RBAKDN

Summary

RBAKDN (RBAK downstream neighbor, HGNC:33770) is a protein-coding gene on chromosome 7p22.1, encoding RBAK downstream neighbor protein (A6NC62).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33770
Approved symbol	RBAKDN
Name	RBAK downstream neighbor
Location	7p22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273313
Ensembl biotype	protein_coding
Entrez	389458
RNAcentral	URS000075C759 — lncRNA, 599 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000498308

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498308 — 3 exons

Exon	Start	End
ENSE00001845464	5072125	5072200
ENSE00001859903	5072922	5073223
ENSE00003499656	5072362	5072497

Expression profiles

Bgee: expression breadth ubiquitous, 119 present calls, max score 99.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.7552 / max 672.5677, expressed in 45 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77087	0.7188	42
77086	0.0203	3
77085	0.0161	5

Top tissues by expression

119 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	99.55	gold quality
testis	UBERON:0000473	99.20	gold quality
right testis	UBERON:0004534	99.02	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.32	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.10	gold quality
hypothalamus	UBERON:0001898	73.02	gold quality
granulocyte	CL:0000094	68.94	gold quality
ganglionic eminence	UBERON:0004023	65.90	gold quality
ventricular zone	UBERON:0003053	64.91	gold quality
temporal lobe	UBERON:0001871	64.72	gold quality
amygdala	UBERON:0001876	64.66	gold quality
muscle tissue	UBERON:0002385	63.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	62.91	gold quality
nucleus accumbens	UBERON:0001882	62.39	gold quality
skeletal muscle tissue	UBERON:0001134	62.18	gold quality
skin of leg	UBERON:0001511	62.03	gold quality
zone of skin	UBERON:0000014	61.65	gold quality
skin of abdomen	UBERON:0001416	61.14	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	61.09	gold quality
tibial artery	UBERON:0007610	61.05	gold quality
popliteal artery	UBERON:0002250	61.03	gold quality
ectocervix	UBERON:0012249	61.00	gold quality
hindlimb stylopod muscle	UBERON:0004252	60.64	gold quality
bone marrow	UBERON:0002371	60.63	gold quality
tibial nerve	UBERON:0001323	60.33	gold quality
prefrontal cortex	UBERON:0000451	59.60	gold quality
right lung	UBERON:0002167	59.60	gold quality
endocervix	UBERON:0000458	59.56	gold quality
anterior cingulate cortex	UBERON:0009835	59.41	gold quality
blood	UBERON:0000178	59.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.39

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

RBAK downstream neighbor protein — A6NC62 (reviewed: A6NC62)

All UniProt accessions (1): A6NC62

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Secreted.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

UniProt features (4 total): signal peptide 1, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-A6NC62-F1	55.03	0.00

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 7 (showing top): chr7p22, NOUSHMEHR_GBM_GERMLINE_MUTATED, KLF7_TARGET_GENES, NFE2L1_TARGET_GENES, GSE15659_TREG_VS_TCONV_UP, ZNF680_TARGET_GENES, GSE37416_CTRL_VS_0H_F_TULARENSIS_LVS_NEUTROPHIL_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (1): extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A2RUT3, A6NC62, A6NHS1, A8MTW9, B2KGE5, C9JUS6, C9JVW0, F1MQW7, H3BQW9, I3L1E1, O09800, O75474, O75638, O95411, P0C678, P0C685, P0C689, P0C7X2, P19998, P20975, P20976, P20977, P57738, P70339, Q08648, Q67923, Q69027, Q69604, Q69607, Q6NUI1, Q6P050, Q6PDA7, Q6UYE1, Q6ZSJ8, Q6ZTI0, Q80IU5, Q81163, Q86SI9, Q8CHZ8, Q8K1M5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

209 predictions. Top by Δscore:

Variant	Effect	Δscore
7:5072473:G:GT	donor_gain	1.0000
7:5072474:A:T	donor_gain	1.0000
7:5072522:G:T	donor_gain	1.0000
7:5072360:A:AG	acceptor_gain	0.9900
7:5072361:G:GG	acceptor_gain	0.9900
7:5072361:GCC:G	acceptor_gain	0.9900
7:5072360:AGCC:A	acceptor_gain	0.9800
7:5072361:GCCG:G	acceptor_gain	0.9800
7:5072533:G:GT	donor_gain	0.9800
7:5072358:ACAG:A	acceptor_loss	0.9700
7:5072359:CA:C	acceptor_loss	0.9700
7:5072361:GCCGC:G	acceptor_gain	0.9700
7:5072477:GCCT:G	donor_gain	0.9600
7:5072493:CCAAG:C	donor_loss	0.9600
7:5072494:CAAG:C	donor_loss	0.9600
7:5072495:AAGGT:A	donor_loss	0.9600
7:5072496:AGGTT:A	donor_loss	0.9600
7:5072497:GGTTT:G	donor_loss	0.9600
7:5072498:G:A	donor_loss	0.9600
7:5072499:T:G	donor_loss	0.9600
7:5072361:GC:G	acceptor_gain	0.9500
7:5072518:G:GT	donor_gain	0.9500
7:5072356:C:CA	acceptor_gain	0.9400
7:5072356:CGACA:C	acceptor_gain	0.9400
7:5072357:GACAG:G	acceptor_gain	0.9400
7:5072522:G:GT	donor_gain	0.9300
7:5072360:AGCCG:A	acceptor_gain	0.9200
7:5072492:TCCAA:T	donor_loss	0.9200
7:5072921:GGA:G	acceptor_gain	0.9200
7:5072361:G:T	acceptor_gain	0.9100

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1001053797 (7:5071354 A>G), RS1001623452 (7:5072749 C>A), RS1004133434 (7:5071959 G>A,C,T), RS1005560359 (7:5072156 C>A,G), RS1005861303 (7:5073142 G>A,T), RS1006116083 (7:5070630 G>A), RS1006978413 (7:5073073 C>T), RS1007075317 (7:5073538 C>T), RS1007859059 (7:5070855 T>C), RS1008325820 (7:5071059 T>C), RS1008901397 (7:5070141 C>G,T), RS1010396669 (7:5072456 C>A,T), RS1010858406 (7:5070384 G>A,C), RS1011222963 (7:5070222 A>C), RS1012030459 (7:5070661 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
Benzo(a)pyrene	affects methylation	1
Smoke	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.