RASSF8-AS1

Summary

RASSF8-AS1 (RASSF8 antisense RNA 1, HGNC:48637) is a long non-coding RNA gene on chromosome 12p12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48637
Approved symbol	RASSF8-AS1
Name	RASSF8 antisense RNA 1
Location	12p12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000246695
Ensembl biotype	lncRNA
Entrez	100506451
RNAcentral	URS000075DAC8 — lncRNA, 977 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 33 — 33 lncRNA

ENST00000500102, ENST00000500276, ENST00000502069, ENST00000535436, ENST00000537801, ENST00000542086, ENST00000545226, ENST00000545729, ENST00000546134, ENST00000656802, ENST00000657944, ENST00000658700, ENST00000660703, ENST00000663256, ENST00000663439, ENST00000665934, ENST00000669929, ENST00000670839, ENST00000671391, ENST00000671454, ENST00000773027, ENST00000773028, ENST00000773029, ENST00000773030, ENST00000773031, ENST00000773032, ENST00000773033, ENST00000773034, ENST00000773035, ENST00000773036, ENST00000773037, ENST00000773038, ENST00000773039

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000500102 — 4 exons

Exon	Start	End
ENSE00001967668	25954921	25955241
ENSE00001984456	25957453	25957585
ENSE00001992057	25956227	25956347
ENSE00002243619	25956639	25956761

Expression profiles

Bgee: expression breadth ubiquitous, 215 present calls, max score 87.46.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2797 / max 4.6914, expressed in 132 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
130195	0.1473	61
130194	0.1325	34

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adenohypophysis	UBERON:0002196	87.46	gold quality
pituitary gland	UBERON:0000007	86.72	gold quality
cartilage tissue	UBERON:0002418	86.20	silver quality
adult mammalian kidney	UBERON:0000082	85.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.24	gold quality
caput epididymis	UBERON:0004358	84.81	gold quality
stromal cell of endometrium	CL:0002255	84.52	gold quality
sural nerve	UBERON:0015488	84.52	gold quality
kidney	UBERON:0002113	83.84	gold quality
metanephros cortex	UBERON:0010533	83.77	gold quality
pigmented layer of retina	UBERON:0001782	83.62	gold quality
right adrenal gland cortex	UBERON:0035827	83.39	gold quality
left adrenal gland	UBERON:0001234	83.35	gold quality
left adrenal gland cortex	UBERON:0035825	83.34	gold quality
right adrenal gland	UBERON:0001233	83.31	gold quality
cortex of kidney	UBERON:0001225	83.01	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.98	gold quality
adrenal cortex	UBERON:0001235	82.66	gold quality
adrenal gland	UBERON:0002369	82.17	gold quality
spinal cord	UBERON:0002240	82.10	gold quality
hindlimb stylopod muscle	UBERON:0004252	82.03	gold quality
right atrium auricular region	UBERON:0006631	81.36	gold quality
left ovary	UBERON:0002119	81.29	gold quality
muscle of leg	UBERON:0001383	81.06	gold quality
renal medulla	UBERON:0000362	80.82	gold quality
amygdala	UBERON:0001876	80.68	gold quality
gastrocnemius	UBERON:0001388	80.63	gold quality
tibia	UBERON:0000979	80.40	gold quality
germinal epithelium of ovary	UBERON:0001304	80.34	gold quality
right ovary	UBERON:0002118	80.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• lncRNA RASSF8AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR664b3p/TLE1 axis. (PMID:33000257)
• RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration. (PMID:35839610)
• A RASSF8-AS1 based exosomal lncRNAs panel used for diagnostic and prognostic biomarkers for esophageal squamous cell carcinoma. (PMID:36266257)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.