RASIP1

Summary

RASIP1 (Ras interacting protein 1, HGNC:24716) is a protein-coding gene on chromosome 19q13.33, encoding Ras-interacting protein 1 (Q5U651). Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.

Enables GTPase binding activity and protein homodimerization activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of metabolic process; and positive regulation of integrin activation. Located in cell-cell junction. Part of protein-containing complex.

Source: NCBI Gene 54922 — RefSeq curated summary.

At a glance

• GWAS associations: 36
• Clinical variants (ClinVar): 135 total
• MANE Select transcript: NM_017805

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24716
Approved symbol	RASIP1
Name	Ras interacting protein 1
Location	19q13.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20401, RAIN
Ensembl gene	ENSG00000105538
Ensembl biotype	protein_coding
OMIM	609623
Entrez	54922

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 1 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000222145, ENST00000594232, ENST00000599291, ENST00000601530, ENST00000862294, ENST00000862295, ENST00000862296, ENST00000862297, ENST00000862298, ENST00000963671, ENST00000963672, ENST00000963673, ENST00000963674

RefSeq mRNA: 1 — MANE Select: NM_017805 NM_017805

CCDS: CCDS12731

Canonical transcript exons

ENST00000222145 — 12 exons

Exon	Start	End
ENSE00000718041	48724717	48724960
ENSE00000718044	48726785	48726888
ENSE00000718048	48727007	48727158
ENSE00001058790	48727393	48727430
ENSE00001238208	48728937	48729590
ENSE00001238218	48738960	48739645
ENSE00001238226	48740146	48740286
ENSE00001238231	48740521	48740610
ENSE00003483016	48724337	48724509
ENSE00003502890	48721854	48722001
ENSE00003504405	48735196	48735551
ENSE00003529887	48720585	48720997

Expression profiles

Bgee: expression breadth ubiquitous, 217 present calls, max score 92.47.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2317 / max 60.0711, expressed in 422 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
181923	1.1388	280
181922	0.4856	205
181917	0.3688	147
181921	0.2385	141

Top tissues by expression

262 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lung	UBERON:0002167	92.47	gold quality
upper lobe of left lung	UBERON:0008952	91.94	gold quality
apex of heart	UBERON:0002098	91.48	gold quality
upper lobe of lung	UBERON:0008948	91.47	gold quality
omental fat pad	UBERON:0010414	91.33	gold quality
peritoneum	UBERON:0002358	91.26	gold quality
adipose tissue of abdominal region	UBERON:0007808	90.79	gold quality
spleen	UBERON:0002106	89.09	gold quality
subcutaneous adipose tissue	UBERON:0002190	88.47	gold quality
lower lobe of lung	UBERON:0008949	87.47	gold quality
left uterine tube	UBERON:0001303	87.42	gold quality
lung	UBERON:0002048	87.24	gold quality
heart left ventricle	UBERON:0002084	86.58	gold quality
adipose tissue	UBERON:0001013	86.48	gold quality
cardiac ventricle	UBERON:0002082	86.18	gold quality
right atrium auricular region	UBERON:0006631	85.57	gold quality
connective tissue	UBERON:0002384	85.54	gold quality
body of uterus	UBERON:0009853	85.15	gold quality
cardiac atrium	UBERON:0002081	84.62	gold quality
body of pancreas	UBERON:0001150	84.54	gold quality
ectocervix	UBERON:0012249	84.41	gold quality
body of stomach	UBERON:0001161	84.13	gold quality
heart	UBERON:0000948	84.11	gold quality
right lobe of thyroid gland	UBERON:0001119	83.89	gold quality
left lobe of thyroid gland	UBERON:0001120	83.83	gold quality
lower esophagus mucosa	UBERON:0035834	83.81	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.14	gold quality
lower esophagus	UBERON:0013473	83.12	gold quality
thyroid gland	UBERON:0002046	82.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	82.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.35

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CUX1

miRNA regulators (miRDB)

5 targeting RASIP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-4713-5P	99.78	67.80	1794
HSA-MIR-498-5P	99.76	69.64	1807
HSA-MIR-6748-3P	97.20	65.66	836

Literature-anchored findings (GeneRIF, showing 6)

