RAB2B

Summary

RAB2B (RAB2B, member RAS oncogene family, HGNC:20246) is a protein-coding gene on chromosome 14q11.2, encoding Ras-related protein Rab-2B (Q8WUD1). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes.

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.

Source: NCBI Gene 84932 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 51 total
• MANE Select transcript: NM_032846

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20246
Approved symbol	RAB2B
Name	RAB2B, member RAS oncogene family
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14824
Ensembl gene	ENSG00000129472
Ensembl biotype	protein_coding
OMIM	607466
Entrez	84932

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding_CDS_not_defined, 2 protein_coding, 1 nonsense_mediated_decay

ENST00000397762, ENST00000417141, ENST00000461909, ENST00000475857, ENST00000485996, ENST00000649801

RefSeq mRNA: 2 — MANE Select: NM_032846 NM_001163380, NM_032846

CCDS: CCDS9570

Canonical transcript exons

ENST00000397762 — 8 exons

Exon	Start	End
ENSE00001493846	21459020	21461303
ENSE00001530048	21476827	21476959
ENSE00003471496	21468357	21468449
ENSE00003482234	21462350	21462418
ENSE00003501815	21474867	21474934
ENSE00003541888	21468670	21468752
ENSE00003548082	21476528	21476599
ENSE00003563469	21463656	21463767

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 95.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.7664 / max 1685.5116, expressed in 1787 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
142177	8.9053	1751
142175	8.1412	1644
142176	2.9462	1250
142174	0.5209	150
142173	0.2527	98

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	95.00	silver quality
ileal mucosa	UBERON:0000331	94.44	gold quality
calcaneal tendon	UBERON:0003701	93.10	gold quality
secondary oocyte	CL:0000655	92.03	gold quality
oviduct epithelium	UBERON:0004804	91.67	gold quality
trabecular bone tissue	UBERON:0002483	91.21	gold quality
cortical plate	UBERON:0005343	90.87	gold quality
bone marrow	UBERON:0002371	90.77	gold quality
epithelial cell of pancreas	CL:0000083	90.60	gold quality
ganglionic eminence	UBERON:0004023	89.77	gold quality
upper leg skin	UBERON:0004262	89.74	gold quality
upper arm skin	UBERON:0004263	89.64	gold quality
islet of Langerhans	UBERON:0000006	89.43	gold quality
skin of hip	UBERON:0001554	88.73	gold quality
bone marrow cell	CL:0002092	88.57	gold quality
adrenal tissue	UBERON:0018303	88.28	gold quality
adult organism	UBERON:0007023	88.18	gold quality
cartilage tissue	UBERON:0002418	88.17	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.09	gold quality
ventricular zone	UBERON:0003053	87.79	gold quality
corpus callosum	UBERON:0002336	87.67	gold quality
smooth muscle tissue	UBERON:0001135	87.54	gold quality
monocyte	CL:0000576	87.13	gold quality
corpus epididymis	UBERON:0004359	87.01	gold quality
caput epididymis	UBERON:0004358	86.86	gold quality
gingival epithelium	UBERON:0001949	86.82	gold quality
prefrontal cortex	UBERON:0000451	86.81	gold quality
tibialis anterior	UBERON:0001385	86.79	silver quality
leukocyte	CL:0000738	86.77	gold quality
stromal cell of endometrium	CL:0002255	86.73	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.75
E-HCAD-10	no	2.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

90 targeting RAB2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-12118	100.00	65.88	1270
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-3173-3P	99.98	66.49	1217
HSA-MIR-6891-5P	99.98	66.53	1372
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-545-3P	99.95	70.74	2783
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-448	99.79	72.37	2103

Literature-anchored findings (GeneRIF, showing 2)

• Data show that Rab2B and a Rab2B-specific effector, GARI-L4, regulate Golgi morphology. (PMID:26209634)
• High RAB2B expression is associated with pancreatic cancer. (PMID:30015954)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rab2b	ENSMUSG00000022159
rattus_norvegicus	Rab2b	ENSRNOG00000012488
caenorhabditis_elegans		WBGENE00008671
caenorhabditis_elegans		WBGENE00008672

