RASL10A

Summary

RASL10A (RAS like family 10 member A, HGNC:16954) is a protein-coding gene on chromosome 22q12.2, encoding Ras-like protein family member 10A (Q92737). Potent inhibitor of cellular proliferation.

Predicted to enable GTPase activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in nucleolus and plasma membrane.

Source: NCBI Gene 10633 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 27 total
• MANE Select transcript: NM_006477

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16954
Approved symbol	RASL10A
Name	RAS like family 10 member A
Location	22q12.2
Locus type	gene with protein product
Status	Approved
Aliases	RRP22
Ensembl gene	ENSG00000100276
Ensembl biotype	protein_coding
OMIM	602220
Entrez	10633

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000216101, ENST00000401450, ENST00000474590, ENST00000608559, ENST00000942940, ENST00000942941

RefSeq mRNA: 1 — MANE Select: NM_006477 NM_006477

CCDS: CCDS13854

Canonical transcript exons

ENST00000216101 — 3 exons

Exon	Start	End
ENSE00000652040	29313863	29313987
ENSE00000879733	29315028	29315697
ENSE00001326105	29312933	29313568

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 89.54.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2224 / max 66.7850, expressed in 320 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193518	0.7043	254
193517	0.2978	77
193519	0.1565	84
193515	0.0420	28
193516	0.0218	16

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
amygdala	UBERON:0001876	89.54	gold quality
middle temporal gyrus	UBERON:0002771	88.16	gold quality
Brodmann (1909) area 9	UBERON:0013540	88.02	gold quality
right frontal lobe	UBERON:0002810	87.66	gold quality
cingulate cortex	UBERON:0003027	87.23	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	87.11	gold quality
anterior cingulate cortex	UBERON:0009835	87.06	gold quality
temporal lobe	UBERON:0001871	87.02	gold quality
cortical plate	UBERON:0005343	86.54	gold quality
prefrontal cortex	UBERON:0000451	85.77	gold quality
frontal cortex	UBERON:0001870	84.86	gold quality
neocortex	UBERON:0001950	84.81	gold quality
nucleus accumbens	UBERON:0001882	84.65	gold quality
cerebral cortex	UBERON:0000956	84.35	gold quality
caudate nucleus	UBERON:0001873	84.26	gold quality
entorhinal cortex	UBERON:0002728	84.22	gold quality
Brodmann (1909) area 46	UBERON:0006483	83.92	gold quality
telencephalon	UBERON:0001893	83.80	gold quality
orbitofrontal cortex	UBERON:0004167	83.79	gold quality
putamen	UBERON:0001874	83.39	gold quality
Ammon’s horn	UBERON:0001954	83.02	gold quality
forebrain	UBERON:0001890	82.88	gold quality
superior frontal gyrus	UBERON:0002661	82.18	gold quality
primary visual cortex	UBERON:0002436	82.06	gold quality
Brodmann (1909) area 10	UBERON:0013541	81.84	silver quality
hypothalamus	UBERON:0001898	81.82	gold quality
endothelial cell	CL:0000115	81.31	silver quality
CA1 field of hippocampus	UBERON:0003881	80.89	gold quality
brain	UBERON:0000955	80.75	gold quality
central nervous system	UBERON:0001017	80.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.88

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting RASL10A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-6086	99.70	65.38	699
HSA-MIR-6832-3P	99.52	70.44	1726
HSA-MIR-3688-5P	99.12	69.67	1091
HSA-MIR-891A-3P	98.05	67.99	970
HSA-MIR-6072	98.00	66.47	804
HSA-MIR-6762-5P	96.55	64.62	972
HSA-MIR-6845-5P	96.55	64.65	969
HSA-MIR-7973	96.48	65.54	502
HSA-MIR-644A	96.02	66.52	786
HSA-MIR-6891-3P	95.80	65.76	683
HSA-MIR-6874-5P	95.73	64.94	545
HSA-MIR-1247-5P	85.92	61.07	65

Literature-anchored findings (GeneRIF, showing 4)

