RANBP17

gene
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Summary

RANBP17 (RAN binding protein 17, HGNC:14428) is a protein-coding gene on chromosome 5q35.1, encoding Ran-binding protein 17 (Q9H2T7). May function as a nuclear transport receptor.

The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.

Source: NCBI Gene 64901 — RefSeq curated summary.

At a glance

  • GWAS associations: 9
  • Clinical variants (ClinVar): 223 total
  • MANE Select transcript: NM_022897

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:14428
Approved symbolRANBP17
NameRAN binding protein 17
Location5q35.1
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000204764
Ensembl biotypeprotein_coding
OMIM606141
Entrez64901

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 8 protein_coding_CDS_not_defined, 7 nonsense_mediated_decay, 5 protein_coding, 4 retained_intron

ENST00000389118, ENST00000443155, ENST00000517629, ENST00000518492, ENST00000519130, ENST00000519256, ENST00000519944, ENST00000519949, ENST00000520586, ENST00000520864, ENST00000520879, ENST00000521165, ENST00000521759, ENST00000521834, ENST00000522066, ENST00000522380, ENST00000522533, ENST00000522734, ENST00000523189, ENST00000523665, ENST00000523727, ENST00000524364, ENST00000961945, ENST00000961946

RefSeq mRNA: 1 — MANE Select: NM_022897 NM_022897

CCDS: CCDS34287

Canonical transcript exons

ENST00000523189 — 28 exons

ExonStartEnd
ENSE00001473667170953597170953702
ENSE00001473671170916465170916584
ENSE00001473672170914167170914240
ENSE00001473674170910969170911134
ENSE00002690636170862018170862051
ENSE00003465000171221758171221840
ENSE00003515094171183322171183430
ENSE00003524506170881806170881896
ENSE00003537276170918713170918859
ENSE00003539375171295887171296014
ENSE00003555773171293883171293981
ENSE00003564267170892387170892553
ENSE00003584457171298762171300015
ENSE00003592947170919441170919613
ENSE00003601758170968242170968377
ENSE00003612618171171206171171286
ENSE00003630608171205524171205612
ENSE00003631913170909661170909765
ENSE00003637617171170130171170203
ENSE00003638179171242682171242820
ENSE00003641619171183167171183230
ENSE00003641733171199670171199773
ENSE00003646920170878097170878243
ENSE00003648152171240928171241142
ENSE00003659704170924357170924550
ENSE00003675311170896050170896115
ENSE00003679237171213631171213738
ENSE00003681284171265681171265847

Expression profiles

Bgee: expression breadth ubiquitous, 197 present calls, max score 94.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 5.2120 / max 104.1038, expressed in 1240 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
601663.10791016
601652.1041949

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
calcaneal tendonUBERON:000370194.97gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047393.20gold quality
adrenal tissueUBERON:001830392.11gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099188.22gold quality
right testisUBERON:000453487.51gold quality
left testisUBERON:000453387.43gold quality
testisUBERON:000047386.16gold quality
spermCL:000001983.69gold quality
right uterine tubeUBERON:000130283.62gold quality
ventricular zoneUBERON:000305383.10gold quality
sural nerveUBERON:001548881.84gold quality
male germ cellCL:000001581.37gold quality
left lobe of thyroid glandUBERON:000112081.25gold quality
right adrenal gland cortexUBERON:003582781.15gold quality
minor salivary glandUBERON:000183081.14gold quality
right lobe of thyroid glandUBERON:000111980.85gold quality
right adrenal glandUBERON:000123380.81gold quality
thyroid glandUBERON:000204680.61gold quality
body of pancreasUBERON:000115080.33gold quality
cortical plateUBERON:000534380.21gold quality
left adrenal gland cortexUBERON:003582580.19gold quality
endometriumUBERON:000129580.02gold quality
left adrenal glandUBERON:000123479.99gold quality
adrenal glandUBERON:000236979.81gold quality
pancreatic ductal cellCL:000207979.51gold quality
stromal cell of endometriumCL:000225579.49gold quality
tendonUBERON:000004379.23gold quality
upper lobe of left lungUBERON:000895279.09gold quality
corpus callosumUBERON:000233678.93gold quality
adrenal cortexUBERON:000123578.72gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes6.80
E-GEOD-124858no275.73

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYOD1

miRNA regulators (miRDB)

