RAPGEF5

Summary

RAPGEF5 (Rap guanine nucleotide exchange factor 5, HGNC:16862) is a protein-coding gene on chromosome 7p15.3, encoding Rap guanine nucleotide exchange factor 5 (Q92565). Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP.

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).

Source: NCBI Gene 9771 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 110 total — 1 likely-pathogenic
• MANE Select transcript: NM_012294

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16862
Approved symbol	RAPGEF5
Name	Rap guanine nucleotide exchange factor 5
Location	7p15.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0277, GFR, MR-GEF
Ensembl gene	ENSG00000136237
Ensembl biotype	protein_coding
OMIM	609527
Entrez	9771

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000344041, ENST00000401957, ENST00000405243, ENST00000420196, ENST00000451559, ENST00000458533, ENST00000468825, ENST00000471484, ENST00000475788, ENST00000488366, ENST00000497668, ENST00000665637

RefSeq mRNA: 5 — MANE Select: NM_012294 NM_001367600, NM_001367601, NM_001367602, NM_001367603, NM_012294

CCDS: CCDS55093, CCDS94064

Canonical transcript exons

ENST00000665637 — 26 exons

Exon	Start	End
ENSE00000923960	22156810	22156888
ENSE00000923961	22154455	22154604
ENSE00000923963	22146897	22147019
ENSE00000923965	22140025	22140115
ENSE00000923966	22136933	22136983
ENSE00000923967	22136038	22136125
ENSE00001029106	22157855	22157885
ENSE00001378896	22145044	22145222
ENSE00001490604	22308339	22308507
ENSE00001548515	22150407	22150504
ENSE00003480015	22230846	22230919
ENSE00003497648	22193367	22193455
ENSE00003498753	22162397	22162541
ENSE00003511361	22317987	22318037
ENSE00003521254	22309969	22310090
ENSE00003528792	22291175	22291241
ENSE00003545237	22315370	22315476
ENSE00003562989	22219866	22219991
ENSE00003611177	22266964	22267012
ENSE00003619476	22131037	22131101
ENSE00003629941	22193915	22194033
ENSE00003672022	22125604	22125658
ENSE00003675963	22160518	22160615
ENSE00003786273	22167070	22167148
ENSE00003851584	22356830	22357154
ENSE00003856251	22118236	22122521

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 99.57.

FANTOM5 (CAGE): breadth broad, TPM avg 15.4198 / max 759.8381, expressed in 837 samples.

FANTOM5 promoters (18 alternative TSS)

Promoter ID	TPM avg	Samples expressed
83061	3.4579	634
83040	3.1552	142
83041	2.0154	178
83043	1.9293	162
83050	1.1508	272
83060	0.8382	224
83042	0.6869	145
83048	0.6307	231
83062	0.4613	235
83039	0.3203	71

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
inferior vagus X ganglion	UBERON:0005363	99.57	gold quality
pons	UBERON:0000988	99.30	gold quality
inferior olivary complex	UBERON:0002127	99.22	gold quality
medulla oblongata	UBERON:0001896	99.21	gold quality
corpus callosum	UBERON:0002336	99.19	gold quality
superior vestibular nucleus	UBERON:0007227	98.99	gold quality
substantia nigra pars reticulata	UBERON:0001966	98.97	gold quality
subthalamic nucleus	UBERON:0001906	98.60	gold quality
postcentral gyrus	UBERON:0002581	98.49	gold quality
parietal lobe	UBERON:0001872	98.39	gold quality
lateral globus pallidus	UBERON:0002476	98.39	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	98.17	gold quality
substantia nigra pars compacta	UBERON:0001965	98.07	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	98.07	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.01	gold quality
spinal cord	UBERON:0002240	97.98	gold quality
ventral tegmental area	UBERON:0002691	97.98	gold quality
middle frontal gyrus	UBERON:0002702	97.79	gold quality
orbitofrontal cortex	UBERON:0004167	97.32	gold quality
globus pallidus	UBERON:0001875	97.31	gold quality
superior frontal gyrus	UBERON:0002661	97.26	gold quality
CA1 field of hippocampus	UBERON:0003881	97.10	gold quality
medial globus pallidus	UBERON:0002477	96.93	gold quality
occipital lobe	UBERON:0002021	96.92	gold quality
dorsal plus ventral thalamus	UBERON:0001897	96.87	gold quality
cranial nerve II	UBERON:0000941	96.70	gold quality
entorhinal cortex	UBERON:0002728	96.70	gold quality
middle temporal gyrus	UBERON:0002771	96.38	gold quality
primary visual cortex	UBERON:0002436	96.34	gold quality
midbrain	UBERON:0001891	96.02	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 5.