• Rain is a novel protein that can serve as an effector of endomembrane-localized Ras (PMID:15031288)
• results reveal an effector pathway for Rap1 in the modulation of Rho signaling and actin dynamics, through which Rap1 modulates endothelial barrier function (PMID:23798437)
• These studies establish that the binding of HEG1 to Rasip1 mediates Rap1-dependent recruitment of Rasip1 to and stabilization of endothelial cell cell-cell junctions. (PMID:26780829)
• Results show that Rasip1 RA domain formed a dimer that can bind two Rap1 or Ras molecules and solved the Rap1-RRA complex and found that Rasip1 binds Rap1 in the Switch I region, and Rap1 binding induces few conformation changes to Rasip1 stabilizing a beta strand and an unstructured loop. (PMID:27839947)
• RAIN Is a Novel Enhancer-Associated lncRNA That Controls RUNX2 Expression and Promotes Breast and Thyroid Cancer. (PMID:31624086)
• Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells. (PMID:36967521)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	rasip1	ENSDARG00000074829
mus_musculus	Rasip1	ENSMUSG00000044562
rattus_norvegicus	Rasip1	ENSRNOG00000021004

Paralogs (1): RADIL (ENSG00000157927)

Protein

Protein identifiers

Ras-interacting protein 1 — Q5U651 (reviewed: Q5U651)

All UniProt accessions (2): Q5U651, M0R148

UniProt curated annotations — full annotation on UniProt →

Function. Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Subunit / interactions. Interacts with Ras family members that have been activated by GTP binding. Interacts with HRAS, RAP1A, RAP2, RRAS, RAF1 and RRAS2. Interacts with MYH9 and ARHGAP29.

Subcellular location. Cytoplasm. Perinuclear region. Golgi apparatus. Golgi stack.

Tissue specificity. Highly expressed in heart. Detected at lower levels in placenta and pancreas.

RefSeq proteins (1): NP_060275* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000159	RA_dom	Domain
IPR002710	Dilute_dom	Domain
IPR008984	SMAD_FHA_dom_sf	Homologous_superfamily
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR037983	CBD_Rasip1/Radil	Domain
IPR052072	Vascular_dev_regulator	Family

Pfam: PF00788, PF01843

UniProt features (35 total): modified residue 8, compositionally biased region 6, strand 6, helix 4, sequence conflict 3, region of interest 3, domain 2, chain 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5KHO	X-RAY DIFFRACTION	2.78
5KHQ	X-RAY DIFFRACTION	2.8

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5U651-F1	72.23	0.40

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 94, 188, 280, 292, 326, 328, 331, 419

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 165 (showing top): GOBP_MORPHOGENESIS_OF_AN_EPITHELIUM, GOBP_EPITHELIUM_DEVELOPMENT, GOBP_REGULATION_OF_AUTOPHAGY, GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_NEGATIVE_REGULATION_OF_KINASE_ACTIVITY, GOBP_REGULATION_OF_GTPASE_ACTIVITY, GOBP_REGULATION_OF_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, DARWICHE_SKIN_TUMOR_PROMOTER_DN, GOBP_REGULATION_OF_TRANSFERASE_ACTIVITY, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, GOMF_GTPASE_BINDING, GOBP_REGULATION_OF_CELLULAR_COMPONENT_BIOGENESIS, GGGTGGRR_PAX4_03

GO Biological Process (10): angiogenesis (GO:0001525), vasculogenesis (GO:0001570), signal transduction (GO:0007165), negative regulation of autophagy (GO:0010507), positive regulation of integrin activation (GO:0033625), negative regulation of Rho protein signal transduction (GO:0035024), regulation of GTPase activity (GO:0043087), branching morphogenesis of an epithelial tube (GO:0048754), negative regulation of membrane permeability (GO:1905709), obsolete negative regulation of Rho-dependent protein serine/threonine kinase activity (GO:2000299)

GO Molecular Function (3): protein homodimerization activity (GO:0042803), GTPase binding (GO:0051020), protein binding (GO:0005515)

