RASA3

Summary

RASA3 (RAS p21 protein activator 3, HGNC:20331) is a protein-coding gene on chromosome 13q34, encoding Ras GTPase-activating protein 3 (Q14644). Inhibitory regulator of the Ras-cyclic AMP pathway.

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 22821 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 165 total — 1 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_007368

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20331
Approved symbol	RASA3
Name	RAS p21 protein activator 3
Location	13q34
Locus type	gene with protein product
Status	Approved
Aliases	GAP1IP4BP, GAPIII
Ensembl gene	ENSG00000185989
Ensembl biotype	protein_coding
OMIM	605182
Entrez	22821

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000334062, ENST00000542651, ENST00000881265, ENST00000881266, ENST00000912835, ENST00000947915, ENST00000947916, ENST00000947917

RefSeq mRNA: 3 — MANE Select: NM_007368 NM_001320821, NM_001320822, NM_007368

CCDS: CCDS32016

Canonical transcript exons

ENST00000334062 — 24 exons

Exon	Start	End
ENSE00001334925	113981675	113981858
ENSE00001334926	113992485	113992588
ENSE00001334928	113996531	113996739
ENSE00001334932	113999585	113999667
ENSE00001334935	114000826	114000932
ENSE00001334936	114007533	114007606
ENSE00001334938	114009387	114009464
ENSE00001334940	114011171	114011248
ENSE00001334941	114013142	114013248
ENSE00001334942	114015209	114015332
ENSE00001334944	114016197	114016271
ENSE00001334946	114017237	114017351
ENSE00001334956	114041000	114041094
ENSE00001334957	114052052	114052155
ENSE00001603051	113977783	113979422
ENSE00001912227	114132435	114132623
ENSE00003514006	114021404	114021508
ENSE00003517174	114018104	114018252
ENSE00003560806	114024279	114024355
ENSE00003600219	114073720	114073837
ENSE00003621816	114027389	114027461
ENSE00003624165	114027847	114027927
ENSE00003628538	114018763	114018919
ENSE00003683454	114029811	114029887

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 96.15.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.5094 / max 362.0558, expressed in 1765 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138407	22.5469	1758
138405	0.8437	499
138406	0.8288	480
138388	0.1325	52
138396	0.1027	54
138389	0.0548	32

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	96.15	gold quality
stromal cell of endometrium	CL:0002255	92.74	gold quality
leukocyte	CL:0000738	92.64	gold quality
sural nerve	UBERON:0015488	92.33	gold quality
monocyte	CL:0000576	92.32	gold quality
blood	UBERON:0000178	90.83	gold quality
subcutaneous adipose tissue	UBERON:0002190	90.38	gold quality
lymph node	UBERON:0000029	89.88	gold quality
adipose tissue	UBERON:0001013	89.64	gold quality
right uterine tube	UBERON:0001302	89.38	gold quality
tibial nerve	UBERON:0001323	88.98	gold quality
omental fat pad	UBERON:0010414	88.70	gold quality
endocervix	UBERON:0000458	88.64	gold quality
vermiform appendix	UBERON:0001154	88.27	gold quality
mucosa of stomach	UBERON:0001199	86.99	gold quality
temporal lobe	UBERON:0001871	86.70	gold quality
amygdala	UBERON:0001876	86.68	gold quality
ascending aorta	UBERON:0001496	86.66	gold quality
thoracic aorta	UBERON:0001515	86.62	gold quality
spleen	UBERON:0002106	86.50	gold quality
primary visual cortex	UBERON:0002436	86.48	gold quality
lower esophagus muscularis layer	UBERON:0035833	86.47	gold quality
thoracic mammary gland	UBERON:0005200	86.41	gold quality
lower esophagus	UBERON:0013473	86.40	gold quality
right frontal lobe	UBERON:0002810	86.33	gold quality
Ammon’s horn	UBERON:0001954	86.10	gold quality
descending thoracic aorta	UBERON:0002345	86.04	gold quality
left uterine tube	UBERON:0001303	86.02	gold quality
ectocervix	UBERON:0012249	85.85	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	85.81	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.70
E-CURD-119	yes	4.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

37 targeting RASA3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-3120-3P	99.54	70.28	2669
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-12113	99.32	67.54	1072
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-4504	99.10	69.14	1328
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-4716-5P	98.82	68.57	1168
HSA-MIR-4297	98.77	66.95	2013
HSA-MIR-758-3P	98.42	68.60	1122
HSA-MIR-4691-5P	98.41	66.77	1343
HSA-MIR-6792-3P	98.41	66.86	1359
HSA-MIR-5088-3P	98.29	66.63	1310
HSA-MIR-6771-3P	98.20	66.53	971
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-5581-5P	97.91	66.50	965
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-10398-5P	97.12	64.94	1051
HSA-MIR-335-5P	97.10	68.12	1022

