RANBP10

Summary

RANBP10 (RAN binding protein 10, HGNC:29285) is a protein-coding gene on chromosome 16q22, encoding Ran-binding protein 10 (Q6VN20). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways.

RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 57610 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 102 total
• MANE Select transcript: NM_020850

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29285
Approved symbol	RANBP10
Name	RAN binding protein 10
Location	16q22
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1464
Ensembl gene	ENSG00000141084
Ensembl biotype	protein_coding
OMIM	614031
Entrez	57610

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 11 protein_coding, 3 nonsense_mediated_decay, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000317506, ENST00000448631, ENST00000602506, ENST00000602525, ENST00000602638, ENST00000602677, ENST00000602815, ENST00000602887, ENST00000863257, ENST00000863258, ENST00000863259, ENST00000863260, ENST00000924472, ENST00000924473, ENST00000924474, ENST00000942173

RefSeq mRNA: 5 — MANE Select: NM_020850 NM_001320238, NM_001320239, NM_001320240, NM_001410883, NM_020850

CCDS: CCDS32469, CCDS81999, CCDS92180

Canonical transcript exons

ENST00000317506 — 14 exons

Exon	Start	End
ENSE00001237518	67723070	67726558
ENSE00003464616	67772034	67772086
ENSE00003489885	67727751	67727896
ENSE00003522981	67729280	67729484
ENSE00003526416	67728390	67728511
ENSE00003553740	67729680	67729828
ENSE00003555135	67729938	67730046
ENSE00003573229	67738013	67738035
ENSE00003616976	67806302	67806560
ENSE00003626856	67744288	67744455
ENSE00003641341	67734858	67735042
ENSE00003645796	67731472	67731584
ENSE00003677989	67805428	67805539
ENSE00003682881	67727327	67727438

Expression profiles

Bgee: expression breadth ubiquitous, 261 present calls, max score 92.50.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 34.5842 / max 799.2251, expressed in 1818 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
157818	32.8291	1818
157817	1.7551	114

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	92.50	gold quality
right adrenal gland cortex	UBERON:0035827	90.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.33	gold quality
right adrenal gland	UBERON:0001233	90.20	gold quality
right lobe of liver	UBERON:0001114	90.06	gold quality
cerebellar hemisphere	UBERON:0002245	89.64	gold quality
left adrenal gland	UBERON:0001234	89.47	gold quality
cerebellar cortex	UBERON:0002129	89.45	gold quality
left adrenal gland cortex	UBERON:0035825	89.45	gold quality
adrenal cortex	UBERON:0001235	88.87	gold quality
gastrocnemius	UBERON:0001388	88.50	gold quality
cerebellum	UBERON:0002037	88.02	gold quality
adrenal gland	UBERON:0002369	87.89	gold quality
lower esophagus mucosa	UBERON:0035834	87.86	gold quality
muscle of leg	UBERON:0001383	87.59	gold quality
hindlimb stylopod muscle	UBERON:0004252	86.93	gold quality
left ovary	UBERON:0002119	85.65	gold quality
body of uterus	UBERON:0009853	85.29	gold quality
blood	UBERON:0000178	85.21	gold quality
ectocervix	UBERON:0012249	85.19	gold quality
right ovary	UBERON:0002118	85.12	gold quality
endocervix	UBERON:0000458	84.87	gold quality
skin of leg	UBERON:0001511	84.79	gold quality
trabecular bone tissue	UBERON:0002483	84.61	gold quality
skin of abdomen	UBERON:0001416	84.55	gold quality
metanephros cortex	UBERON:0010533	84.46	gold quality
body of pancreas	UBERON:0001150	84.42	gold quality
granulocyte	CL:0000094	84.40	gold quality
tendon of biceps brachii	UBERON:0008188	84.03	silver quality
pancreatic ductal cell	CL:0002079	83.97	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.67
E-GEOD-100618	no	243.26

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): YY1

miRNA regulators (miRDB)

149 targeting RANBP10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6888-3P	99.97	65.95	1170
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-6825-5P	99.96	69.81	3431

Literature-anchored findings (GeneRIF, showing 6)

• RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules (PMID:18347012)
• data support the idea that RanBP9 and RanBP10 may function as signaling integrators and dictate the efficient regulation of D(1) receptor signaling by PKCdelta and PKCgamma (PMID:20395553)
• The results showed that ICP0 interacted with cell protein RanBP10, a known transcriptional coactivator, in human herpesvirus 1-infected cells. (PMID:26739050)
• Authors provide evidence that enhancement of neuronal morphology through RANBP10 is one of the neuroprotective mechanisms for miR-196a. (PMID:28744327)
• A Ran-binding protein facilitates nuclear import of human papillomavirus type 16. (PMID:33974675)
• RANBP10 promotes glioblastoma progression by regulating the FBXW7/c-Myc pathway. (PMID:34671019)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	ranbp10	ENSDARG00000062138
mus_musculus	Ranbp10	ENSMUSG00000037415
rattus_norvegicus	Ranbp10	ENSRNOG00000018000
drosophila_melanogaster	RanBPM	FBGN0262114

Paralogs (3): RANBP9 (ENSG00000010017), GID8 (ENSG00000101193), SPRYD3 (ENSG00000167778)

Protein

Protein identifiers

Ran-binding protein 10 — Q6VN20 (reviewed: Q6VN20)

All UniProt accessions (5): Q6VN20, R4GMX7, R4GMX8, R4GN91, R4GNA3

UniProt curated annotations — full annotation on UniProt →

Function. May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function.

Subunit / interactions. May form homodimers. Identified in the CTLH complex that contains GID4, RANBP9 and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA, RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. Interacts with YPEL5. May interact with TUBB5. Interacts with DDX4.

Subcellular location. Cytoplasm. Cytosol. Nucleus.

Tissue specificity. Broadly expressed, with highest levels in skeletal muscle.

Domain organisation. The SPRY domain mediates the interaction with MET.

Similarity. Belongs to the RANBP9/10 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6VN20-1	1	yes
Q6VN20-2	2
Q6VN20-3	3

RefSeq proteins (5): NP_001307167, NP_001307168, NP_001307169, NP_001397812, NP_065901* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001870	B30.2/SPRY	Domain
IPR003877	SPRY_dom	Domain
IPR006594	LisH	Conserved_site
IPR006595	CTLH_C	Domain
IPR013144	CRA_dom	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR024964	CTLH/CRA	Domain
IPR035782	SPRY_RanBP9/10	Domain
IPR043136	B30.2/SPRY_sf	Homologous_superfamily
IPR050618	Ubq-SigPath_Reg	Family

Pfam: PF00622, PF08513, PF10607

UniProt features (24 total): modified residue 9, splice variant 3, domain 3, compositionally biased region 3, sequence conflict 2, region of interest 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6VN20-F1	78.14	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (9): 2, 361, 362, 365, 367, 369, 422, 451, 453

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-8851805	MET activates RAS signaling

MSigDB gene sets: 245 (showing top): CREL_01, ACTACCT_MIR196A_MIR196B, chr16q22, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, AACYNNNNTTCCS_UNKNOWN, TGACCTY_ERR1_Q2, FOXO4_01, GOMF_GTPASE_BINDING, GGAMTNNNNNTCCY_UNKNOWN, SP1_Q2_01, GNF2_ANK1, GTGCCTT_MIR506, NFKB_C, GNF2_SPTA1, FONTAINE_PAPILLARY_THYROID_CARCINOMA_DN

GO Biological Process (2): microtubule cytoskeleton organization (GO:0000226), cytoskeleton organization (GO:0007010)

GO Molecular Function (4): guanyl-nucleotide exchange factor activity (GO:0005085), small GTPase binding (GO:0031267), beta-tubulin binding (GO:0048487), protein binding (GO:0005515)

GO Cellular Component (5): ubiquitin ligase complex (GO:0000151), nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), microtubule cytoskeleton (GO:0015630)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Signaling by MET	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoskeleton organization	1
microtubule-based process	1
organelle organization	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
GTPase binding	1
tubulin binding	1
binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
cytoskeleton	1

Protein interactions and networks

STRING

1234 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RANBP10	MKLN1	Q9UL63	843
RANBP10	YPEL5	P62699	839
RANBP10	GID4	Q8IVV7	812
RANBP10	ARMC8	Q8IUR7	804
RANBP10	WDR26	Q9H7D7	783
RANBP10	RMND5A	Q9H871	731
RANBP10	GID8	Q9NWU2	727
RANBP10	RMND5B	Q96G75	716
RANBP10	MAEA	Q7L5Y9	707
RANBP10	TUBB	P05218	610
RANBP10	RANBP3	Q9H6Z4	525
RANBP10	UBE2H	P37286	444
RANBP10	RANBP1	P43487	444
RANBP10	RAB40AL	P0C0E4	431
RANBP10	NACC1	Q96RE7	429
RANBP10	LRIF1	Q5T3J3	429