Experiment	Marker?	Max mean expression
E-GEOD-180759	yes	1413.68
E-CURD-119	yes	14.81
E-ANND-3	yes	13.83
E-GEOD-84465	yes	9.70
E-CURD-112	yes	7.97
E-CURD-10	no	147.91
E-MTAB-6678	no	2.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

186 targeting RAPGEF5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4514	99.99	67.10	1870
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-512-3P	99.97	67.35	1049
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-218-5P	99.93	72.22	2103
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872

Literature-anchored findings (GeneRIF, showing 3)

• Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation. (PMID:37705041)
• CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion. (PMID:38489970)
• Downregulation of circ-RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3). (PMID:38775215)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rapgef5b	ENSDARG00000074307
mus_musculus	Rapgef5	ENSMUSG00000041992
rattus_norvegicus	Rapgef5	ENSRNOG00000005271

Paralogs (24): RASGRF1 (ENSG00000058335), RASGRP2 (ENSG00000068831), RAPGEF3 (ENSG00000079337), RAPGEF4 (ENSG00000091428), SOS2 (ENSG00000100485), RAPGEF1 (ENSG00000107263), RAPGEFL1 (ENSG00000108352), RAPGEF2 (ENSG00000109756), RASGRF2 (ENSG00000113319), SOS1 (ENSG00000115904), RALGPS2 (ENSG00000116191), RALGPS1 (ENSG00000136828), RASGEF1B (ENSG00000138670), RGL1 (ENSG00000143344), RASGEF1C (ENSG00000146090), RASGRP3 (ENSG00000152689), RAPGEF6 (ENSG00000158987), RGL4 (ENSG00000159496), RALGDS (ENSG00000160271), RASGRP4 (ENSG00000171777), RASGRP1 (ENSG00000172575), RASGEF1A (ENSG00000198915), RGL3 (ENSG00000205517), RGL2 (ENSG00000237441)

Protein

Protein identifiers

Rap guanine nucleotide exchange factor 5 — Q92565 (reviewed: Q92565)

Alternative names: Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, Related to Epac

All UniProt accessions (8): A0A0S2Z561, A0A590UJR0, A8MQ07, C9JBS6, C9JHM4, E9PGY3, Q92565, F8WD32

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.

Subcellular location. Nucleus.

Tissue specificity. Widely expressed with highest levels in brain.

Isoforms (2)

UniProt ID	Names	Canonical?
Q92565-1	1	yes
Q92565-2	2

RefSeq proteins (5): NP_001354529, NP_001354530, NP_001354531, NP_001354532, NP_036426* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000651	Ras-like_Gua-exchang_fac_N	Domain
IPR001895	RASGEF_cat_dom	Domain
IPR008937	Ras-like_GEF	Family
IPR019804	Ras_G-nucl-exch_fac_CS	Conserved_site
IPR023578	Ras_GEF_dom_sf	Homologous_superfamily
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR036964	RASGEF_cat_dom_sf	Homologous_superfamily

Pfam: PF00617, PF00618

UniProt features (14 total): strand 7, domain 2, helix 2, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
1WGY	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92565-F1	77.62	0.54

