RABL2B

Summary

RABL2B (RAB, member of RAS oncogene family like 2B, HGNC:9800) is a protein-coding gene on chromosome 22q13.33, encoding Rab-like protein 2B (Q9UNT1). Small GTPase required for ciliation.

The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene.

Source: NCBI Gene 11158 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 52 total — 1 pathogenic
• MANE Select transcript: NM_001130919

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:9800
Approved symbol	RABL2B
Name	RAB, member of RAS oncogene family like 2B
Location	22q13.33
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000079974
Ensembl biotype	protein_coding
OMIM	605413
Entrez	11158

Gene structure

Transcript identifiers

Ensembl transcripts: 100 — 91 protein_coding, 5 nonsense_mediated_decay, 3 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000354869, ENST00000395590, ENST00000395591, ENST00000395593, ENST00000395595, ENST00000395598, ENST00000413505, ENST00000425098, ENST00000435118, ENST00000436958, ENST00000464678, ENST00000464740, ENST00000465063, ENST00000468451, ENST00000482308, ENST00000685352, ENST00000690024, ENST00000691320, ENST00000887284, ENST00000887285, ENST00000887286, ENST00000887287, ENST00000887288, ENST00000887289, ENST00000887290, ENST00000887291, ENST00000887292, ENST00000887293, ENST00000887294, ENST00000887295, ENST00000887296, ENST00000887297, ENST00000887298, ENST00000887299, ENST00000887300, ENST00000887301, ENST00000887302, ENST00000887303, ENST00000887304, ENST00000887305, ENST00000887306, ENST00000887307, ENST00000887308, ENST00000887309, ENST00000887310, ENST00000887311, ENST00000887312, ENST00000887313, ENST00000887314, ENST00000887315, ENST00000887316, ENST00000887317, ENST00000887318, ENST00000887319, ENST00000887320, ENST00000887321, ENST00000913954, ENST00000913955, ENST00000913956, ENST00000913957, ENST00000913958, ENST00000913959, ENST00000913960, ENST00000913961, ENST00000913962, ENST00000913963, ENST00000913964, ENST00000913965, ENST00000913966, ENST00000913967, ENST00000913968, ENST00000913969, ENST00000913970, ENST00000913971, ENST00000913972, ENST00000913973, ENST00000913974, ENST00000913975, ENST00000913976, ENST00000913977, ENST00000913978, ENST00000913979, ENST00000913980, ENST00000961112, ENST00000961113, ENST00000961114, ENST00000961115, ENST00000961116, ENST00000961117, ENST00000961118, ENST00000961119, ENST00000961120, ENST00000961121, ENST00000961122, ENST00000961123, ENST00000961124, ENST00000961125, ENST00000961126, ENST00000961127, ENST00000961128

RefSeq mRNA: 24 — MANE Select: NM_001130919 NM_001003789, NM_001130919, NM_001130920, NM_001130921, NM_001130922, NM_001130923, NM_001350003, NM_001350004, NM_001350005, NM_001350006, NM_001350007, NM_001350008, NM_001350009, NM_001350010, NM_001350011, NM_001350012, NM_001350013, NM_001350014, NM_001350015, NM_001350016, NM_001350017, NM_001394054, NM_001394055, NM_007081

CCDS: CCDS14102, CCDS33683, CCDS46738

Canonical transcript exons

ENST00000691320 — 9 exons

Exon	Start	End
ENSE00001890928	50783501	50783636
ENSE00002474834	50769905	50770016
ENSE00003497028	50782188	50782347
ENSE00003523827	50776670	50776749
ENSE00003570915	50769041	50769124
ENSE00003625751	50777952	50777981
ENSE00003632578	50769455	50769552
ENSE00003635536	50775772	50775851
ENSE00003666330	50767506	50768874

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 99.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3905 / max 60.5031, expressed in 1721 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
194809	5.3980	1699
194810	0.9925	634

