RAD51-AS1

Summary

RAD51-AS1 (RAD51 antisense RNA 1, HGNC:48621) is a long non-coding RNA gene on chromosome 15q15.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48621
Approved symbol	RAD51-AS1
Name	RAD51 antisense RNA 1
Location	15q15.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	TODRA
Ensembl gene	ENSG00000245849
Ensembl biotype	lncRNA
Entrez	100505648
RNAcentral	URS000075BE45 — lncRNA, 1156 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 lncRNA, 1 retained_intron

ENST00000499988, ENST00000526635, ENST00000533146, ENST00000650326, ENST00000671605, ENST00000743886, ENST00000743887

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499988 — 2 exons

Exon	Start	End
ENSE00004082695	40693721	40694795
ENSE00004082697	40695012	40695128

Expression profiles

Bgee: expression breadth ubiquitous, 194 present calls, max score 94.04.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.5731 / max 67.4229, expressed in 1433 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
149501	3.6929	1308
149500	0.8802	450

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	94.04	gold quality
right lobe of thyroid gland	UBERON:0001119	90.06	gold quality
cerebellar hemisphere	UBERON:0002245	90.05	gold quality
left lobe of thyroid gland	UBERON:0001120	90.03	gold quality
cerebellar cortex	UBERON:0002129	89.94	gold quality
right hemisphere of cerebellum	UBERON:0014890	89.75	gold quality
thyroid gland	UBERON:0002046	89.31	gold quality
cerebellum	UBERON:0002037	88.38	gold quality
left ovary	UBERON:0002119	87.85	gold quality
adenohypophysis	UBERON:0002196	87.10	gold quality
minor salivary gland	UBERON:0001830	87.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	86.85	gold quality
right ovary	UBERON:0002118	86.63	gold quality
body of pancreas	UBERON:0001150	86.46	gold quality
pituitary gland	UBERON:0000007	86.26	gold quality
endocervix	UBERON:0000458	85.70	gold quality
spleen	UBERON:0002106	85.47	gold quality
body of uterus	UBERON:0009853	85.37	gold quality
metanephros cortex	UBERON:0010533	85.15	gold quality
right lung	UBERON:0002167	84.66	gold quality
body of stomach	UBERON:0001161	84.57	gold quality
mucosa of stomach	UBERON:0001199	84.55	gold quality
muscle layer of sigmoid colon	UBERON:0035805	84.41	gold quality
transverse colon	UBERON:0001157	84.33	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	84.18	gold quality
lower esophagus mucosa	UBERON:0035834	84.17	gold quality
small intestine	UBERON:0002108	84.15	gold quality
rectum	UBERON:0001052	83.95	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.92	gold quality
lower esophagus	UBERON:0013473	83.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.76

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• results identify TPIP as a novel E2F1 co-activator, suggest a similar role for other TPTEs, and indicate that the TODRA lncRNA affects RAD51 dysregulation and RAD51-dependent DSB repair in malignancy (PMID:26230935)
• Overexpression of RAD51-AS1 promoted EOC cell proliferation, while silencing of RAD51-AS1 inhibited EOC cell proliferation, delayed cell cycle progression and promoted apoptosis in vitro and in vivo. (PMID:28667302)
• Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. (PMID:29749376)
• LncRNA RAD51-AS1/miR-29b/c-3p/NDRG2 crosstalk repressed proliferation, invasion and glycolysis of colorectal cancer. (PMID:33314669)
• LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis. (PMID:35727431)
• Long non-coding RNA RAD51-AS1 promotes the tumorigenesis of ovarian cancer by elevating EIF5A2 expression. (PMID:38584230)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.