GO Cellular Component (6): Golgi stack (GO:0005795), cell-cell junction (GO:0005911), protein-containing complex (GO:0032991), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), Golgi apparatus (GO:0005794)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
blood vessel morphogenesis	2
cytoplasm	2
cellular anatomical structure	2
anatomical structure formation involved in morphogenesis	1
cell differentiation	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
autophagy	1
negative regulation of catabolic process	1
regulation of autophagy	1
positive regulation of protein-containing complex assembly	1
integrin activation	1
regulation of integrin activation	1
Rho protein signal transduction	1
regulation of Rho protein signal transduction	1
negative regulation of small GTPase mediated signal transduction	1
GTPase activity	1
regulation of hydrolase activity	1
tube morphogenesis	1
epithelial tube morphogenesis	1
morphogenesis of a branching epithelium	1
regulation of membrane permeability	1
identical protein binding	1
protein dimerization activity	1
enzyme binding	1
binding	1
Golgi apparatus subcompartment	1
anchoring junction	1
cellular_component	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

2615 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RASIP1	ARHGAP29	Q52LW3	942
RASIP1	LRPAP1	P30533	783
RASIP1	KRIT1	O00522	754
RASIP1	RRAS2	P17082	720
RASIP1	HEG1	Q9ULI3	662
RASIP1	RRAS	P10301	652
RASIP1	RAP1A	P10113	628
RASIP1	RAP2A	P10114	588
RASIP1	IZUMO1	Q8IYV9	526
RASIP1	RASA1	P20936	509
RASIP1	CCM2L	Q9NUG4	507
RASIP1	IZUMO2	Q6UXV1	471
RASIP1	ISOC2	Q96AB3	465
RASIP1	CTNNB1	P35222	456
RASIP1	CCM2	Q9BSQ5	425

IntAct

25 interactions, top by confidence:

A	B	Type	Score
RASIP1	CFL1	psi-mi:“MI:0915”(physical association)	0.400
RASIP1	Sdc4	psi-mi:“MI:0915”(physical association)	0.400
LDB2	RASIP1	psi-mi:“MI:0915”(physical association)	0.370
RASIP1	ARFGAP1	psi-mi:“MI:0915”(physical association)	0.370
CDC42	BBX	psi-mi:“MI:0914”(association)	0.350
RACGAP1	STX18	psi-mi:“MI:0914”(association)	0.350
ZWINT	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
RNF41	CLEC16A	psi-mi:“MI:0914”(association)	0.350
Sgo2a	SORBS3	psi-mi:“MI:0914”(association)	0.350
Csnk1d	WWP2	psi-mi:“MI:0914”(association)	0.350
Pals2	RBM10	psi-mi:“MI:0914”(association)	0.350
FGFR1OP2	STK24	psi-mi:“MI:0914”(association)	0.350
SIKE1	STK24	psi-mi:“MI:0914”(association)	0.350
BAG3	MAP3K4	psi-mi:“MI:0914”(association)	0.350
Bap1	HCFC1	psi-mi:“MI:0914”(association)	0.350
HNRNPD	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
BUB3	ZNF207	psi-mi:“MI:0914”(association)	0.350
PPP1R18	OGA	psi-mi:“MI:0914”(association)	0.350
CDH5	ESYT2	psi-mi:“MI:2364”(proximity)	0.270
CDH5	MYO1C	psi-mi:“MI:2364”(proximity)	0.270
RASIP1	lysU	psi-mi:“MI:0915”(physical association)	0.000
	RASIP1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (24): RASIP1 (Two-hybrid), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS), RASIP1 (Affinity Capture-MS)

ESM2 similar proteins: A1L188, A2AMZ4, A2XK00, A7YY73, B4FGS2, B4FTR7, B8B624, C0HAV3, C5E268, G2TRP6, O13973, O75012, O95159, O95872, Q0VDN7, Q12894, Q28H71, Q2YDD3, Q3SZA2, Q3SZW4, Q3U0S6, Q3UJV1, Q49AH0, Q4G012, Q5FVV3, Q5U509, Q5U651, Q61858, Q6ASS9, Q6P0I6, Q756Q5, Q7S4Y4, Q7XAM0, Q7XK12, Q8BGD8, Q8BGX2, Q8CC36, Q8VED2, Q96BP2, Q96C34

