RBKS

Summary

RBKS (ribokinase, HGNC:30325) is a protein-coding gene on chromosome 2p23.2, encoding Ribokinase (Q9H477). Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium.

This gene encodes a member of the carbohydrate kinase PfkB family. The encoded protein phosphorylates ribose to form ribose-5-phosphate in the presence of ATP and magnesium as a first step in ribose metabolism. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 64080 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 40 total
• MANE Select transcript: NM_022128

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30325
Approved symbol	RBKS
Name	ribokinase
Location	2p23.2
Locus type	gene with protein product
Status	Approved
Aliases	DKFZp686G13268, RBSK
Ensembl gene	ENSG00000171174
Ensembl biotype	protein_coding
OMIM	611132
Entrez	64080

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 nonsense_mediated_decay

ENST00000302188, ENST00000449378, ENST00000453412, ENST00000458185, ENST00000861376, ENST00000861377

RefSeq mRNA: 2 — MANE Select: NM_022128 NM_001287580, NM_022128

CCDS: CCDS1762

Canonical transcript exons

ENST00000302188 — 8 exons

Exon	Start	End
ENSE00001260853	27781379	27781788
ENSE00001260860	27890257	27890387
ENSE00003530674	27832686	27832777
ENSE00003531362	27858439	27858571
ENSE00003570329	27843067	27843231
ENSE00003601136	27827567	27827755
ENSE00003607822	27848034	27848097
ENSE00003608648	27847042	27847104

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 93.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.2606 / max 156.7750, expressed in 1501 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
27538	3.5905	1418
27540	0.4339	144
27539	0.1262	52
27537	0.0723	12
202129	0.0377	8

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	93.99	gold quality
nephron tubule	UBERON:0001231	93.13	gold quality
bronchial epithelial cell	CL:0002328	93.10	gold quality
right adrenal gland	UBERON:0001233	92.78	gold quality
left adrenal gland	UBERON:0001234	92.71	gold quality
left adrenal gland cortex	UBERON:0035825	92.68	gold quality
right adrenal gland cortex	UBERON:0035827	92.07	gold quality
epithelium of bronchus	UBERON:0002031	91.35	gold quality
adrenal cortex	UBERON:0001235	91.27	gold quality
duodenum	UBERON:0002114	90.64	gold quality
bronchus	UBERON:0002185	90.22	gold quality
adrenal gland	UBERON:0002369	90.13	gold quality
kidney epithelium	UBERON:0004819	89.96	gold quality
right uterine tube	UBERON:0001302	89.89	gold quality
right lobe of liver	UBERON:0001114	89.79	gold quality
adult mammalian kidney	UBERON:0000082	89.34	gold quality
liver	UBERON:0002107	89.06	gold quality
renal glomerulus	UBERON:0000074	88.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.63	gold quality
metanephric glomerulus	UBERON:0004736	88.16	gold quality
adenohypophysis	UBERON:0002196	87.06	gold quality
kidney	UBERON:0002113	86.37	gold quality
amniotic fluid	UBERON:0000173	85.79	gold quality
cortex of kidney	UBERON:0001225	85.70	gold quality
mucosa of transverse colon	UBERON:0004991	85.21	gold quality
endothelial cell	CL:0000115	85.06	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.93	gold quality
pituitary gland	UBERON:0000007	84.92	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.79	gold quality
ileal mucosa	UBERON:0000331	84.51	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93
E-MTAB-7303	no	120.81