Literature-anchored findings (GeneRIF, showing 6)

• role in intracellular calcium homeostasis (PMID:12356770)
• model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger (PMID:19433443)
• the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. (PMID:25294679)
• these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. (PMID:27903653)
• Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. (PMID:29381707)
• GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate. (PMID:7637787)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	rasa3	ENSDARG00000063371
mus_musculus	Rasa3	ENSMUSG00000031453
rattus_norvegicus	Rasa3	ENSRNOG00000017671
drosophila_melanogaster	RasGAP1	FBGN0004390
drosophila_melanogaster	raskol	FBGN0261570
caenorhabditis_elegans		WBGENE00001515
caenorhabditis_elegans		WBGENE00001516

Paralogs (10): RASAL2 (ENSG00000075391), RASAL3 (ENSG00000105122), RASA4 (ENSG00000105808), RASAL1 (ENSG00000111344), DAB2IP (ENSG00000136848), RASA1 (ENSG00000145715), RASA2 (ENSG00000155903), RASA4B (ENSG00000170667), NF1 (ENSG00000196712), SYNGAP1 (ENSG00000197283)

Protein

Protein identifiers

Ras GTPase-activating protein 3 — Q14644 (reviewed: Q14644)

Alternative names: GAP1(IP4BP), Ins P4-binding protein

All UniProt accessions (1): Q14644

UniProt curated annotations — full annotation on UniProt →

Function. Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Subcellular location. Cell membrane.

Isoforms (2)

UniProt ID	Names	Canonical?
Q14644-1	1	yes
Q14644-2	2

RefSeq proteins (3): NP_001307750, NP_001307751, NP_031394* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000008	C2_dom	Domain
IPR001562	Znf_Btk_motif	Conserved_site
IPR001849	PH_domain	Domain
IPR001936	RasGAP_dom	Domain
IPR008936	Rho_GTPase_activation_prot	Homologous_superfamily
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR023152	RasGAP_CS	Conserved_site
IPR035892	C2_domain_sf	Homologous_superfamily
IPR037774	RASA3_PH	Domain
IPR039360	Ras_GTPase	Family

Pfam: PF00168, PF00169, PF00616, PF00779

UniProt features (23 total): modified residue 6, binding site 4, domain 4, mutagenesis site 3, initiator methionine 1, chain 1, site 1, splice variant 1, sequence conflict 1, zinc finger region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q14644-F1	84.79	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 371 (arginine finger; crucial for gtp hydrolysis by stabilizing the transition state)

Ligand- & substrate-binding residues (4): 709; 687; 698; 699

Post-translational modifications (6): 2, 66, 77, 110, 809, 833

Mutagenesis-validated functional residues (3):

Position	Phenotype
599	no binding to ip4 and loss of plasma membrane localization.
600	no binding to ip4 and loss of plasma membrane localization.
601	no binding to ip4 and loss of plasma membrane localization.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5658442	Regulation of RAS by GAPs

MSigDB gene sets: 252 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_DN, GSE18804_SPLEEN_MACROPHAGE_VS_COLON_TUMORAL_MACROPHAGE_UP, GOBP_PLATELET_ACTIVATION, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, GOBP_WOUND_HEALING, chr13q34, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_DN, ATTCTTT_MIR186, TGACATY_UNKNOWN, MYB_Q3, ABBUD_LIF_SIGNALING_1_UP, RYTTCCTG_ETS2_B

GO Biological Process (7): signal transduction (GO:0007165), platelet activation (GO:0030168), intracellular signal transduction (GO:0035556), negative regulation of Ras protein signal transduction (GO:0046580), regulation of intracellular signal transduction (GO:1902531), response to stress (GO:0006950), regulation of GTPase activity (GO:0043087)

GO Molecular Function (4): GTPase activator activity (GO:0005096), calcium channel regulator activity (GO:0005246), zinc ion binding (GO:0008270), metal ion binding (GO:0046872)

GO Cellular Component (4): cytosol (GO:0005829), cytoplasmic side of plasma membrane (GO:0009898), plasma membrane (GO:0005886), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
RAF/MAP kinase cascade	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
GTPase activity	2
cellular anatomical structure	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell activation	1
blood coagulation	1
intracellular anatomical structure	1
signal transduction	1
Ras protein signal transduction	1
regulation of Ras protein signal transduction	1
negative regulation of small GTPase mediated signal transduction	1
regulation of signal transduction	1
intracellular signal transduction	1
response to stimulus	1
regulation of hydrolase activity	1
enzyme activator activity	1
GTPase regulator activity	1
calcium channel activity	1
ion channel regulator activity	1
transition metal ion binding	1
cation binding	1
cytoplasm	1
plasma membrane	1
cytoplasmic side of membrane	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

