RAPGEF4-AS1

Summary

RAPGEF4-AS1 (RAPGEF4 antisense RNA 1, HGNC:28081) is a long non-coding RNA gene on chromosome 2q31.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28081
Approved symbol	RAPGEF4-AS1
Name	RAPGEF4 antisense RNA 1
Location	2q31.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000228016
Ensembl biotype	lncRNA
Entrez	91149
RNAcentral	URS000075C22D — lncRNA, 4622 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000430128, ENST00000435328, ENST00000455435, ENST00000773796, ENST00000773797, ENST00000773798, ENST00000773799

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430128 — 2 exons

Exon	Start	End
ENSE00001666098	172677141	172677582
ENSE00001675835	172678878	172679027

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 74.99.

Top tissues by expression

199 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	74.99	gold quality
nucleus accumbens	UBERON:0001882	66.10	gold quality
prefrontal cortex	UBERON:0000451	64.85	gold quality
putamen	UBERON:0001874	64.23	gold quality
anterior cingulate cortex	UBERON:0009835	62.92	gold quality
Brodmann (1909) area 9	UBERON:0013540	62.64	gold quality
caudate nucleus	UBERON:0001873	62.07	gold quality
right frontal lobe	UBERON:0002810	62.01	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.25	gold quality
cortical plate	UBERON:0005343	59.87	silver quality
neocortex	UBERON:0001950	59.64	gold quality
frontal cortex	UBERON:0001870	59.41	gold quality
cerebellar hemisphere	UBERON:0002245	58.65	gold quality
cerebellar cortex	UBERON:0002129	58.59	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.79	gold quality
cerebellum	UBERON:0002037	57.33	gold quality
amygdala	UBERON:0001876	57.02	gold quality
cerebral cortex	UBERON:0000956	56.78	gold quality
forebrain	UBERON:0001890	56.72	gold quality
buccal mucosa cell	CL:0002336	56.36	gold quality
brain	UBERON:0000955	56.20	gold quality
ganglionic eminence	UBERON:0004023	55.90	silver quality
hypothalamus	UBERON:0001898	54.93	gold quality
monocyte	CL:0000576	54.29	gold quality
islet of Langerhans	UBERON:0000006	54.00	gold quality
oocyte	CL:0000023	53.61	gold quality
pancreas	UBERON:0001264	52.35	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	51.57	gold quality
Ammon’s horn	UBERON:0001954	51.43	gold quality
substantia nigra	UBERON:0002038	50.12	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.