RASGEF1B

Summary

RASGEF1B (RasGEF domain family member 1B, HGNC:24881) is a protein-coding gene on chromosome 4q21.21, encoding Ras-GEF domain-containing family member 1B (Q0VAM2). Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn’t seems to activate other Ras family proteins (in vitro).

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in early endosome; late endosome; and midbody. Predicted to be active in plasma membrane.

Source: NCBI Gene 153020 — RefSeq curated summary.

At a glance

• GWAS associations: 28
• Clinical variants (ClinVar): 73 total
• MANE Select transcript: NM_152545

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24881
Approved symbol	RASGEF1B
Name	RasGEF domain family member 1B
Location	4q21.21
Locus type	gene with protein product
Status	Approved
Aliases	GPIG4, FLJ31695
Ensembl gene	ENSG00000138670
Ensembl biotype	protein_coding
OMIM	614532
Entrez	153020

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 12 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000264400, ENST00000335927, ENST00000436139, ENST00000504863, ENST00000507538, ENST00000508294, ENST00000509081, ENST00000510780, ENST00000512343, ENST00000512716, ENST00000514050, ENST00000514889, ENST00000638048, ENST00000900842, ENST00000900843, ENST00000900844, ENST00000939400, ENST00000961893

RefSeq mRNA: 3 — MANE Select: NM_152545 NM_001300735, NM_001300736, NM_152545

CCDS: CCDS34022, CCDS75151, CCDS75152

Canonical transcript exons

ENST00000264400 — 14 exons

Exon	Start	End
ENSE00000969840	81433840	81433963
ENSE00000969842	81432299	81432371
ENSE00001007127	81457499	81457621
ENSE00001073139	81448069	81448284
ENSE00001073141	81445743	81445838
ENSE00001073143	81445526	81445628
ENSE00001073144	81440834	81440929
ENSE00001073145	81447504	81447578
ENSE00001687202	81459332	81459514
ENSE00001688119	81471770	81471907
ENSE00002081551	81426393	81427792
ENSE00002515483	81442297	81442376
ENSE00002530310	81434639	81434734
ENSE00003566128	81456651	81456788

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 95.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.9426 / max 947.5551, expressed in 1009 samples.

FANTOM5 promoters (11 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52794	15.0306	898
52793	8.9078	594
52792	3.0036	388
52822	0.5231	211
52821	0.2238	103
52825	0.0868	38
52820	0.0557	22
52826	0.0419	18
52824	0.0389	14
52827	0.0201	5

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	95.53	gold quality
right lobe of liver	UBERON:0001114	88.76	gold quality
monocyte	CL:0000576	88.58	gold quality
bone marrow cell	CL:0002092	88.53	gold quality
right lung	UBERON:0002167	88.24	gold quality
buccal mucosa cell	CL:0002336	87.81	gold quality
leukocyte	CL:0000738	87.69	gold quality
skin of abdomen	UBERON:0001416	87.44	gold quality
skin of leg	UBERON:0001511	86.21	gold quality
lower esophagus mucosa	UBERON:0035834	86.03	gold quality
gall bladder	UBERON:0002110	85.92	gold quality
upper lobe of left lung	UBERON:0008952	85.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.34	gold quality
cortical plate	UBERON:0005343	83.68	gold quality
islet of Langerhans	UBERON:0000006	82.69	gold quality
sural nerve	UBERON:0015488	82.10	gold quality
calcaneal tendon	UBERON:0003701	81.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	81.79	gold quality
zone of skin	UBERON:0000014	81.78	gold quality
upper lobe of lung	UBERON:0008948	81.74	gold quality
vermiform appendix	UBERON:0001154	81.35	gold quality
metanephros cortex	UBERON:0010533	80.61	gold quality
esophagus mucosa	UBERON:0002469	80.46	gold quality
caudate nucleus	UBERON:0001873	80.25	gold quality
putamen	UBERON:0001874	80.24	gold quality
minor salivary gland	UBERON:0001830	79.92	gold quality
omental fat pad	UBERON:0010414	79.50	gold quality
peritoneum	UBERON:0002358	79.40	gold quality
right uterine tube	UBERON:0001302	79.13	gold quality
colonic epithelium	UBERON:0000397	79.05	gold quality