796 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RASA3	RAP1A	P10113	716
RASA3	PLEK2	Q9NYT0	622
RASA3	PLEK	P08567	622
RASA3	RASGRP2	Q7LDG7	571
RASA3	RRAS	P10301	570
RASA3	RASA1	P20936	512
RASA3	RASGRP1	O95267	508
RASA3	RASAL2	Q9UJF2	480
RASA3	RAP1GAP	P47736	475
RASA3	AKT1	P31749	454
RASA3	RAP1B	P09526	453
RASA3	CBL	P22681	421
RASA3	TNFAIP8	O95379	416
RASA3	DAPP1	Q9UN19	410
RASA3	ADAP1	O75689	399

IntAct

4 interactions, top by confidence:

A	B	Type	Score
Mbd2	MTA3	psi-mi:“MI:0914”(association)	0.350
PPP2R2D	BAG2	psi-mi:“MI:0914”(association)	0.350
ZBTB18	DNASE1L1	psi-mi:“MI:0914”(association)	0.350

BioGRID (53): RASA3 (Co-fractionation), RASA3 (Affinity Capture-MS), RASA3 (Affinity Capture-MS), GNAI2 (Reconstituted Complex), GNAI3 (Reconstituted Complex), GNAI2 (Affinity Capture-Western), GNAI3 (Affinity Capture-Western), RASA3 (Affinity Capture-RNA), RASA3 (Affinity Capture-MS), RASA3 (Affinity Capture-MS), RASA3 (Proximity Label-MS), RASA3 (Proximity Label-MS), RASA3 (Proximity Label-MS), RASA3 (Proximity Label-MS), RASA3 (Affinity Capture-MS)

ESM2 similar proteins: A0AVI2, A0FGR9, A2AP18, A3KGK3, A6QQP7, F1LYQ8, F8VPU2, O00329, O08835, O14976, O15068, O35904, O75038, O75923, O94887, P19687, P40749, P50232, P58069, P97610, P97874, Q14644, Q15283, Q28013, Q5DTI8, Q5FWL4, Q5M7N9, Q5RAB8, Q5RJH2, Q60790, Q63406, Q63713, Q64096, Q6DN12, Q6P7F1, Q7L8C5, Q7ZWU7, Q8IV01, Q8VHQ7, Q91VS8

Diamond homologs: A6QQ91, F6SEU4, P48423, P97526, Q14644, Q15283, Q28013, Q3UHC7, Q54Y08, Q5VWQ8, Q60790, Q6P730, Q86YV0, Q8C2K5, Q8MLZ5, Q8T498, Q96PV0, Q9QUH6, Q9QYJ2, Q9UJF2, Q9Z268, A3KGK3, A8KBH6, B2RUP2, B3DLH6, C9J798, K8FE10, O00445, O08625, O35681, O43374, O43581, O75923, O95294, P04409, P05126, P05128, P05129, P05130, P05696

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

165 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	1
Uncertain significance	121
Likely benign	10
Benign	3

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
599497	NM_007368.4(RASA3):c.892_895del (p.Asp298fs)	Pathogenic
599498	NM_007368.4(RASA3):c.254T>C (p.Val85Ala)	Likely pathogenic

SpliceAI

6593 predictions. Top by Δscore:

Variant	Effect	Δscore
13:113979418:GCTCC:G	acceptor_gain	1.0000
13:113979419:CTCC:C	acceptor_gain	1.0000
13:113979419:CTCCC:C	acceptor_gain	1.0000
13:113979420:TCC:T	acceptor_gain	1.0000
13:113979420:TCCCT:T	acceptor_gain	1.0000
13:113979421:CC:C	acceptor_gain	1.0000
13:113979421:CCC:C	acceptor_gain	1.0000
13:113979422:CC:C	acceptor_gain	1.0000
13:113979423:C:CC	acceptor_gain	1.0000
13:113979423:C:T	acceptor_gain	1.0000
13:113979423:CTGA:C	acceptor_loss	1.0000
13:113979424:T:C	acceptor_loss	1.0000
13:113981671:TCACT:T	donor_loss	1.0000
13:113981672:CAC:C	donor_loss	1.0000
13:113981673:A:AC	donor_gain	1.0000
13:113981673:ACT:A	donor_loss	1.0000
13:113981673:ACTGG:A	donor_gain	1.0000
13:113981674:C:CA	donor_gain	1.0000
13:113981674:CT:C	donor_gain	1.0000
13:113981674:CTGG:C	donor_gain	1.0000
13:113981674:CTGGC:C	donor_gain	1.0000
13:113981859:C:CC	acceptor_gain	1.0000
13:113992480:CTCA:C	donor_loss	1.0000
13:113992481:TCACC:T	donor_loss	1.0000
13:113992482:CAC:C	donor_loss	1.0000
13:113992483:A:AC	donor_gain	1.0000
13:113992483:AC:A	donor_gain	1.0000
13:113992484:C:A	donor_loss	1.0000
13:113992484:C:CC	donor_gain	1.0000
13:113992484:CC:C	donor_gain	1.0000