• RRP22 localizes to the nucleolus in a GTP-dependent manner and can serve as a potential tumor suppressor. (PMID:15833841)
• chromosome 22 have specific motor deficits in axial stability and graphomotor skills. (PMID:20646714)
• RRP22 is a special neural tumor suppressor for human astrocytomas (PMID:21264544)
• Both 5’-CpG island hypermethylation and histone modifications contribute to the frequent and prognostically unfavorable transcriptional downregulation of RRP22 in malignant gliomas. (PMID:21631628)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Rasl10a	ENSMUSG00000034209
rattus_norvegicus	Rasl10a	ENSRNOG00000008951

Paralogs (35): RALA (ENSG00000006451), REM1 (ENSG00000088320), RASD2 (ENSG00000100302), RASL12 (ENSG00000103710), RHEB (ENSG00000106615), RASD1 (ENSG00000108551), RERGL (ENSG00000111404), RAP1A (ENSG00000116473), RASL11A (ENSG00000122035), RAP2C (ENSG00000123728), RAP2A (ENSG00000125249), RRAS (ENSG00000126458), RAP1B (ENSG00000127314), RASL11B (ENSG00000128045), KRAS (ENSG00000133703), RRAS2 (ENSG00000133818), RERG (ENSG00000134533), REM2 (ENSG00000139890), RIT1 (ENSG00000143622), RALB (ENSG00000144118), RIT2 (ENSG00000152214), MRAS (ENSG00000158186), DIRAS3 (ENSG00000162595), GEM (ENSG00000164949), DIRAS2 (ENSG00000165023), RRAD (ENSG00000166592), RHEBL1 (ENSG00000167550), NKIRAS2 (ENSG00000168256), HRAS (ENSG00000174775), DIRAS1 (ENSG00000176490), RAP2B (ENSG00000181467), ERAS (ENSG00000187682), NKIRAS1 (ENSG00000197885), NRAS (ENSG00000213281), RASL10B (ENSG00000270885)

Protein

Protein identifiers

Ras-like protein family member 10A — Q92737 (reviewed: Q92737)

Alternative names: Ras-like protein RRP22, Ras-related protein on chromosome 22

All UniProt accessions (1): Q92737

UniProt curated annotations — full annotation on UniProt →

Function. Potent inhibitor of cellular proliferation.

Subcellular location. Cell membrane. Nucleus. Nucleolus.

Tissue specificity. Expression appears to be strictly limited to the central nervous system.

Post-translational modifications. Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.

Similarity. Belongs to the small GTPase superfamily. Ras family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q92737-1	1	yes
Q92737-2	2, B

RefSeq proteins (1): NP_006468* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR052661	Ras-like_GTPase_Reg	Family

Pfam: PF00071

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (11 total): binding site 3, chain 1, propeptide 1, sequence conflict 1, region of interest 1, short sequence motif 1, modified residue 1, lipid moiety-binding region 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92737-F1	81.77	0.55

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 11–18; 59–62; 129–132

Post-translational modifications (2): 200, 200

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 88 (showing top): BENPORATH_ES_WITH_H3K27ME3, CAGCTG_AP4_Q5, MODULE_66, MODULE_157, MODULE_113, MODULE_242, MODULE_11, GOBP_SMALL_GTPASE_MEDIATED_SIGNAL_TRANSDUCTION, CAGCCTC_MIR4855P, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, MULLIGHAN_MLL_SIGNATURE_2_DN, MODULE_104, DOANE_BREAST_CANCER_CLASSES_UP, GOCC_NUCLEOLUS, GOMF_GTPASE_ACTIVITY

GO Biological Process (1): small GTPase-mediated signal transduction (GO:0007264)

GO Molecular Function (5): GTPase activity (GO:0003924), G protein activity (GO:0003925), GTP binding (GO:0005525), nucleotide binding (GO:0000166), hydrolase activity (GO:0016787)