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 215 (showing top): TGACCTY_ERR1_Q2, MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN, JIANG_TIP30_TARGETS_UP, KOYAMA_SEMA3B_TARGETS_UP, NF1_Q6_01, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, MODULE_157, AACTTT_UNKNOWN, PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_UP, CUI_TCF21_TARGETS_2_DN, BOQUEST_STEM_CELL_DN, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, TGACCTTG_SF1_Q6, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, GOCC_NUCLEAR_BODY

GO Biological Process (4): small GTPase-mediated signal transduction (GO:0007264), Ras protein signal transduction (GO:0007265), nervous system development (GO:0007399), intracellular signal transduction (GO:0035556)

GO Molecular Function (3): guanyl-nucleotide exchange factor activity (GO:0005085), GTP-dependent protein binding (GO:0030742), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), nucleoplasm (GO:0005654), plasma membrane (GO:0005886), nuclear body (GO:0016604)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular signaling cassette	1
small GTPase-mediated signal transduction	1
system development	1
intracellular anatomical structure	1
signal transduction	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
protein binding	1
binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
membrane	1
cell periphery	1
nucleoplasm	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

945 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RAPGEF5	SLC35C1	Q96A29	838
RAPGEF5	MRAS	O14807	780
RAPGEF5	RAP1A	P10113	730
RAPGEF5	RAP2A	P10114	555
RAPGEF5	SELP	P16109	544
RAPGEF5	ESR2	Q92731	508
RAPGEF5	SELE	P16111	469
RAPGEF5	FAM227B	Q96M60	449
RAPGEF5	RAP1B	P09526	440
RAPGEF5	CLCN6	P51797	436
RAPGEF5	TMEM196	Q5HYL7	436
RAPGEF5	HRAS	P01112	418
RAPGEF5	CTNNB1	P35222	415
RAPGEF5	DIPK2B	Q9H7Y0	412
RAPGEF5	HDHD2	Q9H0R4	388

IntAct

7 interactions, top by confidence:

A	B	Type	Score
RAPGEF5	ANK3	psi-mi:“MI:0915”(physical association)	0.500
RAPGEF5	PDIA4	psi-mi:“MI:0915”(physical association)	0.400
VANGL1	RAPGEF5	psi-mi:“MI:0915”(physical association)	0.370
RAPGEF5	PLAC9	psi-mi:“MI:0915”(physical association)	0.370
RAPGEF5	TMEM253	psi-mi:“MI:0915”(physical association)	0.370
RAPGEF5	DDHD2	psi-mi:“MI:0914”(association)	0.350

BioGRID (59): ANK3 (Affinity Capture-MS), ANK1 (Affinity Capture-MS), MAPK8IP2 (Affinity Capture-MS), ANK2 (Affinity Capture-MS), DDHD2 (Affinity Capture-MS), TUBB1 (Affinity Capture-MS), HSP90AA4P (Affinity Capture-MS), CCDC88A (Affinity Capture-MS), UBB (Affinity Capture-MS), HERC1 (Affinity Capture-MS), PPFIBP1 (Affinity Capture-MS), RICTOR (Affinity Capture-MS), PLEC (Affinity Capture-MS), ZNHIT2 (Affinity Capture-MS), WNK1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2JTR4, A0MQH0, A2RSQ0, A6QNS3, B2RTY4, E7EZG2, E7F3F0, E9PTA2, F4I507, O43795, O54865, P09851, P16068, P20595, P20936, P24786, P46735, P50904, P83900, P85298, Q02153, Q02440, Q05096, Q09LZ8, Q12979, Q13459, Q13507, Q16288, Q25BN1, Q49A26, Q4ZHR9, Q5R6F2, Q5SSL4, Q5ZLX4, Q63358, Q6TUI4, Q6ZUT9, Q8C170, Q8NHH1, Q91X46

Diamond homologs: A0JM95, A4IFE4, F1M386, F1MSG6, F1PBJ0, O95398, P28818, P83900, Q02342, Q0VAM2, Q28EC1, Q5RC04, Q6DBW1, Q6DHR3, Q8C0Q9, Q8CHG7, Q8IS19, Q8JZL7, Q8MVR1, Q8N431, Q8N9B8, Q8VCC8, Q8WZA2, Q92565, Q95KH6, Q9D300, Q9EQZ6, Q9UHV5, Q9Y4G8, Q9Z1C7, Q9Z1C8, A2AR50, A2CEA7, B0M0P8, B0UXH6, O14827, O77086, P04821, P27671, P70392

SIGNOR signaling

4 interactions.