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting RBKS, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-6744-5P	99.93	66.82	748
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-LET-7A-2-3P	99.87	70.53	1921
HSA-LET-7G-3P	99.85	70.43	1929
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-518A-5P	99.70	69.01	2209
HSA-MIR-527	99.70	69.01	2209
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-1915-3P	99.58	66.79	1988
HSA-MIR-105-5P	99.54	69.24	2060
HSA-MIR-7853-5P	99.54	69.30	2055
HSA-MIR-511-5P	98.97	70.94	2268
HSA-MIR-655-5P	98.74	65.93	888
HSA-MIR-6840-3P	98.68	65.95	1923
HSA-MIR-5011-3P	98.63	64.81	638
HSA-MIR-4726-3P	98.49	63.89	1385
HSA-MIR-4511	98.32	67.97	1500
HSA-MIR-7843-3P	98.31	67.94	803
HSA-MIR-3129-3P	97.85	67.63	1246
HSA-MIR-5583-5P	97.85	67.61	1243
HSA-MIR-15B-3P	97.85	66.68	974
HSA-MIR-127-5P	97.78	67.64	869
HSA-MIR-3131	95.33	65.74	102

Literature-anchored findings (GeneRIF, showing 2)

• Identification and characterization of human ribokinase. (PMID:17585908)
• Asn199 and Glu202 play an important role in the regulation of human ribokinase activity. (PMID:25749547)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	rbks	ENSDARG00000019877
mus_musculus	Rbks	ENSMUSG00000029136
rattus_norvegicus	Rbks	ENSRNOG00000004710
drosophila_melanogaster	CG13369	FBGN0025640
drosophila_melanogaster	CG17010	FBGN0032424
caenorhabditis_elegans		WBGENE00008548

Paralogs (3): KHK (ENSG00000138030), ADK (ENSG00000156110), TMEM256 (ENSG00000205544)

Protein

Protein identifiers

Ribokinase — Q9H477 (reviewed: Q9H477)

All UniProt accessions (4): E7EQ18, E9PBU0, Q9H477, H7C091

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.

Subunit / interactions. Homodimer.

Subcellular location. Cytoplasm. Nucleus.

Activity regulation. Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity. Competitively inhibited by phosphonoacetic acid, etidronate, 2-carboxethylphosphonic acid, N-(phosphonomethyl)glycine, N-(phosphonomethyl)iminodiacetic acid and clodronate.

Cofactor. Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

Pathway. Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.

Similarity. Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H477-1	1	yes
Q9H477-2	2

RefSeq proteins (2): NP_001274509, NP_071411* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002139	Ribo/fructo_kinase	Family
IPR002173	Carboh/pur_kinase_PfkB_CS	Conserved_site
IPR011611	PfkB_dom	Domain
IPR011877	Ribokinase	Family
IPR029056	Ribokinase-like	Homologous_superfamily

Pfam: PF00294

Enzyme classification (BRENDA):

• EC 2.7.1.15 — ribokinase (BRENDA: 22 organisms, 28 substrates, 30 inhibitors, 41 Km, 15 kcat entries)

Substrate kinetics (BRENDA)

4 substrates with measured Km, best-characterized 4. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
D-RIBOSE	0.022–2	22
ATP	0.029–7.48	14
2-DEOXY-D-RIBOSE	0.035–1.8	4
2-DEOXY-D-RIBITOL	33.3	1

Catalyzed reactions (Rhea), 1 shown:

• D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+) (RHEA:13697)

UniProt features (51 total): strand 16, binding site 15, helix 15, chain 1, active site 1, splice variant 1, sequence conflict 1, turn 1

Structure

Experimental structures (PDB)

14 structures.

PDB	Method	Resolution (Å)
9CVB	X-RAY DIFFRACTION	1.45
9CWU	X-RAY DIFFRACTION	1.45
5C40	X-RAY DIFFRACTION	1.5
9CVA	X-RAY DIFFRACTION	1.6
5BYE	X-RAY DIFFRACTION	1.75
6WJZ	X-RAY DIFFRACTION	1.8
5C3Z	X-RAY DIFFRACTION	1.9
5BYC	X-RAY DIFFRACTION	1.95
5C41	X-RAY DIFFRACTION	1.95
5BYF	X-RAY DIFFRACTION	2
6WK0	X-RAY DIFFRACTION	2
2FV7	X-RAY DIFFRACTION	2.1
5BYD	X-RAY DIFFRACTION	2.1
5C3Y	X-RAY DIFFRACTION	2.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H477-F1	94.83	0.95

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 269 (proton acceptor)