GO Cellular Component (4): nucleolus (GO:0005730), plasma membrane (GO:0005886), nucleus (GO:0005634), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular signaling cassette	1
ribonucleoside triphosphate phosphatase activity	1
GTPase activity	1
molecular function regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
catalytic activity	1
nuclear lumen	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1279 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RASL10A	GAS2L1	Q99501	922
RASL10A	AP1B1	P78436	888
RASL10A	GAS2L2	Q8NHY3	812
RASL10A	GAS2	O43903	787
RASL10A	SPA17	Q15506	763
RASL10A	EWSR1	Q01844	751
RASL10A	RASL12	Q9NYN1	494
RASL10A	RFPL1	O75677	417
RASL10A	AFTPH	Q6ULP2	341
RASL10A	GLT8D2	Q9H1C3	341
RASL10A	ARFGAP3	Q9NP61	314
RASL10A	ZBTB8A	Q96BR9	313
RASL10A	AGMAT	Q9BSE5	313
RASL10A	ZMAT5	Q9UDW3	307
RASL10A	RER1	O15258	305

IntAct

5 interactions, top by confidence:

A	B	Type	Score
	RASL10A	psi-mi:“MI:0915”(physical association)	0.560
RASL10A	PRKRA	psi-mi:“MI:0914”(association)	0.350
RASL10A		psi-mi:“MI:0915”(physical association)	0.000

BioGRID (16): RAP1GDS1 (Affinity Capture-MS), RAP1B (Affinity Capture-MS), RIC8B (Affinity Capture-MS), RHOA (Affinity Capture-MS), PRKRA (Affinity Capture-MS), RAP1GDS1 (Affinity Capture-MS), RHOA (Affinity Capture-MS), RAP1B (Affinity Capture-MS), PRKRA (Affinity Capture-MS), RASL10A (Synthetic Lethality), HOMEZ (Two-hybrid), PRKRA (Affinity Capture-MS), RAP1GDS1 (Affinity Capture-MS), RAP1B (Affinity Capture-MS), RHOA (Affinity Capture-MS)

ESM2 similar proteins: A1A5C7, A5D7B1, A6H7A0, A6NCF5, A6QLN9, A8MUP2, D3YYU8, D3ZZ80, O43688, O75147, O88843, P08887, Q14CX5, Q3SZQ2, Q3UHH2, Q58CT4, Q5EA19, Q5R4Q7, Q5R7S9, Q5RCI5, Q5RFN0, Q5SP67, Q5SUV1, Q642A6, Q6IA17, Q6PCB0, Q7TPB4, Q86TI4, Q8BGR6, Q8BZI6, Q8K5A4, Q8N5I2, Q8N653, Q8R2Z5, Q8TBF2, Q8VE98, Q92737, Q969P0, Q96NJ5, Q96NT3

Diamond homologs: A5A6J7, A6NIZ1, C4YKT4, E9R5S0, O35626, P01119, P0CY32, P11234, P13856, P18613, P22123, P22279, P36860, P52498, P61223, P61224, P62833, P62834, P62835, P62836, P79737, Q18246, Q19143, Q32NS2, Q4R379, Q4R9D4, Q4X241, Q550Q4, Q55BW0, Q59XU5, Q5R4B8, Q5RDM6, Q5ZHX1, Q5ZJW6, Q62636, Q640R7, Q6DGL2, Q6DGQ1, Q6IP71, Q6TEN1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

27 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	27
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

699 predictions. Top by Δscore:

Variant	Effect	Δscore
22:29313857:CCCTA:C	donor_loss	1.0000
22:29313862:C:CT	donor_loss	1.0000
22:29313983:CACTC:C	acceptor_gain	1.0000
22:29313985:CTC:C	acceptor_gain	1.0000
22:29315029:T:TA	donor_gain	1.0000
22:29313861:A:AC	donor_gain	0.9900
22:29313862:C:CC	donor_gain	0.9900
22:29313988:C:CC	acceptor_gain	0.9900
22:29315003:C:A	donor_gain	0.9900
22:29313986:TC:T	acceptor_gain	0.9800
22:29313987:CC:C	acceptor_gain	0.9800
22:29315013:T:A	donor_gain	0.9800
22:29314980:ACACC:A	donor_gain	0.9700
22:29314981:CACCC:C	donor_gain	0.9700
22:29314990:CA:C	donor_gain	0.9700
22:29315002:C:CA	donor_gain	0.9700
22:29315023:GCTA:G	donor_loss	0.9700
22:29315024:CTAC:C	donor_loss	0.9700
22:29315026:A:C	donor_loss	0.9700
22:29315027:C:CA	donor_loss	0.9700
22:29313569:C:CC	acceptor_gain	0.9600
22:29315029:TCCGG:T	donor_gain	0.9600
22:29313564:CCGGC:C	acceptor_gain	0.9500
22:29313565:CGGCC:C	acceptor_gain	0.9500
22:29313569:CTGGG:C	acceptor_loss	0.9500
22:29313570:T:A	acceptor_loss	0.9500
22:29313577:C:T	acceptor_gain	0.9500
22:29313984:ACTC:A	acceptor_gain	0.9500
22:29313985:CTCC:C	acceptor_gain	0.9500
22:29313986:TCCT:T	acceptor_gain	0.9500

AlphaMissense

1291 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:29313523:C:A	K130N	0.998
22:29313523:C:G	K130N	0.998
22:29313526:G:C	N129K	0.998
22:29313526:G:T	N129K	0.998
22:29313907:A:C	S100R	0.998
22:29313907:A:T	S100R	0.998
22:29313909:T:G	S100R	0.998
22:29313434:G:A	S160F	0.997
22:29313926:T:A	D94V	0.997
22:29313935:A:T	L91H	0.997
22:29315077:A:T	I57N	0.997
22:29313436:G:C	C159W	0.996
22:29313525:T:C	K130E	0.996
22:29313530:C:T	G128D	0.996
22:29315077:A:G	I57T	0.996
22:29315176:A:G	F24S	0.996
22:29315197:T:A	K17M	0.996
22:29315200:C:A	G16V	0.996
22:29313431:G:T	A161D	0.995
22:29313524:T:A	K130M	0.995
22:29313932:A:T	V92D	0.995
22:29313434:G:T	S160Y	0.994
22:29313441:C:T	E158K	0.994
22:29313457:C:A	W152C	0.994
22:29313457:C:G	W152C	0.994
22:29313930:A:C	Y93D	0.994
22:29313938:A:T	V90E	0.994
22:29315188:A:T	I20N	0.994
22:29315200:C:T	G16D	0.994
22:29315216:C:G	G11R	0.994

dbSNP variants (sampled 300 via entrez): RS1000001882 (22:29318208 T>C,G), RS1000142819 (22:29315986 C>T), RS1000520114 (22:29318002 A>C), RS1000865897 (22:29316166 A>G), RS1001123125 (22:29316680 T>C), RS1001554584 (22:29316953 G>T), RS1001565668 (22:29313489 G>C,T), RS1002604041 (22:29314168 G>A), RS1002668764 (22:29315472 C>T), RS1003334607 (22:29314499 C>G,T), RS1003867283 (22:29321346 G>A), RS1003893016 (22:29319000 T>G), RS1003902260 (22:29314781 A>G), RS1003962936 (22:29314121 T>C), RS1003963416 (22:29321083 C>T)

Disease associations

OMIM: gene MIM:602220 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST002553_2	Pancreatic cancer	1.000000e-08
GCST004599_220	Mean platelet volume	3.000000e-12
GCST90002395_618	Mean platelet volume	3.000000e-30

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic Trioxide	decreases expression	2
Benzo(a)pyrene	increases methylation, increases expression	2
Valproic Acid	increases expression, affects expression	2
aristolochic acid I	increases expression	1
butyraldehyde	increases expression	1
abrine	increases expression	1
licochalcone B	increases expression	1
(+)-JQ1 compound	decreases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Cisplatin	affects expression	1
Dinitrochlorobenzene	affects binding	1
Melphalan	increases expression	1
Smoke	decreases expression	1
Tretinoin	increases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.