A	Effect	B	Mechanism
RAPGEF5	up-regulates	HRAS	“guanine nucleotide exchange factor”
RAPGEF5	up-regulates	KRAS	“guanine nucleotide exchange factor”
RAPGEF5	up-regulates	NRAS	“guanine nucleotide exchange factor”
RAPGEF5	“up-regulates activity”	RAP1A	“guanine nucleotide exchange factor”

Disease & clinical

Clinical variants and AI predictions

ClinVar

110 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	71
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
1693113	NM_012294.5(RAPGEF5):c.2431C>T (p.His811Tyr)	Likely pathogenic

SpliceAI

5544 predictions. Top by Δscore:

Variant	Effect	Δscore
7:22136135:C:CT	acceptor_gain	1.0000
7:22136136:A:T	acceptor_gain	1.0000
7:22136139:CAGAT:C	acceptor_gain	1.0000
7:22136143:T:C	acceptor_gain	1.0000
7:22136143:T:TC	acceptor_gain	1.0000
7:22136931:A:AC	donor_gain	1.0000
7:22136932:C:CC	donor_gain	1.0000
7:22145042:A:AC	donor_gain	1.0000
7:22145043:C:CC	donor_gain	1.0000
7:22145043:CTGAG:C	donor_gain	1.0000
7:22150401:CCTTA:C	donor_loss	1.0000
7:22150402:CTTA:C	donor_loss	1.0000
7:22150403:TTAC:T	donor_loss	1.0000
7:22150404:TA:T	donor_loss	1.0000
7:22150405:A:AC	donor_gain	1.0000
7:22150405:A:C	donor_loss	1.0000
7:22150406:C:CC	donor_gain	1.0000
7:22150406:C:CG	donor_loss	1.0000
7:22150500:CTTTT:C	acceptor_gain	1.0000
7:22150501:TTTT:T	acceptor_gain	1.0000
7:22150505:C:CC	acceptor_gain	1.0000
7:22150507:T:C	acceptor_gain	1.0000
7:22150507:T:TC	acceptor_gain	1.0000
7:22150510:T:C	acceptor_gain	1.0000
7:22150510:T:TC	acceptor_gain	1.0000
7:22150511:T:C	acceptor_gain	1.0000
7:22150511:T:TC	acceptor_gain	1.0000
7:22154448:AACTT:A	donor_loss	1.0000
7:22154449:ACTTA:A	donor_loss	1.0000
7:22154450:CTTAC:C	donor_loss	1.0000

AlphaMissense

5826 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:22125636:C:G	R532P	1.000
7:22131046:A:C	F521L	1.000
7:22131046:A:T	F521L	1.000
7:22131048:A:G	F521L	1.000
7:22131049:A:C	N520K	1.000
7:22131049:A:T	N520K	1.000
7:22131053:A:T	V519D	1.000
7:22131056:A:G	L518P	1.000
7:22131081:C:G	G510R	1.000
7:22131081:C:T	G510R	1.000
7:22131091:A:C	F506L	1.000
7:22131091:A:T	F506L	1.000
7:22131092:A:G	F506S	1.000
7:22131093:A:G	F506L	1.000
7:22136039:T:A	K502N	1.000
7:22136039:T:G	K502N	1.000
7:22136040:T:A	K502I	1.000
7:22136096:T:A	R483S	1.000
7:22136096:T:G	R483S	1.000
7:22136097:C:A	R483I	1.000
7:22136097:C:G	R483T	1.000
7:22136098:T:C	R483G	1.000
7:22136110:G:C	H479D	1.000
7:22136111:A:C	N478K	1.000
7:22136111:A:T	N478K	1.000
7:22140065:A:G	L443P	1.000
7:22140069:C:G	G442R	1.000
7:22125648:G:T	A528E	0.999
7:22125649:C:G	A528P	0.999
7:22131038:A:G	L524P	0.999