AlphaMissense

5561 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:113996670:A:G	W668R	1.000
13:113996670:A:T	W668R	1.000
13:114000920:C:A	K585N	1.000
13:114000920:C:G	K585N	1.000
13:114011210:C:A	K517N	1.000
13:114011210:C:G	K517N	1.000
13:114011231:C:A	R510S	1.000
13:114011231:C:G	R510S	1.000
13:114011232:C:A	R510M	1.000
13:114011232:C:G	R510T	1.000
13:114013185:G:T	A490D	1.000
13:114013200:C:A	R485M	1.000
13:114013200:C:G	R485T	1.000
13:114013203:A:G	L484P	1.000
13:114015325:A:G	L430P	1.000
13:114018851:A:G	L285P	1.000
13:114018857:A:G	L283P	1.000
13:114021458:C:T	G244E	1.000
13:114029887:C:G	G125R	1.000
13:114041041:A:G	W111R	1.000
13:114041041:A:T	W111R	1.000
13:114073768:A:G	L42P	1.000
13:113981681:C:T	G808E	0.999
13:113996729:A:T	V648D	0.999
13:114000872:T:A	R601S	0.999
13:114000872:T:G	R601S	0.999
13:114000917:C:A	R586S	0.999
13:114000917:C:G	R586S	0.999
13:114000918:C:G	R586T	0.999
13:114011193:C:T	G523D	0.999

dbSNP variants (sampled 300 via entrez): RS1000065173 (13:114042317 A>T), RS1000069060 (13:114002466 C>G,T), RS1000080103 (13:114090375 G>A), RS1000089611 (13:114109458 C>G), RS1000097152 (13:114063390 G>A,C), RS1000108898 (13:114100127 C>A,G,T), RS1000114781 (13:114016069 T>G), RS1000139018 (13:114055332 C>A,T), RS1000153473 (13:114109846 C>T), RS1000165958 (13:114039987 G>A,T), RS1000181054 (13:114073632 GA>G), RS1000189465 (13:114054979 T>C), RS1000198421 (13:114110323 C>T), RS1000205640 (13:114089951 G>A), RS1000221837 (13:114130933 C>T)

Disease associations

OMIM: gene MIM:605182 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST007465_12	Phoneme awareness	6.000000e-06
GCST009200_12	Whole brain grey matter density	3.000000e-06
GCST010302_7	Cutaneous melanoma or hair colour	5.000000e-12
GCST90002388_127	Lymphocyte count	3.000000e-34
GCST90002388_128	Lymphocyte count	9.000000e-13
GCST90002389_481	Lymphocyte percentage of white cells	2.000000e-13
GCST90002389_482	Lymphocyte percentage of white cells	1.000000e-17
GCST90002401_69	Platelet distribution width	1.000000e-10
GCST90002407_616	White blood cell count	8.000000e-10
GCST90006897_1	Anti-Epstein-Barr virus IgG seropositivity	2.000000e-08

EFO canonical traits (7, from GWAS)

EFO ID	Trait name
EFO:0005301	reading and spelling ability
EFO:0010306	Grey matter density measurement
EFO:0003924	hair color
EFO:0004587	lymphocyte count
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007984	platelet component distribution width
EFO:0007034	seropositivity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

45 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, increases expression	3
Estradiol	affects expression, affects cotreatment, increases expression	3
sodium arsenite	decreases expression, affects methylation	2
Benzo(a)pyrene	increases expression, affects methylation	2
Cisplatin	decreases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
Tobacco Smoke Pollution	decreases expression	2
Valproic Acid	increases expression, increases methylation	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
FR900359	decreases phosphorylation	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects methylation, affects cotreatment	1
tris(2-butoxyethyl) phosphate	affects expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	decreases methylation	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
quinocetone	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects methylation, affects cotreatment	1
Glyphosate	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	affects methylation	1
Azacitidine	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.