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RABGGTA

gene
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Also known as PTAR3

Summary

RABGGTA (Rab geranylgeranyltransferase subunit alpha, HGNC:9795) is a protein-coding gene on chromosome 14q12, encoding Geranylgeranyl transferase type-2 subunit alpha (Q92696). Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. It is a common-essential gene (DepMap: required in 99.5% of cancer cell lines).

Predicted to enable small GTPase binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein geranylgeranylation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of Rab-protein geranylgeranyltransferase complex. Predicted to be active in cytoplasm.

Source: NCBI Gene 5875 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 107 total
  • Druggable target: yes
  • Cancer dependency (DepMap): dependent in 99.5% of screened cell lines (common-essential)
  • MANE Select transcript: NM_182836

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:9795
Approved symbolRABGGTA
NameRab geranylgeranyltransferase subunit alpha
Location14q12
Locus typegene with protein product
StatusApproved
AliasesPTAR3
Ensembl geneENSG00000100949
Ensembl biotypeprotein_coding
OMIM601905
Entrez5875

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 8 protein_coding, 8 retained_intron, 5 protein_coding_CDS_not_defined, 4 nonsense_mediated_decay

ENST00000216840, ENST00000399409, ENST00000543002, ENST00000558376, ENST00000558534, ENST00000558649, ENST00000558936, ENST00000558954, ENST00000559551, ENST00000559586, ENST00000559850, ENST00000559974, ENST00000560127, ENST00000560163, ENST00000560207, ENST00000560243, ENST00000560521, ENST00000560777, ENST00000560871, ENST00000560998, ENST00000561055, ENST00000876595, ENST00000876596, ENST00000876597, ENST00000947203

RefSeq mRNA: 2 — MANE Select: NM_182836 NM_004581, NM_182836

CCDS: CCDS45088

Canonical transcript exons

ENST00000216840 — 17 exons

ExonStartEnd
ENSE000013484762427148724271597
ENSE000034765052426811024268198
ENSE000034776592426677624266889
ENSE000034821402426949124269694
ENSE000034859522427111324271169
ENSE000034938042426787024267958
ENSE000035001382426643024266517
ENSE000035412892427033424270458
ENSE000035624572426766024267776
ENSE000035653492426851424268619
ENSE000035665032426891124268993
ENSE000035849362426553824265763
ENSE000035906862426908024269163
ENSE000036154912427083724270947
ENSE000036309852426995324270140
ENSE000036485072426872524268826
ENSE000036924082426836924268420

Expression profiles

Bgee: expression breadth ubiquitous, 138 present calls, max score 98.82.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.4898 / max 85.0012, expressed in 1807 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
14257914.57781800
1425780.9120526

Top tissues by expression

138 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lower esophagus mucosaUBERON:003583498.82gold quality
esophagus mucosaUBERON:000246997.59gold quality
granulocyteCL:000009494.30gold quality
spleenUBERON:000210694.14gold quality
right uterine tubeUBERON:000130293.70gold quality
pituitary glandUBERON:000000793.50gold quality
minor salivary glandUBERON:000183093.42gold quality
vaginaUBERON:000099693.36gold quality
right hemisphere of cerebellumUBERON:001489093.26gold quality
apex of heartUBERON:000209893.19gold quality
saliva-secreting glandUBERON:000104493.15gold quality
esophagusUBERON:000104393.07gold quality
metanephros cortexUBERON:001053392.64gold quality
cerebellar hemisphereUBERON:000224592.61gold quality
cerebellar cortexUBERON:000212992.59gold quality
cerebellumUBERON:000203792.58gold quality
adenohypophysisUBERON:000219692.53gold quality
skin of legUBERON:000151192.46gold quality
right lobe of thyroid glandUBERON:000111992.40gold quality
primary visual cortexUBERON:000243692.35gold quality
zone of skinUBERON:000001492.29gold quality
right adrenal gland cortexUBERON:003582792.28gold quality
skin of abdomenUBERON:000141692.21gold quality
right adrenal glandUBERON:000123392.20gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047392.12gold quality
left lobe of thyroid glandUBERON:000112092.03gold quality
tibial nerveUBERON:000132392.00gold quality
ectocervixUBERON:001224991.99gold quality
upper lobe of left lungUBERON:000895291.90gold quality
body of pancreasUBERON:000115091.89gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes5.46
E-MTAB-6386no212.18

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.5% of screened cell lines, common-essential.

