RAB6C-AS1

Summary

RAB6C-AS1 (RAB6C antisense RNA 1, HGNC:49278) is a unprocessed pseudogene on chromosome 2q21.1.

At a glance

• Gene type: non-coding (transcribed_unprocessed_pseudogene) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49278
Approved symbol	RAB6C-AS1
Name	RAB6C antisense RNA 1
Location	2q21.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000225449
Ensembl biotype	transcribed_unprocessed_pseudogene
Entrez	100131320
RNAcentral	URS0000759F3A — lncRNA, 2474 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 transcribed_unprocessed_pseudogene

ENST00000433431

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433431 — 1 exons

Exon	Start	End
ENSE00001690761	129968258	129968380

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 80.71.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	77.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	76.93	gold quality
spinal cord	UBERON:0002240	76.85	gold quality
endocervix	UBERON:0000458	76.13	gold quality
Ammon’s horn	UBERON:0001954	75.68	gold quality
endometrium	UBERON:0001295	75.51	gold quality
cerebellar vermis	UBERON:0004720	74.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	74.38	gold quality
right frontal lobe	UBERON:0002810	74.08	gold quality
substantia nigra	UBERON:0002038	74.01	gold quality
right testis	UBERON:0004534	73.16	gold quality
cerebral cortex	UBERON:0000956	72.71	gold quality
hypothalamus	UBERON:0001898	72.67	gold quality
left testis	UBERON:0004533	72.10	gold quality
frontal cortex	UBERON:0001870	71.98	gold quality
primary visual cortex	UBERON:0002436	71.88	gold quality
testis	UBERON:0000473	71.79	gold quality
superior frontal gyrus	UBERON:0002661	71.73	gold quality
amygdala	UBERON:0001876	71.69	gold quality
temporal lobe	UBERON:0001871	71.65	gold quality
putamen	UBERON:0001874	71.53	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.41	gold quality
lower esophagus	UBERON:0013473	71.25	gold quality
caudate nucleus	UBERON:0001873	71.23	gold quality
prostate gland	UBERON:0002367	71.23	gold quality
corpus callosum	UBERON:0002336	70.95	gold quality
anterior cingulate cortex	UBERON:0009835	70.73	gold quality
prefrontal cortex	UBERON:0000451	70.66	gold quality
nucleus accumbens	UBERON:0001882	69.47	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-GEOD-99795	no	94.13
E-ANND-3	no	3.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• RAB6C-AS1 could be considered as a candidate biomarker for various malignancies, especially prostate and brain cancers. According to our results, RAB6C-AS1 has a notable prognostic value for patients with brain lower grade glioma. (PMID:30076712)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.