67 targeting RANBP17, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-9-5P100.0072.282361
HSA-MIR-569699.9872.364487
HSA-MIR-19A-3P99.9875.332762
HSA-MIR-19B-3P99.9875.442754
HSA-MIR-4666A-3P99.9671.713434
HSA-MIR-4778-3P99.9370.401818
HSA-MIR-338-5P99.9272.342951
HSA-MIR-6809-3P99.9171.453814
HSA-MIR-4753-3P99.9071.033786
HSA-MIR-367199.9073.043897
HSA-MIR-568299.8972.561005
HSA-MIR-3140-3P99.8868.472069
HSA-MIR-391999.8769.452489
HSA-MIR-659-3P99.8570.691620
HSA-MIR-576-5P99.8470.462582
HSA-MIR-684499.8270.692423
HSA-MIR-205299.7969.372031
HSA-MIR-6762-3P99.6666.941188
HSA-MIR-10394-5P99.6566.831852
HSA-MIR-120599.6566.761826
HSA-MIR-6516-3P99.6568.571238
HSA-MIR-3158-5P99.6567.511763
HSA-MIR-56799.6368.571219
HSA-MIR-6757-3P99.6366.881089
HSA-MIR-449999.6267.291470
HSA-MIR-3942-3P99.5769.032854
HSA-MIR-510-3P99.5470.062965
HSA-MIR-361299.4566.021333
HSA-MIR-65099.4565.771309
HSA-MIR-372-5P99.4169.112299

Literature-anchored findings (GeneRIF, showing 3)

  • These biochemical and functional data reveal RANBP16 and RANBP17 as novel regulators of E2A protein action, and demonstrate specific interaction of E12 with RANBP17. (PMID:20503194)
  • The importin beta superfamily member RanBP17 exhibits a role in cell proliferation and is associated with improved survival of patients with HPV+ HNSCC. (PMID:35850701)
  • RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons. (PMID:38438257)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
mus_musculusRanbp17ENSMUSG00000040594
rattus_norvegicusRanbp17ENSRNOG00000005042
drosophila_melanogasterRanbp16FBGN0053180
caenorhabditis_elegansWBGENE00007952

Paralogs (2): XPO7 (ENSG00000130227), XPO4 (ENSG00000132953)

Protein

Protein identifiers

Ran-binding protein 17Q9H2T7 (reviewed: Q9H2T7)

All UniProt accessions (7): E5RHX1, Q9H2T7, H0YAS2, H0YBM6, H0YBY7, Q546R4, Q8IVM9

UniProt curated annotations — full annotation on UniProt →

Function. May function as a nuclear transport receptor.

Subunit / interactions. Binds to nucleoporins and the GTP-bound form of Ran.

Subcellular location. Cytoplasm. Nucleus. Nuclear pore complex.

Tissue specificity. Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.

Similarity. Belongs to the exportin family.

Isoforms (2)

UniProt IDNamesCanonical?
Q9H2T7-11yes
Q9H2T7-22

RefSeq proteins (1): NP_075048* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR001494Importin-beta_NDomain
IPR011989ARM-likeHomologous_superfamily
IPR016024ARM-type_foldHomologous_superfamily
IPR044189XPO4/7-likeFamily
IPR057947TPR_XPO7/RBP17Domain

Pfam: PF03810, PF25795

UniProt features (8 total): modified residue 2, splice variant 2, sequence conflict 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9H2T7-F185.420.44

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 569

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 108 (showing top): GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOMF_GTPASE_BINDING, GOBP_NUCLEAR_TRANSPORT, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_NUCLEAR_EXPORT, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MODULE_207, GOBP_RNA_LOCALIZATION, GOBP_PROTEIN_LOCALIZATION_TO_NUCLEUS, GOCC_NUCLEAR_ENVELOPE, GOCC_NUCLEAR_PORE, GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN

GO Biological Process (8): protein import into nucleus (GO:0006606), protein export from nucleus (GO:0006611), mRNA transport (GO:0051028), intracellular protein transport (GO:0006886), nucleocytoplasmic transport (GO:0006913), protein transport (GO:0015031), nuclear export (GO:0051168), nuclear transport (GO:0051169)

GO Molecular Function (3): nuclear export signal receptor activity (GO:0005049), GTP binding (GO:0005525), small GTPase binding (GO:0031267)