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_reriorabggtaENSDARG00000061024
mus_musculusRabggtaENSMUSG00000040472
rattus_norvegicusRabggtaENSRNOG00000030483
drosophila_melanogasterRabGGTaFBGN0037293
caenorhabditis_elegansWBGENE00019778

Paralogs (2): FNTA (ENSG00000168522), PTAR1 (ENSG00000188647)

Protein

Protein identifiers

Geranylgeranyl transferase type-2 subunit alpha — Q92696 (reviewed: Q92696)

Alternative names: Geranylgeranyl transferase type II subunit alpha, Rab geranyl-geranyltransferase subunit alpha, Rab geranylgeranyltransferase subunit alpha

All UniProt accessions (6): Q92696, H0YKP6, H0YKZ8, H0YLG7, H0YLH3, H0YMG5

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.

Subunit / interactions. Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interacts with non-phosphorylated form of RAB8A; phosphorylation of RAB8A at ‘Thr-72’ disrupts this interaction.

Activity regulation. The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

Similarity. Belongs to the protein prenyltransferase subunit alpha family.

RefSeq proteins (2): NP_004572, NP_878256* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001611Leu-rich_rptRepeat
IPR002088Prenyl_trans_aRepeat
IPR009087RabGGT_asu_insert-domainDomain
IPR032675LRR_dom_sfHomologous_superfamily
IPR036254RabGGT_asu_insert-dom_sfHomologous_superfamily

Pfam: PF00560, PF01239, PF07711

Catalyzed reactions (Rhea), 1 shown:

  • geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate (RHEA:21240)

UniProt features (14 total): repeat 11, chain 1, modified residue 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q92696-F193.810.85

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 98

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

IDPathway
R-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-8873719RAB geranylgeranylation

MSigDB gene sets: 158 (showing top): LFA1_Q6, PID_PRL_SIGNALING_EVENTS_PATHWAY, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, GOMF_GTPASE_BINDING, chr14q12, GCM_PRKCG, WANG_ESOPHAGUS_CANCER_VS_NORMAL_DN, GCM_RING1, GOBP_ENDOPLASMIC_RETICULUM_TO_GOLGI_VESICLE_MEDIATED_TRANSPORT, KLEIN_PRIMARY_EFFUSION_LYMPHOMA_UP, GOBP_SENSORY_PERCEPTION_OF_LIGHT_STIMULUS, GCM_FCGR2B, MORF_PML, GOBP_SENSORY_PERCEPTION

GO Biological Process (6): endoplasmic reticulum to Golgi vesicle-mediated transport (GO:0006888), visual perception (GO:0007601), protein geranylgeranylation (GO:0018344), protein modification process (GO:0036211), protein prenylation (GO:0018342), prenylation (GO:0097354)

GO Molecular Function (8): Rab geranylgeranyltransferase activity (GO:0004663), zinc ion binding (GO:0008270), small GTPase binding (GO:0031267), prenyltransferase activity (GO:0004659), protein geranylgeranyltransferase activity (GO:0004661), protein binding (GO:0005515), protein prenyltransferase activity (GO:0008318), transferase activity (GO:0016740)

GO Cellular Component (4): cytoplasm (GO:0005737), cytosol (GO:0005829), plasma membrane (GO:0005886), Rab-protein geranylgeranyltransferase complex (GO:0005968)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
TP53 Regulates Transcription of Cell Death Genes1
Post-translational protein modification1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cytoplasm3
cellular anatomical structure2
intercellular transport1
intracellular transport1
Golgi vesicle transport1
sensory perception of light stimulus1
protein prenylation1
protein metabolic process1
macromolecule modification1
protein modification process1
prenylation1
metabolic process1
protein geranylgeranyltransferase activity1
transition metal ion binding1
GTPase binding1
transferase activity, transferring alkyl or aryl (other than methyl) groups1
protein prenyltransferase activity1
binding1
prenyltransferase activity1
catalytic activity, acting on a protein1
catalytic activity1
intracellular anatomical structure1
membrane1
cell periphery1
transferase complex1

