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RASGRP4

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Summary

RASGRP4 (RAS guanyl releasing protein 4, HGNC:18958) is a protein-coding gene on chromosome 19q13.2, encoding RAS guanyl-releasing protein 4 (Q8TDF6). Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP.

The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 115727 — RefSeq curated summary.

At a glance

  • GWAS associations: 13
  • Clinical variants (ClinVar): 106 total
  • MANE Select transcript: NM_170604

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:18958
Approved symbolRASGRP4
NameRAS guanyl releasing protein 4
Location19q13.2
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000171777
Ensembl biotypeprotein_coding
OMIM607320
Entrez115727

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 8 protein_coding, 6 retained_intron, 2 nonsense_mediated_decay

ENST00000454404, ENST00000586305, ENST00000587287, ENST00000587738, ENST00000587753, ENST00000588404, ENST00000588708, ENST00000589100, ENST00000589358, ENST00000589474, ENST00000592322, ENST00000614135, ENST00000615340, ENST00000615439, ENST00000617966, ENST00000622174

RefSeq mRNA: 7 — MANE Select: NM_170604 NM_001146202, NM_001146203, NM_001146204, NM_001146205, NM_001146206, NM_001146207, NM_170604

CCDS: CCDS46068, CCDS59382, CCDS59383, CCDS59384

Canonical transcript exons

ENST00000615439 — 17 exons

ExonStartEnd
ENSE000034587253841267238412816
ENSE000034661293841111538411249
ENSE000034978353841293138413049
ENSE000035284563840905838410096
ENSE000035409313842013138420262
ENSE000035451613841319338413297
ENSE000035506543841339438413474
ENSE000035582233841839138418564
ENSE000035630323842196938422153
ENSE000036087723841088638410998
ENSE000036169893841134538411381
ENSE000036299963841484838415123
ENSE000036697723841705238417168
ENSE000036753783841986038420013
ENSE000038510953842606938426219
ENSE000038890673842090838420970
ENSE000038954063842109538421200

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 94.35.

FANTOM5 (CAGE): breadth broad, TPM avg 5.5811 / max 489.2848, expressed in 523 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
1807765.0155510
1807740.317088
1807750.237979
1807720.01074

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
granulocyteCL:000009494.35gold quality
leukocyteCL:000073893.74gold quality
monocyteCL:000057693.70gold quality
bloodUBERON:000017891.30gold quality
spleenUBERON:000210686.02gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099184.46gold quality
bone marrow cellCL:000209284.30gold quality
right lungUBERON:000216781.17gold quality
vermiform appendixUBERON:000115479.75gold quality
upper lobe of left lungUBERON:000895278.16gold quality
upper lobe of lungUBERON:000894876.19gold quality
bone marrowUBERON:000237175.45gold quality
omental fat padUBERON:001041472.53gold quality
peritoneumUBERON:000235872.45gold quality
adipose tissue of abdominal regionUBERON:000780871.85gold quality
right coronary arteryUBERON:000162571.79gold quality
caecumUBERON:000115371.29gold quality
gall bladderUBERON:000211071.05gold quality
bone elementUBERON:000147470.52gold quality
apex of heartUBERON:000209870.21gold quality
smooth muscle tissueUBERON:000113569.52gold quality
left uterine tubeUBERON:000130369.39gold quality
right adrenal gland cortexUBERON:003582769.20gold quality
mucosa of stomachUBERON:000119968.81gold quality
descending thoracic aortaUBERON:000234568.42gold quality
right adrenal glandUBERON:000123367.57gold quality
left coronary arteryUBERON:000162667.48gold quality
lungUBERON:000204867.36gold quality
hindlimb stylopod muscleUBERON:000425267.08gold quality
subcutaneous adipose tissueUBERON:000219066.97gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

ExperimentMarker?Max mean expression
E-MTAB-9067yes13.10
E-ANND-3yes5.64
E-MTAB-5061yes4.26