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	99.44	gold quality
fallopian tube	UBERON:0003889	96.01	gold quality
right lobe of thyroid gland	UBERON:0001119	95.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.64	gold quality
cerebellar hemisphere	UBERON:0002245	95.38	gold quality
cerebellar cortex	UBERON:0002129	95.35	gold quality
cerebellum	UBERON:0002037	95.30	gold quality
pituitary gland	UBERON:0000007	95.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.21	gold quality
thyroid gland	UBERON:0002046	95.17	gold quality
left lobe of thyroid gland	UBERON:0001120	95.11	gold quality
endocervix	UBERON:0000458	94.46	gold quality
primary visual cortex	UBERON:0002436	94.33	gold quality
adenohypophysis	UBERON:0002196	94.25	gold quality
left uterine tube	UBERON:0001303	94.16	gold quality
right ovary	UBERON:0002118	94.04	gold quality
granulocyte	CL:0000094	93.96	gold quality
left ovary	UBERON:0002119	93.86	gold quality
right frontal lobe	UBERON:0002810	93.72	gold quality
nucleus accumbens	UBERON:0001882	93.67	gold quality
metanephros cortex	UBERON:0010533	93.66	gold quality
body of uterus	UBERON:0009853	93.62	gold quality
cortical plate	UBERON:0005343	93.56	gold quality
superior frontal gyrus	UBERON:0002661	93.46	gold quality
ovary	UBERON:0000992	93.39	gold quality
caudate nucleus	UBERON:0001873	93.24	gold quality
left testis	UBERON:0004533	92.94	gold quality
hypothalamus	UBERON:0001898	92.76	gold quality
Brodmann (1909) area 9	UBERON:0013540	92.73	gold quality
brain	UBERON:0000955	92.72	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-114	yes	61.91
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

64 targeting RABL2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4496	99.88	68.89	2236
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-6766-5P	99.68	67.70	2325
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-3975	99.62	65.97	697
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-4261	99.59	70.30	3415
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-147B-5P	99.45	70.62	2432

Literature-anchored findings (GeneRIF, showing 4)

• In human samples no deviations of the euploid genomic state could be detected indicating that 22q13 microdeletions involving RABL2B are rare. (PMID:20138207)
• According to the present study, 50776482 delC allele in the RABL2B gene could be a risk factor in Iranian infertile men with oligoasthenoteratozoospermia defect, but more genetic studies are required to understand the accurate role of this variant in pathogenesis of human male infertility. (PMID:28138870)
• CEP19 is recruited to the ciliary base by the centriolar CEP350/FOP complex and then specifically captures GTP-bound RABL2B, which is activated via its intrinsic nucleotide exchange. (PMID:28625565)
• RABL2 controls localization of GPR161 independently of TULP3, which promotes entry of ciliary GPCRs. (PMID:30578315)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rabl2	ENSDARG00000063321
mus_musculus	Rabl2	ENSMUSG00000022621
rattus_norvegicus	Rabl2	ENSRNOG00000013947

Paralogs (68): RAB27B (ENSG00000041353), RAB27A (ENSG00000069974), RAB7A (ENSG00000075785), RAB21 (ENSG00000080371), RAB10 (ENSG00000084733), RAB18 (ENSG00000099246), RAB36 (ENSG00000100228), IFT27 (ENSG00000100360), RAB40AL (ENSG00000102128), RAB11A (ENSG00000103769), RAB2A (ENSG00000104388), RAB3D (ENSG00000105514), RAB3A (ENSG00000105649), RAB5C (ENSG00000108774), RAB34 (ENSG00000109113), RAB5B (ENSG00000111540), RAB35 (ENSG00000111737), RAB23 (ENSG00000112210), DNAJC27 (ENSG00000115137), RAB29 (ENSG00000117280), RAB32 (ENSG00000118508), RAB14 (ENSG00000119396), RAB9B (ENSG00000123570), RAB9A (ENSG00000123595), RAB38 (ENSG00000123892), RAB22A (ENSG00000124209), RAB17 (ENSG00000124839), RAB2B (ENSG00000129472), RAB25 (ENSG00000132698), RAB33A (ENSG00000134594), RAB30 (ENSG00000137502), RAB1A (ENSG00000138069), RAB20 (ENSG00000139832), RAB15 (ENSG00000139998), RAB40B (ENSG00000141542), RAB13 (ENSG00000143545), RABL2A (ENSG00000144134), RAB5A (ENSG00000144566), RAB19 (ENSG00000146955), RAB41 (ENSG00000147127)

Protein

Protein identifiers

Rab-like protein 2B — Q9UNT1 (reviewed: Q9UNT1)

All UniProt accessions (9): Q9UNT1, A0A0S2SW46, A0A8I5KRY9, A0A8I5KX29, A8MXF6, C9JFZ0, F2Z2T3, F2Z3A9, F2Z3J7

UniProt curated annotations — full annotation on UniProt →

Function. Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability. Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia.

Subunit / interactions. Interacts (in its GTP-bound form) with CEP19 (via residues 121-150); this interaction is required for its localization to the mother centriole and cilium basal body. Interacts (in its GTP-bound form) with the intraflagellar transport (IFT) complex B (via the IFT74-IFT81 heterodimer). Binding to CEP19 and the IFT74-IFT81 heterodimer is mutually exclusive.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome. Centriole. Cilium basal body.

Tissue specificity. Expressed in the testis.

Domain organisation. Switch I, switch II and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.