Single-cell (SCXA)

Detected in 11 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-ANND-2	yes	7331.84
E-GEOD-75688	yes	1577.26
E-GEOD-75140	yes	1287.68
E-CURD-7	yes	749.70
E-GEOD-84465	yes	35.91
E-ANND-3	yes	26.36
E-MTAB-9467	yes	18.86
E-GEOD-93593	yes	8.60
E-CURD-11	no	97.03
E-GEOD-124858	no	12.03
E-CURD-112	no	2.15

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ARX, E2F1

miRNA regulators (miRDB)

110 targeting RASGEF1B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-495-3P	99.96	72.81	4197

Literature-anchored findings (GeneRIF, showing 4)

• Mutation of the Ser39 in Rap1 changed the specificity and allowed the nucleotide exchange of Rap1(S39F) to be stimulated by RasGEF1B (PMID:19645719)
• As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. (PMID:22303795)
• We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs. (PMID:27362560)
• study provides evidence for two novel candidate genes, SPG7 and RASGEF1B, associating with white coat effect (PMID:31044621)

Cross-species orthologs

7 orthologs

Organism	Symbol	Gene ID
danio_rerio	rasgef1ba	ENSDARG00000033614
danio_rerio	rasgef1bb	ENSDARG00000044251
mus_musculus	Rasgef1b	ENSMUSG00000089809
rattus_norvegicus	Rasgef1b	ENSRNOG00000002345
drosophila_melanogaster	CG4853	FBGN0034230
drosophila_melanogaster	CG7369	FBGN0037188
caenorhabditis_elegans		WBGENE00019902

Paralogs (24): RASGRF1 (ENSG00000058335), RASGRP2 (ENSG00000068831), RAPGEF3 (ENSG00000079337), RAPGEF4 (ENSG00000091428), SOS2 (ENSG00000100485), RAPGEF1 (ENSG00000107263), RAPGEFL1 (ENSG00000108352), RAPGEF2 (ENSG00000109756), RASGRF2 (ENSG00000113319), SOS1 (ENSG00000115904), RALGPS2 (ENSG00000116191), RAPGEF5 (ENSG00000136237), RALGPS1 (ENSG00000136828), RGL1 (ENSG00000143344), RASGEF1C (ENSG00000146090), RASGRP3 (ENSG00000152689), RAPGEF6 (ENSG00000158987), RGL4 (ENSG00000159496), RALGDS (ENSG00000160271), RASGRP4 (ENSG00000171777), RASGRP1 (ENSG00000172575), RASGEF1A (ENSG00000198915), RGL3 (ENSG00000205517), RGL2 (ENSG00000237441)

Protein

Protein identifiers

Ras-GEF domain-containing family member 1B — Q0VAM2 (reviewed: Q0VAM2)

Alternative names: GPI gamma-4

All UniProt accessions (6): A0A0G2JLL4, A0A1B0GVA7, A0A1B0GW78, D6RE71, Q0VAM2, Q8N437

UniProt curated annotations — full annotation on UniProt →

Function. Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn’t seems to activate other Ras family proteins (in vitro).

Subunit / interactions. Interacts with Ras family proteins. Interacts with CCDC124 during cytokinesis.

Subcellular location. Early endosome. Late endosome. Midbody.

Induction. Up-regulated in macrophages stimulated with IFNG, GPI-mucins or bacterial lipopolysaccharides (LPS).