GO Cellular Component (3): nuclear pore (GO:0005643), cytoplasm (GO:0005737), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
intracellular protein transport2
nuclear export2
intracellular protein localization2
intracellular transport2
protein localization to nucleus1
import into nucleus1
establishment of protein localization to organelle1
RNA transport1
protein transport1
nuclear transport1
transport1
establishment of protein localization1
nucleocytoplasmic transport1
intercellular transport1
nucleocytoplasmic carrier activity1
guanyl ribonucleotide binding1
purine ribonucleoside triphosphate binding1
GTPase binding1
nuclear envelope1
nuclear protein-containing complex1
intracellular anatomical structure1
cellular anatomical structure1
intracellular membrane-bounded organelle1

Protein interactions and networks

STRING

706 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
RANBP17TLX3O43711797
RANBP17TLX2O43763759
RANBP17BCL11BQ9C0K0754
RANBP17LYL1P12980648
RANBP17XPO1O14980637
RANBP17RANBP6O60518622
RANBP17LMO1P25800615
RANBP17TLX1P31314611
RANBP17XPOTO43592578
RANBP17CSE1LP55060550
RANBP17TNPO2O14787545
RANBP17IPO4Q8TEX9528
RANBP17IPO5O00410506
RANBP17TNPO1Q92973506
RANBP17IPO11Q9UI26506

IntAct

7 interactions, top by confidence:

ABTypeScore
GYPBTCAF2psi-mi:“MI:0914”(association)0.530
PLEKHG3psi-mi:“MI:0914”(association)0.350
RANBP17TCERG1psi-mi:“MI:0914”(association)0.350
NPTNRTL8Cpsi-mi:“MI:0914”(association)0.350
RANBP17HMGA2psi-mi:“MI:0914”(association)0.350

BioGRID (22): RANBP17 (Affinity Capture-RNA), RANBP17 (Affinity Capture-RNA), RANBP17 (Affinity Capture-MS), RANBP17 (Affinity Capture-RNA), RANBP17 (Affinity Capture-MS), ACTA2 (Affinity Capture-MS), MUL1 (Affinity Capture-MS), EEF1A2 (Affinity Capture-MS), XPO7 (Affinity Capture-MS), CHRAC1 (Affinity Capture-MS), HMGA2 (Affinity Capture-MS), RANBP17 (Affinity Capture-MS), TCERG1 (Affinity Capture-MS), XPO7 (Affinity Capture-MS), XPO7 (Negative Genetic)

ESM2 similar proteins: A1CAU2, A1DEK2, A2QMS5, A5D785, A5WW24, A6RVT8, A7EPT5, B0Y4D6, B2AXG6, B8ARW2, B9FDR3, O13671, O13864, O14089, O18388, O43747, O59809, P14068, P30822, P33307, P55060, Q06142, Q0CIL3, Q1DY99, Q2H6R9, Q2U3V3, Q4WUV9, Q54EV7, Q569Z2, Q5R9G4, Q5R9J2, Q5ZLT0, Q6GMY9, Q704U0, Q7PC79, Q7RWV9, Q7SZC2, Q8AY73, Q8H0U4, Q8K2V6

Diamond homologs: Q54DN3, Q569Z2, Q5R9G4, Q5ZLT0, Q704U0, Q99NF8, Q9EPK7, Q9GQN0, Q9H2T7, Q9UIA9

SIGNOR signaling

1 interactions.

AEffectBMechanism
RANBP17up-regulatesTCF3binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

223 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance159
Likely benign16
Benign6

Top pathogenic / likely-pathogenic (0)

SpliceAI

6325 predictions. Top by Δscore:

VariantEffectΔscore
5:170862048:CCAG:Cdonor_loss1.0000
5:170862049:CAGGT:Cdonor_loss1.0000
5:170862050:AGGTC:Adonor_loss1.0000
5:170862051:GGTC:Gdonor_loss1.0000
5:170862052:GTCA:Gdonor_loss1.0000
5:170878244:G:GGdonor_gain1.0000
5:170881804:A:AGacceptor_gain1.0000
5:170881805:G:GGacceptor_gain1.0000
5:170881805:GAC:Gacceptor_gain1.0000
5:170881894:TCA:Tdonor_gain1.0000
5:170881897:G:GGdonor_gain1.0000
5:170892549:TCCAG:Tdonor_loss1.0000
5:170892550:CCAG:Cdonor_loss1.0000
5:170892551:CAGG:Cdonor_loss1.0000
5:170892552:AGG:Adonor_loss1.0000
5:170892553:GG:Gdonor_loss1.0000
5:170892554:GTAA:Gdonor_loss1.0000
5:170892555:T:Gdonor_loss1.0000
5:170896141:GAGCC:Gdonor_gain1.0000
5:170896155:T:Gdonor_gain1.0000
5:170909656:TTTA:Tacceptor_loss1.0000
5:170909659:A:AGacceptor_gain1.0000
5:170909659:AG:Aacceptor_gain1.0000
5:170909659:AGGTT:Aacceptor_gain1.0000
5:170909660:G:GGacceptor_gain1.0000
5:170909660:GG:Gacceptor_gain1.0000
5:170909660:GGTT:Gacceptor_gain1.0000
5:170909660:GGTTG:Gacceptor_gain1.0000
5:170909762:AGAG:Adonor_gain1.0000
5:170909762:AGAGG:Adonor_loss1.0000

AlphaMissense

7165 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
5:170911125:T:AW251R1.000
5:170911125:T:CW251R1.000
5:170919486:T:AW383R1.000
5:170919486:T:CW383R1.000
5:171205557:G:AG726R1.000
5:171205557:G:CG726R1.000
5:170892485:T:AW119R0.999
5:170892485:T:CW119R0.999
5:170916499:G:CR290T0.999
5:170916499:G:TR290I0.999
5:170918746:T:CC330R0.999
5:170918747:G:AC330Y0.999
5:170918748:T:GC330W0.999
5:170918750:G:CR331P0.999
5:170918843:C:TT362I0.999
5:170918851:A:CS365R0.999
5:170918853:C:AS365R0.999
5:170918853:C:GS365R0.999
5:170918855:T:CL366P0.999
5:170919462:A:CS375R0.999
5:170919464:T:AS375R0.999
5:170919464:T:GS375R0.999
5:170919488:G:CW383C0.999
5:170919488:G:TW383C0.999
5:170953683:G:CD519H0.999
5:171205552:T:CL724P0.999
5:171205557:G:TG726W0.999
5:171205558:G:AG726E0.999
5:171221765:C:AR783S0.999
5:171296009:A:CR1055S0.999

dbSNP variants (sampled 300 via entrez): RS1000002188 (5:171020376 C>A), RS1000005393 (5:171236181 C>T), RS1000006793 (5:171160989 A>G), RS1000011330 (5:171292243 C>A), RS1000012964 (5:171111018 C>A,G,T), RS1000014554 (5:171053610 A>G), RS1000019760 (5:170942203 C>T), RS1000023412 (5:170983982 A>C,G), RS1000026440 (5:171290053 A>G), RS1000033879 (5:170909577 C>A,T), RS1000036215 (5:171282381 C>T), RS1000036698 (5:171236472 T>C), RS1000042025 (5:170942261 C>A), RS1000043972 (5:171022941 G>A), RS1000049534 (5:171030618 A>C,G)

Disease associations

OMIM: gene MIM:606141 | disease phenotypes: MIM:236600

GenCC curated gene-disease

Mondo (2): autism spectrum disorder (MONDO:0005258), congenital hydrocephalus (MONDO:0016349)

Orphanet (2): Congenital hydrocephalus (Orphanet:2185), NON RARE IN EUROPE: Autism (Orphanet:106)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

StudyTraitp-value
GCST001525_3Visceral fat5.000000e-06
GCST005830_104Hand grip strength1.000000e-11
GCST006611_80HDL cholesterol2.000000e-14
GCST007327_4Smoking status (ever vs never smokers)3.000000e-10
GCST010242_214HDL cholesterol levels7.000000e-09
GCST010988_348Adult body size5.000000e-17
GCST011995_2Restless legs syndrome7.000000e-10
GCST012490_379Femur bone mineral density x serum urate levels interaction4.000000e-08
GCST90000047_113Age at first sexual intercourse2.000000e-09

EFO canonical traits (5, from GWAS)