Ligand- & substrate-binding residues (15): 268–269; 269; 295; 301; 304; 306; 310; 25–27; 53–57; 154; 199; 235–240 …

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-71336	Pentose phosphate pathway

MSigDB gene sets: 175 (showing top): ATF_B, MULLIGHAN_NPM1_SIGNATURE_3_UP, GOBP_NADPPLUS_METABOLIC_PROCESS, GOBP_MONOSACCHARIDE_CATABOLIC_PROCESS, GOBP_CARBOHYDRATE_PHOSPHORYLATION, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, LUCAS_HNF4A_TARGETS_UP, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_GLUCOSE_6_PHOSPHATE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, ROSS_LEUKEMIA_WITH_MLL_FUSIONS, ATF1_Q6, GOBP_CARBOHYDRATE_METABOLIC_PROCESS, LASTOWSKA_COAMPLIFIED_WITH_MYCN

GO Biological Process (6): pentose-phosphate shunt (GO:0006098), D-ribose catabolic process (GO:0019303), D-ribose metabolic process (GO:0006014), phosphate-containing compound metabolic process (GO:0006796), small molecule metabolic process (GO:0044281), carbohydrate phosphorylation (GO:0046835)

GO Molecular Function (8): ribokinase activity (GO:0004747), ATP binding (GO:0005524), identical protein binding (GO:0042802), metal ion binding (GO:0046872), nucleotide binding (GO:0000166), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (3): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Metabolism of carbohydrates and carbohydrate derivatives	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metabolic process	2
cellular anatomical structure	2
NADPH regeneration	1
pentose-phosphate shunt, oxidative branch	1
pentose-phosphate shunt, non-oxidative branch	1
glucose 6-phosphate metabolic process	1
D-ribose metabolic process	1
pentose catabolic process	1
pentose metabolic process	1
carbohydrate metabolic process	1
phosphorylation	1
phosphotransferase activity, alcohol group as acceptor	1
carbohydrate kinase activity	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
protein binding	1
cation binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

2052 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
RBKS	RPIA	P49247	704
RBKS	MGAM	O43451	702
RBKS	SI	P14410	673
RBKS	CSDC2	Q9Y534	654
RBKS	RPE	Q96AT9	600
RBKS	TALDO1	P37837	594
RBKS	H6PD	O95479	593
RBKS	DERA	Q9Y315	593
RBKS	ADK	P55263	591
RBKS	XYLB	O75191	577
RBKS	GALE	Q14376	577
RBKS	ADSL	P30566	572
RBKS	PRPS1L1	P21108	566
RBKS	TKT	P29401	566
RBKS	PGD	P52209	556

IntAct

17 interactions, top by confidence:

A	B	Type	Score
RBKS	RBKS	psi-mi:“MI:0915”(physical association)	0.670
RBKS	NSF	psi-mi:“MI:0915”(physical association)	0.560
GPR173	CBX6	psi-mi:“MI:0914”(association)	0.560
RBKS	NSF	psi-mi:“MI:0914”(association)	0.560
RBKS	ACD	psi-mi:“MI:0915”(physical association)	0.510
POT1	RBKS	psi-mi:“MI:0915”(physical association)	0.370
Kctd5		psi-mi:“MI:0914”(association)	0.350
Hax1	DERL1	psi-mi:“MI:0914”(association)	0.350
Magoh	TRAPPC13	psi-mi:“MI:0914”(association)	0.350
ATL3	SNX14	psi-mi:“MI:0914”(association)	0.350
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
RBKS	RPS4Y1	psi-mi:“MI:0914”(association)	0.350
ACD	RBKS	psi-mi:“MI:0915”(physical association)	0.000
RBKS	RBKS	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (26): NSF (Affinity Capture-MS), ZADH2 (Affinity Capture-MS), PHPT1 (Co-fractionation), RPE (Co-fractionation), RBKS (Affinity Capture-MS), RBKS (Affinity Capture-MS), RBKS (Affinity Capture-MS), RBKS (Affinity Capture-MS), NSF (Affinity Capture-MS), RBKS (Two-hybrid), RBKS (Affinity Capture-MS), RPS4Y1 (Affinity Capture-MS), RBKS (Affinity Capture-MS), ZADH2 (Affinity Capture-MS), NAPA (Affinity Capture-MS)