IntAct

176 interactions, top by confidence:

A	B	Type	Score
ARMC8	HTRA2	psi-mi:“MI:0914”(association)	0.750
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
CRIPTO	AIP	psi-mi:“MI:0914”(association)	0.640
NDUFS6	NDUFS8	psi-mi:“MI:0914”(association)	0.640
RANBP10	MAEA	psi-mi:“MI:0914”(association)	0.640
PRG2	YPEL5	psi-mi:“MI:0914”(association)	0.640
INAVA	CYTH3	psi-mi:“MI:0914”(association)	0.640
GID8	HTRA2	psi-mi:“MI:0914”(association)	0.610
MAGEA11	RANBP10	psi-mi:“MI:0915”(physical association)	0.560
CTAG1A	RANBP10	psi-mi:“MI:0915”(physical association)	0.560
IGFBP6	RANBP10	psi-mi:“MI:0915”(physical association)	0.560
INSL6	POTEF	psi-mi:“MI:0914”(association)	0.530
PRG3	ZNF324	psi-mi:“MI:0914”(association)	0.530
PIGT	ZNF609	psi-mi:“MI:0914”(association)	0.530
PRICKLE3	SIAH2	psi-mi:“MI:0914”(association)	0.530
BMP1	TLL1	psi-mi:“MI:0914”(association)	0.530
MRPL38	DUSP14	psi-mi:“MI:0914”(association)	0.530
NME1	NME2P1	psi-mi:“MI:0914”(association)	0.530
JPH4	ZSWIM8	psi-mi:“MI:0914”(association)	0.530
TIGD5	P4HA2	psi-mi:“MI:0914”(association)	0.530
EMILIN3	ZZEF1	psi-mi:“MI:0914”(association)	0.530

BioGRID (177): RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Co-fractionation), WDR26 (Co-fractionation), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS), RANBP10 (Affinity Capture-MS)

ESM2 similar proteins: A0JMA8, A1A5P5, A1L252, A1YVX4, A3KMI0, A3KMV8, A6H8H2, F4HYD7, F4HYJ7, O73630, O94712, P29375, P41229, P41230, P69566, Q04861, Q1LUS8, Q28FM1, Q30DN6, Q32SG6, Q38JA7, Q3B8D5, Q3UXZ9, Q4R8E0, Q5F3R2, Q5U245, Q5VZ89, Q5XUN4, Q62240, Q63185, Q6IQX0, Q6P158, Q6P5D3, Q6VN19, Q6VN20, Q7Z3E5, Q7Z401, Q80Y84, Q94545, Q96S59

Diamond homologs: A1CNW8, A1D1S7, A1L252, A3KMV8, A6S3E0, A6ZZJ6, A7EQ00, A7TE03, O74497, O94712, P18160, P32343, P69566, Q03212, Q1E2D2, Q1LUS8, Q28FM1, Q4WRW0, Q4Z8K6, Q5RBR6, Q6BSU1, Q6FJG2, Q6VN19, Q6VN20, Q8NCJ5, Q96S59, Q96UB6, Q9PTY5, A0A5F9C6I2, D3ZXK7, F4HYD7, P53076, Q19614, Q54X16, Q5XPI3, Q5XPI4, Q84WK5, Q9C8J7, Q9SIZ8, Q5XH91

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 167 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of pyruvate metabolism	10	50.1×	8e-13
Pyruvate metabolism	5	17.9×	3e-03

GO biological processes:

GO term	Partners	Fold	FDR
proteasome-mediated ubiquitin-dependent protein catabolic process	13	4.6×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

102 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	77
Likely benign	5
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

3039 predictions. Top by Δscore:

Variant	Effect	Δscore
16:67727742:AT:A	donor_gain	1.0000
16:67727743:T:TA	donor_gain	1.0000
16:67727745:CTGTA:C	donor_loss	1.0000
16:67727746:TGTA:T	donor_loss	1.0000
16:67727747:GTAC:G	donor_loss	1.0000
16:67727748:TA:T	donor_loss	1.0000
16:67727749:A:AG	donor_loss	1.0000
16:67727750:CCT:C	donor_loss	1.0000
16:67727789:C:CA	donor_gain	1.0000
16:67727809:AATG:A	donor_gain	1.0000
16:67727904:C:CT	acceptor_gain	1.0000
16:67727911:C:T	acceptor_gain	1.0000
16:67728385:CTCAC:C	donor_loss	1.0000
16:67728386:TCA:T	donor_loss	1.0000
16:67728387:CA:C	donor_loss	1.0000
16:67728388:AC:A	donor_gain	1.0000
16:67728389:CC:C	donor_gain	1.0000
16:67728389:CCCA:C	donor_loss	1.0000
16:67728403:AT:A	donor_gain	1.0000
16:67728510:CG:C	acceptor_gain	1.0000
16:67728512:C:CC	acceptor_gain	1.0000
16:67729483:TCCTA:T	acceptor_loss	1.0000
16:67729484:CCTAG:C	acceptor_loss	1.0000
16:67729748:T:TA	donor_gain	1.0000
16:67729826:CAC:C	acceptor_gain	1.0000
16:67729827:ACCT:A	acceptor_loss	1.0000
16:67729829:C:CC	acceptor_gain	1.0000
16:67729829:CTGT:C	acceptor_loss	1.0000
16:67729830:T:A	acceptor_loss	1.0000
16:67729934:TTAC:T	donor_loss	1.0000

AlphaMissense

4082 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:67727344:A:G	L572P	1.000
16:67727425:A:G	L545P	1.000
16:67729817:A:G	F337S	1.000
16:67729941:A:G	L332P	1.000
16:67731476:T:A	R295S	1.000
16:67731476:T:G	R295S	1.000
16:67731567:A:G	L265P	1.000
16:67734968:G:C	F222L	1.000
16:67734968:G:T	F222L	1.000
16:67734969:A:G	F222S	1.000
16:67734970:A:C	F222V	1.000
16:67734970:A:G	F222L	1.000
16:67734970:A:T	F222I	1.000
16:67734981:C:A	G218V	1.000
16:67734981:C:T	G218E	1.000
16:67734983:A:C	F217L	1.000
16:67734983:A:T	F217L	1.000
16:67734984:A:C	F217C	1.000
16:67734984:A:G	F217S	1.000
16:67734985:A:G	F217L	1.000
16:67734986:G:C	N216K	1.000
16:67734986:G:T	N216K	1.000
16:67735002:T:A	E211V	1.000
16:67735003:C:T	E211K	1.000
16:67735011:G:A	T208I	1.000
16:67735013:C:A	Q207H	1.000
16:67735013:C:G	Q207H	1.000
16:67735014:T:G	Q207P	1.000
16:67735017:A:G	L206P	1.000
16:67735017:A:T	L206Q	1.000

dbSNP variants (sampled 300 via entrez): RS1000004764 (16:67736109 C>T), RS1000013726 (16:67769897 C>T), RS1000051477 (16:67805252 G>C), RS1000061138 (16:67767581 G>A), RS1000063364 (16:67799125 G>A), RS1000071685 (16:67749060 C>T), RS1000087109 (16:67732615 A>G), RS1000103529 (16:67804846 T>A,G), RS1000118081 (16:67745615 G>A), RS1000139784 (16:67732914 C>T), RS1000222238 (16:67785450 C>T), RS1000239122 (16:67779502 T>A), RS1000250912 (16:67794368 C>T), RS1000259981 (16:67725487 A>G), RS1000278167 (16:67729799 C>G)

Disease associations

OMIM: gene MIM:614031 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST002539_84	Schizophrenia	2.000000e-08
GCST002899_33	HDL cholesterol	9.000000e-26
GCST004604_73	Hematocrit	4.000000e-11
GCST004615_105	Hemoglobin concentration	2.000000e-11
GCST005751_4	Empathy quotient	9.000000e-07
GCST006803_42	Schizophrenia	4.000000e-08
GCST010002_113	Refractive error	2.000000e-14
GCST90002383_245	Hematocrit	3.000000e-27
GCST90020029_574	Waist circumference adjusted for body mass index	2.000000e-09

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement
EFO:0009183	empathy measurement
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
cobaltous chloride	increases expression	2
Benzo(a)pyrene	decreases expression, decreases methylation	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
dicrotophos	increases expression	1
bisphenol A	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
sodium arsenite	increases abundance, increases expression	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
abrine	increases expression	1
Sunitinib	increases expression	1
Acetaminophen	increases expression	1
Arsenic	increases abundance, increases expression	1
Caffeine	increases phosphorylation	1
Ethyl Methanesulfonate	increases expression	1
Methyl Methanesulfonate	increases expression	1
Quercetin	increases expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	affects expression	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2DC	Abcam HeLa RANBP10 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.