RAMP2-AS1

Summary

RAMP2-AS1 (RAMP2 antisense RNA 1, HGNC:44358) is a long non-coding RNA gene on chromosome 17q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44358
Approved symbol	RAMP2-AS1
Name	RAMP2 antisense RNA 1
Location	17q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000197291
Ensembl biotype	lncRNA
Entrez	100190938
RNAcentral	URS000075A5EF — lncRNA, 3272 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000587694, ENST00000589716, ENST00000591082, ENST00000592195, ENST00000592670, ENST00000662231, ENST00000769756, ENST00000769757, ENST00000769758, ENST00000769759, ENST00000769760, ENST00000769761, ENST00000769762, ENST00000769763, ENST00000769764, ENST00000769765, ENST00000769766, ENST00000769767

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000587694 — 3 exons

Exon	Start	End
ENSE00002756839	42760426	42761117
ENSE00002778250	42753931	42755213
ENSE00003624532	42759739	42759880

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 80.64.

FANTOM5 (CAGE): breadth broad, TPM avg 0.5187 / max 17.7147, expressed in 268 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166186	0.2374	120
166187	0.1637	66
166185	0.1177	71

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.64	gold quality
omental fat pad	UBERON:0010414	80.21	gold quality
peritoneum	UBERON:0002358	80.11	gold quality
tibial nerve	UBERON:0001323	79.26	gold quality
endocervix	UBERON:0000458	78.84	gold quality
mucosa of stomach	UBERON:0001199	78.76	gold quality
adipose tissue of abdominal region	UBERON:0007808	78.05	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.75	gold quality
ectocervix	UBERON:0012249	76.41	gold quality
calcaneal tendon	UBERON:0003701	75.16	gold quality
right lung	UBERON:0002167	75.05	gold quality
right ovary	UBERON:0002118	74.93	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.84	gold quality
minor salivary gland	UBERON:0001830	73.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	73.30	gold quality
cortical plate	UBERON:0005343	73.27	gold quality
left uterine tube	UBERON:0001303	72.90	gold quality
right atrium auricular region	UBERON:0006631	72.53	gold quality
apex of heart	UBERON:0002098	72.44	gold quality
uterine cervix	UBERON:0000002	72.16	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.15	gold quality
left ovary	UBERON:0002119	71.89	gold quality
cardiac atrium	UBERON:0002081	71.71	gold quality
ventricular zone	UBERON:0003053	71.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.40	gold quality
lower esophagus	UBERON:0013473	71.28	gold quality
ganglionic eminence	UBERON:0004023	71.27	gold quality
muscle of leg	UBERON:0001383	70.96	gold quality
right coronary artery	UBERON:0001625	70.86	gold quality
sural nerve	UBERON:0015488	70.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	13.26

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• RAMP2-AS1 inhibits CXCL11 expression to suppress malignant phenotype of breast cancer by recruiting DNMT1 and DNMT3B. (PMID:35390315)
• RAMP2-AS1 stabilized RAPM2 mRNA through TIA1 to inhibit the progression of non-small cell lung cancer. (PMID:38279501)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.