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

52 targeting RASGRP4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-607799.9968.042299
HSA-MIR-373-5P99.9875.364753
HSA-MIR-616-5P99.9875.584775
HSA-MIR-314899.9775.066478
HSA-MIR-568099.9169.833421
HSA-MIR-6780A-5P99.8866.692776
HSA-MIR-4728-5P99.8569.394718
HSA-MIR-444799.8567.812900
HSA-MIR-6785-5P99.8268.684428
HSA-MIR-4668-5P99.7970.583782
HSA-MIR-548AJ-5P99.7871.123085
HSA-MIR-548F-5P99.7871.023093
HSA-MIR-548G-5P99.7871.123085
HSA-MIR-548X-5P99.7871.123085
HSA-MIR-1273H-5P99.7766.322471
HSA-MIR-149-3P99.7268.223963
HSA-MIR-6779-5P99.7065.762363
HSA-MIR-30B-3P99.7065.762325
HSA-MIR-3689A-3P99.7065.732306
HSA-MIR-3689B-3P99.7065.712311
HSA-MIR-3689C99.7065.712311
HSA-MIR-182799.6368.573265
HSA-MIR-7106-5P99.5367.473574
HSA-MIR-5584-5P99.4968.222814
HSA-MIR-127599.4767.902749
HSA-MIR-312399.4767.152693
HSA-MIR-391599.4568.491905
HSA-MIR-4685-5P99.2565.991563

Literature-anchored findings (GeneRIF, showing 10)

  • RasGRP4 plays a role in myeloid cell signaling growth regulation pathways that are responsive to diacylglycerol levels (PMID:11880369)
  • RasGRP4 is a cation-dependent, guanine nucleotide exchange factor and diacylglycerol/phorbol ester receptor that is selectively expressed in mast cells and their progenitors. RasGRP4 regulates the final stages of mast cell development. (PMID:11956218)
  • identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function (PMID:11956218)
  • RasGRP4 regulates the expression of prostaglandin D2 in mast cells (PMID:12493770)
  • RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell’s ability to respond to IL-13. (PMID:18024961)
  • RasGRP4 cooperates with AML1 mutations in T cell leukemogenesis as a class I mutation (PMID:19350351)
  • Identification of defective isoforms of hRasGRP4 transcripts in rheumatoid arthritis(RA) patients raises the possibility that dysregulated expression of hRasGRP4 in developing monocytes plays a pathogenic role in this subset of RA patients. (PMID:21933395)
  • GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. (PMID:22728827)
  • Ras guanine nucleotide-releasing protein 4 is aberrantly expressed in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and controls their proliferation. (PMID:25330932)
  • The findings indicate the oncogenic role of RasGRP4 in diffuse large B cell lymphoma (DLBCL), suggesting it as a prognostic biomarker and potential therapeutic target in DLBCL. (PMID:31409422)

Cross-species orthologs

3 orthologs

OrganismSymbolGene ID
danio_reriorasgrp4ENSDARG00000061796
mus_musculusRasgrp4ENSMUSG00000030589
rattus_norvegicusRasgrp4ENSRNOG00000033744

Paralogs (24): RASGRF1 (ENSG00000058335), RASGRP2 (ENSG00000068831), RAPGEF3 (ENSG00000079337), RAPGEF4 (ENSG00000091428), SOS2 (ENSG00000100485), RAPGEF1 (ENSG00000107263), RAPGEFL1 (ENSG00000108352), RAPGEF2 (ENSG00000109756), RASGRF2 (ENSG00000113319), SOS1 (ENSG00000115904), RALGPS2 (ENSG00000116191), RAPGEF5 (ENSG00000136237), RALGPS1 (ENSG00000136828), RASGEF1B (ENSG00000138670), RGL1 (ENSG00000143344), RASGEF1C (ENSG00000146090), RASGRP3 (ENSG00000152689), RAPGEF6 (ENSG00000158987), RGL4 (ENSG00000159496), RALGDS (ENSG00000160271), RASGRP1 (ENSG00000172575), RASGEF1A (ENSG00000198915), RGL3 (ENSG00000205517), RGL2 (ENSG00000237441)

Protein

Protein identifiers

RAS guanyl-releasing protein 4 — Q8TDF6 (reviewed: Q8TDF6)

All UniProt accessions (1): Q8TDF6

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses. In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells. May function in mast cell differentiation. Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells.