Similarity. Belongs to the small GTPase superfamily. Rab family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9UNT1-1	1	yes
Q9UNT1-2	2
Q9UNT1-3	3

RefSeq proteins (24): NP_001003789, NP_001124391, NP_001124392, NP_001124393, NP_001124394, NP_001124395, NP_001336932, NP_001336933, NP_001336934, NP_001336935, NP_001336936, NP_001336937, NP_001336938, NP_001336939, NP_001336940, NP_001336941, NP_001336942, NP_001336943, NP_001336944, NP_001336945, NP_001336946, NP_001380983, NP_001380984, NP_009012 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR005225	Small_GTP-bd	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR041835	RabL2	Family

Pfam: PF00071

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (23 total): binding site 14, region of interest 3, mutagenesis site 3, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UNT1-F1	79.88	0.50

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (14): 53; 53; 76; 79; 133; 134; 136; 160; 30; 31; 33; 34 …

Mutagenesis-validated functional residues (3):

Position	Phenotype
35	gdp-locked form; mild defects in ciliary assembly. loss of interaction with the intraflagellar transport (ift) complex b
73	mild defects in ciliary assembly. loss of interaction with the intraflagellar transport (ift) complex b via the ift74-if
80	gtp-locked form; interacts with the intraflagellar transport (ift) complex b via the ift74-ift81 heterodimer. localizes

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 66 (showing top): GCM_MAP4K4, GCM_GSPT1, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_CILIUM_ORGANIZATION, GOCC_CENTROSOME, GOBP_ORGANELLE_ASSEMBLY, GCM_SUFU, GCM_NF2, GOBP_CELL_PROJECTION_ORGANIZATION, GOCC_CENTRIOLE, GCM_PTK2, chr22q13, GOCC_PERICENTRIOLAR_MATERIAL, GOCC_CILIUM

GO Biological Process (5): intracellular protein transport (GO:0006886), intraciliary transport (GO:0042073), cilium assembly (GO:0060271), microtubule-based movement (GO:0007018), cell projection organization (GO:0030030)

GO Molecular Function (5): GTPase activity (GO:0003924), G protein activity (GO:0003925), GTP binding (GO:0005525), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (8): pericentriolar material (GO:0000242), cytoplasm (GO:0005737), centriole (GO:0005814), endomembrane system (GO:0012505), ciliary basal body (GO:0036064), cytoskeleton (GO:0005856), cilium (GO:0005929), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cilium	2
cilium organization	2
microtubule organizing center	2
intracellular membraneless organelle	2
intracellular protein localization	1
protein transport	1
intracellular transport	1
transport along microtubule	1
axoneme assembly	1
intraciliary transport involved in cilium assembly	1
protein localization to cilium	1
organelle assembly	1
trans-Golgi to periciliary membrane compartment transport	1
plasma membrane bounded cell projection assembly	1
ciliary transition zone assembly	1
microtubule-based process	1
cellular component organization	1
ribonucleoside triphosphate phosphatase activity	1
GTPase activity	1
molecular function regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
centrosome	1
intracellular anatomical structure	1
vacuole	1
plasma membrane	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

2079 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RABL2B	SHANK3	Q9BYB0	932
RABL2B	APPL2	Q8NEU8	895
RABL2B	ALG12	Q9BV10	777
RABL2B	CEP19	Q96LK0	659
RABL2B	PIM3	Q86V86	572
RABL2B	IFT22	Q9H7X7	554
RABL2B	SULT4A1	Q9BR01	512
RABL2B	SHANK2	Q9UPX8	471
RABL2B	MAPK8IP2	Q13387	449
RABL2B	ARL13B	Q3SXY8	443
RABL2B	IFT38	Q96AJ1	441
RABL2B	IFT56	A0AVF1	438
RABL2B	IFT74	Q96LB3	433
RABL2B	IFT27	Q9BW83	430
RABL2B	CPLANE2	Q9BU20	427

IntAct

7 interactions, top by confidence:

A	B	Type	Score
RABL2B	CEP19	psi-mi:“MI:0915”(physical association)	0.550
RABL2B	TUFM	psi-mi:“MI:0915”(physical association)	0.400
M		psi-mi:“MI:0914”(association)	0.350
RABL2B	CEP43	psi-mi:“MI:0914”(association)	0.350
HPN	DDX39A	psi-mi:“MI:0914”(association)	0.350

BioGRID (23): RASEF (Affinity Capture-MS), IDI2 (Affinity Capture-MS), CEP19 (Two-hybrid), RASEF (Affinity Capture-MS), IDI2 (Affinity Capture-MS), RABL2B (Affinity Capture-MS), RABL2B (Reconstituted Complex), RABL2B (Co-localization), RABL2B (Co-localization), IFT88 (Co-localization), CEP19 (Two-hybrid), RABL2B (Proximity Label-MS), FGFR1OP (Affinity Capture-MS), RASEF (Affinity Capture-MS), IDI2 (Affinity Capture-MS)