Paralogs (68): RAB27B (ENSG00000041353), RAB27A (ENSG00000069974), RAB7A (ENSG00000075785), RABL2B (ENSG00000079974), RAB21 (ENSG00000080371), RAB10 (ENSG00000084733), RAB18 (ENSG00000099246), RAB36 (ENSG00000100228), IFT27 (ENSG00000100360), RAB40AL (ENSG00000102128), RAB11A (ENSG00000103769), RAB2A (ENSG00000104388), RAB3D (ENSG00000105514), RAB3A (ENSG00000105649), RAB5C (ENSG00000108774), RAB34 (ENSG00000109113), RAB5B (ENSG00000111540), RAB35 (ENSG00000111737), RAB23 (ENSG00000112210), DNAJC27 (ENSG00000115137), RAB29 (ENSG00000117280), RAB32 (ENSG00000118508), RAB14 (ENSG00000119396), RAB9B (ENSG00000123570), RAB9A (ENSG00000123595), RAB38 (ENSG00000123892), RAB22A (ENSG00000124209), RAB17 (ENSG00000124839), RAB25 (ENSG00000132698), RAB33A (ENSG00000134594), RAB30 (ENSG00000137502), RAB1A (ENSG00000138069), RAB20 (ENSG00000139832), RAB15 (ENSG00000139998), RAB40B (ENSG00000141542), RAB13 (ENSG00000143545), RABL2A (ENSG00000144134), RAB5A (ENSG00000144566), RAB19 (ENSG00000146955), RAB41 (ENSG00000147127)

Protein

Protein identifiers

Ras-related protein Rab-2B — Q8WUD1 (reviewed: Q8WUD1)

All UniProt accessions (3): Q8WUD1, A0A3B3ITL1, E9PE37

UniProt curated annotations — full annotation on UniProt →

Function. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi. Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis. Together with RAB2A redundantly required for efficient autophagic flux.

Subunit / interactions. Interacts (in GTP-bound form) with GARIN4 (via N-terminus). Interacts (in GTP-bound form) with GARIN5A. Interacts (in GTP-bound form) with GARIN1B. Interacts with VPS39 and VPS41.

Subcellular location. Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle. Secretory vesicle. Acrosome. Autophagosome membrane.

Tissue specificity. Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Activity regulation. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors (GDIs) which inhibit the dissociation of the nucleotide from the GTPase.

Domain organisation. Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drives interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.

Similarity. Belongs to the small GTPase superfamily. Rab family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8WUD1-1	1	yes
Q8WUD1-2	2

RefSeq proteins (2): NP_001156852, NP_116235* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR005225	Small_GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR050209	Rab_GTPases_membrane_traffic	Family

Pfam: PF00071

Enzyme classification (BRENDA):

• EC 3.6.5.2 — small monomeric GTPase (BRENDA: 49 organisms, 138 substrates, 55 inhibitors, 5 Km, 1 kcat entries)

Substrate kinetics (BRENDA)

1 substrates with measured Km, best-characterized 1. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
GTP	—	0

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (51 total): binding site 26, helix 8, strand 6, short sequence motif 2, lipid moiety-binding region 2, chain 1, region of interest 1, modified residue 1, splice variant 1, sequence variant 1, sequence conflict 1, turn 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2A5J	X-RAY DIFFRACTION	1.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8WUD1-F1	87.92	0.66

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (26): 19; 19; 20; 20; 20; 21; 21; 38; 38; 61; 64; 119 …

Post-translational modifications (3): 202, 215, 216

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8873719	RAB geranylgeranylation

MSigDB gene sets: 166 (showing top): GOBP_POSITIVE_REGULATION_OF_TYPE_I_INTERFERON_PRODUCTION, GOCC_VACUOLAR_MEMBRANE, GOCC_SECRETORY_GRANULE, GOBP_REGULATION_OF_EXOCYTOSIS, DARWICHE_SKIN_TUMOR_PROMOTER_UP, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_UP, GOBP_POSITIVE_REGULATION_OF_CYTOKINE_PRODUCTION, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, GOBP_VESICLE_MEDIATED_TRANSPORT, SP1_Q2_01, GOBP_MACROAUTOPHAGY, GOBP_REGULATION_OF_VESICLE_MEDIATED_TRANSPORT, MARTINEZ_RB1_TARGETS_UP, GOBP_EXOCYTOSIS

GO Biological Process (8): Golgi organization (GO:0007030), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192), macroautophagy (GO:0016236), positive regulation of type I interferon production (GO:0032481), innate immune response (GO:0045087), positive regulation of exocytosis (GO:0045921), defense response to virus (GO:0051607)