Protein interactions and networks

STRING

764 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
RABGGTARABGGTBP53611986
RABGGTAHERC2O95714767
RABGGTAPGGT1BP53609764
RABGGTAHLTFQ14527761
RABGGTATGM1P22735726
RABGGTACHMLP26374723
RABGGTARAB1AP11476672
RABGGTARAB27AP51159667
RABGGTAFNTBP49356638
RABGGTAFNTAP49354585
RABGGTARAB3AP20336544
RABGGTAOCA2Q04671544
RABGGTACHMP24386535
RABGGTAFGD3Q5JSP0492
RABGGTARAB32Q13637487

IntAct

99 interactions, top by confidence:

ABTypeScore
RABGGTBPTAR1psi-mi:“MI:0914”(association)0.920
RABGGTARABGGTBpsi-mi:“MI:0914”(association)0.880
RABGGTBRABGGTApsi-mi:“MI:0915”(physical association)0.880
RABGGTACHMpsi-mi:“MI:0915”(physical association)0.800
VPS25VPS36psi-mi:“MI:0914”(association)0.800
RAB31CHMpsi-mi:“MI:0914”(association)0.640
RAB32CHMpsi-mi:“MI:0914”(association)0.640
ILVBLCOG7psi-mi:“MI:0914”(association)0.640
CHMRAB5Cpsi-mi:“MI:0914”(association)0.640
SEC13SEC16Apsi-mi:“MI:0914”(association)0.640
RAB9ACHMpsi-mi:“MI:0914”(association)0.610
RAB8AWDR91psi-mi:“MI:0914”(association)0.600
RABGGTBPIPSLpsi-mi:“MI:0914”(association)0.530
LAMP3METTL15psi-mi:“MI:0914”(association)0.530
RABGGTAYKT6psi-mi:“MI:0914”(association)0.530
RAB5AATE1psi-mi:“MI:0914”(association)0.530
RAB7BATE1psi-mi:“MI:0914”(association)0.530
RAB30UBBpsi-mi:“MI:0914”(association)0.530
RAB29CHMpsi-mi:“MI:0914”(association)0.530
RAB1ACHMpsi-mi:“MI:0914”(association)0.530
RAB1BCHMpsi-mi:“MI:0914”(association)0.530
RAB9BCHMpsi-mi:“MI:0914”(association)0.530

BioGRID (127): RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), ETFB (Co-fractionation), RABGGTA (Co-fractionation), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), RABGGTA (Affinity Capture-MS), DPCD (Affinity Capture-MS)

ESM2 similar proteins: A4IG72, A5A779, A5PK19, A7MB11, D3ZUM2, E1BP36, O60294, O95801, P47823, Q08602, Q0P5H9, Q13144, Q1JPJ9, Q3UR70, Q5BK48, Q5EA11, Q5EA80, Q5NVK5, Q5XIA3, Q64350, Q6AY79, Q6SZW1, Q7TMC8, Q7YS91, Q86Y56, Q8BYR1, Q8CHW4, Q8MIR4, Q8N0W3, Q8N0Z6, Q8N6R0, Q8R3H9, Q8WUH2, Q91YR5, Q921Q3, Q924T7, Q92696, Q96EP0, Q96G04, Q96T76

Diamond homologs: A3KPW7, A5A779, O93829, O94412, Q00618, Q08602, Q55DQ4, Q5EA80, Q5NVK5, Q92696, Q9JHK4, Q9USX8, Q9V895, Q8VYB7, Q9FJ32, O60052, Q8N1F8, F4JT78, O49329, P34268, Q4R3P6, Q5M8G4, Q5RFE9, Q5ZLN0, Q6GPJ5, Q6K7R2, Q7SXW3, Q9CRC8, Q9H9A6, Q3TAA7, Q5F479, Q6IRN0, Q6P4K6, P09661, P43333, P57784, Q08963, Q1X8D7, Q4P5F9, Q4R8Y8

SIGNOR signaling

3 interactions.