Isoforms (3)

UniProt ID	Names	Canonical?
Q0VAM2-1	1	yes
Q0VAM2-2	2
Q0VAM2-3	3

RefSeq proteins (3): NP_001287664, NP_001287665, NP_689758* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000651	Ras-like_Gua-exchang_fac_N	Domain
IPR001895	RASGEF_cat_dom	Domain
IPR008937	Ras-like_GEF	Family
IPR019804	Ras_G-nucl-exch_fac_CS	Conserved_site
IPR023578	Ras_GEF_dom_sf	Homologous_superfamily
IPR036964	RASGEF_cat_dom_sf	Homologous_superfamily

Pfam: PF00617, PF00618

UniProt features (5 total): domain 2, splice variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q0VAM2-F1	87.31	0.72

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 209 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, FREAC2_01, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, GCANCTGNY_MYOD_Q6, MEF2_02, FOXO1_01, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, POU3F2_02, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, MEF2_Q6_01, CTAWWWATA_RSRFC4_Q2, FOXO4_02, chr4q21, MEF2_03, GOMF_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY

GO Biological Process (2): Ras protein signal transduction (GO:0007265), small GTPase-mediated signal transduction (GO:0007264)

GO Molecular Function (2): guanyl-nucleotide exchange factor activity (GO:0005085), protein binding (GO:0005515)

GO Cellular Component (5): early endosome (GO:0005769), late endosome (GO:0005770), plasma membrane (GO:0005886), midbody (GO:0030496), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
endosome	2
small GTPase-mediated signal transduction	1
intracellular signaling cassette	1
GTP binding	1
GDP binding	1
GTPase regulator activity	1
binding	1
membrane	1
cell periphery	1
cellular anatomical structure	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

752 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RASGEF1B	PRKG2	Q13237	918
RASGEF1B	ICAM1	P05362	532
RASGEF1B	ENOPH1	Q9UHY7	505
RASGEF1B	HAUS8	Q9BT25	441
RASGEF1B	LINGO1	Q96FE5	436
RASGEF1B	SLC26A3	P40879	432
RASGEF1B	UNC5D	Q6UXZ4	411
RASGEF1B	ARHGAP12	Q8IWW6	389
RASGEF1B	GDF10	P55107	377
RASGEF1B	GDF3	Q9NR23	367
RASGEF1B	WSCD1	Q658N2	363
RASGEF1B	ZC3H4	Q9UPT8	362
RASGEF1B	CUX2	O14529	357
RASGEF1B	GDF2	Q9UK05	355
RASGEF1B	DLL1	O00548	349

IntAct

2 interactions, top by confidence:

A	B	Type	Score
RASGEF1B	GAPDHS	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): RASGEF1B (Affinity Capture-MS), COL1A1 (Affinity Capture-MS), GAPDHS (Affinity Capture-MS), RASGEF1B (Affinity Capture-RNA), RASGEF1B (Two-hybrid), TSGA10IP (Two-hybrid), PLEKHF2 (Two-hybrid), PDLIM7 (Two-hybrid), RASGEF1B (Affinity Capture-RNA), GAPDHS (Affinity Capture-MS), COL1A1 (Affinity Capture-MS), RASGEF1B (Positive Genetic), RASGEF1B (Affinity Capture-RNA)

ESM2 similar proteins: A0A0G2JTR4, A0A2R8QFQ6, A0JM95, A4IFE4, A6QNS3, C1C3R6, D3Z649, D4ABL6, E9PV86, F1QH17, G3MWR8, O46404, Q0VAM2, Q12800, Q12979, Q13507, Q28EC1, Q3ULA2, Q3UNW5, Q4V860, Q5R6F2, Q5RB16, Q5RC04, Q5SSL4, Q5VWJ9, Q5ZLX4, Q63789, Q64143, Q6DHR3, Q6NZH6, Q6UVM3, Q6UVM4, Q6ZPR4, Q7RTP6, Q7T2U9, Q7Z6J6, Q8CE50, Q8CJ19, Q8JZL7, Q8N431

Diamond homologs: A0JM95, A4IFE4, F1M386, F1MSG6, F1PBJ0, Q0VAM2, Q28EC1, Q5RC04, Q6DBW1, Q6DHR3, Q8CHG7, Q8IS18, Q8IS19, Q8JZL7, Q8MVR1, Q8N431, Q8N9B8, Q95KH6, Q9D300, Q9Y4G8, O95398, P28818, P83900, Q02342, Q8C0Q9, Q8VCC8, Q8WZA2, Q92565, Q9EQZ6, Q9UHV5, Q9Z1C7, Q9Z1C8, A2AR50, A2CEA7, A7A0P0, B0M0P8, B3LTF3, B5VMS9, C8ZCV7, E9Q9W7

SIGNOR signaling

5 interactions.