Subcellular location. Cytoplasm. Cell membrane.

Tissue specificity. Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.

Domain organisation. The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.

Miscellaneous. Probably inactive. Probably inactive.

Similarity. Belongs to the RASGRP family.

Isoforms (8)

UniProt IDNamesCanonical?
Q8TDF6-11yes
Q8TDF6-22, variant 2
Q8TDF6-33, variant 1
Q8TDF6-54
Q8TDF6-65
Q8TDF6-76
Q8TDF6-87
Q8TDF6-98

RefSeq proteins (7): NP_001139674, NP_001139675, NP_001139676, NP_001139677, NP_001139678, NP_001139679, NP_733749* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000651Ras-like_Gua-exchang_fac_NDomain
IPR001895RASGEF_cat_domDomain
IPR002048EF_hand_domDomain
IPR002219PKC_DAG/PEDomain
IPR008937Ras-like_GEFFamily
IPR020454DAG/PE-bdDomain
IPR023578Ras_GEF_dom_sfHomologous_superfamily
IPR036964RASGEF_cat_dom_sfHomologous_superfamily
IPR046349C1-like_sfHomologous_superfamily

Pfam: PF00130, PF00617

UniProt features (51 total): helix 18, splice variant 7, sequence variant 6, sequence conflict 4, region of interest 4, domain 3, compositionally biased region 2, turn 2, strand 2, chain 1, mutagenesis site 1, zinc finger region 1

Structure

Experimental structures (PDB)

1 structures.

PDBMethodResolution (Å)
6AXGX-RAY DIFFRACTION3.3

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8TDF6-F176.720.43

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Mutagenesis-validated functional residues (1):

PositionPhenotype
548loss of cell membrane targeting.

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

IDPathway
R-HSA-2871837FCERI mediated NF-kB activation
R-HSA-5673001RAF/MAP kinase cascade

MSigDB gene sets: 149 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, GOBP_MYELOID_CELL_DIFFERENTIATION, TGGTGCT_MIR29A_MIR29B_MIR29C, CREL_01, REACTOME_INNATE_IMMUNE_SYSTEM, KEGG_MAPK_SIGNALING_PATHWAY, ACTGCAG_MIR173P, GOBP_LEUKOCYTE_MEDIATED_IMMUNITY, GOBP_POSITIVE_REGULATION_OF_RESPONSE_TO_EXTERNAL_STIMULUS, GOBP_REGULATION_OF_IMMUNE_RESPONSE, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_LYMPHOCYTE_MEDIATED_IMMUNITY, GOBP_REGULATION_OF_RESPONSE_TO_STRESS, GOBP_RAS_PROTEIN_SIGNAL_TRANSDUCTION, GOBP_REGULATION_OF_LYMPHOCYTE_MEDIATED_IMMUNITY

GO Biological Process (7): positive regulation of natural killer cell mediated immunity (GO:0002717), phospholipase C-activating G protein-coupled receptor signaling pathway (GO:0007200), Ras protein signal transduction (GO:0007265), myeloid cell differentiation (GO:0030099), antibacterial innate immune response (GO:0140367), small GTPase-mediated signal transduction (GO:0007264), cell differentiation (GO:0030154)

GO Molecular Function (8): guanyl-nucleotide exchange factor activity (GO:0005085), calcium ion binding (GO:0005509), zinc ion binding (GO:0008270), diacylglycerol binding (GO:0019992), protein binding (GO:0005515), lipid binding (GO:0008289), GTPase regulator activity (GO:0030695), metal ion binding (GO:0046872)

GO Cellular Component (6): nucleoplasm (GO:0005654), cytosol (GO:0005829), plasma membrane (GO:0005886), cytoplasmic side of plasma membrane (GO:0009898), membrane (GO:0016020), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