AEffectBMechanism
CHM“down-regulates activity”RABGGTAbinding
RABGGTA“up-regulates activity”RAB5Alipidation
RABGGTA“up-regulates activity”RAB3Alipidation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 81 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
RAB geranylgeranylation2773.0×3e-43
RAB GEFs exchange GTP for GDP on RABs1834.9×2e-21
TBC/RABGAPs832.4×1e-08
Retrograde transport at the Trans-Golgi-Network620.6×4e-05
COPII-mediated vesicle transport717.8×1e-05

GO biological processes:

GO termPartnersFoldFDR
Rab protein signal transduction566.1×8e-07
antigen processing and presentation656.2×9e-08
positive regulation of exocytosis540.1×1e-05
endoplasmic reticulum to Golgi vesicle-mediated transport1018.1×3e-08
autophagosome assembly618.0×6e-05
Golgi organization1017.8×3e-08
retrograde transport, endosome to Golgi616.4×9e-05
intracellular protein transport1815.6×3e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

107 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance90
Likely benign0
Benign1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2901 predictions. Top by Δscore:

VariantEffectΔscore
14:24266888:TC:Tacceptor_gain1.0000
14:24266889:CC:Cacceptor_gain1.0000
14:24266889:CCTGG:Cacceptor_loss1.0000
14:24266890:C:CCacceptor_gain1.0000
14:24266891:T:Cacceptor_loss1.0000
14:24267654:CCATA:Cdonor_loss1.0000
14:24267655:CATAC:Cdonor_loss1.0000
14:24267656:ATAC:Adonor_loss1.0000
14:24267657:TAC:Tdonor_loss1.0000
14:24267658:ACCTT:Adonor_loss1.0000
14:24267773:CGGC:Cacceptor_gain1.0000
14:24267782:G:Cacceptor_gain1.0000
14:24267782:G:GCacceptor_gain1.0000
14:24267786:A:ACacceptor_gain1.0000
14:24267786:A:Cacceptor_gain1.0000
14:24267864:A:Cdonor_gain1.0000
14:24267864:ACTT:Adonor_loss1.0000
14:24267865:CTTG:Cdonor_loss1.0000
14:24267866:TTGCC:Tdonor_loss1.0000
14:24267867:TG:Tdonor_loss1.0000
14:24267869:C:CAdonor_loss1.0000
14:24267955:CACC:Cacceptor_gain1.0000
14:24267957:CC:Cacceptor_gain1.0000
14:24267958:CC:Cacceptor_gain1.0000
14:24267959:C:CCacceptor_gain1.0000
14:24268108:A:ACdonor_gain1.0000
14:24268109:C:CCdonor_gain1.0000
14:24268357:C:Adonor_gain1.0000
14:24268713:AT:Adonor_gain1.0000
14:24268714:T:TAdonor_gain1.0000

AlphaMissense

3633 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
14:24269581:A:GW181R1.000
14:24269581:A:TW181R1.000
14:24269591:G:CN177K1.000
14:24269591:G:TN177K1.000
14:24269684:C:AW146C1.000
14:24269684:C:GW146C1.000
14:24269686:A:GW146R1.000
14:24269686:A:TW146R1.000
14:24269693:A:CF143L1.000
14:24269693:A:TF143L1.000
14:24269953:A:GF143L1.000
14:24269954:G:CN142K1.000
14:24269954:G:TN142K1.000
14:24268136:A:GL374P0.999
14:24268154:A:GL368P0.999
14:24268766:A:GW287R0.999
14:24268766:A:TW287R0.999
14:24269104:A:CY231D0.999
14:24269110:A:GW229R0.999
14:24269110:A:TW229R0.999
14:24269114:A:CS227R0.999
14:24269114:A:TS227R0.999
14:24269116:T:GS227R0.999
14:24269135:G:CF220L0.999
14:24269135:G:TF220L0.999
14:24269137:A:GF220L0.999
14:24269572:G:TR184S0.999
14:24269579:C:AW181C0.999
14:24269579:C:GW181C0.999
14:24269676:C:GR149P0.999

