RASL10B

Summary

RASL10B (RAS like family 10 member B, HGNC:30295) is a protein-coding gene on chromosome 17q12, encoding Ras-like protein family member 10B (Q96S79). May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Predicted to enable G protein activity and GTP binding activity. Predicted to be involved in positive regulation of peptide hormone secretion and regulation of systemic arterial blood pressure by atrial natriuretic peptide. Predicted to be located in plasma membrane.

Source: NCBI Gene 91608 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 22 total
• MANE Select transcript: NM_033315

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30295
Approved symbol	RASL10B
Name	RAS like family 10 member B
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	VTS58635, RRP17
Ensembl gene	ENSG00000270885
Ensembl biotype	protein_coding
OMIM	612128
Entrez	91608

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000603017, ENST00000603498, ENST00000899282, ENST00000932375, ENST00000932376, ENST00000932377, ENST00000949794, ENST00000949795

RefSeq mRNA: 1 — MANE Select: NM_033315 NM_033315

CCDS: CCDS11297

Canonical transcript exons

ENST00000603017 — 4 exons

Exon	Start	End
ENSE00003476579	35735038	35735400
ENSE00003517820	35731639	35731878
ENSE00003631760	35740409	35740533
ENSE00003671969	35741035	35743521

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 95.86.

FANTOM5 (CAGE): breadth broad, TPM avg 5.3057 / max 168.1756, expressed in 881 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160373	5.1282	873
160374	0.1243	57
208133	0.0532	19

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney epithelium	UBERON:0004819	95.86	silver quality
nasal cavity epithelium	UBERON:0005384	93.69	gold quality
vena cava	UBERON:0004087	92.96	silver quality
left ventricle myocardium	UBERON:0006566	92.48	silver quality
cardiac muscle of right atrium	UBERON:0003379	92.17	silver quality
lateral nuclear group of thalamus	UBERON:0002736	91.12	gold quality
nucleus accumbens	UBERON:0001882	90.74	gold quality
parotid gland	UBERON:0001831	90.61	silver quality
putamen	UBERON:0001874	90.48	gold quality
body of tongue	UBERON:0011876	90.38	silver quality
amygdala	UBERON:0001876	89.39	gold quality
substantia nigra pars compacta	UBERON:0001965	89.23	gold quality
dorsal plus ventral thalamus	UBERON:0001897	89.07	gold quality
pons	UBERON:0000988	89.03	gold quality
caudate nucleus	UBERON:0001873	88.95	gold quality
substantia nigra pars reticulata	UBERON:0001966	88.85	gold quality
subthalamic nucleus	UBERON:0001906	88.71	silver quality
lateral globus pallidus	UBERON:0002476	88.68	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	88.61	gold quality
anterior cingulate cortex	UBERON:0009835	88.31	gold quality
myocardium	UBERON:0002349	88.20	silver quality
epithelial cell of pancreas	CL:0000083	88.02	silver quality
pharyngeal mucosa	UBERON:0000355	87.97	silver quality
prefrontal cortex	UBERON:0000451	87.97	gold quality
cerebellar vermis	UBERON:0004720	87.82	gold quality
tongue	UBERON:0001723	87.52	silver quality
heart right ventricle	UBERON:0002080	87.29	silver quality
right frontal lobe	UBERON:0002810	87.07	gold quality
pericardium	UBERON:0002407	87.04	silver quality
medulla oblongata	UBERON:0001896	86.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.28

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

107 targeting RASL10B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-4487	99.96	64.58	1252
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-4447	99.85	67.81	2900
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-6842-5P	99.80	67.54	1587
HSA-MIR-7110-5P	99.80	67.84	1712
HSA-MIR-6745	99.74	65.33	1321
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-3660	99.68	67.33	1149
HSA-MIR-4526	99.68	67.07	1136
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-1249-5P	99.61	66.55	2049
HSA-MIR-6797-5P	99.61	66.55	2084
HSA-MIR-6752-5P	99.59	67.32	1243

Literature-anchored findings (GeneRIF, showing 2)