CategoryPathways
Fc epsilon receptor (FCERI) signaling1
MAPK1/MAPK3 signaling1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular anatomical structure4
binding2
natural killer cell mediated immunity1
positive regulation of lymphocyte mediated immunity1
regulation of natural killer cell mediated immunity1
positive regulation of innate immune response1
G protein-coupled receptor signaling pathway1
phospholipase C activator activity1
small GTPase-mediated signal transduction1
hemopoiesis1
cell differentiation1
defense response to bacterium1
innate immune response1
intracellular signaling cassette1
cellular developmental process1
GTP binding1
GDP binding1
GTPase regulator activity1
metal ion binding1
transition metal ion binding1
lipid binding1
GTPase activity1
nucleoside-triphosphatase regulator activity1
cation binding1
nuclear lumen1
cytoplasm1
membrane1
cell periphery1
plasma membrane1
cytoplasmic side of membrane1
intracellular anatomical structure1

Protein interactions and networks

STRING

1082 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
RASGRP4RASA4O43374581
RASGRP4HRASP01112550
RASGRP4PTGDSP41222510
RASGRP4NF1P21359495
RASGRP4ATP7AQ04656475
RASGRP4MAPKAPK3Q16644465
RASGRP4RABIFP47224459
RASGRP4CDC25BP30305457
RASGRP4PPM1AP35813433
RASGRP4RASGEF1AQ8N9B8429
RASGRP4RASA1P20936426
RASGRP4MAPKAPK5Q8IW41426
RASGRP4CMA1P23946424
RASGRP4VAV3Q9UKW4396
RASGRP4TAB1Q15750393

IntAct

5 interactions, top by confidence:

ABTypeScore
RASGRP4HSP90B1psi-mi:“MI:0915”(physical association)0.400
SCRIBCHD2psi-mi:“MI:0914”(association)0.350
RASGRP4DUSP14psi-mi:“MI:0914”(association)0.350
RASGRP4RAP1Apsi-mi:“MI:2364”(proximity)0.270

BioGRID (13): RAP1A (Co-localization), DUSP14 (Affinity Capture-MS), DSG4 (Affinity Capture-MS), SELENBP1 (Affinity Capture-MS), RASGRP4 (Two-hybrid), RASGRP4 (Two-hybrid), RASGRP4 (Two-hybrid), RASGRP4 (Two-hybrid), RASGRP4 (Proximity Label-MS), RASGRP4 (Positive Genetic), DUSP14 (Affinity Capture-MS), DSG4 (Affinity Capture-MS), RASGRP4 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: A1IGU3, A1IGU4, A1IGU5, A2VDW6, A6QP75, A7E3N7, B2RUP2, C3VPR6, D3ZI76, Q0VCR8, Q14DK4, Q1LZ97, Q3MIN7, Q3TAA7, Q3UR97, Q4FZD7, Q53B87, Q53B88, Q5D0E6, Q60I26, Q60I27, Q61085, Q641Y9, Q69Z89, Q6NUI2, Q6P5Z2, Q6PFY1, Q6PJN8, Q70J99, Q86UR1, Q86VI1, Q86WN1, Q8BI71, Q8BTM9, Q8C0R7, Q8C190, Q8K045, Q8N1F8, Q8N9H8, Q8R5I4

Diamond homologs: A4IJ06, A6N9I4, A8KBH6, O14795, O45818, O94806, O95267, P04409, P05126, P05128, P05129, P05130, P05696, P05771, P05772, P09215, P09216, P0C643, P10102, P10829, P10830, P13677, P13678, P15882, P16054, P17252, P20444, P23298, P24723, P27715, P28867, P30337, P34578, P34722, P34885, P52757, P63318, P68403, P68404, P83099

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

106 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance92
Likely benign5
Benign2

Top pathogenic / likely-pathogenic (0)

SpliceAI

2300 predictions. Top by Δscore:

VariantEffectΔscore
19:38411377:CAGAG:Cacceptor_gain1.0000
19:38412670:A:ACdonor_gain1.0000
19:38412671:C:CCdonor_gain1.0000
19:38412929:ACC:Adonor_gain1.0000
19:38412930:CCC:Cdonor_gain1.0000
19:38413053:C:CTacceptor_gain1.0000
19:38413054:A:Tacceptor_gain1.0000
19:38413060:G:GCacceptor_gain1.0000
19:38413062:G:GCacceptor_gain1.0000
19:38413293:GGTGG:Gacceptor_gain1.0000
19:38413294:GTGG:Gacceptor_gain1.0000
19:38413295:TGG:Tacceptor_gain1.0000
19:38413296:GG:Gacceptor_gain1.0000
19:38413296:GGCTG:Gacceptor_loss1.0000
19:38413298:C:CCacceptor_gain1.0000
19:38413304:C:CTacceptor_gain1.0000
19:38413388:TCTCA:Tdonor_loss1.0000
19:38413389:CTCAC:Cdonor_loss1.0000
19:38413390:TCACC:Tdonor_loss1.0000
19:38413391:CA:Cdonor_loss1.0000
19:38413392:A:ACdonor_gain1.0000
19:38413392:ACCAG:Adonor_loss1.0000
19:38413393:C:CCdonor_gain1.0000
19:38413393:C:Gdonor_loss1.0000
19:38413393:CCAGG:Cdonor_gain1.0000
19:38413470:GAGAG:Gacceptor_gain1.0000
19:38413471:AGAG:Aacceptor_gain1.0000
19:38413472:GAG:Gacceptor_gain1.0000
19:38413473:AG:Aacceptor_gain1.0000
19:38413473:AGC:Aacceptor_loss1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000100969 (19:38422152 T>A), RS1000693191 (19:38410890 T>G), RS1000703638 (19:38423569 G>A), RS1000719767 (19:38427732 A>G), RS1000993809 (19:38415983 TG>T), RS1001083743 (19:38410414 CTTTTTTTTTT>C,CTT,CTTT,CTTTTTT,CTTTTTTT,CTTTTTTTT,CTTTTTTTTT,CTTTTTTTTTTT,CTTTTTTTTTTTT,CTTTTTTTTTTTTT,CTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTT,CTTTTTTTTTTTTTTTTTTTTT), RS1001116076 (19:38423387 G>A,C), RS1001296472 (19:38412131 G>T), RS1001429099 (19:38417204 G>T), RS1001665808 (19:38412382 C>A,G), RS1001880201 (19:38417418 T>C), RS1001893117 (19:38421559 A>G), RS1002119862 (19:38426923 C>CGGT), RS1002201507 (19:38409598 C>T), RS1002383592 (19:38415586 T>A)

Disease associations

OMIM: gene MIM:607320 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

StudyTraitp-value
GCST002875_93Diisocyanate-induced asthma5.000000e-06
GCST004600_108Eosinophil percentage of white cells1.000000e-09
GCST004606_37Eosinophil count2.000000e-09
GCST004623_95Neutrophil percentage of granulocytes2.000000e-09
GCST004624_19Sum eosinophil basophil counts3.000000e-09
GCST90002379_151Basophil count7.000000e-57
GCST90002379_152Basophil count2.000000e-33
GCST90002380_16Basophil percentage of white cells1.000000e-53
GCST90002380_17Basophil percentage of white cells3.000000e-31
GCST90002381_341Eosinophil count7.000000e-17
GCST90002381_342Eosinophil count7.000000e-10
GCST90002382_464Eosinophil percentage of white cells7.000000e-16
GCST90002393_659Monocyte count1.000000e-10

EFO canonical traits (7, from GWAS)

EFO IDTrait name
EFO:0006995response to diisocyanate
EFO:0007991eosinophil percentage of leukocytes
EFO:0004842eosinophil count
EFO:0007994neutrophil percentage of granulocytes
EFO:0005090basophil count
EFO:0007992basophil percentage of leukocytes
EFO:0005091monocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyreneaffects methylation, increases expression2
Nickelincreases expression2
triphenyl phosphateaffects expression1
bisphenol Adecreases expression, affects cotreatment1
di-n-butylphosphoric acidaffects expression1
CGP 52608affects binding, increases reaction1
Air Pollutantsaffects expression, increases abundance1
Vehicle Emissionsdecreases methylation1
Dexamethasoneaffects cotreatment, decreases expression1
Indomethacinaffects cotreatment, decreases expression1
Ozoneaffects expression, increases abundance1
Tretinoinincreases expression1
1-Methyl-3-isobutylxanthineaffects cotreatment, decreases expression1
Asbestos, Crocidoliteaffects expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
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BioBTree
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Sources 75

This page pulls from 75 datasets indexed by BioBTree:

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