GO Molecular Function (7): GTPase activity (GO:0003924), G protein activity (GO:0003925), GTP binding (GO:0005525), metal ion binding (GO:0046872), nucleotide binding (GO:0000166), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (11): Golgi membrane (GO:0000139), autophagosome membrane (GO:0000421), acrosomal vesicle (GO:0001669), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Post-translational protein modification	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	3
transport	2
endomembrane system	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
organelle organization	1
endomembrane system organization	1
intracellular protein localization	1
establishment of protein localization	1
cellular process	1
autophagosome assembly	1
autophagy	1
positive regulation of cytokine production	1
regulation of type I interferon production	1
type I interferon production	1
immune response	1
defense response to symbiont	1
exocytosis	1
regulation of exocytosis	1
positive regulation of secretion by cell	1
defense response	1
response to virus	1
ribonucleoside triphosphate phosphatase activity	1
GTPase activity	1
molecular function regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
cation binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
catalytic activity	1
Golgi apparatus	1
bounding membrane of organelle	1
vacuolar membrane	1
autophagosome	1
secretory granule	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

2570 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RAB2B	FGA	P02671	639
RAB2B	GARIN4	Q8IYT1	474
RAB2B	YKT6	O15498	423
RAB2B	FAM209B	Q5JX69	417
RAB2B	VAMP7	P51809	415
RAB2B	VPS39	Q96JC1	393
RAB2B	RNF212B	A8MTL3	359
RAB2B	OCEL1	Q9H607	351
RAB2B	TBC1D20	Q96BZ9	338
RAB2B	TSG101	Q99816	335
RAB2B	OR10G3	Q8NGC4	334
RAB2B	OR10G2	Q8NGC3	330
RAB2B	FCF1	Q9Y324	329
RAB2B	CD63	P08962	324
RAB2B	SDCBP	O00560	312

IntAct

111 interactions, top by confidence:

A	B	Type	Score
FAM114A1	RAB2B	psi-mi:“MI:0915”(physical association)	0.780
RAB2B	FAM114A1	psi-mi:“MI:0915”(physical association)	0.780
GARIN6	RAB2B	psi-mi:“MI:0915”(physical association)	0.720
RAB2B	GOLGA2	psi-mi:“MI:0915”(physical association)	0.720
BLZF1	RAB2B	psi-mi:“MI:0915”(physical association)	0.720
GOLGA2	RAB2B	psi-mi:“MI:0915”(physical association)	0.720
RAB2B	GARIN6	psi-mi:“MI:0915”(physical association)	0.720
RAB2B	BLZF1	psi-mi:“MI:0915”(physical association)	0.720
ICA1	RAB2B	psi-mi:“MI:0915”(physical association)	0.670
GARIN1A	RAB2A	psi-mi:“MI:0914”(association)	0.670
RAB2B	ICA1	psi-mi:“MI:0915”(physical association)	0.670
GARIN1A	RAB2B	psi-mi:“MI:0915”(physical association)	0.670
RAB2B	ADAMTSL4	psi-mi:“MI:0915”(physical association)	0.560
ADAMTSL4	RAB2B	psi-mi:“MI:0915”(physical association)	0.560
MEOX2	RAB2B	psi-mi:“MI:0915”(physical association)	0.560
RAB2B	VRTN	psi-mi:“MI:0915”(physical association)	0.560
RAB2B	FAM114A2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (106): RAB2B (Two-hybrid), RAB2B (Two-hybrid), RAB2B (Two-hybrid), RAB2B (Two-hybrid), FAM114A1 (Two-hybrid), FAM71C (Two-hybrid), RAB2B (Two-hybrid), RAB2B (Affinity Capture-MS), RAB2A (Affinity Capture-MS), GDI1 (Affinity Capture-MS), RAB5B (Affinity Capture-MS), RAB14 (Affinity Capture-MS), PRUNE (Affinity Capture-MS), RAB4A (Affinity Capture-MS), RAB9A (Affinity Capture-MS)

ESM2 similar proteins: O01803, O04486, O18333, O23561, O49513, P05712, P17610, P25766, P36409, P36863, P40393, P49103, P49104, P53994, P59279, P61019, P61105, P61106, P61107, P92963, Q01111, Q01971, Q05975, Q1PEX3, Q38922, Q39434, Q39570, Q39572, Q40193, Q40194, Q40195, Q40521, Q40523, Q40723, Q4R4X6, Q52NJ6, Q5R6B6, Q5R8Z8, Q5ZKU5, Q8WUD1

Diamond homologs: A1DZY4, A6QP66, A8NU18, C4YKT4, O08989, O14807, O35929, O88667, O93856, O94363, P01119, P03967, P08645, P08647, P0CY32, P10114, P10536, P11233, P11234, P15064, P17609, P22124, P22126, P22278, P22279, P22280, P28775, P32254, P36860, P36863, P48555, P59279, P61105, P61225, P61226, P61227, P62070, P62071, P63320, P63321

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

51 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1246 predictions. Top by Δscore:

Variant	Effect	Δscore
14:21462344:TCTTA:T	donor_loss	1.0000
14:21462345:CTTA:C	donor_loss	1.0000
14:21462346:TTA:T	donor_loss	1.0000
14:21462347:TAC:T	donor_loss	1.0000
14:21462348:ACCTC:A	donor_loss	1.0000
14:21462349:C:CA	donor_loss	1.0000
14:21462419:C:CC	acceptor_gain	1.0000
14:21463650:TAGTA:T	donor_loss	1.0000
14:21463651:AGTAC:A	donor_loss	1.0000
14:21463652:GTA:G	donor_loss	1.0000
14:21463653:TA:T	donor_loss	1.0000
14:21463654:A:AT	donor_loss	1.0000
14:21463655:C:CT	donor_loss	1.0000
14:21463655:CCT:C	donor_gain	1.0000
14:21463765:TCA:T	acceptor_gain	1.0000
14:21463766:CA:C	acceptor_gain	1.0000
14:21463766:CAC:C	acceptor_gain	1.0000
14:21463768:C:CC	acceptor_gain	1.0000
14:21476523:CTTA:C	donor_loss	1.0000
14:21476524:TTA:T	donor_loss	1.0000
14:21476525:TA:T	donor_loss	1.0000
14:21476526:A:AC	donor_gain	1.0000
14:21476527:C:CA	donor_loss	1.0000
14:21476527:C:CC	donor_gain	1.0000
14:21476527:CCT:C	donor_gain	1.0000
14:21476527:CCTA:C	donor_gain	1.0000
14:21476527:CCTAT:C	donor_gain	1.0000
14:21462416:GGC:G	acceptor_gain	0.9900
14:21462417:GC:G	acceptor_gain	0.9900
14:21462418:CC:C	acceptor_gain	0.9900

AlphaMissense

1415 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:21462402:G:T	A164D	1.000
14:21462413:G:C	F160L	1.000
14:21462413:G:T	F160L	1.000
14:21462415:A:G	F160L	1.000
14:21463681:G:T	A150D	1.000
14:21463717:G:T	A138D	1.000
14:21468359:C:A	K120N	1.000
14:21468359:C:G	K120N	1.000
14:21468361:T:C	K120E	1.000
14:21468366:C:T	G118E	1.000
14:21468367:C:A	G118W	1.000
14:21468419:C:A	W100C	1.000
14:21468419:C:G	W100C	1.000
14:21468421:A:G	W100R	1.000
14:21468421:A:T	W100R	1.000
14:21468688:A:G	L84P	1.000
14:21468691:A:G	L83P	1.000
14:21468697:C:T	G81E	1.000
14:21468709:C:A	R77M	1.000
14:21468727:A:T	I71N	1.000
14:21468735:G:C	F68L	1.000
14:21468735:G:T	F68L	1.000
14:21468736:A:C	F68C	1.000
14:21468737:A:G	F68L	1.000
14:21468737:A:T	F68I	1.000
14:21468748:C:A	G64V	1.000
14:21468748:C:T	G64E	1.000
14:21468749:C:A	G64W	1.000
14:21468749:C:G	G64R	1.000
14:21468749:C:T	G64R	1.000

dbSNP variants (sampled 300 via entrez): RS1000014645 (14:21467467 A>G,T), RS1000061699 (14:21462571 G>A), RS1000075727 (14:21473419 C>T), RS1000421889 (14:21478885 C>T), RS1000616826 (14:21469005 T>C), RS1000708603 (14:21470869 A>G), RS1001026487 (14:21474260 T>A), RS1001090633 (14:21476397 T>C), RS1001294350 (14:21476608 G>A,C), RS1001326281 (14:21463224 C>T), RS1001568849 (14:21470101 C>T), RS1001717193 (14:21463717 G>A), RS1002015301 (14:21458643 AT>A), RS1002027231 (14:21475823 C>A,G), RS1002080986 (14:21476020 T>C)

Disease associations

OMIM: gene MIM:607466 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST008839_536	Height	1.000000e-26

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	3
2,4,6-tribromophenol	decreases expression	1
decabromobiphenyl ether	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
tetrabromobisphenol A	decreases expression	1
coumarin	increases phosphorylation	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
ochratoxin B	affects binding	1
CGP 52608	affects binding, increases reaction	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
pentabrominated diphenyl ether 100	decreases expression	1
hexabrominated diphenyl ether 153	decreases expression	1
LDN 193189	affects cotreatment, increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Sunitinib	increases expression	1
Zoledronic Acid	increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Benzene	increases expression	1
Caffeine	decreases phosphorylation	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Ivermectin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Urethane	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.