Diamond homologs: A0A140LI67, A1A5G4, A7UA95, E2QYC9, F1MAD2, G5ECY0, O14910, O15018, O35274, O35867, O54824, O55164, O60333, O75970, O88382, O88658, O88951, O88952, P31007, P31016, P57105, P70175, P78352, Q0P5F3, Q12923, Q14005, Q14160, Q15700, Q24008, Q28C55, Q2KIB6, Q32LM6, Q3T0C9, Q3U0S6, Q4KL35, Q4L1J4, Q5F425, Q5F488, Q5PYH5, Q5PYH6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

135 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	124
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1736 predictions. Top by Δscore:

Variant	Effect	Δscore
19:48727005:AC:A	donor_gain	1.0000
19:48727006:CC:C	donor_gain	1.0000
19:48727006:CCCT:C	donor_gain	1.0000
19:48727021:T:TA	donor_gain	1.0000
19:48727156:TGG:T	acceptor_gain	1.0000
19:48727157:GG:G	acceptor_gain	1.0000
19:48727159:C:CC	acceptor_gain	1.0000
19:48727160:T:C	acceptor_gain	1.0000
19:48727160:T:TC	acceptor_gain	1.0000
19:48727391:A:AC	donor_gain	1.0000
19:48727392:C:CC	donor_gain	1.0000
19:48728947:T:TA	donor_gain	1.0000
19:48735190:GGTTA:G	donor_loss	1.0000
19:48735194:A:C	donor_loss	1.0000
19:48735195:CCTGG:C	donor_loss	1.0000
19:48735203:T:TA	donor_gain	1.0000
19:48738955:CTCA:C	donor_loss	1.0000
19:48738956:TCAC:T	donor_loss	1.0000
19:48738957:CACCT:C	donor_loss	1.0000
19:48738958:ACC:A	donor_loss	1.0000
19:48721437:ATGT:A	donor_gain	0.9900
19:48722000:GC:G	acceptor_gain	0.9900
19:48722001:CC:C	acceptor_gain	0.9900
19:48722002:C:CA	acceptor_loss	0.9900
19:48722002:C:CC	acceptor_gain	0.9900
19:48722003:T:C	acceptor_loss	0.9900
19:48724332:GTCA:G	donor_loss	0.9900
19:48724333:TCACC:T	donor_loss	0.9900
19:48724334:CACCT:C	donor_loss	0.9900
19:48724335:ACCT:A	donor_loss	0.9900

AlphaMissense

6089 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:48720961:A:T	L910H	1.000
19:48720971:G:C	H907D	1.000
19:48720978:G:C	F904L	1.000
19:48720978:G:T	F904L	1.000
19:48720979:A:C	F904C	1.000
19:48720980:A:G	F904L	1.000
19:48721893:A:G	W885R	1.000
19:48721893:A:T	W885R	1.000
19:48724455:A:G	L809P	1.000
19:48724484:C:A	W799C	1.000
19:48724484:C:G	W799C	1.000
19:48724733:G:C	N785K	1.000
19:48724733:G:T	N785K	1.000
19:48724740:A:G	L783P	1.000
19:48724754:G:C	F778L	1.000
19:48724754:G:T	F778L	1.000
19:48724755:A:G	F778S	1.000
19:48724756:A:G	F778L	1.000
19:48724757:G:C	F777L	1.000
19:48724757:G:T	F777L	1.000
19:48724759:A:G	F777L	1.000
19:48724768:A:G	Y774H	1.000
19:48724788:A:G	L767P	1.000
19:48724916:G:C	F724L	1.000
19:48724916:G:T	F724L	1.000
19:48724918:A:G	F724L	1.000
19:48726785:C:A	K709N	1.000
19:48726785:C:G	K709N	1.000
19:48726792:A:G	L707P	1.000
19:48726799:A:C	Y705D	1.000

dbSNP variants (sampled 300 via entrez): RS1000154500 (19:48742383 T>G), RS1000228340 (19:48724400 C>T), RS1000274117 (19:48723975 T>C), RS1000580411 (19:48724643 T>C), RS1000659642 (19:48722657 C>G,T), RS1000906373 (19:48722967 C>A), RS1000962579 (19:48729825 C>T), RS1000964668 (19:48723053 T>A), RS1000969087 (19:48729633 C>T), RS1001108060 (19:48729162 G>A), RS1001275986 (19:48740742 T>G), RS1001307678 (19:48728121 T>C,G), RS1001319689 (19:48733903 G>C), RS1001383061 (19:48735303 T>A), RS1001384672 (19:48735848 T>G)

