RASSF1-AS1

Summary

RASSF1-AS1 (RASSF1 antisense RNA 1, HGNC:49091) is a long non-coding RNA gene on chromosome 3p21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49091
Approved symbol	RASSF1-AS1
Name	RASSF1 antisense RNA 1
Location	3p21.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	ANRASSF1
Ensembl gene	ENSG00000281358
Ensembl biotype	lncRNA
Entrez	102060282
RNAcentral	URS000031B4E0 — lncRNA, 790 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000629828, ENST00000730284

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000629828 — 1 exons

Exon	Start	End
ENSE00004058684	50337425	50338300

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 83.72.

FANTOM5 (CAGE): breadth broad, TPM avg 0.6057 / max 25.0367, expressed in 313 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36729	0.6057	313

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	83.72	gold quality
monocyte	CL:0000576	77.65	gold quality
leukocyte	CL:0000738	77.40	gold quality
bone marrow cell	CL:0002092	72.14	gold quality
blood	UBERON:0000178	69.89	gold quality
buccal mucosa cell	CL:0002336	68.27	gold quality
spleen	UBERON:0002106	66.65	gold quality
hindlimb stylopod muscle	UBERON:0004252	66.03	gold quality
bone marrow	UBERON:0002371	64.97	gold quality
stromal cell of endometrium	CL:0002255	63.87	gold quality
colonic epithelium	UBERON:0000397	63.78	silver quality
right lobe of liver	UBERON:0001114	63.11	gold quality
parotid gland	UBERON:0001831	63.11	gold quality
right adrenal gland cortex	UBERON:0035827	62.62	gold quality
corpus epididymis	UBERON:0004359	61.92	silver quality
right adrenal gland	UBERON:0001233	61.55	gold quality
vermiform appendix	UBERON:0001154	61.42	gold quality
adipose tissue	UBERON:0001013	61.41	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.28	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.96	gold quality
mucosa of transverse colon	UBERON:0004991	60.92	gold quality
cortical plate	UBERON:0005343	60.72	gold quality
adenohypophysis	UBERON:0002196	60.63	gold quality
omental fat pad	UBERON:0010414	60.30	gold quality
left uterine tube	UBERON:0001303	60.28	gold quality
peritoneum	UBERON:0002358	60.24	gold quality
adipose tissue of abdominal region	UBERON:0007808	60.17	gold quality
pituitary gland	UBERON:0000007	60.15	gold quality
mucosa of stomach	UBERON:0001199	60.08	gold quality
ganglionic eminence	UBERON:0004023	59.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.10

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer. (PMID:30834580)
• Results found ANRASSF1 expression levels increased in breast cancer cell lines (BCC). (PMID:31062660)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.