dbSNP variants (sampled 300 via entrez): RS1001689568 (14:24272741 A>G), RS1002121704 (14:24269320 A>T), RS1002200778 (14:24272416 A>G,T), RS1002402298 (14:24265528 C>T), RS1002565484 (14:24267797 A>G), RS1002772936 (14:24271977 C>G,T), RS1003596245 (14:24266205 C>G), RS1004626294 (14:24267388 T>C), RS1005048875 (14:24272786 T>C), RS1005054995 (14:24267211 G>A,C), RS1005544531 (14:24273608 C>G), RS1006481656 (14:24269972 C>T), RS1006531950 (14:24270505 A>T), RS1006702513 (14:24271277 G>A), RS1007058793 (14:24270223 T>C)

Disease associations

OMIM: gene MIM:601905 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL4523994 (PROTEIN COMPLEX), CHEMBL5249 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

11 potent at pChembl≥5 of 11 total, top 10 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
5.87Ki1360nMCHEMBL1221574
5.68IC502100nMCHEMBL1221574
5.66IC502200nMCHEMBL1221575
5.51IC503100nMCHEMBL4558573
5.44IC503600nMCHEMBL4518286
5.35IC504500nMCHEMBL1221621
5.33IC504700nMCHEMBL4443727
5.32IC504800nMCHEMBL4456846
5.16IC507000nMCHEMBL4469845
5.16IC507000nMCHEMBL4467525

PubChem BioAssay actives

1 with measured affinity, of 25 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
(2R,3R,4S,5R)-2-(4-bromophenyl)-4-hexylsulfanyl-1-(4-methylphenyl)sulfonyl-5-propylpyrrolidine-3-carboxylic acid1920874: Inhibition of Geranylgeranyl transferase type-2 in human NIH3T3 cells assessed as inhibition of Rab geranylgeranylation incubated for 48 hrs by immunoblotting assayic502.1000uM

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
sodium arsenitedecreases expression, increases abundance, increases expression3
Acetaminophendecreases expression2
Benzo(a)pyrenedecreases methylation, increases expression2
Tobacco Smoke Pollutionaffects expression2
FR900359decreases phosphorylation1
bisphenol Fincreases expression1
bufotalindecreases expression1
triphenyl phosphateaffects expression1
alpha-pineneaffects cotreatment, increases oxidation, increases abundance1
beta-lapachoneincreases expression1
methacrylaldehydeincreases abundance, affects cotreatment, increases oxidation1
perfluorooctane sulfonic acidincreases expression1
GW 4064affects cotreatment, decreases expression1
jinfukangaffects cotreatment, increases expression1
(+)-JQ1 compounddecreases expression1
Sunitinibincreases expression1
Arsenic Trioxideaffects cotreatment, increases expression1
Acroleinincreases abundance, affects cotreatment, increases oxidation1
Air Pollutantsaffects cotreatment, increases abundance, increases oxidation1
Arsenicincreases abundance, increases expression1
Aspirinincreases expression1
Cadmiumincreases expression1
Cisplatinaffects cotreatment, increases expression1
Estradiolaffects cotreatment, decreases expression1
Farnesolaffects cotreatment, decreases expression1
Formaldehydeincreases expression1
Ivermectindecreases expression1
Ozoneincreases oxidation, increases abundance, affects cotreatment1
Testosteronedecreases expression1
Tretinoinaffects cotreatment, increases expression1

ChEMBL screening assays

24 unique, capped per target: 24 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL4315908BindingInhibition of GGtase-2 in human cells assessed as minimum effective dose required for increase in intracellular lambda chain level after 48 hrs by ELISANovel benzimidazole phosphonates as potential inhibitors of protein prenylation. — Bioorg Med Chem Lett

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 78

This page pulls from 78 datasets indexed by BioBTree:

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