ESM2 similar proteins: A0A6N3IN21, A3KCL7, A6QQF5, B0BNC9, O35678, O75911, O77769, O88876, O97764, P00333, P05336, P11415, P14673, P14674, P14675, P17648, P28032, P47199, P50336, Q08257, Q0MVN8, Q0P5F9, Q28452, Q28GQ2, Q2R8Z5, Q3MIE4, Q3UGR5, Q3UNZ8, Q5BJJ5, Q5R4B4, Q5R4S7, Q60HD5, Q62465, Q6AYR6, Q6AYT0, Q75ZX4, Q80TB8, Q8LEB2, Q8R1Q9, Q8R238

Diamond homologs: A0A0H2WZY4, A1A6H3, B5EEZ1, E9AD19, O60116, P0A9J6, P0A9J7, P0DX97, P36945, P44331, P83534, Q54UQ4, Q55EK9, Q7CPF5, Q8R1Q9, Q9CF42, Q9H477, Q9K6K1, A7GZF6, A7H2L7, A8FMK8, O14242, O49923, P0AEW9, P0AEX0, P0AEX1, P0AEX2, Q5HTW1, Q5JEK6, Q6TG09, Q9SX54, P25332, P45416, A1RGD1, A2WXV8, A4Y9Z9, A4YYB6, A5EN78, A5W9W6, A6VDB5

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
RBKS	“down-regulates quantity”	D-ribofuranose	“chemical modification”
RBKS	“up-regulates quantity”	“D-ribofuranose 5-phosphate(2-)”	“chemical modification”

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	33
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2263 predictions. Top by Δscore:

Variant	Effect	Δscore
2:27781666:T:TA	donor_gain	1.0000
2:27781685:A:AC	donor_gain	1.0000
2:27781686:C:CC	donor_gain	1.0000
2:27781686:CTG:C	donor_gain	1.0000
2:27827565:A:AC	donor_gain	1.0000
2:27827566:C:CC	donor_gain	1.0000
2:27827752:CAGC:C	acceptor_gain	1.0000
2:27827756:C:CC	acceptor_gain	1.0000
2:27832680:CCTTA:C	donor_loss	1.0000
2:27832681:CTTAC:C	donor_loss	1.0000
2:27832683:TACCT:T	donor_loss	1.0000
2:27832685:CCTCA:C	donor_gain	1.0000
2:27832773:TTTCA:T	acceptor_gain	1.0000
2:27832774:TTCA:T	acceptor_gain	1.0000
2:27832775:TCA:T	acceptor_gain	1.0000
2:27832776:CA:C	acceptor_gain	1.0000
2:27832776:CAC:C	acceptor_gain	1.0000
2:27832776:CACTA:C	acceptor_loss	1.0000
2:27832778:C:CC	acceptor_gain	1.0000
2:27832781:C:CT	acceptor_gain	1.0000
2:27843062:ATTAC:A	donor_loss	1.0000
2:27843063:TTAC:T	donor_loss	1.0000
2:27843064:TA:T	donor_loss	1.0000
2:27843065:A:AT	donor_loss	1.0000
2:27843227:CTGGC:C	acceptor_gain	1.0000
2:27847037:CTTA:C	donor_loss	1.0000
2:27847038:TTA:T	donor_loss	1.0000
2:27847039:TA:T	donor_loss	1.0000
2:27847040:A:AC	donor_gain	1.0000
2:27847040:AC:A	donor_gain	1.0000

