RB1-DT

Summary

RB1-DT (RB1 divergent transcript, HGNC:42778) is a long non-coding RNA gene on chromosome 13q14.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42778
Approved symbol	RB1-DT
Name	RB1 divergent transcript
Location	13q14.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	ncRNA-RB1
Ensembl gene	ENSG00000231473
Ensembl biotype	lncRNA
Entrez	100862704
RNAcentral	URS0000E60ABC — lncRNA, 1184 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 19 lncRNA

ENST00000433480, ENST00000436963, ENST00000669900, ENST00000700890, ENST00000700897, ENST00000701097, ENST00000718572, ENST00000718573, ENST00000718574, ENST00000718575, ENST00000718576, ENST00000718577, ENST00000718578, ENST00000718579, ENST00000718580, ENST00000718581, ENST00000718582, ENST00000718583, ENST00000718584

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000433480 — 3 exons

Exon	Start	End
ENSE00001699283	48302339	48302492
ENSE00004035462	48303291	48303723
ENSE00004035477	48296111	48297130

Expression profiles

Bgee: expression breadth ubiquitous, 156 present calls, max score 93.53.

FANTOM5 (CAGE): breadth broad, TPM avg 1.1071 / max 25.0981, expressed in 505 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
137250	0.7365	348
137249	0.3706	164

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.53	gold quality
buccal mucosa cell	CL:0002336	85.14	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.59	gold quality
sperm	CL:0000019	77.68	gold quality
left testis	UBERON:0004533	69.96	gold quality
right testis	UBERON:0004534	69.21	gold quality
testis	UBERON:0000473	68.19	gold quality
ventricular zone	UBERON:0003053	67.33	gold quality
right uterine tube	UBERON:0001302	67.27	gold quality
bone marrow cell	CL:0002092	66.67	silver quality
calcaneal tendon	UBERON:0003701	62.23	gold quality
bronchial epithelial cell	CL:0002328	62.21	gold quality
tendon	UBERON:0000043	61.49	gold quality
bronchus	UBERON:0002185	61.22	gold quality
granulocyte	CL:0000094	60.98	gold quality
tendon of biceps brachii	UBERON:0008188	59.95	gold quality
endothelial cell	CL:0000115	58.43	gold quality
islet of Langerhans	UBERON:0000006	58.07	gold quality
upper leg skin	UBERON:0004262	57.80	silver quality
leukocyte	CL:0000738	57.64	gold quality
monocyte	CL:0000576	57.36	gold quality
ganglionic eminence	UBERON:0004023	56.53	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.40	silver quality
right lung	UBERON:0002167	55.07	gold quality
right lobe of liver	UBERON:0001114	53.95	gold quality
prefrontal cortex	UBERON:0000451	53.93	gold quality
lymph node	UBERON:0000029	53.77	gold quality
epithelium of nasopharynx	UBERON:0001951	53.75	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.63	gold quality
left ovary	UBERON:0002119	53.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.72

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The epigenetic interaction between Linc00441 and bidirectional transcripted neighbor RB1 may be a de novo theory cutting-point for the inactivation of RB1 in HCC. (PMID:28300839)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.