EFO IDTrait name
EFO:0006941grip strength measurement
EFO:0004612high density lipoprotein cholesterol measurement
EFO:0004318smoking behavior
EFO:0004531urate measurement
EFO:0009749age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, decreases expression3
Benzo(a)pyreneaffects methylation, increases methylation2
aristolochic acid Idecreases expression1
sodium arseniteincreases expression1
benzo(e)pyreneincreases methylation1
aflatoxin B2increases methylation1
CGP 52608affects binding, increases reaction1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
dorsomorphindecreases expression, affects cotreatment1
jinfukangaffects cotreatment, decreases expression1
Resveratrolaffects cotreatment, decreases expression1
Leflunomideincreases expression1
Arsenicincreases expression1
Cisplatinaffects cotreatment, decreases expression1
Copperaffects cotreatment, decreases expression1
Daunorubicinaffects response to substance1
Methapyrileneincreases methylation1
Testosteroneincreases expression1
Tobacco Smoke Pollutiondecreases expression1
Aflatoxin B1increases methylation1

Clinical trials (associated diseases)

300 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT00391261PHASE4COMPLETEDAn Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
NCT01028820PHASE4COMPLETEDFMRI Brain Activation of Aripiprazole Treatment in Autism Spectrum Disorders
NCT01333865PHASE4COMPLETEDA Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders
NCT01337700PHASE4COMPLETEDMilnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
NCT01695200PHASE4COMPLETEDOmega-3 Fatty Acids in Autism Spectrum Disorders
NCT02096952PHASE4COMPLETEDMethylphenidate ER Liquid Formulation in Adults With ASD and ADHD
NCT02235467PHASE4COMPLETEDMultisite Study: Parental Training Using Video Modelling to Develop Social Skills in Children With Autism
NCT02940574PHASE4COMPLETEDNeural and Behavioral Effects of Oxytocin in Autism Spectrum Disorders
NCT03333629PHASE4COMPLETEDPromoting Positive Outcomes for Individuals With ASD: Linking Early Detection, Treatment, and Long-term Outcomes
NCT03337646PHASE4COMPLETEDEvaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism
NCT03538431PHASE4COMPLETEDImproving Driving in Young People With Autism Spectrum Disorders
NCT03757585PHASE4COMPLETEDNatural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)
NCT04903353PHASE4COMPLETEDPragmatic Trial Comparing Weight Gain in Children With Autism Taking Risperidone Versus Aripiprazole
NCT05063656PHASE4COMPLETEDBiomarker-Driven Pharmacological Treatment of Adolescents With Autism Spectrum Disorder With Gabapentin
NCT05146245PHASE4UNKNOWNSafety and Pharmacokinetics of Antipsychotics in Children 2: Studying TDM in an RCT
NCT05916339PHASE4RECRUITINGAWARE: Management of ADHD in Autism Spectrum Disorder
NCT05954052PHASE4TERMINATEDA Study of Glutathione in Children With Autism Spectrum Disorder
NCT06853665PHASE4RECRUITINGThe TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine
NCT07054697PHASE4COMPLETEDPilot-RCT With Individualized Homeopathic Treatment in the Children With Autism Spectrum Disorder
NCT07161804PHASE4COMPLETEDPilot RCT Using Homeopathic Medicines in ASD
NCT07439042PHASE4NOT_YET_RECRUITINGBuspirone for Anxiety in Autistic Youth
NCT01302964PHASE3COMPLETEDMirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders
NCT01706523PHASE3TERMINATEDOpen Label Extension Study of STX209 (Arbaclofen) in Autism Spectrum Disorders
NCT01825798PHASE3COMPLETEDTreatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)
NCT01972074PHASE3COMPLETEDBehavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder
NCT02985749PHASE3COMPLETEDA Study of Oxytocin for the Treatment of Social Impairment in Individuals With High Functioning Autism Spectrum Disorder
NCT03197922PHASE3COMPLETEDTreatment of Encopresis in Children With Autism Spectrum Disorders
NCT03504917PHASE3TERMINATEDA Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension
NCT03553875PHASE3TERMINATEDMemantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions
NCT03640156PHASE3COMPLETEDModulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin
NCT03715153PHASE3TERMINATEDEfficacy and Safety of Bumetanide Oral Liquid Formulation in Children Aged From 2 to Less Than 7 Years Old With Autism Spectrum Disorder.
NCT03715166PHASE3TERMINATEDEfficacy and Safety of Bumetanide Oral Liquid Formulation in Children and Adolescents Aged From 7 to Less Than 18 Years Old With Autism Spectrum Disorder
NCT04233502PHASE3WITHDRAWNEfficacy and Safety of Slenyto for Insomnia in Children With ASD
NCT04578756PHASE3COMPLETEDOpen-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
NCT04623398PHASE3COMPLETEDEffect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency)
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