ESM2 similar proteins: A0A8I5ZNK2, A1L1L6, A2YNT8, A9TF79, D4AE59, E9Q9D5, O54833, O95057, P19784, P20427, P24786, P43291, P43292, P49137, P49138, P87027, Q0D4J7, Q0GGW5, Q16288, Q16644, Q2HJF8, Q32LJ6, Q4R4K5, Q5E9J4, Q5FVJ7, Q5IFJ9, Q5IS37, Q5N942, Q5R573, Q5ZKR4, Q66H84, Q6NVC5, Q6ZI44, Q75H77, Q75LR7, Q75V57, Q7XQP4, Q8BG51, Q8IXI2, Q91604

Diamond homologs: E9Q9D5, G4MYS1, I1RMF2, O01803, O04486, O35509, O42819, O49513, O76173, O94655, P07560, P10536, P11620, P22125, P22129, P24408, P28185, P28187, P28188, P31584, P32939, P33519, P33723, P34139, P34140, P35293, P36412, P38545, P38555, P40392, P40393, P41924, P46638, P51151, P62490, P62491, P62492, P62493, P62494, P62820

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

52 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	40
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
979616	GRCh37/hg19 22q13.33(chr22:51122307-51224091)x1	Pathogenic

SpliceAI

2264 predictions. Top by Δscore:

Variant	Effect	Δscore
22:50768779:G:C	donor_gain	1.0000
22:50768798:T:TA	donor_gain	1.0000
22:50769036:CCTA:C	donor_loss	1.0000
22:50769039:A:C	donor_loss	1.0000
22:50769125:C:CC	acceptor_gain	1.0000
22:50782186:A:AC	donor_gain	1.0000
22:50782187:C:CC	donor_gain	1.0000
22:50768873:TT:T	acceptor_gain	0.9900
22:50768875:C:A	acceptor_loss	0.9900
22:50768875:C:CC	acceptor_gain	0.9900
22:50769121:AGAG:A	acceptor_gain	0.9900
22:50769122:GAG:G	acceptor_gain	0.9900
22:50769123:AGCT:A	acceptor_loss	0.9900
22:50769124:GCTG:G	acceptor_loss	0.9900
22:50769550:CTG:C	acceptor_gain	0.9900
22:50769920:C:CT	donor_gain	0.9900
22:50769921:C:CT	donor_gain	0.9900
22:50769923:C:CT	donor_gain	0.9900
22:50769953:C:CA	donor_gain	0.9900
22:50770013:ACACC:A	acceptor_loss	0.9900
22:50770014:CACCT:C	acceptor_loss	0.9900
22:50770015:ACCT:A	acceptor_loss	0.9900
22:50770017:C:A	acceptor_loss	0.9900
22:50770018:T:A	acceptor_loss	0.9900
22:50775735:G:A	donor_gain	0.9900
22:50776757:CAGGT:C	acceptor_gain	0.9900
22:50776761:T:TC	acceptor_gain	0.9900
22:50777835:CACT:C	donor_loss	0.9900
22:50777836:ACTT:A	donor_loss	0.9900
22:50777837:CTTAC:C	donor_loss	0.9900

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1054698 (22:50769673 G>A,T), RS111231340 (22:50779722 A>G), RS111254433 (22:50767582 T>A), RS111356418 (22:50775105 A>C), RS111547533 (22:50781129 C>A,T), RS111565638 (22:50768634 A>T), RS112000803 (22:50778350 C>T), RS112046010 (22:50771045 ATTTTTTT>A,AT,ATTT,ATTTT,ATTTTT,ATTTTTT,ATTTTTTTT,ATTTTTTTTT,ATTTTTTTTTTT,ATTTTTTTTTTTTTTT), RS112423828 (22:50771298 T>A), RS112565862 (22:50771861 C>A,T), RS112650036 (22:50768128 C>T), RS112718844 (22:50771452 G>T), RS112796042 (22:50779913 G>A), RS112852441 (22:50780547 C>T), RS112869710 (22:50768549 C>A,T)

Disease associations

OMIM: gene MIM:605413 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
Smoke	decreases expression, increases abundance, increases expression	2
Cadmium Chloride	decreases expression, increases abundance	2
dicrotophos	increases expression	1
beta-lapachone	decreases expression, increases expression	1
cobaltous chloride	decreases expression	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
Resveratrol	affects cotreatment, decreases expression	1
Zoledronic Acid	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Cadmium	decreases expression, increases abundance	1
Gallic Acid	increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Plant Extracts	affects cotreatment, decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Aflatoxin B1	increases methylation	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.