AlphaMissense

2093 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:27781778:T:A	D269V	0.999
2:27858500:T:A	K54I	0.999
2:27781778:T:G	D269A	0.998
2:27781778:T:C	D269G	0.997
2:27781779:C:G	D269H	0.997
2:27847059:A:T	I111K	0.997
2:27858470:C:G	R64P	0.997
2:27858499:T:A	K54N	0.997
2:27858499:T:G	K54N	0.997
2:27781774:G:C	S270R	0.996
2:27781774:G:T	S270R	0.996
2:27781776:T:G	S270R	0.996
2:27781777:G:C	D269E	0.996
2:27781777:G:T	D269E	0.996
2:27847065:G:T	A109D	0.995
2:27858500:T:G	K54T	0.995
2:27858501:T:G	K54Q	0.995
2:27890263:A:G	L28P	0.995
2:27827755:C:G	A203P	0.994
2:27847059:A:C	I111R	0.993
2:27858484:A:C	C59W	0.993
2:27858490:G:C	N57K	0.993
2:27858490:G:T	N57K	0.993
2:27858506:C:T	G52E	0.993
2:27781766:C:T	G273E	0.992
2:27781787:C:T	G266D	0.992
2:27843224:A:C	N119K	0.992
2:27843224:A:T	N119K	0.992
2:27848078:C:T	G81D	0.992
2:27858501:T:C	K54E	0.992

dbSNP variants (sampled 300 via entrez): RS1000005908 (2:27855259 G>A), RS1000021092 (2:27834215 C>T), RS1000021341 (2:27783714 C>A,G,T), RS1000070815 (2:27831821 G>A), RS1000119720 (2:27812425 T>C), RS1000139319 (2:27857313 A>G), RS1000145104 (2:27877676 T>A), RS1000150176 (2:27891731 C>T), RS1000186332 (2:27790829 C>A), RS1000186991 (2:27856996 T>C,G), RS1000195149 (2:27812794 C>T), RS1000239653 (2:27862543 T>C), RS1000255600 (2:27802656 C>T), RS1000264239 (2:27849277 T>G), RS1000355318 (2:27869508 C>T)

Disease associations

OMIM: gene MIM:611132 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST003048_130	Schizophrenia	4.000000e-08
GCST004946_111	Schizophrenia	3.000000e-08
GCST005986_3	Blood urea nitrogen levels	4.000000e-08
GCST005994_18	Hematocrit	8.000000e-09
GCST006409_8	Allergic rhinitis	7.000000e-13
GCST006479_145	Diverticular disease	5.000000e-08
GCST007201_17	Schizophrenia	5.000000e-08
GCST007201_340	Schizophrenia	1.000000e-06
GCST008062_78	Blood urea nitrogen levels	5.000000e-13
GCST008103_38	Bipolar disorder	1.000000e-07
GCST009391_1338	Metabolite levels	3.000000e-06
GCST009600_107	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	8.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004348	hematocrit
EFO:0009959	diverticular disease
EFO:0010362	lysophosphatidylcholine 20:3 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	increases expression, decreases expression, affects expression, increases abundance	5
Benzo(a)pyrene	decreases expression, increases expression	4
Aflatoxin B1	decreases expression, decreases methylation, affects expression	3
bisphenol A	decreases expression, decreases methylation	2
Acetaminophen	decreases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
quercitrin	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
afimoxifene	decreases response to substance	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
aflatoxin B2	decreases methylation	1
dinophysistoxin 1	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
bisphenol AF	decreases expression	1
Rosiglitazone	increases expression	1
Sunitinib	increases expression	1
Amiodarone	increases expression	1
Coal	decreases expression, increases abundance	1
Estradiol	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ozone	affects expression, increases abundance	1
Quercetin	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
Isotretinoin	decreases expression	1

Cellosaurus cell lines

5 cell lines: 5 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_E0WQ	Ubigene K-562 RBKS KO	Cancer cell line	Female
CVCL_TI63	HAP1 RBKS (-) 1	Cancer cell line	Male
CVCL_XS15	HAP1 RBKS (-) 2	Cancer cell line	Male
CVCL_XS16	HAP1 RBKS (-) 3	Cancer cell line	Male
CVCL_XS17	HAP1 RBKS (-) 4	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.