Disease associations

OMIM: gene MIM:609623 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

36 associations (top):

Study	Trait	p-value
GCST000847_1	Retinal vascular caliber	2.000000e-25
GCST000879_14	Crohn’s disease	7.000000e-12
GCST001241_6	Bipolar disorder	3.000000e-06
GCST001844_2	Dietary macronutrient intake	8.000000e-09
GCST002559_6	Vitamin B levels in ischemic stroke	9.000000e-07
GCST002740_15	Inflammatory skin disease	4.000000e-22
GCST003679_20	C-reactive protein levels or LDL-cholesterol levels (pleiotropy)	3.000000e-08
GCST004131_128	Inflammatory bowel disease	5.000000e-06
GCST004132_59	Crohn’s disease	4.000000e-11
GCST004599_155	Mean platelet volume	1.000000e-11
GCST006716_15	Alcohol use disorder (total score)	3.000000e-08
GCST007483_34	Waist-to-hip ratio adjusted for BMI (additive genetic model)	2.000000e-09
GCST007487_44	Waist-to-hip ratio adjusted for BMI (additive genetic model)	2.000000e-08
GCST007500_36	Waist-to-hip ratio adjusted for BMI (additive genetic model)	3.000000e-09
GCST007502_34	Waist-to-hip ratio adjusted for BMI (additive genetic model)	5.000000e-09
GCST007876_80	Estimated glomerular filtration rate	5.000000e-08
GCST008757_4	Alcohol consumption	3.000000e-15
GCST008790_58	Urinary albumin-to-creatinine ratio	2.000000e-14
GCST009731_12	Blood protein levels in cardiovascular risk	2.000000e-12
GCST009731_76	Blood protein levels in cardiovascular risk	6.000000e-10
GCST010132_5	Processed meat consumption	2.000000e-11
GCST010134_4	Non-oily fish consumption	3.000000e-16
GCST010135_4	Oily fish consumption	2.000000e-16
GCST010136_42	Fruit consumption	3.000000e-10
GCST010137_4	Cooked vegetable consumption	3.000000e-09
GCST010140_48	Pork consumption	2.000000e-16
GCST010142_1	Fish- and plant-related diet	7.000000e-13
GCST010142_45	Fish- and plant-related diet	3.000000e-08
GCST010142_68	Fish- and plant-related diet	6.000000e-10
GCST010143_10	Meat-related diet	4.000000e-09

EFO canonical traits (15, from GWAS)

EFO ID	Trait name
EFO:0004731	eye measurement
EFO:0003939	energy intake
EFO:0004620	vitamin B12 measurement
EFO:0004458	C-reactive protein measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0009458	alcohol use disorder measurement
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0007778	urinary albumin to creatinine ratio
EFO:0010621	obsolete_stromelysin‐2 measurement
EFO:0008137	galectin-3 measurement
EFO:0008111	diet measurement
EFO:0006925	lipoprotein A measurement
EFO:0004309	platelet count
EFO:0004736	aspartate aminotransferase measurement
EFO:0004532	serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, affects cotreatment	2
sodium arsenite	affects expression, increases expression	2
FR900359	increases phosphorylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
butyraldehyde	increases expression	1
isobutyl alcohol	affects cotreatment, increases abundance, increases expression	1
CGP 52608	affects binding, increases reaction	1
Sunitinib	increases expression	1
Vorinostat	decreases expression	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Arsenic	affects methylation	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Etoposide	affects response to substance	1
Gasoline	increases expression, affects cotreatment, increases abundance	1
Hydrogen Peroxide	affects expression	1
Phenolsulfonphthalein	affects cotreatment, increases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, increases abundance, increases expression	1
Zinc	decreases expression	1
8-Bromo Cyclic Adenosine Monophosphate	decreases expression	1
1-Butanol	affects cotreatment, increases abundance, increases expression	1
Particulate Matter	increases expression, affects cotreatment, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.