RASGRP3-AS1

Summary

RASGRP3-AS1 (RASGRP3 antisense RNA 1, HGNC:40689) is a long non-coding RNA gene on chromosome 2p22.3.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40689
Approved symbol	RASGRP3-AS1
Name	RASGRP3 antisense RNA 1
Location	2p22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000237133
Entrez	105374454
RNAcentral	URS0000BC4559 — lncRNA, 2766 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 85.68.

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.68	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	83.00	gold quality
corpus callosum	UBERON:0002336	78.07	gold quality
skeletal muscle tissue	UBERON:0001134	73.40	gold quality
muscle tissue	UBERON:0002385	72.12	gold quality
Brodmann (1909) area 9	UBERON:0013540	71.56	gold quality
granulocyte	CL:0000094	71.45	gold quality
gastrocnemius	UBERON:0001388	71.39	gold quality
Ammon’s horn	UBERON:0001954	71.17	gold quality
colonic epithelium	UBERON:0000397	71.09	silver quality
muscle of leg	UBERON:0001383	70.96	gold quality
anterior cingulate cortex	UBERON:0009835	70.69	gold quality
substantia nigra	UBERON:0002038	70.54	gold quality
popliteal artery	UBERON:0002250	70.28	gold quality
tibial artery	UBERON:0007610	70.24	gold quality
bone marrow cell	CL:0002092	70.23	silver quality
hypothalamus	UBERON:0001898	70.19	gold quality
smooth muscle tissue	UBERON:0001135	70.03	gold quality
mucosa of stomach	UBERON:0001199	69.94	gold quality
spleen	UBERON:0002106	69.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.58	gold quality
lower esophagus	UBERON:0013473	69.57	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.47	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.40	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.34	gold quality
fundus of stomach	UBERON:0001160	69.29	gold quality
right lobe of liver	UBERON:0001114	69.13	gold quality
right coronary artery	UBERON:0001625	69.07	gold quality
amygdala	UBERON:0001876	69.04	gold quality
left coronary artery	UBERON:0001626	69.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000290569 (2:33562262 T>A,C,G), RS1000393196 (2:33568337 G>A), RS1000466930 (2:33567921 T>C), RS1000681769 (2:33561980 A>G,T), RS1000728242 (2:33557285 T>C), RS1000773026 (2:33556721 A>G), RS1000840456 (2:33562953 C>A,G,T), RS1000894200 (2:33567876 A>AGTT), RS1000967378 (2:33567640 G>A), RS1001772507 (2:33554604 C>T), RS1001813537 (2:33570730 C>A), RS1001925391 (2:33563430 G>A,T), RS1002009628 (2:33565438 T>C), RS1002021566 (2:33569401 C>T), RS1002073841 (2:33569809 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.