RARA-AS1

Summary

RARA-AS1 (RARA antisense RNA 1, HGNC:49577) is a long non-coding RNA gene on chromosome 17q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49577
Approved symbol	RARA-AS1
Name	RARA antisense RNA 1
Location	17q21.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000265666
Ensembl biotype	lncRNA
Entrez	101929693
RNAcentral	URS00003D6015 — lncRNA, 1790 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000581080

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581080 — 3 exons

Exon	Start	End
ENSE00002689614	40340867	40341700
ENSE00002692184	40342876	40343136
ENSE00002703208	40341996	40342690

Expression profiles

Bgee: expression breadth ubiquitous, 182 present calls, max score 92.76.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0283 / max 6.3973, expressed in 11 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165708	0.0283	11

Top tissues by expression

245 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.76	gold quality
ileal mucosa	UBERON:0000331	86.14	gold quality
blood	UBERON:0000178	84.86	gold quality
sperm	CL:0000019	83.71	silver quality
tibialis anterior	UBERON:0001385	80.62	silver quality
granulocyte	CL:0000094	78.36	gold quality
pancreatic ductal cell	CL:0002079	78.08	silver quality
endothelial cell	CL:0000115	77.47	silver quality
monocyte	CL:0000576	77.30	gold quality
leukocyte	CL:0000738	77.28	gold quality
upper arm skin	UBERON:0004263	75.38	gold quality
right lung	UBERON:0002167	74.88	gold quality
mucosa of transverse colon	UBERON:0004991	74.72	gold quality
layer of synovial tissue	UBERON:0007616	74.71	silver quality
jejunal mucosa	UBERON:0000399	73.95	gold quality
tibial artery	UBERON:0007610	73.47	gold quality
popliteal artery	UBERON:0002250	73.44	gold quality
bone marrow	UBERON:0002371	73.21	gold quality
apex of heart	UBERON:0002098	73.15	gold quality
bone marrow cell	CL:0002092	73.13	silver quality
left uterine tube	UBERON:0001303	73.11	gold quality
aorta	UBERON:0000947	72.96	gold quality
descending thoracic aorta	UBERON:0002345	72.87	gold quality
cortical plate	UBERON:0005343	72.69	gold quality
ascending aorta	UBERON:0001496	72.54	gold quality
thoracic aorta	UBERON:0001515	72.41	gold quality
left coronary artery	UBERON:0001626	71.99	gold quality
nasal cavity epithelium	UBERON:0005384	71.97	gold quality
coronary artery	UBERON:0001621	71.73	gold quality
synovial joint	UBERON:0002217	71.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA RARA-AS1 could serve as a novel prognostic biomarker in pan-cancer and promote proliferation and migration in glioblastoma. (PMID:37833349)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.