A	Effect	B	Mechanism
RASGEF1B	up-regulates	NRAS	binding
RASGEF1B	up-regulates	HRAS	binding
RASGEF1B	up-regulates	KRAS	binding
E2F1	“up-regulates quantity by expression”	RASGEF1B	“transcriptional regulation”
PLPPR1	“up-regulates activity”	RASGEF1B	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	56
Likely benign	4
Benign	4

Top pathogenic / likely-pathogenic (0)

SpliceAI

1549 predictions. Top by Δscore:

Variant	Effect	Δscore
4:81432372:C:CC	acceptor_gain	1.0000
4:81433834:CCTTA:C	donor_loss	1.0000
4:81433835:CTTA:C	donor_loss	1.0000
4:81433836:TTA:T	donor_loss	1.0000
4:81433837:TACCA:T	donor_loss	1.0000
4:81433838:A:AC	donor_gain	1.0000
4:81433838:AC:A	donor_gain	1.0000
4:81433838:ACC:A	donor_loss	1.0000
4:81433838:ACCAT:A	donor_gain	1.0000
4:81433839:C:CC	donor_gain	1.0000
4:81433839:C:CT	donor_loss	1.0000
4:81433839:CC:C	donor_gain	1.0000
4:81433839:CCA:C	donor_gain	1.0000
4:81433839:CCAT:C	donor_gain	1.0000
4:81433839:CCATC:C	donor_gain	1.0000
4:81433856:TGG:T	donor_gain	1.0000
4:81433959:AATTT:A	acceptor_gain	1.0000
4:81433960:ATTT:A	acceptor_gain	1.0000
4:81433961:TTT:T	acceptor_gain	1.0000
4:81433961:TTTC:T	acceptor_loss	1.0000
4:81433962:TT:T	acceptor_gain	1.0000
4:81433963:TC:T	acceptor_loss	1.0000
4:81433964:C:CA	acceptor_loss	1.0000
4:81433964:C:CC	acceptor_gain	1.0000
4:81433971:A:AC	acceptor_gain	1.0000
4:81433971:A:C	acceptor_gain	1.0000
4:81433975:G:C	acceptor_gain	1.0000
4:81433975:G:GC	acceptor_gain	1.0000
4:81434634:CTCA:C	donor_loss	1.0000
4:81434635:TCA:T	donor_loss	1.0000

AlphaMissense

3170 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:81432356:G:A	S447F	1.000
4:81434703:T:A	K379I	1.000
4:81440892:C:G	R349P	1.000
4:81440903:G:C	F345L	1.000
4:81440903:G:T	F345L	1.000
4:81440905:A:G	F345L	1.000
4:81442346:A:G	L320P	1.000
4:81442349:C:G	R319P	1.000
4:81442355:A:T	V317D	1.000
4:81442373:C:T	G311D	1.000
4:81442374:C:G	G311R	1.000
4:81445531:A:T	I308K	1.000
4:81445545:G:C	N303K	1.000
4:81445545:G:T	N303K	1.000
4:81445551:G:C	N301K	1.000
4:81445551:G:T	N301K	1.000
4:81445566:A:C	C296W	1.000
4:81445759:G:T	A270D	1.000
4:81448085:A:G	L213P	1.000
4:81456740:A:G	W117R	1.000
4:81456740:A:T	W117R	1.000
4:81432356:G:T	S447Y	0.999
4:81432357:A:G	S447P	0.999
4:81432368:A:G	L443P	0.999
4:81433948:C:G	A406P	0.999
4:81434700:T:A	D380V	0.999
4:81434700:T:G	D380A	0.999
4:81434701:C:G	D380H	0.999
4:81434702:T:A	K379N	0.999
4:81434702:T:G	K379N	0.999

dbSNP variants (sampled 300 via entrez): RS1000035766 (4:81466933 T>C), RS1000037505 (4:81464761 A>G), RS1000052272 (4:81436814 T>C), RS1000055130 (4:81460988 G>C), RS1000071995 (4:81460586 C>G), RS1000131240 (4:81453274 A>G), RS1000215211 (4:81432778 T>C), RS1000229927 (4:81467031 G>A), RS1000307172 (4:81454320 G>T), RS1000344335 (4:81429421 G>C), RS1000352961 (4:81446863 C>T), RS1000443301 (4:81440437 G>A), RS1000490578 (4:81449428 T>A,C), RS1000636689 (4:81466237 TCTTC>T), RS1000646290 (4:81434767 G>A,T)