• RasL10B is a new member of Ras superfamily with tumor suppressor potential (PMID:17028781)
• RRP17 is a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues (PMID:17984325)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	RASL10B	ENSDARG00000109436
mus_musculus	Rasl10b	ENSMUSG00000020684
rattus_norvegicus	Rasl10b	ENSRNOG00000010302

Paralogs (35): RALA (ENSG00000006451), REM1 (ENSG00000088320), RASL10A (ENSG00000100276), RASD2 (ENSG00000100302), RASL12 (ENSG00000103710), RHEB (ENSG00000106615), RASD1 (ENSG00000108551), RERGL (ENSG00000111404), RAP1A (ENSG00000116473), RASL11A (ENSG00000122035), RAP2C (ENSG00000123728), RAP2A (ENSG00000125249), RRAS (ENSG00000126458), RAP1B (ENSG00000127314), RASL11B (ENSG00000128045), KRAS (ENSG00000133703), RRAS2 (ENSG00000133818), RERG (ENSG00000134533), REM2 (ENSG00000139890), RIT1 (ENSG00000143622), RALB (ENSG00000144118), RIT2 (ENSG00000152214), MRAS (ENSG00000158186), DIRAS3 (ENSG00000162595), GEM (ENSG00000164949), DIRAS2 (ENSG00000165023), RRAD (ENSG00000166592), RHEBL1 (ENSG00000167550), NKIRAS2 (ENSG00000168256), HRAS (ENSG00000174775), DIRAS1 (ENSG00000176490), RAP2B (ENSG00000181467), ERAS (ENSG00000187682), NKIRAS1 (ENSG00000197885), NRAS (ENSG00000213281)

Protein

Protein identifiers

Ras-like protein family member 10B — Q96S79 (reviewed: Q96S79)

Alternative names: Ras-like protein VTS58635, Ras-related protein 17

All UniProt accessions (1): Q96S79

UniProt curated annotations — full annotation on UniProt →

Function. May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.

Subunit / interactions. Interacts with CADPS.

Subcellular location. Cell membrane.

Tissue specificity. Expressed at high levels in skeletal muscle and, at much lower levels, in heart, brain and pancreas.

Similarity. Belongs to the small GTPase superfamily. Ras family.

RefSeq proteins (1): NP_201572* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001806	Small_GTPase	Family
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR052661	Ras-like_GTPase_Reg	Family

Pfam: PF00071

Catalyzed reactions (Rhea), 1 shown:

• GTP + H2O = GDP + phosphate + H(+) (RHEA:19669)

UniProt features (11 total): binding site 3, chain 1, propeptide 1, sequence conflict 1, region of interest 1, short sequence motif 1, modified residue 1, lipid moiety-binding region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96S79-F1	87.14	0.70

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 11–18; 59–62; 128–131

Post-translational modifications (2): 200, 200

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 97 (showing top): GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE, GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_HORMONE_TRANSPORT, AP4_Q6, LHX3_01, CHX10_01, CAGCTG_AP4_Q5, GOBP_CELL_CELL_SIGNALING, HEN1_01, GOBP_SECRETION, GOBP_POSITIVE_REGULATION_OF_HORMONE_SECRETION, GOBP_SIGNAL_RELEASE, AFP1_Q6

GO Biological Process (2): regulation of systemic arterial blood pressure by atrial natriuretic peptide (GO:0003050), positive regulation of peptide hormone secretion (GO:0090277)

GO Molecular Function (6): G protein activity (GO:0003925), GTP binding (GO:0005525), nucleotide binding (GO:0000166), GTPase activity (GO:0003924), protein binding (GO:0005515), hydrolase activity (GO:0016787)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
regulation of systemic arterial blood pressure by hormone	1
positive regulation of peptide secretion	1
peptide hormone secretion	1
positive regulation of hormone secretion	1
regulation of peptide hormone secretion	1
GTPase activity	1
molecular function regulator activity	1
guanyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
ribonucleoside triphosphate phosphatase activity	1
binding	1
catalytic activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1492 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RASL10B	CADPS	Q9ULU8	826
RASL10B	ETNPPL	Q8TBG4	628
RASL10B	NPPA	P01160	598
RASL10B	SCPEP1	Q9HB40	476
RASL10B	OR51T1	Q8NGJ9	436
RASL10B	DEPDC7	Q96QD5	428
RASL10B	RASL12	Q9NYN1	427
RASL10B	UTS2R	Q9UKP6	421
RASL10B	SLCO6A1	Q86UG4	421
RASL10B	C3orf22	Q8N5N4	419
RASL10B	SMTNL2	Q2TAL5	419
RASL10B	ABHD12B	Q7Z5M8	412
RASL10B	TMEM47	Q9BQJ4	405
RASL10B	OR2M2	Q96R28	396
RASL10B	RNASE12	Q5GAN4	392