dbSNP variants (sampled 300 via entrez): RS1000014356 (7:22171224 C>T), RS1000026032 (7:22244931 T>C), RS1000033557 (7:22152740 A>T), RS1000064180 (7:22225769 A>G), RS1000085357 (7:22175082 A>G,T), RS1000102113 (7:22314869 G>C), RS1000135691 (7:22231823 G>A), RS1000136560 (7:22134518 G>T), RS1000139745 (7:22350493 C>G,T), RS1000147800 (7:22355599 G>A,T), RS1000154285 (7:22315206 A>C), RS1000158864 (7:22296310 C>T), RS1000178551 (7:22212459 G>A), RS1000199812 (7:22269076 C>G), RS1000204268 (7:22278240 C>T)

Disease associations

OMIM: gene MIM:609527 | disease phenotypes: MIM:115200

GenCC curated gene-disease

Mondo (1): dilated cardiomyopathy 1A (MONDO:0007269)

Orphanet (1): Familial dilated cardiomyopathy with conduction defect due to LMNA mutation (Orphanet:300751)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST000100_3	Thyroid stimulating hormone levels	8.000000e-06
GCST001066_8	Dialysis-related mortality	4.000000e-06
GCST003081_10	Glucocorticoid-induced osteonecrosis (age 10 years and older)	4.000000e-06
GCST003542_181	Night sleep phenotypes	3.000000e-06
GCST004750_17	Squamous cell lung carcinoma	5.000000e-06
GCST006427_47	Depression in smokers	1.000000e-07
GCST006627_100	Diastolic blood pressure	9.000000e-14
GCST009306_2	Spatial processing	1.000000e-06
GCST010304_57	Cutaneous malignant melanoma	2.000000e-08
GCST010307_5	Urinary albumin excretion	1.000000e-10
GCST011349_6	Gamma glutamyl transferase levels	4.000000e-09
GCST90014325_33	Asthma	2.000000e-09

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure
EFO:0008354	cognitive function measurement
EFO:0004285	albuminuria
EFO:0004532	serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

1 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs16873129	Efficacy	3	antidepressants	Major Depressive Disorder

PharmGKB variants

2 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs6461639	RAPGEF5		0.00	0
rs16873129	RAPGEF5	3	0.00	1	antidepressants

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects expression, affects methylation, decreases expression	4
Valproic Acid	affects expression, increases expression	4
Cyclosporine	decreases expression, increases expression, increases methylation	3
sodium arsenite	affects acetylation, affects methylation	2
Tetrachlorodibenzodioxin	decreases expression	2
Aflatoxin B1	decreases methylation	2
aristolochic acid I	decreases expression	1
sotorasib	affects cotreatment, decreases expression	1
bisphenol A	affects cotreatment, decreases methylation	1
trichostatin A	decreases expression	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
CGP 52608	increases reaction, affects binding	1
monomethylarsonous acid	affects acetylation, affects methylation	1
ICG 001	decreases expression	1
abrine	decreases expression	1
asparanin A	decreases expression	1
bisphenol S	decreases methylation	1
NSC 689534	affects binding, decreases expression	1
trametinib	affects cotreatment, decreases expression	1
NVP-BKM120	affects cotreatment, decreases expression	1
Arsenic Trioxide	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Vorinostat	increases expression	1
Leflunomide	increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Carbamazepine	affects expression	1
Copper	affects binding, decreases expression	1

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E2IH	HAP1 RAPGEF5 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT05394506	Not specified	RECRUITING	Modifying Factors in Striated Muscle Laminopathies