Disease associations

OMIM: gene MIM:614532 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

28 associations (top):

Study	Trait	p-value
GCST000175_43	Height	2.000000e-06
GCST001850_15	Major depressive disorder	6.000000e-06
GCST002702_49	Height	3.000000e-15
GCST005024_68	Pursuit maintenance gain	6.000000e-07
GCST006291_54	Spherical equivalent or myopia (age of diagnosis)	3.000000e-11
GCST006427_39	Depression in smokers	7.000000e-06
GCST006431_1	Plasma parathyroid hormone levels	1.000000e-08
GCST006817_4	Response to antidepressants in depression	2.000000e-06
GCST007637_42	Diffusing capacity of carbon monoxide	6.000000e-06
GCST008151_106	Waist circumference	2.000000e-06
GCST008158_110	Body mass index	2.000000e-06
GCST008160_108	Waist circumference	2.000000e-06
GCST008399_19	Cocaine dependence	2.000000e-06
GCST008839_421	Height	3.000000e-38
GCST008969_5	White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure)	5.000000e-06
GCST010002_9	Refractive error	2.000000e-65
GCST010397_30	Gut microbiota (bacterial taxa, rank normal transformation method)	2.000000e-06
GCST010479_68	Coronary artery disease	4.000000e-08
GCST010866_22	Coronary artery disease	2.000000e-13
GCST011365_61	Myocardial infarction	5.000000e-11
GCST012226_221	Waist circumference adjusted for body mass index	6.000000e-11
GCST012226_223	Waist circumference adjusted for body mass index	6.000000e-10
GCST012227_1287	Hip circumference adjusted for BMI	3.000000e-12
GCST012227_1288	Hip circumference adjusted for BMI	4.000000e-10
GCST012400_41	Low myopia vs hyperopia	6.000000e-09
GCST90000015_4	Parkinson’s disease motor subtype (tremor to postural instability/gait difficulty score ratio)	1.000000e-06
GCST90020028_1941	Hip circumference adjusted for BMI	1.000000e-13
GCST90020028_1943	Hip circumference adjusted for BMI	9.000000e-13

EFO canonical traits (9, from GWAS)

EFO ID	Trait name
EFO:0008433	pursuit maintenance gain measurement
EFO:0004847	age at onset
EFO:0009369	diffusing capacity of the lung for carbon monoxide
EFO:0004340	body mass index
EFO:0006945	diastolic blood pressure change measurement
EFO:0007874	gut microbiome measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0008039	BMI-adjusted hip circumference
EFO:0600011	Parkinson’s disease symptom measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	2
Estradiol	decreases expression	2
GSK-J4	increases expression	1
kojic acid	decreases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
butyraldehyde	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
lei gong teng	increases expression	1
epigallocatechin gallate	increases expression	1
pentanal	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
bisphenol S	decreases methylation	1
Sunitinib	increases expression	1
Air Pollutants	increases abundance, increases expression	1
Air Pollutants, Occupational	increases expression	1
Arbutin	decreases expression	1
Arsenic	increases methylation	1
Cadmium	increases expression	1
Diquat	increases expression	1
Endosulfan	decreases expression, decreases reaction	1
Lipopolysaccharides	increases expression, affects response to substance	1
Nickel	increases expression	1
Phthalic Acids	affects methylation	1
Tetrachlorodibenzodioxin	decreases expression, decreases reaction	1
Thiram	increases expression	1
Tobacco Smoke Pollution	affects expression	1
Urethane	increases expression	1
Cyclosporine	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.