IntAct

16 interactions, top by confidence:

A	B	Type	Score
MAPK9	RASL10B	psi-mi:“MI:0915”(physical association)	0.670
RASL10B	AHCYL1	psi-mi:“MI:0914”(association)	0.530
RASL10B	NDUFS3	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	CFTR	psi-mi:“MI:0915”(physical association)	0.370
AKT1	RASL10B	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	BAG4	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	FGFR2	psi-mi:“MI:0915”(physical association)	0.370
FGFR4	RASL10B	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	PARP1	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	PAX2	psi-mi:“MI:0915”(physical association)	0.370
TSG101	RASL10B	psi-mi:“MI:0915”(physical association)	0.370
RASL10B	VWA8	psi-mi:“MI:0914”(association)	0.350
MAPK9	RASL10B	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (69): RASL10B (Two-hybrid), RASL10B (Two-hybrid), RASL10B (Two-hybrid), RASL10B (Two-hybrid), RASL10B (Two-hybrid), RASL10B (Two-hybrid), RASL10B (Two-hybrid), AHCYL2 (Affinity Capture-MS), MMADHC (Affinity Capture-MS), FAM192A (Affinity Capture-MS), PSME3 (Affinity Capture-MS), AHCYL1 (Affinity Capture-MS), ZNF507 (Affinity Capture-MS), MAPK9 (Affinity Capture-MS), HSPD1 (Affinity Capture-MS)

ESM2 similar proteins: A0A2R8QFQ6, A0A2R8RWN9, A0JN27, D3K5L7, E2R222, E9Q9D5, O89050, O95057, P40938, Q28D01, Q2HJ19, Q2TBV1, Q5EA19, Q5PR73, Q5R573, Q5R6S2, Q5RB35, Q5RFN0, Q5SP67, Q5SRY7, Q5SSG5, Q5XHZ9, Q5XIJ5, Q5ZJW6, Q5ZJX1, Q62956, Q67FW5, Q6DGQ1, Q6T311, Q8BGR6, Q8BTG7, Q8CEC5, Q8K5A4, Q91854, Q91Z61, Q92737, Q95KD9, Q96GS6, Q96HU8, Q96S79

Diamond homologs: A1DZY4, A6QP66, A8NU18, C4YL11, E9R5S0, G4MZY8, O04486, O14807, O35929, O35963, O42277, O42785, O88667, P01117, P01119, P01120, P08647, P0CQ42, P0CQ43, P0CY30, P0CY31, P19892, P20791, P22278, P22279, P22280, P25378, P28775, P32253, P32254, P34143, P35288, P36861, P48555, P51153, P55042, P55043, P59279, P62070, P62071

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

22 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	21
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

625 predictions. Top by Δscore:

Variant	Effect	Δscore
17:35740529:ACGAG:A	donor_loss	1.0000
17:35740530:CGAG:C	donor_loss	1.0000
17:35740531:GAGG:G	donor_loss	1.0000
17:35740532:AGGT:A	donor_loss	1.0000
17:35740535:T:G	donor_loss	1.0000
17:35741030:CACA:C	acceptor_loss	1.0000
17:35741032:CAGG:C	acceptor_loss	1.0000
17:35741033:A:AG	acceptor_gain	1.0000
17:35741033:AG:A	acceptor_gain	1.0000
17:35741033:AGG:A	acceptor_gain	1.0000
17:35741033:AGGGT:A	acceptor_gain	1.0000
17:35741034:G:GG	acceptor_gain	1.0000
17:35741034:GG:G	acceptor_gain	1.0000
17:35741034:GGG:G	acceptor_gain	1.0000
17:35741034:GGGT:G	acceptor_gain	1.0000
17:35741034:GGGTG:G	acceptor_gain	1.0000
17:35731877:GG:G	donor_gain	0.9900
17:35731878:GG:G	donor_gain	0.9900
17:35731878:GGT:G	donor_loss	0.9900
17:35731879:G:GG	donor_gain	0.9900
17:35731879:GTAA:G	donor_loss	0.9900
17:35731880:T:A	donor_loss	0.9900
17:35735397:CCAGG:C	donor_loss	0.9900
17:35735398:CAG:C	donor_loss	0.9900
17:35735399:AGG:A	donor_loss	0.9900
17:35735401:G:GC	donor_loss	0.9900
17:35735402:T:A	donor_loss	0.9900
17:35738699:GGA:G	donor_gain	0.9900
17:35740404:TGCAG:T	acceptor_loss	0.9900
17:35740405:GCAGG:G	acceptor_loss	0.9900

AlphaMissense

1318 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:35740487:A:C	S99R	0.998
17:35740489:C:A	S99R	0.998
17:35740489:C:G	S99R	0.998
17:35741080:G:C	K129N	0.997
17:35741080:G:T	K129N	0.997
17:35741144:T:A	W151R	0.997
17:35741144:T:C	W151R	0.997
17:35735269:T:C	F29L	0.996
17:35735271:C:A	F29L	0.996
17:35735271:C:G	F29L	0.996
17:35740464:T:A	V91D	0.996
17:35740470:A:T	D93V	0.996
17:35740512:G:C	R107P	0.996
17:35741067:T:A	I125N	0.996
17:35741073:G:A	G127D	0.996
17:35741077:C:A	N128K	0.996
17:35741077:C:G	N128K	0.996
17:35741167:C:G	C158W	0.996
17:35735215:G:A	G11R	0.995
17:35735215:G:C	G11R	0.995
17:35735354:T:C	I57T	0.995
17:35735215:G:T	G11W	0.994
17:35735216:G:A	G11E	0.994
17:35735231:G:A	G16D	0.994
17:35740491:T:C	F100S	0.994
17:35741070:T:A	V126E	0.994
17:35741078:A:G	K129E	0.994
17:35741165:T:C	C158R	0.994
17:35741172:C:A	A160D	0.994
17:35735234:A:T	K17M	0.993

dbSNP variants (sampled 300 via entrez): RS1000820520 (17:35738713 A>T), RS1000851786 (17:35738961 G>T), RS1001258463 (17:35737692 A>G), RS1001416129 (17:35731681 G>C), RS1002090495 (17:35742675 G>C,T), RS1002546274 (17:35742946 G>A,T), RS1002855512 (17:35736330 C>G), RS1002929082 (17:35736516 G>A), RS1003188662 (17:35734657 A>T), RS1003261274 (17:35735071 C>A,G,T), RS1003490844 (17:35730641 C>G,T), RS1003815731 (17:35741531 T>G), RS1004047500 (17:35742975 G>A), RS1004136200 (17:35736368 C>G), RS1004174987 (17:35741304 G>A)

Disease associations

OMIM: gene MIM:612128 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST007001_12	Cerebrospinal AB1-42 levels in normal cognition	4.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	2
(+)-JQ1 compound	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
aristolochic acid I	increases expression	1
aminomethylphosphonic acid (AMPA)	decreases expression	1
methyleugenol	decreases expression	1
2,4,5,2’,4’,5’-hexachlorobiphenyl	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
3,4,5,3’,4’-pentachlorobiphenyl	decreases expression	1
perfluorooctanoic acid	decreases expression	1
CD 437	decreases expression	1
2,2’,4,4’-tetrabromodiphenyl ether	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Tretinoin	increases expression	1
Triclosan	decreases expression	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
1-Methyl-4-phenylpyridinium	increases expression	1
Aflatoxin B1	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.