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Polychlorinated Biphenyls	affects expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Tunicamycin	increases expression	1
Urethane	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.